{"id":"https://openalex.org/W4242985601","doi":"https://doi.org/10.2337/figshare.15113193","title":"Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMI-RHAPSODY Study","display_name":"Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMI-RHAPSODY Study","publication_year":2021,"publication_date":"2021-08-10","ids":{"openalex":"https://openalex.org/W4242985601","doi":"https://doi.org/10.2337/figshare.15113193"},"language":"en","primary_location":{"id":"doi:10.2337/figshare.15113193","doi":"https://doi.org/10.2337/figshare.15113193","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.15113193","pdf_url":"https://diabetesjournals.figshare.com/ndownloader/files/29052012","source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://diabetesjournals.figshare.com/ndownloader/files/29052012","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032505274","display_name":"Roderick C. Slieker","orcid":"https://orcid.org/0000-0003-0961-9152","observed_orcids":["https://orcid.org/0000-0003-0961-9152"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roderick C Slieker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082891416","display_name":"Louise A. Donnelly","orcid":"https://orcid.org/0000-0003-4902-1040","observed_orcids":["https://orcid.org/0000-0003-4902-1040"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louise A Donnelly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042428378","display_name":"Hugo Fitipaldi","orcid":"https://orcid.org/0000-0001-5352-2134","observed_orcids":["https://orcid.org/0000-0001-5352-2134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hugo Fitipaldi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014034688","display_name":"Gerard A. Bouland","orcid":"https://orcid.org/0000-0002-4311-8725","observed_orcids":["https://orcid.org/0000-0002-4311-8725"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerard A Bouland","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031147884","display_name":"Giuseppe Nicola Giordano","orcid":"https://orcid.org/0000-0002-6719-6680","observed_orcids":["https://orcid.org/0000-0002-6719-6680"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuseppe N. Giordano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079953058","display_name":"Mikael \u00c5kerlund","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mikael \u00c5kerlund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076980316","display_name":"Mathias J. Gerl","orcid":"https://orcid.org/0000-0002-8074-7221","observed_orcids":["https://orcid.org/0000-0002-8074-7221"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mathias J. Gerl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016205185","display_name":"Emma Ahlqvist","orcid":"https://orcid.org/0000-0002-6513-2384","observed_orcids":["https://orcid.org/0000-0002-6513-2384"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma Ahlqvist","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016139943","display_name":"Ashfaq Ali","orcid":"https://orcid.org/0000-0002-0164-2166","observed_orcids":["https://orcid.org/0000-0002-0164-2166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ashfaq Ali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041358594","display_name":"Iulian Dragan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iulian Dragan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036526464","display_name":"Petra J. M. Elders","orcid":"https://orcid.org/0000-0002-5907-7219","observed_orcids":["https://orcid.org/0000-0002-5907-7219"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petra Elders","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111922692","display_name":"Andreas Festa","orcid":"https://orcid.org/0009-0009-4278-2964","observed_orcids":["https://orcid.org/0009-0009-4278-2964"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Festa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018696269","display_name":"Michael K. Hansen","orcid":"https://orcid.org/0000-0002-0062-0520","observed_orcids":["https://orcid.org/0000-0002-0062-0520"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael K. Hansen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054193238","display_name":"Amber A. W. A. van der Heijden","orcid":"https://orcid.org/0000-0002-6383-3187","observed_orcids":["https://orcid.org/0000-0002-6383-3187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amber A van der Heijden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009402640","display_name":"Dina Mansour Aly","orcid":"https://orcid.org/0000-0002-9510-4691","observed_orcids":["https://orcid.org/0000-0002-9510-4691","https://orcid.org/0009-0006-2005-9909"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dina Mansour Aly","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100383166","display_name":"Min Gyu Kim","orcid":"https://orcid.org/0000-0002-8769-4804","observed_orcids":["https://orcid.org/0000-0002-8769-4804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Dmitry Kuznetsov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dmitry Kuznetsov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017135540","display_name":"Florence Mehl","orcid":"https://orcid.org/0000-0002-9619-1707","observed_orcids":["https://orcid.org/0000-0002-9619-1707"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florence Mehl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071326290","display_name":"Christian