{"id":"https://openalex.org/W4243436331","doi":"https://doi.org/10.1007/s12020-008-9116-4","title":"Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hypothyroidism","display_name":"Increased thrombin-activatable fibrinolysis inhibitor and decreased tissue factor pathway inhibitor in patients with hypothyroidism","publication_year":2008,"publication_date":"2008-10-28","ids":{"openalex":"https://openalex.org/W4243436331","doi":"https://doi.org/10.1007/s12020-008-9116-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/18958631"},"language":"en","primary_location":{"id":"doi:10.1007/s12020-008-9116-4","doi":"https://doi.org/10.1007/s12020-008-9116-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12020-008-9116-4","pdf_url":null,"source":{"id":"https://openalex.org/S194842327","display_name":"Endocrine","issn_l":"0969-711X","issn":["0969-711X","1355-008X","1559-0100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W4243436331"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109109219","display_name":"Cihangir Erem","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Cihangir Erem","raw_affiliation_strings":["Department of Internal Medicine, Karadeniz Technical University, 61080, Trabzon, Turkey. cihangirerem@hotmail.com","Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Karadeniz Technical University, 61080, Trabzon, Turkey. cihangirerem@hotmail.com","institution_ids":["https://openalex.org/I162720556"]},{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089089679","display_name":"\u00d6zge \u00dc\u00e7\u00fcnc\u00fc","orcid":"https://orcid.org/0000-0003-4658-7778","observed_orcids":["https://orcid.org/0000-0003-4658-7778"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ozge Ucuncu","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101512650","display_name":"Mustafa Y\u0131lmaz","orcid":"https://orcid.org/0000-0003-3320-108X","observed_orcids":["https://orcid.org/0000-0003-3320-108X"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Yilmaz","raw_affiliation_strings":["Division of Hematology, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011152330","display_name":"Mustafa Ko\u00e7ak","orcid":"https://orcid.org/0000-0002-8269-2869","observed_orcids":["https://orcid.org/0000-0002-8269-2869","https://orcid.org/0000-0003-3092-0601"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Kocak","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050558976","display_name":"\u0130rfan Nuho\u011flu","orcid":"https://orcid.org/0000-0003-0650-3242","observed_orcids":["https://orcid.org/0000-0003-0650-3242"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"\u0130rfan Nuhoglu","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008804868","display_name":"Halil \u00d6nder Ers\u00f6z","orcid":"https://orcid.org/0000-0001-7157-1116","observed_orcids":["https://orcid.org/0000-0001-7157-1116"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Halil Onder Ersoz","raw_affiliation_strings":["Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, 61080, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109109219"],"corresponding_institution_ids":["https://openalex.org/I162720556"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":null,"fwci":1.0619,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.78073428,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"35","issue":"1","first_page":"75","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.7554000020027161,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.17720000445842743,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation","score":0.05620000138878822,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypothyroidism","display_name":"hypothyroidism","score":1.0},{"id":"https://openalex.org/keywords/thrombin-activatable-fibrinolysis-inhibitor","display_name":"thrombin-activatable fibrinolysis inhibitor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/tissue-factor-pathway-inhibitor","display_name":"tissue factor pathway inhibitor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/coagulation-fibrinolysis-system","display_name":"coagulation-fibrinolysis system","score":0.902999997138977},{"id":"https://openalex.org/keywords/hemostasis","display_name":"hemostasis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hypercoagulability","display_name":"hypercoagulability","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hypofibrinolysis","display_name":"hypofibrinolysis","score":0.9819999933242798},{"id":"https://openalex.org/keywords/factor-vii-activity","display_name":"factor VII activity","score":0.7549999952316284},{"id":"https://openalex.org/keywords/thrombomodulin","display_name":"thrombomodulin","score":0.9390000104904175},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/protein-c","display_name":"protein C","score":0.8519999980926514},{"id":"https://openalex.org/keywords/protein-s","display_name":"protein S","score":0.9909999966621399},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.9390000104904175},{"id":"https://openalex.org/keywords/atherothrombotic-risk","display_name":"atherothrombotic