{"id":"https://openalex.org/W4243144366","doi":"https://doi.org/10.3410/f.736847409.793567091","title":"Faculty Opinions recommendation of Large-scale analysis of acquired chromosomal alterations in non-tumor samples from patients with cancer.","display_name":"Faculty Opinions recommendation of Large-scale analysis of acquired chromosomal alterations in non-tumor samples from patients with cancer.","publication_year":2019,"publication_date":"2019-11-08","ids":{"openalex":"https://openalex.org/W4243144366","doi":"https://doi.org/10.3410/f.736847409.793567091"},"language":"en","primary_location":{"id":"doi:10.3410/f.736847409.793567091","doi":"https://doi.org/10.3410/f.736847409.793567091","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.736847409.793567091","pdf_url":"https://facultyopinions.com/download/736847409","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://facultyopinions.com/download/736847409","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000317216","display_name":"Alejandro A. Sch\u00e4ffer","orcid":"https://orcid.org/0000-0002-2147-8033","observed_orcids":["https://orcid.org/0000-0002-2147-8033"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alejandro Schaffer","raw_affiliation_strings":["Cancer Data Science Laboratory (CDSL),, National Cancer Institute (NCI), USA"],"raw_orcid":"https://orcid.org/0000-0002-2147-8033","affiliations":[{"raw_affiliation_string":"Cancer Data Science Laboratory (CDSL),, National Cancer Institute (NCI), USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000317216"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatic-copy-number-alterations","display_name":"somatic copy number alterations","score":0.9739999771118164},{"id":"https://openalex.org/keywords/somatic-mosaicism","display_name":"somatic mosaicism","score":0.8560000061988831},{"id":"https://openalex.org/keywords/field-cancerization","display_name":"field cancerization","score":0.8880000114440918},{"id":"https://openalex.org/keywords/clonal-origin","display_name":"clonal origin","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6252975463867188},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.6194074153900146},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5253421664237976},{"id":"https://openalex.org/C60120401","wikidata":"https://www.wikidata.org/wiki/Q17119253","display_name":"Field cancerization","level":3,"score":0.4733978509902954},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4366283714771271},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3304283618927002},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15261417627334595}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.736847409.793567091","doi":"https://doi.org/10.3410/f.736847409.793567091","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.736847409.793567091","pdf_url":"https://facultyopinions.com/download/736847409","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":{"id":"doi:10.3410/f.736847409.793567091","doi":"https://doi.org/10.3410/f.736847409.793567091","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.736847409.793567091","pdf_url":"https://facultyopinions.com/download/736847409","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4446442847","display_name":"Population genetics for large-scale sequencing studies of diverse populations","funder_award_id":"R01HG005855","funder_id":"https://openalex.org/F4320337348","funder_display_name":"National Human Genome Research Institute"},{"id":"https://openalex.org/G8497463034","display_name":"M.D. Anderson Education Program in Cancer Prevention","funder_award_id":"R25CA057730","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332521","display_name":"University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07"},{"id":"https://openalex.org/F4320334350","display_name":"High Performance Research Computing, Texas A and M University","ror":null},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4243144366.pdf","grobid_xml":"https://content.openalex.org/works/W4243144366.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1527347967","https://openalex.org/W1969892080","https://openalex.org/W1984068087","https://openalex.org/W1992826811","https://openalex.org/W2004224646","https://openalex.org/W2016661249","https://openalex.org/W2039732706","https://openalex.org/W2041472888","https://openalex.org/W2065890382","https://openalex.org/W2089091170","https://openalex.org/W2112250552","https://openalex.org/W2117257585","https://openalex.org/W2123176147","https://openalex.org/W2126816979","https://openalex.org/W2133920348","https://openalex.org/W2140968934","https://openalex.org/W2153056550","https://openalex.org/W2168122333","https://openalex.org/W2256016639","https://openalex.org/W2283458346","https://openalex.org/W2288416828","https://openalex.org/W2398928104","https://openalex.org/W2432277981","https://openalex.org/W2568131867","https://openalex.org/W2609243345","https://openalex.org/W2766676715","https://openalex.org/W2774841093","https://openalex.org/W2795441313","https://openalex.org/W2843925039","https://openalex.org/W2885069342","https://openalex.org/W2889734305","https://openalex.org/W2891750848","https://openalex.org/W2897064819","https://openalex.org/W2900923665","https://openalex.org/W2905258468","https://openalex.org/W2921447440","https://openalex.org/W2922916833","https://openalex.org/W2924733048","https://openalex.org/W3020114628","https://openalex.org/W4253347679","https://openalex.org/W4299376968","https://openalex.org/W4299944320"],"related_works":["https://openalex.org/W2986810323","https://openalex.org/W2997320184","https://openalex.org/W4388020341","https://openalex.org/W2886283895","https://openalex.org/W3185053431","https://openalex.org/W7163594853","https://openalex.org/W2004224646","https://openalex.org/W2153056550","https://openalex.org/W2025956621","https://openalex.org/W7207730560"],"abstract_inverted_index":{"Mosaicism,":[0],"the":[1,71,88,92,116,136],"presence":[2,137],"of":[3,5,76,115,133,138],"subpopulations":[4],"cells":[6,26],"bearing":[7],"somatic":[8,39],"mutations,":[9],"is":[10],"associated":[11],"with":[12],"disease":[13],"and":[14,16,55,74,91,109],"aging":[15],"has":[17],"been":[18],"detected":[19],"in":[20,44,56,70,87,104,120],"diverse":[21],"tissues,":[22],"including":[23,78],"apparently":[24],"normal":[25],"adjacent":[27,93,141],"to":[28,142],"tumors.To":[29],"analyze":[30],"mosaicism":[31],"on":[32,129],"a":[33,96,113],"large":[34],"scale,":[35],"we":[36],"surveyed":[37],"haplotype-specific":[38],"copy":[40],"number":[41],"alterations":[42],"(sCNAs)":[43],"1,708":[45],"normal-appearing":[46],"adjacent-to-tumor":[47],"(NAT)":[48],"tissue":[49,90,108,111],"samples":[50,59],"from":[51,60,122],"27":[52],"cancer":[53,143],"sites":[54],"7,149":[57],"blood":[58],"The":[61],"Cancer":[62],"Genome":[63],"Atlas.We":[64],"find":[65],"substantial":[66],"variation":[67],"across":[68],"tissues":[69],"rate,":[72],"burden":[73],"types":[75],"sCNAs,":[77],"those":[79],"spanning":[80],"entire":[81],"chromosome":[82],"arms.We":[83],"document":[84],"matching":[85],"sCNAs":[86],"NAT":[89,107],"tumor,":[94],"suggesting":[95],"shared":[97],"clonal":[98],"origin,":[99],"as":[100,102],"well":[101],"instances":[103],"which":[105],"both":[106],"tumor":[110],"harbor":[112],"gain":[114],"same":[117],"oncogene":[118],"arising":[119],"parallel":[121],"distinct":[123],"parental":[124],"haplotypes.These":[125],"results":[126],"shed":[127],"light":[128],"pan-tissue":[130],"mutations":[131],"characteristic":[132],"field":[134],"cancerization,":[135],"oncogenic":[139],"processes":[140],"cells.":[144]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-05-12T00:00:00"}