D. Klose","orcid":"https://orcid.org/0000-0003-2853-4533","observed_orcids":["https://orcid.org/0000-0003-2853-4533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Klose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000708652","display_name":"Kai Simons","orcid":"https://orcid.org/0000-0002-9231-9996","observed_orcids":["https://orcid.org/0000-0002-9231-9996"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai Simons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026505577","display_name":"Imre J. Pavo","orcid":"https://orcid.org/0000-0002-2016-7049","observed_orcids":["https://orcid.org/0000-0002-2016-7049"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Imre Pavo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080977969","display_name":"Timothy J. Pullen","orcid":"https://orcid.org/0000-0002-6853-5701","observed_orcids":["https://orcid.org/0000-0002-6853-5701"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy J. Pullen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011475028","display_name":"Tommi Suvitaival","orcid":"https://orcid.org/0000-0002-2583-4912","observed_orcids":["https://orcid.org/0000-0002-2583-4912"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tommi Suvitaival","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003040516","display_name":"Asger Wretlind","orcid":"https://orcid.org/0000-0001-6083-5227","observed_orcids":["https://orcid.org/0000-0001-6083-5227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Asger Wretlind","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085592050","display_name":"Peter R Rossing","orcid":"https://orcid.org/0000-0002-1531-4294","observed_orcids":["https://orcid.org/0000-0002-1531-4294","https://orcid.org/0009-0004-5073-0009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Rossing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089395013","display_name":"Valeriya Lyssenko","orcid":"https://orcid.org/0000-0002-0198-6524","observed_orcids":["https://orcid.org/0000-0002-0198-6524"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Valeriya Lyssenko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045907715","display_name":"Cristina Legido\u2010Quigley","orcid":"https://orcid.org/0000-0002-4018-214X","observed_orcids":["https://orcid.org/0000-0002-4018-214X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristina Legido Quigley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074771810","display_name":"Leif Groop","orcid":"https://orcid.org/0000-0002-0187-3263","observed_orcids":["https://orcid.org/0000-0002-0187-3263"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leif Groop","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079729308","display_name":"Bernard Thorens","orcid":"https://orcid.org/0000-0002-3738-0129","observed_orcids":["https://orcid.org/0000-0002-3738-0129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard Thorens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024645589","display_name":"Paul W. Franks","orcid":"https://orcid.org/0000-0002-0520-7604","observed_orcids":["https://orcid.org/0000-0002-0520-7604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul W Franks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001478163","display_name":"Mark R. Ibberson","orcid":"https://orcid.org/0000-0003-3152-5670","observed_orcids":["https://orcid.org/0000-0003-3152-5670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Ibberson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015737554","display_name":"Guy A. Rutter","orcid":"https://orcid.org/0000-0001-6360-0343","observed_orcids":["https://orcid.org/0000-0001-6360-0343"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guy A Rutter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085784987","display_name":"Joline W. J. Beulens","orcid":"https://orcid.org/0000-0002-4181-0937","observed_orcids":["https://orcid.org/0000-0002-4181-0937","https://orcid.org/0000-0002-6788-5232"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joline WJ Beulens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015404078","display_name":"Leen M. \u2018t Hart","orcid":"https://orcid.org/0000-0003-4401-2938","observed_orcids":["https://orcid.org/0000-0003-4401-2938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leen M \u2019t Hart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5087774397","display_name":"Ewan R. Pearson","orcid":"https://orcid.org/0000-0001-9237-8585","observed_orcids":["https://orcid.org/0000-0001-9237-8585"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ewan R Pearson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.5023999810218811,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.12430000305175781,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.10440000146627426,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9890000224113464},{"id":"https://openalex.org/keywords/diabetes-subtypes","display_name":"diabetes subtypes","score":0.8180000185966492},{"id":"https://openalex.org/keywords/molecular-signatures","display_name":"molecular signatures","score":0.8100000023841858},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7459999918937683},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9210000038146973},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.6330000162124634},{"id":"https://openalex.org/keywords/branched-chain-amino-acids","display_name":"branched-chain amino acids","score":0.9629999995231628},{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.875},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9549999833106995},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.8059999942779541},{"id":"https://openalex.org/keywords/plasma-proteomics","display_name":"plasma