{"id":"https://openalex.org/W4243087799","doi":"https://doi.org/10.1056/nejm196306132682406","title":"The Adrenogenital Syndrome","display_name":"The Adrenogenital Syndrome","publication_year":1963,"publication_date":"1963-06-13","ids":{"openalex":"https://openalex.org/W4243087799","doi":"https://doi.org/10.1056/nejm196306132682406","pmid":"https://pubmed.ncbi.nlm.nih.gov/13968790"},"language":"en","primary_location":{"id":"doi:10.1056/nejm196306132682406","doi":"https://doi.org/10.1056/nejm196306132682406","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm196306132682406","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104022574","display_name":"Alfred M. Bongiovanni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alfred M. Bongiovanni","raw_affiliation_strings":["Professor of pediatrics, University of Pennsylvania School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor of pediatrics, University of Pennsylvania School of Medicine","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066790658","display_name":"Allen W. Root","orcid":"https://orcid.org/0000-0001-6191-3872","observed_orcids":["https://orcid.org/0000-0001-6191-3872"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen W. Root","raw_affiliation_strings":["Fellow in pediatric endocrinology and instructor in pediatrics, University of Pennsylvania School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fellow in pediatric endocrinology and instructor in pediatrics, University of Pennsylvania School of Medicine","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":null,"apc_paid":null,"fwci":3.7366,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.9546504,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"268","issue":"24","first_page":"1342","last_page":"1351"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11956","display_name":"Sexual Differentiation and Disorders","score":0.9384999871253967,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.05860000103712082,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenogenital-syndrome","display_name":"adrenogenital syndrome","score":0.9150000214576721},{"id":"https://openalex.org/keywords/congenital-adrenal-hyperplasia","display_name":"congenital adrenal hyperplasia","score":0.9649999737739563},{"id":"https://openalex.org/keywords/3beta-hydroxysteroid-dehydrogenase","display_name":"3\u03b2-hydroxysteroid dehydrogenase","score":0.9290000200271606},{"id":"https://openalex.org/keywords/steroidogenesis","display_name":"steroidogenesis","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2780193516","wikidata":"https://www.wikidata.org/wiki/Q412158","display_name":"Pregnenolone","level":4,"score":0.8022540211677551},{"id":"https://openalex.org/C2911041269","wikidata":"https://www.wikidata.org/wiki/Q366868","display_name":"Adrenogenital syndrome","level":2,"score":0.7854381799697876},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.735771656036377},{"id":"https://openalex.org/C2776317432","wikidata":"https://www.wikidata.org/wiki/Q412547","display_name":"Dehydrogenase","level":3,"score":0.6429416537284851},{"id":"https://openalex.org/C2781264208","wikidata":"https://www.wikidata.org/wiki/Q118026","display_name":"Isomerase","level":3,"score":0.47810429334640503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4672906994819641},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.46286875009536743},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4319485127925873},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34011781215667725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29788267612457275},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.1834794282913208},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.14455702900886536}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000312","descriptor_name":"Adrenal Hyperplasia, Congenital","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013256","descriptor_name":"Steroids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047808","descriptor_name":"Adrenogenital Syndrome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1056/nejm196306132682406","doi":"https://doi.org/10.1056/nejm196306132682406","is_oa":false,"landing_page_url":"https://doi.org/10.1056/nejm196306132682406","pdf_url":null,"source":{"id":"https://openalex.org/S62468778","display_name":"New England Journal of Medicine","issn_l":"0028-4793","issn":["0028-4793","0096-6762","1533-4406","2331-4710"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320239","host_organization_name":"Massachusetts Medical Society","host_organization_lineage":["https://openalex.org/P4310320239"],"host_organization_lineage_names":["Massachusetts Medical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"New England Journal of Medicine","raw_type":"journal-article"},{"id":"pmid:13968790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13968790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New England journal of medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W31230006","https://openalex.org/W45788725","https://openalex.org/W100346553","https://openalex.org/W104407972","https://openalex.org/W1535594882","https://openalex.org/W1640616698","https://openalex.org/W1963584139","https://openalex.org/W1968950153","https://openalex.org/W1969806517","https://openalex.org/W1970617948","https://openalex.org/W1974844265","https://openalex.org/W1976133978","https://openalex.org/W1977694141","https://openalex.org/W1980986759","https://openalex.org/W1987576906","https://openalex.org/W1996551089","https://openalex.org/W1998510652","https://openalex.org/W1999689946","https://openalex.org/W2000859807","https://openalex.org/W2001995891","https://openalex.org/W2004599745","https://openalex.org/W2004848048","https://openalex.org/W2006012368","https://openalex.org/W2011423786","https://openalex.org/W2015540039","https://openalex.org/W2031350226","https://openalex.org/W2035956286","https://openalex.org/W2042018666","https://openalex.org/W2051811747","https://openalex.org/W2057153414","https://openalex.org/W2061243668","https://openalex.org/W2069485113","https://openalex.org/W2077491805","https://openalex.org/W2078295819","https://openalex.org/W2080246191","https://openalex.org/W2081520430","https://openalex.org/W2085799988","https://openalex.org/W2093315369","https://openalex.org/W2114382582","https://openalex.org/W2119073700","https://openalex.org/W2163858168","https://openalex.org/W2346874326","https://openalex.org/W2402821378","https://openalex.org/W2403439277","https://openalex.org/W2411949595","https://openalex.org/W3211535136","https://openalex.org/W4235357930"],"related_works":["https://openalex.org/W5692200","https://openalex.org/W2020387392","https://openalex.org/W1976655698","https://openalex.org/W1965191706","https://openalex.org/W2076246877","https://openalex.org/W2023636379","https://openalex.org/W2091050119","https://openalex.org/W2088004649","https://openalex.org/W1965962096","https://openalex.org/W4388117933"],"abstract_inverted_index":{"A":[0],"brief":[1],"resume":[2],"of":[3,18,30,49,84,88],"the":[4,9,19,28,47,50,54,67,82],"adrenocortical":[5],"enzymes":[6],"concerned":[7],"with":[8],"steroidal":[10],"transformations":[11],"discussed":[12],"herein":[13],"and":[14,57],"a":[15,62],"partial":[16],"review":[17],"literature":[20],"follow.":[21],"The":[22,92],"enzyme":[23],"(or":[24],"enzymes)":[25],"responsible":[26],"for":[27],"conversation":[29],"pregnenolone":[31],"to":[32,35,72,79],"progesterone":[33],"(1":[34],"2":[36],"in":[37,53,81],"Fig.":[38],"1)":[39],"is":[40,59,77],"termed":[41],"3-beta-hydroxysteroid":[42,94],"dehydrogenase":[43],"(A).":[44],"This":[45],"catalyzes":[46],"oxidation":[48,87],"-OH":[51],"group":[52],"C-3":[55],"position,":[56],"it":[58],"probable":[60],"that":[61],"second":[63],"enzyme,":[64,93],"\"isomerase,\"":[65],"converts":[66],"unsaturated":[68],"compound":[69],"from":[70],"\u03945":[71],"\u03944,":[73],"although":[74],"this":[75,89],"alteration":[76],"known":[78],"occur":[80],"course":[83],"ordinary":[85],"chemical":[86],"hydroxyl":[90],"group.":[91],"dehydrogenase,":[95],"was":[96],".":[97,98,99]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}