{"id":"https://openalex.org/W4243301773","doi":"https://doi.org/10.2176/nmc.31.702","title":"Intraoperative Radiation Therapy for Malignant Glioma","display_name":"Intraoperative Radiation Therapy for Malignant Glioma","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W4243301773","doi":"https://doi.org/10.2176/nmc.31.702","pmid":"https://pubmed.ncbi.nlm.nih.gov/1723157"},"language":"en","primary_location":{"id":"doi:10.2176/nmc.31.702","doi":"https://doi.org/10.2176/nmc.31.702","is_oa":true,"landing_page_url":"https://doi.org/10.2176/nmc.31.702","pdf_url":"https://www.jstage.jst.go.jp/article/nmc1959/31/11/31_11_702/_pdf","source":{"id":"https://openalex.org/S170822592","display_name":"Neurologia medico-chirurgica","issn_l":"0470-8105","issn":["0470-8105","1349-8029"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313358","host_organization_name":"Japan Neurological Society","host_organization_lineage":["https://openalex.org/P4310313358"],"host_organization_lineage_names":["Japan Neurological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia medico-chirurgica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/nmc1959/31/11/31_11_702/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022020363","display_name":"Noboru Sakai","orcid":"https://orcid.org/0000-0003-2166-4343","observed_orcids":["https://orcid.org/0000-0003-2166-4343"]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noboru SAKAI","raw_affiliation_strings":["Departments of Neurosurgery, Gifu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery, Gifu University School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109846792","display_name":"Hiromu Yamada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiromu YAMADA","raw_affiliation_strings":["Departments of Neurosurgery, Gifu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery, Gifu University School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089738889","display_name":"Takashi Andoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi ANDOH","raw_affiliation_strings":["Departments of Neurosurgery, Gifu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery, Gifu University School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Toshifumi HIRATA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshifumi HIRATA","raw_affiliation_strings":["Departments of Neurosurgery, Gifu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery, Gifu University School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113494489","display_name":"Yasuaki Nishimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasuaki NISHIMURA","raw_affiliation_strings":["Departments of Neurosurgery, Gifu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery, Gifu University School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109115078","display_name":"Yoshiaki Miwa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshiaki MIWA","raw_affiliation_strings":["Departments of Neurosurgery, Gifu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery, Gifu University School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052810073","display_name":"Kotoyuki Shimizu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kotoyuki SHIMIZU","raw_affiliation_strings":["Departments of Neurosurgery, Gifu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurosurgery, Gifu University School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112797809","display_name":"Shigeo Yanagawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42405503","display_name":"Gifu University","ror":"https://ror.org/024exxj48","country_code":"JP","type":"education","lineage":["https://openalex.org/I42405503"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeo YANAGAWA","raw_affiliation_strings":["Departments of Radiology, Gifu University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Radiology, Gifu University School of Medicine","institution_ids":["https://openalex.org/I42405503"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I42405503"],"apc_list":{"value":10000,"currency":"JPY","value_usd":75},"apc_paid":null,"fwci":0.2393,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.56404003,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"31","issue":"11","first_page":"702","last_page":"707"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11251","display_name":"Meningioma and schwannoma management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intraoperative-radiotherapy","display_name":"intraoperative radiotherapy","score":0.9890000224113464},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anaplastic-astrocytoma","display_name":"anaplastic astrocytoma","score":0.9869999885559082},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.9520000219345093},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.8510000109672546},{"id":"https://openalex.org/keywords/tumor-resection","display_name":"tumor resection","score":0.746999979019165},{"id":"https://openalex.org/keywords/external-beam-radiotherapy","display_name":"external beam