proteomics","score":0.7260000109672546},{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.7630000114440918},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.9649999737739563},{"id":"https://openalex.org/keywords/disease-heterogeneity","display_name":"disease heterogeneity","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.6977080702781677},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6633107662200928},{"id":"https://openalex.org/C164866538","wikidata":"https://www.wikidata.org/wiki/Q367351","display_name":"Cluster (spacecraft)","level":2,"score":0.5861913561820984},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5089216232299805},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4958365857601166},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46165478229522705},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.45411327481269836},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.44317513704299927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.434764564037323},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4303070306777954},{"id":"https://openalex.org/C137627325","wikidata":"https://www.wikidata.org/wiki/Q156318","display_name":"Etiology","level":2,"score":0.416686087846756},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3100581169128418},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2337/figshare.15113193","doi":"https://doi.org/10.2337/figshare.15113193","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.15113193","pdf_url":"https://diabetesjournals.figshare.com/ndownloader/files/29052012","source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.2337/figshare.15113193","doi":"https://doi.org/10.2337/figshare.15113193","is_oa":true,"landing_page_url":"https://doi.org/10.2337/figshare.15113193","pdf_url":"https://diabetesjournals.figshare.com/ndownloader/files/29052012","source":null,"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Diabetes Association","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7599999904632568}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1485100654","display_name":null,"funder_award_id":"MR/K001981/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1891855903","display_name":null,"funder_award_id":"MR/L020149/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G609589047","display_name":null,"funder_award_id":"MR/R022259/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G8823668904","display_name":null,"funder_award_id":"MR/R014329/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4242985601.pdf","grobid_xml":"https://content.openalex.org/works/W4242985601.grobid-xml"},"referenced_works_count":1,"referenced_works":["https://openalex.org/W2801047469"],"related_works":["https://openalex.org/W4381378018","https://openalex.org/W4294562645","https://openalex.org/W4392516004","https://openalex.org/W4309656541","https://openalex.org/W7204665478","https://openalex.org/W7166797633","https://openalex.org/W3072343284","https://openalex.org/W4381377993","https://openalex.org/W7204954220","https://openalex.org/W2997136317"],"abstract_inverted_index":{"Type":[0],"2":[1,164,197],"diabetes":[2,21,24,134,165,198],"is":[3,32,199],"a":[4,15,61,202],"multifactorial":[5],"disease":[6,204],"with":[7,20,84,102,136,145,162],"multiple":[8],"underlying":[9,168],"aetiologies.":[10],"To":[11],"address":[12],"this":[13],"heterogeneity":[14],"previous":[16],"study":[17,31,157],"clustered":[18,54],"people":[19,161],"into":[22,185],"five":[23,57],"subtypes.":[25],"The":[26,92,123],"aim":[27],"of":[28,37,131],"the":[29,35,85,90,97,119,132,140,152,186],"current":[30],"to":[33,148,172],"investigate":[34],"aetiology":[36],"these":[38],"clusters":[39,88],"by":[40],"comparing":[41],"their":[42],"molecular":[43,100,143,169],"signatures.":[44],"In":[45,60,77],"three":[46],"independent":[47],"cohorts,":[48],"in":[49,75,113,118,151],"total":[50],"15,940":[51],"individuals":[52],"were":[53,73],"based":[55],"on":[56],"clinical":[58],"characteristics.":[59],"subset,":[62],"genetic-":[63],"(N=12828),":[64],"metabolomic-":[65],"(N=2945),":[66],"lipidomic-":[67],"(N=2593)":[68],"and":[69,106,109,176],"proteomic":[70],"(N=1170)":[71],"data":[72],"obtained":[74],"plasma.":[76],"each":[78,80],"datatype":[79],"cluster":[81,95,125,135],"was":[82],"compared":[83],"other":[86],"four":[87],"as":[89,201],"reference.":[91],"insulin":[93,153],"resistant":[94,154],"showed":[96,126,139,158],"most":[98,141],"distinct":[99],"signature,":[101],"higher":[103,127],"BCAAs,":[104],"DAG":[105],"TAG":[107],"levels":[108,112],"aberrant":[110],"protein":[111],"plasma":[114],"enriched":[115],"for":[116],"proteins":[117],"intracellular":[120],"PI3K/Akt":[121],"pathway.":[122],"obese":[124],"cytokines.":[128],"A":[129],"subset":[130],"mild":[133],"high":[137],"HDL":[138],"beneficial":[142],"profile":[144],"opposite":[146],"effects":[147],"those":[149],"seen":[150],"cluster.":[155],"This":[156,180],"that":[159,190],"clustering":[160],"type":[163,196],"can":[166],"identify":[167],"mechanisms":[170],"related":[171],"pancreatic":[173],"islets,":[174],"liver,":[175],"adipose":[177],"tissue":[178],"metabolism.":[179],"provides":[181],"novel":[182],"biological":[183],"insights":[184],"diverse":[187],"aetiological":[188],"processes":[189],"would":[191],"not":[192],"be":[193],"evident":[194],"when":[195],"viewed":[200],"homogeneous":[203]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-05-12T00:00:00"}
