{"id":"https://openalex.org/W4243498837","doi":"https://doi.org/10.1097/00007890-199806270-00144","title":"IN VIVO MIGRATION AND SURVIVAL OF DONOR-DERIVED DENDRITIC CELL PROGENITORS GENETICALLY MODIFIED USING AN ADENOVIRAL VECTOR ENCODING cDNA FOR TGFB1","display_name":"IN VIVO MIGRATION AND SURVIVAL OF DONOR-DERIVED DENDRITIC CELL PROGENITORS GENETICALLY MODIFIED USING AN ADENOVIRAL VECTOR ENCODING cDNA FOR TGFB1","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W4243498837","doi":"https://doi.org/10.1097/00007890-199806270-00144"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-199806270-00144","doi":"https://doi.org/10.1097/00007890-199806270-00144","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199806270-00144","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113798954","display_name":"Cui-ping Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cui-ping Zhong","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009160972","display_name":"Wei-Cheng Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-Cheng Lee","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100964144","display_name":"Shiguang Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shiguang Qian","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100514334","display_name":"Zhibao Mi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhibao Mi","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040467127","display_name":"Paul D. Robbins","orcid":"https://orcid.org/0000-0003-1068-7099","observed_orcids":["https://orcid.org/0000-0003-1068-7099"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul D. Robbins","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100563871","display_name":"Lina Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lina Lu","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069651723","display_name":"Angus W. Thomson","orcid":"https://orcid.org/0000-0001-6731-8871","observed_orcids":["https://orcid.org/0000-0001-6731-8871"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angus W. Thomson","raw_affiliation_strings":["","Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Thomas E. Starzl Transplantation Institute, and Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":0.1172,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.48668169,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"65","issue":"12","first_page":"S34","last_page":"S34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.035599999129772186,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8270000219345093},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.8169999718666077},{"id":"https://openalex.org/keywords/bone-marrow-derived-dendritic-cells","display_name":"bone marrow-derived dendritic cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/dendritic-cell-migration","display_name":"dendritic cell migration","score":0.7139999866485596},{"id":"https://openalex.org/keywords/dendritic-cell-survival","display_name":"dendritic cell survival","score":0.9700000286102295},{"id":"https://openalex.org/keywords/allograft-tolerance","display_name":"allograft tolerance","score":0.7620000243186951},{"id":"https://openalex.org/keywords/cardiac-allograft-survival","display_name":"cardiac allograft survival","score":0.7260000109672546},{"id":"https://openalex.org/keywords/mhc-class-ii","display_name":"MHC class II","score":0.6330000162124634},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.699999988079071},{"id":"https://openalex.org/keywords/allogeneic-transplantation","display_name":"allogeneic transplantation","score":0.6809999942779541},{"id":"https://openalex.org/keywords/gene-transduction","display_name":"gene transduction","score":0.3149999976158142},{"id":"https://openalex.org/keywords/lymph-node-homing","display_name":"lymph node homing","score":0.4390000104904175},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.5768497586250305},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.5613989233970642},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.5295454263687134},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5216941237449646},{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.4810778796672821},{"id":"https://openalex.org/C147969180","wikidata":"https://www.wikidata.org/wiki/Q5014579","display_name":"CTL*","level":4,"score":0.4798264503479004},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.47067791223526},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.46531084179878235},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4589378237724304},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44803664088249207},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.4330156445503235},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4284842014312744},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.4195195138454437},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.33764660358428955},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3062194287776947},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