radiotherapy","score":0.5910000205039978},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.492000013589859}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7754515409469604},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.6731817722320557},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.669059157371521},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.45887815952301025},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3330264389514923},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.12315374612808228}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D001254","descriptor_name":"Astrocytoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007430","descriptor_name":"Intraoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015376","descriptor_name":"Nimustine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015993","descriptor_name":"Life Tables","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2176/nmc.31.702","doi":"https://doi.org/10.2176/nmc.31.702","is_oa":true,"landing_page_url":"https://doi.org/10.2176/nmc.31.702","pdf_url":"https://www.jstage.jst.go.jp/article/nmc1959/31/11/31_11_702/_pdf","source":{"id":"https://openalex.org/S170822592","display_name":"Neurologia medico-chirurgica","issn_l":"0470-8105","issn":["0470-8105","1349-8029"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313358","host_organization_name":"Japan Neurological Society","host_organization_lineage":["https://openalex.org/P4310313358"],"host_organization_lineage_names":["Japan Neurological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia medico-chirurgica","raw_type":"journal-article"},{"id":"pmid:1723157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1723157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia medico-chirurgica","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.2176/nmc.31.702","doi":"https://doi.org/10.2176/nmc.31.702","is_oa":true,"landing_page_url":"https://doi.org/10.2176/nmc.31.702","pdf_url":"https://www.jstage.jst.go.jp/article/nmc1959/31/11/31_11_702/_pdf","source":{"id":"https://openalex.org/S170822592","display_name":"Neurologia medico-chirurgica","issn_l":"0470-8105","issn":["0470-8105","1349-8029"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313358","host_organization_name":"Japan Neurological Society","host_organization_lineage":["https://openalex.org/P4310313358"],"host_organization_lineage_names":["Japan Neurological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia medico-chirurgica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4243301773.pdf","grobid_xml":"https://content.openalex.org/works/W4243301773.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1764139259","https://openalex.org/W2411265644","https://openalex.org/W1516004509","https://openalex.org/W2004935126","https://openalex.org/W2012613938","https://openalex.org/W4381193898","https://openalex.org/W2003014168","https://openalex.org/W2005591350","https://openalex.org/W56642676","https://openalex.org/W1968512673"],"abstract_inverted_index":{"Intraoperative":[0],"radiation":[1],"therapy":[2,11],"(IORT)":[3],"was":[4,37,50,130],"used":[5],"as":[6],"part":[7],"of":[8,17,59,69,77,94,133,145,158,176,195],"the":[9,126,146,161],"initial":[10,32,92,154],"for":[12,34,186],"malignant":[13,188],"glioma":[14,189],"in":[15,65,143,160],"32":[16,70],"73":[18],"patients":[19,82,105],"with":[20,44,57,172],"histologically":[21],"verified":[22],"anaplastic":[23],"astrocytoma":[24],"(grade":[25],"III":[26],"astrocytoma)":[27],"and":[28,47,88,96,108,138],"glioblastoma":[29],"multiforme.":[30],"The":[31,80,102,180],"treatment":[33,93],"all":[35],"cases":[36,71,157],"subtotal":[38],"or":[39],"total":[40],"tumor":[41,55,78,170,178,192],"resection":[42],"combined":[43],"external":[45],"irradiation":[46],"chemotherapy.":[48],"IORT":[49,73,81,147,162,183],"performed":[51],"1":[52],"week":[53],"after":[54,91,153],"resection,":[56],"doses":[58],"10-50":[60],"Gy":[61],"(mean":[62],"26.7":[63],"Gy)":[64],"one":[66],"session.":[67],"Fourteen":[68],"had":[72,83,106],"two":[74],"times":[75],"because":[76,132,194],"recurrence.":[79],"survival":[84,99,112],"rates":[85],"at":[86],"24":[87],"36":[89],"months":[90,152],"57.1":[95],"33.5%":[97],"(median":[98,111],"26.2":[100],"months).":[101],"other":[103],"41":[104],"23.6":[107],"13.1%":[109],"survivals":[110],"20.7":[113],"months),":[114],"which":[115],"were":[116],"significantly":[117],"lower":[118],"(p":[119],"less":[120],"than":[121],"0.01).":[122],"Tumor":[123],"recurrence":[124,171],"within":[125],"original":[127],"lesion":[128],"site":[129],"suspected":[131],"clinical":[134],"condition,":[135],"computed":[136],"tomography,":[137],"magnetic":[139],"resonance":[140],"imaging":[141],"studies":[142],"65.6%":[144],"group":[148],"(21":[149],"cases)":[150],"12":[151],"treatment.":[155],"Twenty":[156],"death":[159],"group,":[163],"including":[164,191],"five":[165],"autopsy":[166],"cases,":[167],"demonstrated":[168],"regional":[169],"a":[173],"high":[174],"incidence":[175],"intraventricular":[177],"invasion.":[179],"authors":[181],"consider":[182],"is":[184],"beneficial":[185],"selected":[187],"patients,":[190],"recurrence,":[193],"prolonged":[196],"survival.":[197]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
