{"id":"https://openalex.org/W4242967037","doi":"https://doi.org/10.1007/978-3-642-48670-8_3","title":"The relative phospholamban and SERCA2 ratio: a critical determinant of myocardial contractility","display_name":"The relative phospholamban and SERCA2 ratio: a critical determinant of myocardial contractility","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W4242967037","doi":"https://doi.org/10.1007/978-3-642-48670-8_3"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-48670-8_3","doi":"https://doi.org/10.1007/978-3-642-48670-8_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-48670-8_3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463955","display_name":"Steinkopff eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alterations of Excitation-Contraction Coupling in the Failing Human Heart","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2476623008","display_name":"Alterations of Excitation-Contraction Coupling in the Failing Human Heart"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004573621","display_name":"K. L. Koss","orcid":"https://orcid.org/0009-0006-4953-5665","observed_orcids":["https://orcid.org/0009-0006-4953-5665"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. L. Koss","raw_affiliation_strings":["Dept. of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071367476","display_name":"Ingrid L. Grupp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"I. L. Grupp","raw_affiliation_strings":["Dept. of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Bethesda Ave., Cincinnati, Ohio, 45267-0575, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Bethesda Ave., Cincinnati, Ohio, 45267-0575, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080329479","display_name":"Evangelia Galani Kranias","orcid":"https://orcid.org/0000-0002-4621-6179","observed_orcids":["https://orcid.org/0000-0002-4621-6179"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evangelia G. Kranias","raw_affiliation_strings":["Dept. of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Bethesda Ave., Cincinnati, Ohio, 45267-0575, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dept. of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, 231 Bethesda Ave., Cincinnati, Ohio, 45267-0575, USA","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63135867"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58509317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"25","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.025499999523162842,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholamban","display_name":"phospholamban","score":1.0},{"id":"https://openalex.org/keywords/serca2","display_name":"SERCA2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.8240000009536743},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum-ca2-atpase","display_name":"sarcoplasmic reticulum Ca2+-ATPase","score":0.9039999842643738},{"id":"https://openalex.org/keywords/phospholamban-phosphorylation","display_name":"phospholamban phosphorylation","score":0.7590000033378601},{"id":"https://openalex.org/keywords/beta-adrenergic-stimulation","display_name":"beta-adrenergic stimulation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/atrial-muscle","display_name":"atrial muscle","score":0.5830000042915344},{"id":"https://openalex.org/keywords/ventricular-myocardium","display_name":"ventricular myocardium","score":0.9990000128746033},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C17137333","wikidata":"https://www.wikidata.org/wiki/Q410105","display_name":"Phospholamban","level":3,"score":0.9961227178573608},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.8648020625114441},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6208928227424622},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6064843535423279},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5058364868164062},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44772014021873474},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4278411567211151},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3536869287490845},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.34713953733444214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28182411193847656},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11329752206802368},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1066582202911377}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-48670-8_3","doi":"https://doi.org/10.1007/978-3-642-48670-8_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-48670-8_3","pdf_url":null,"source":{"id":"https://openalex.org/S4306463955","display_name":"Steinkopff eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alterations of Excitation-Contraction Coupling in the Failing Human Heart","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W91862947","https://openalex.org/W1516256265","https://openalex.org/W1541276365","https://openalex.org/W1567439646","https://openalex.org/W1606565754","https://openalex.org/W1819240213","https://openalex.org/W1977039063","https://openalex.org/W1991141881","https://openalex.org/W2000125863","https://openalex.org/W2026570608","https://openalex.org/W2074260855","https://openalex.org/W2104874788","https://openalex.org/W2105417752","https://openalex.org/W2142754357","https://openalex.org/W2222922688","https://openalex.org/W2244935535"],"related_works":["https://openalex.org/W1986690550","https://openalex.org/W2280628073","https://openalex.org/W2061245367","https://openalex.org/W1967688761","https://openalex.org/W2142754357","https://openalex.org/W2104874788","https://openalex.org/W2134745065","https://openalex.org/W2792980560","https://openalex.org/W2036061661","https://openalex.org/W2070631962"],"abstract_inverted_index":{"Phospholamban":[0],"is":[1,32,45,60,214],"a":[2,33,132],"regulatory":[3],"phosphoprotein":[4],"which":[5,31,112,130,150,189],"modulates":[6],"the":[7,14,24,27,39,74,77,91,102,209,217,230],"active":[8],"transport":[9],"of":[10,26,36,49,64,80,143,148,166,192,197,219],"Ca":[11,18],"2+":[12,19],"by":[13,100],"cardiac":[15,84],"sarcoplasmic":[16,28],"reticular":[17],"-ATPase":[20],"enzyme":[21],"(SERCA2)":[22],"into":[23],"lumen":[25],"reticulum.":[29],"Phospholamban,":[30],"reversible":[34],"inhibitor":[35],"SERCA2,":[37],"represses":[38],"enzyme\u2019s":[40],"activity,":[41],"and":[42,109,116,120,146,177,222],"this":[43,57,225],"inhibition":[44],"relieved":[46],"upon":[47],"phosphorylation":[48],"phospholamban":[50,59,121,178,186],"in":[51,83,90,200,216,224],"response":[52],"to":[53,202,229],"\u03b2-adrenergic":[54],"stimulation.":[55],"In":[56,181],"way,":[58],"an":[61,87],"important":[62,88],"regulator":[63],"SERCA2-mediated":[65],"myocardial":[66,220],"relaxation":[67,147],"during":[68,234],"diastole.":[69],"This":[70,96],"report":[71],"centers":[72],"on":[73],"hypothesis":[75,97],"that":[76,127,154,208],"relative":[78,210],"levels":[79],"phospholamban:":[81,135,211],"SERCA2":[82,136,212],"muscle":[85],"plays":[86],"role":[89],"muscle\u2019s":[92],"overall":[93],"contractility":[94,199,221],"status.":[95],"was":[98],"tested":[99],"comparing":[101],"contractile":[103],"parameters":[104,156,196],"of:":[105],"a)":[106],"murine":[107,118],"atrial":[108,128],"ventricular":[110,139,158],"muscles,":[111,129,140],"differentially":[113],"express":[114],"phospholamban,":[115,193],"b)":[117],"wild-type":[119,176,203],"knock-out":[122,179,187],"hearts.":[123,204],"These":[124,205],"comparisons":[125,161],"revealed":[126],"have":[131],"4.2-fold":[133],"lower":[134],"ratio":[137,213,226],"than":[138],"exhibited":[141,194],"rates":[142],"force":[144],"development":[145,169],"tension,":[149],"were":[151,162,190],"three-fold":[152],"faster":[153],"these":[155,182],"for":[157,171],"muscles.":[159],"Similar":[160],"made":[163],"via":[164],"analyses":[165],"left-ventricular":[167,198],"pressure":[168],"recorded":[170],"isolated,":[172],"work-performing":[173],"hearts":[174,184],"from":[175,185],"mice.":[180],"studies,":[183],"mice,":[188],"devoid":[191],"enhanced":[195],"comparison":[201],"results":[206],"suggest":[207],"critical":[215],"regulation":[218],"alterations":[223],"may":[227],"contribute":[228],"functional":[231],"deterioration":[232],"observed":[233],"heart":[235],"failure.":[236]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2022-05-12T00:00:00"}
