{"id":"https://openalex.org/W4243383806","doi":"https://doi.org/10.1016/s0248-4900(99)80071-9","title":"Ultrastructural changes in the Golgi apparatus and secretory granules of HL-60 cells treated with the imino sugar N-butyldeoxynojirimycin","display_name":"Ultrastructural changes in the Golgi apparatus and secretory granules of HL-60 cells treated with the imino sugar N-butyldeoxynojirimycin","publication_year":1997,"publication_date":"1997-05-01","ids":{"openalex":"https://openalex.org/W4243383806","doi":"https://doi.org/10.1016/s0248-4900(99)80071-9","mag":"2170135228","pmid":"https://pubmed.ncbi.nlm.nih.gov/9351192"},"language":"en","primary_location":{"id":"doi:10.1016/s0248-4900(99)80071-9","doi":"https://doi.org/10.1016/s0248-4900(99)80071-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0248-4900(99)80071-9","pdf_url":null,"source":{"id":"https://openalex.org/S91329243","display_name":"Biology of the Cell","issn_l":"0248-4900","issn":["0248-4900","1768-322X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of the Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031893261","display_name":"Gabrielle R. Neises","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"G Neises","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5031893261"],"corresponding_institution_ids":[],"apc_list":{"value":3730,"currency":"USD","value_usd":3730},"apc_paid":null,"fwci":0.1985,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.46112082,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"89","issue":"2","first_page":"123","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.48170000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.48170000314712524,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.45339998602867126,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-butyldeoxynojirimycin","display_name":"N-butyldeoxynojirimycin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/iminosugars","display_name":"iminosugars","score":0.9079999923706055},{"id":"https://openalex.org/keywords/secretory-granules","display_name":"secretory granules","score":0.996999979019165},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9810000061988831},{"id":"https://openalex.org/keywords/n-linked-oligosaccharide-processing","display_name":"N-linked oligosaccharide processing","score":0.8870000243186951},{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibition","display_name":"\u03b1-glucosidase inhibition","score":0.8339999914169312},{"id":"https://openalex.org/keywords/ceramide-glucosyltransferase","display_name":"ceramide glucosyltransferase","score":0.8289999961853027},{"id":"https://openalex.org/keywords/potassium-ferrocyanide","display_name":"potassium ferrocyanide","score":0.8889999985694885},{"id":"https://openalex.org/keywords/golgi-cisternae","display_name":"Golgi cisternae","score":0.800000011920929},{"id":"https://openalex.org/keywords/golgi-vesicles","display_name":"Golgi vesicles","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C119062480","wikidata":"https://www.wikidata.org/wiki/Q83181","display_name":"Golgi apparatus","level":3,"score":0.93021559715271},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8733941316604614},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.8590648174285889},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5965917706489563},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.5785465240478516},{"id":"https://openalex.org/C6492254","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretory pathway","level":4,"score":0.5050776600837708},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3449832797050476},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.22091838717460632},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17319244146347046}],"mesh":[{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003594","descriptor_name":"Cytoplasmic Granules","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005964","descriptor_name":"Glucosyltransferases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006056","descriptor_name":"Golgi Apparatus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017485","descriptor_name":"1-Deoxynojirimycin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D017485","descriptor_name":"1-Deoxynojirimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065089","descriptor_name":"Glycoside