risk","score":0.7210000157356262},{"id":"https://openalex.org/keywords/cardiovascular-mortality","display_name":"cardiovascular mortality","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2777151630","wikidata":"https://www.wikidata.org/wiki/Q14878075","display_name":"Tissue factor pathway inhibitor","level":4,"score":0.9264923334121704},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7854411602020264},{"id":"https://openalex.org/C201267052","wikidata":"https://www.wikidata.org/wiki/Q414446","display_name":"Thrombomodulin","level":4,"score":0.7784711122512817},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.6966127157211304},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6936620473861694},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6918492317199707},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.6886368989944458},{"id":"https://openalex.org/C2778589496","wikidata":"https://www.wikidata.org/wiki/Q487937","display_name":"Hemostasis","level":2,"score":0.677236795425415},{"id":"https://openalex.org/C2781287897","wikidata":"https://www.wikidata.org/wiki/Q412810","display_name":"Protein C","level":2,"score":0.6139140129089355},{"id":"https://openalex.org/C2776135265","wikidata":"https://www.wikidata.org/wiki/Q419774","display_name":"Protein S","level":3,"score":0.5682075619697571},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.545940637588501},{"id":"https://openalex.org/C2780930249","wikidata":"https://www.wikidata.org/wiki/Q412850","display_name":"Factor VII","level":3,"score":0.5282639265060425},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.5033847689628601},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.44378402829170227},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.07174021005630493}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001778","descriptor_name":"Blood Coagulation Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001778","descriptor_name":"Blood Coagulation Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006490","descriptor_name":"Hemostatics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018180","descriptor_name":"Thrombomodulin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D025901","descriptor_name":"Carboxypeptidase B2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12020-008-9116-4","doi":"https://doi.org/10.1007/s12020-008-9116-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12020-008-9116-4","pdf_url":null,"source":{"id":"https://openalex.org/S194842327","display_name":"Endocrine","issn_l":"0969-711X","issn":["0969-711X","1355-008X","1559-0100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine","raw_type":"journal-article"},{"id":"pmid:18958631","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18958631","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W108981421","https://openalex.org/W255436070","https://openalex.org/W1492470062","https://openalex.org/W1962851023","https://openalex.org/W1968099177","https://openalex.org/W1976178291","https://openalex.org/W1977497608","https://openalex.org/W1978049330","https://openalex.org/W1979250813","https://openalex.org/W1982079463","https://openalex.org/W1984322179","https://openalex.org/W1994639903","https://openalex.org/W1997487978","https://openalex.org/W2005134321","https://openalex.org/W2018193812","https://openalex.org/W2024681580","https://openalex.org/W2047122524","https://openalex.org/W2055107165","https://openalex.org/W2055259131","https://openalex.org/W2059415529","https://openalex.org/W2060268628","https://openalex.org/W2062692004","https://openalex.org/W2066654051","https://openalex.org/W2073549933","https://openalex.org/W2076115123","https://openalex.org/W2079175463","https://openalex.org/W2080861502","https://openalex.org/W2081377369","https://openalex.org/W2084124265","https://openalex.org/W2091957377","https://openalex.org/W2093790788","https://openalex.org/W2098076038","https://openalex.org/W2101174143","https://openalex.org/W2107137688","https://openalex.org/W2111454506","https://openalex.org/W2118229583","https://openalex.org/W2129362137","https://openalex.org/W2129985458","https://openalex.org/W2132557987","https://openalex.org/W2133640678","https://openalex.org/W2136112480","https://openalex.org/W2143948102","https://openalex.org/W2164313235","https://openalex.org/W2168477209","https://openalex.org/W2252311862","https://openalex.org/W2412293557","https://openalex.org/W2428352015","https://openalex.org/W2461906590","https://openalex.org/W2471645094","https://openalex.org/W2472530317","https://openalex.org/W2789714332","https://openalex.org/W4250512610"],"related_works":["https://openalex.org/W2031468645","https://openalex.org/W108981421","https://openalex.org/W2066774028","https://openalex.org/W1974634847","https://openalex.org/W1981729696","https://openalex.org/W2059415529","https://openalex.org/W1899571140","https://openalex.org/W2091573750","https://openalex.org/W7203580353","https://openalex.org/W1994639903"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-05-12T00:00:00"}