{"id":"https://openalex.org/W4243340539","doi":"https://doi.org/10.1021/la020105a","title":"Temperature Induced Crystallization Transition in Aqueous Solutions of \u03b2-Cyclodextrin, Heptakis(2,6-di-O-methyl)-\u03b2-cyclodextrin (DIMEB), and Heptakis(2,3,6-tri-O-methyl)-\u03b2-cyclodextrin (TRIMEB) Studied by Differential Scanning Calorimetry","display_name":"Temperature Induced Crystallization Transition in Aqueous Solutions of \u03b2-Cyclodextrin, Heptakis(2,6-di-O-methyl)-\u03b2-cyclodextrin (DIMEB), and Heptakis(2,3,6-tri-O-methyl)-\u03b2-cyclodextrin (TRIMEB) Studied by Differential Scanning Calorimetry","publication_year":2002,"publication_date":"2002-07-03","ids":{"openalex":"https://openalex.org/W4243340539","doi":"https://doi.org/10.1021/la020105a"},"language":"en","primary_location":{"id":"doi:10.1021/la020105a","doi":"https://doi.org/10.1021/la020105a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/la020105a","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Joachim Frank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800875726","display_name":"Fritz Haber Institute of the Max Planck Society","ror":"https://ror.org/03k9qs827","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I2800875726"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Joachim Frank","raw_affiliation_strings":["Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, D-14195 Berlin, Germany, and Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin, Takustrasse 6, D-14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, D-14195 Berlin, Germany, and Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin, Takustrasse 6, D-14195 Berlin, Germany","institution_ids":["https://openalex.org/I2800875726","https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109809237","display_name":"Josef F. Holzwarth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800875726","display_name":"Fritz Haber Institute of the Max Planck Society","ror":"https://ror.org/03k9qs827","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I2800875726"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Josef F. Holzwarth","raw_affiliation_strings":["Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, D-14195 Berlin, Germany, and Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin, Takustrasse 6, D-14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, D-14195 Berlin, Germany, and Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin, Takustrasse 6, D-14195 Berlin, Germany","institution_ids":["https://openalex.org/I2800875726","https://openalex.org/I75951250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044758922","display_name":"Wolfram Saenger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800875726","display_name":"Fritz Haber Institute of the Max Planck Society","ror":"https://ror.org/03k9qs827","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I2800875726"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfram Saenger","raw_affiliation_strings":["Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, D-14195 Berlin, Germany, and Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin, Takustrasse 6, D-14195 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fritz-Haber-Institut der Max-Planck-Gesellschaft, Faradayweg 4-6, D-14195 Berlin, Germany, and Institut f\u00fcr Kristallographie, Freie Universit\u00e4t Berlin, Takustrasse 6, D-14195 Berlin, Germany","institution_ids":["https://openalex.org/I2800875726","https://openalex.org/I75951250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2800875726","https://openalex.org/I75951250"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.1544,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.73370726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"18","issue":"16","first_page":"5974","last_page":"5976"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.4909999966621399,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.4909999966621399,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.27219998836517334,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":0.18330000340938568,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-cyclodextrin","display_name":"\u03b2-cyclodextrin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/methylated-cyclodextrins","display_name":"methylated cyclodextrins","score":0.9559999704360962},{"id":"https://openalex.org/keywords/crystallization","display_name":"crystallization","score":0.5440000295639038},{"id":"https://openalex.org/keywords/water-solubility","display_name":"water solubility","score":0.8619999885559082},{"id":"https://openalex.org/keywords/negative-temperature-coefficient","display_name":"negative temperature coefficient","score":0.8259999752044678},{"id":"https://openalex.org/keywords/clathrate-hydrates","display_name":"clathrate hydrates","score":0.7630000114440918},{"id":"https://openalex.org/keywords/anhydrate","display_name":"anhydrate","score":0.7070000171661377},{"id":"https://openalex.org/keywords/monohydrate","display_name":"monohydrate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/enthalpy-of-crystallization","display_name":"crystallization enthalpy","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C203036418","wikidata":"https://www.wikidata.org/wiki/Q284256","display_name":"Crystallization","level":2,"score":0.8387762904167175},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.8112697005271912},{"id":"https://openalex.org/C2779433975","wikidata":"https://www.wikidata.org/wiki/Q40417805","display_name":"Cyclodextrin","level":2,"score":0.7741409540176392},{"id":"https://openalex.org/C3288061","wikidata":"https://www.wikidata.org/wiki/Q161064","display_name":"Enthalpy","level":2,"score":0.7158970832824707},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.6745849847793579},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6377986669540405},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.6097747087478638},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.401674747467041},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.39371803402900696},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.386776328086853},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21199536323547363},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.06156879663467407}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/la020105a","doi":"https://doi.org/10.1021/la020105a","is_oa":false,"landing_page_url":"https://doi.org/10.1021/la020105a","pdf_url":null,"source":{"id":"https://openalex.org/S75741262","display_name":"Langmuir","issn_l":"0743-7463","issn":["0743-7463","1520-5827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Langmuir","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W940951786","https://openalex.org/W2065633781","https://openalex.org/W2072331840","https://openalex.org/W2101287067","https://openalex.org/W2128367206","https://openalex.org/W2951508965","https://openalex.org/W3004982183","https://openalex.org/W4240681501"],"related_works":["https://openalex.org/W1997329413","https://openalex.org/W1774685892","https://openalex.org/W2318209581","https://openalex.org/W2070406363","https://openalex.org/W2009978687","https://openalex.org/W119189767","https://openalex.org/W2004223753","https://openalex.org/W2077767492","https://openalex.org/W2128367206","https://openalex.org/W1681760272"],"abstract_inverted_index":{"Methylated":[0],"cyclodextrins":[1],"were":[2],"investigated":[3],"to":[4,84],"shed":[5],"light":[6],"on":[7],"their":[8],"solubility":[9],"behavior":[10],"in":[11,105],"water":[12,83],"where":[13],"they":[14],"exhibit":[15],"a":[16,70],"negative":[17],"temperature":[18,23,76],"coefficient,":[19],"contrasting":[20],"the":[21,87],"positive":[22,88],"coefficient":[24],"of":[25,42,82],"unmodified":[26],"cyclodextrins.":[27],"Both":[28],"heptakis(2,6-di-":[29],"O":[30,35,108],"-methyl)-\u03b2-cyclodextrin":[31,36],"(DIMEB)":[32],"and":[33,67,109],"heptakis(2,3,6-tri-":[34],"(TRIMEB)":[37],"show":[38],"two":[39],"different":[40],"conditions":[41],"crystallization.":[43],"At":[44],"low":[45],"temperatures":[46,58],"around":[47,59],"18":[48],"\u00b0C,":[49,61],"highly":[50],"hydrated":[51],"clathrates":[52],"are":[53],"formed,":[54],"whereas,":[55],"at":[56,74],"high":[57,75],"60\u221270":[60],"DIMEB":[62],"crystallizes":[63],"as":[64,69,96],"an":[65],"anhydrate":[66],"TRIMEB":[68],"monohydrate.":[71],"The":[72],"crystallization":[73,94],"is":[77],"driven":[78],"by":[79,100],"entropy":[80],"gain":[81],"compensate":[85],"for":[86],"enthalpy":[89],"change":[90],"associated":[91],"with":[92],"this":[93],"process,":[95],"could":[97],"be":[98],"shown":[99],"differential":[101],"scanning":[102],"calorimetry":[103],"experiments":[104],"H":[106],"2":[107,111],"D":[110],"O.":[112]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-05-12T00:00:00"}