Hydrolase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0248-4900(99)80071-9","doi":"https://doi.org/10.1016/s0248-4900(99)80071-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0248-4900(99)80071-9","pdf_url":null,"source":{"id":"https://openalex.org/S91329243","display_name":"Biology of the Cell","issn_l":"0248-4900","issn":["0248-4900","1768-322X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of the Cell","raw_type":"journal-article"},{"id":"pmid:9351192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9351192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology of the cell","raw_type":"Journal Article"},{"id":"mag:2170135228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9351192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W84860847","https://openalex.org/W129763758","https://openalex.org/W282408398","https://openalex.org/W1485152739","https://openalex.org/W1515555384","https://openalex.org/W1516917377","https://openalex.org/W1534517774","https://openalex.org/W1541236883","https://openalex.org/W1565222183","https://openalex.org/W1595759126","https://openalex.org/W1856500711","https://openalex.org/W1970007744","https://openalex.org/W1987775596","https://openalex.org/W1994901740","https://openalex.org/W1996567136","https://openalex.org/W2007673577","https://openalex.org/W2016266703","https://openalex.org/W2029327566","https://openalex.org/W2031370722","https://openalex.org/W2068161396","https://openalex.org/W2115397055","https://openalex.org/W2115864709","https://openalex.org/W2128924784","https://openalex.org/W2137502154","https://openalex.org/W2137535311","https://openalex.org/W2140277678","https://openalex.org/W2141799366","https://openalex.org/W2152704751","https://openalex.org/W2152791827"],"related_works":["https://openalex.org/W3157926797","https://openalex.org/W598451721","https://openalex.org/W4300009671","https://openalex.org/W2471261402","https://openalex.org/W2346373257","https://openalex.org/W2403332412","https://openalex.org/W2035168648","https://openalex.org/W2462450181","https://openalex.org/W147006506","https://openalex.org/W2417585729"],"abstract_inverted_index":{"The":[0,70,136],"imino":[1,54],"sugar":[2,55],"N-butyldeoxynojirimycin":[3],"inhibits":[4],"the":[5,15,21,30,36,62,84,87,124,133,160,169],"N-linked":[6],"oligosaccharide":[7],"processing":[8],"enzymes":[9],"alpha-glucosidases":[10],"I":[11],"and":[12,14,89,106,112,116,154],"II,":[13],"ceramide":[16],"specific":[17],"glucosyltransferase":[18],"which":[19,66],"catalyses":[20],"first":[22],"step":[23],"in":[24,57,68],"glucosphingolipid":[25],"biosynthesis.":[26],"We":[27],"have":[28,119],"studied":[29],"effects":[31],"of":[32,38,45,49,65,83,97,128,152,157,168],"this":[33,46,53],"compound":[34,85],"on":[35,132,166],"ultrastructure":[37],"HL-60":[39,50],"cells":[40,51],"to":[41,86,146],"identify":[42],"novel":[43],"activities":[44],"compound.":[47,170],"Treatment":[48],"with":[52,75],"results":[56],"several":[58],"morphological":[59],"changes":[60,162],"within":[61,78],"cell,":[63],"none":[64],"result":[67],"cytotoxicity.":[69],"plasma":[71],"membrane":[72],"stains":[73],"heavily":[74],"potassium":[76],"ferrocyanide":[77],"30":[79],"min":[80],"following":[81],"addition":[82],"medium,":[88],"there":[90],"is":[91,131],"then":[92],"a":[93,139,147],"time":[94],"dependent":[95],"involvement":[96],"all":[98],"other":[99],"intracellular":[100],"membranes.":[101],"Secretory":[102],"granules":[103],"become":[104],"enlarged":[105],"lose":[107],"their":[108],"dense":[109],"core":[110],"morphology":[111,145],"appear":[113],"either":[114],"empty":[115],"vacuolated":[117],"or":[118],"low":[120],"density":[121],"contents.":[122],"However,":[123],"most":[125],"striking":[126],"effect":[127],"NB-DNJ":[129],"treatment":[130],"Golgi":[134,137,144],"apparatus.":[135],"exhibits":[138],"time-dependent":[140],"change":[141],"from":[142],"typical":[143],"structure":[148],"almost":[149],"completely":[150],"devoid":[151],"cisternae":[153],"consisting":[155],"predominantly":[156],"vesicles.":[158],"All":[159],"observed":[161],"are":[163],"fully":[164],"reversible":[165],"withdrawal":[167]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}