.24885550141334534},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.24621301889419556},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.24101978540420532},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.18655413389205933},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17258423566818237},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.1423514485359192},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08389782905578613},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/00007890-199806270-00144","doi":"https://doi.org/10.1097/00007890-199806270-00144","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-199806270-00144","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.979200005531311,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2131981600","https://openalex.org/W2089394046","https://openalex.org/W4236676198","https://openalex.org/W2167710847","https://openalex.org/W4232678812","https://openalex.org/W1970978600","https://openalex.org/W2031817202","https://openalex.org/W4243528886","https://openalex.org/W2052143222","https://openalex.org/W2380903657"],"abstract_inverted_index":{"125":[0],"Administration":[1],"of":[2,39,52,70,79,95,104,134,165,174,210,225,238,243,261,280,284,292,305,317,355],"mouse":[3,30,330],"donor":[4,44],"bone":[5],"marrow":[6],"(BM)-derived":[7],"DC":[8,81,96,112,167,194,272,293,306,333,359],"propagated":[9],"in":[10,47,82,90,198,234,247,275,307,315,320],"GM-CSF":[11],"and":[12,21,43,77,98,147,149,153,158,221,230,250,344],"TGF\u03b21":[13,125,281,339],"(\"TGF\u03b2":[14],"DC\")":[15],"that":[16,266],"are":[17,87],"MHC":[18],"class":[19],"II+,":[20],"costimulatory":[22],"molecule":[23],"(CD40,":[24],"CD80,":[25],"CD86)":[26],"deficient,":[27],"can":[28,270,334],"prolong":[29],"heart":[31],"allograft":[32,105],"survival.":[33],"This":[34],"is":[35],"associated":[36],"with":[37,72,114,160,178,187,259,325,365],"inhibition":[38],"anti-donor":[40],"CTL":[41],"activity":[42],"leukocyte":[45],"microchimerism":[46],"the":[48,63,68,75,92,171,208,216,219,235,241,290,302,312,346],"recipients.":[49,84,200,277],"Genetic":[50],"modification":[51],"these":[53],"cells":[54,177,203,245,319],"to":[55,102,337,361],"overexpress":[56],"TGF\u03b2":[57,80,111,332,356],"may":[58],"potentiate":[59],"their":[60],"tolerogenicity.":[61],"In":[62,328],"present":[64],"study,":[65],"we":[66],"evaluated":[67],"influences":[69],"transduction":[71,268,283],"Ad-TGF\u03b21":[73,190,285],"on":[74,142],"migration":[76,195,348],"survival":[78],"allogeneic":[83,276],"Such":[85],"studies":[86],"important":[88],"both":[89,248],"understanding":[91],"underlying":[93],"mechanisms":[94],"tolerogenicity":[97],"as":[99,309,351],"an":[100,341],"approach":[101],"therapy":[103],"rejection.":[106],"5\u00d7105":[107],"B10":[108,166],"(H-25)":[109],"BM-derived":[110,331],"transduced":[113,336,358],"replication-deficient":[115],"Ad":[116,267,297],"vectors":[117],"encoding":[118],"genes":[119],"for":[120],"LacZ":[121,368],"(reporter":[122],"gene)":[123],"or":[124,189,196,367],"at":[126,214,228,252,322],"50":[127],"MOI":[128],"were":[129,140,168,204,231],"injected":[130],"into":[131,218],"one":[132],"footpad":[133],"C3H":[135,199],"(H-2k)":[136],"mice.":[137],"The":[138,163],"mice":[139],"sacrificed":[141],"days":[143],"1,":[144],"2,":[145],"7,":[146],"14,":[148],"spleens,":[150],"thymuses,":[151],"popliteal":[152,211],"mesenteric":[154],"lymph":[155],"nodes":[156],"removed":[157],"stained":[159],"anti-IAb":[161],"mAb.":[162],"incidences":[164],"determined":[169],"by":[170,282,296,311],"mean":[172],"number":[173,316],"IAb":[175],"positive":[176],"dendriform":[179],"morphology":[180],"per":[181],"low":[182],"power":[183],"field":[184],"(\u00d710).":[185],"Transduction":[186,237],"Ad-LacZ":[188,239],"did":[191],"not":[192,286],"affect":[193,271],"distribution":[197],"i.e.":[201],"IAb+":[202,244,318],"first":[205],"observed":[206],"under":[207],"capsule":[209],"LN":[212,249],"(peak":[213,227],"d1),":[215],"migrated":[217],"marginal":[220],"T":[222],"dependent":[223],"area":[224],"spleens":[226,251],"d7),":[229],"found":[232],"occasionally":[233],"thymus.":[236],"reduced":[240],"numbers":[242,294],"identified":[246],"all":[253],"time":[254],"points":[255],"post":[256],"injection,":[257],"compared":[258,324,364],"injection":[260],"unmodified":[262,352,366],"control":[263,326],"DC,":[264],"suggesting":[265],"itself":[269],"life":[273,303],"span":[274,304],"Interestingly,":[278],"overexpression":[279],"only":[287],"fully":[288],"reversed":[289],"reduction":[291],"induced":[295],"transduction,":[298],"but":[299],"also":[300],"prolonged":[301],"spleen,":[308],"shown":[310],"2-fold":[313],"increase":[314],"spleen":[321],"d14":[323],"DC.":[327,353,370],"conclusion,":[329],"be":[335,362],"express":[338],"using":[340],"adenoviral":[342],"vector,":[343],"exhibit":[345],"same":[347],"characteristicsin":[349],"vivo":[350],"Survival":[354],"gene":[357],"appears":[360],"enhanced":[363],"gene-transduced":[369]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}