{"id":"https://openalex.org/W4242944102","doi":"https://doi.org/10.1002/ange.201402216","title":"Pericellular Hydrogel/Nanonets Inhibit Cancer Cells","display_name":"Pericellular Hydrogel/Nanonets Inhibit Cancer Cells","publication_year":2014,"publication_date":"2014-05-12","ids":{"openalex":"https://openalex.org/W4242944102","doi":"https://doi.org/10.1002/ange.201402216"},"language":"en","primary_location":{"id":"doi:10.1002/ange.201402216","doi":"https://doi.org/10.1002/ange.201402216","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201402216","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046378309","display_name":"Yi Kuang","orcid":"https://orcid.org/0000-0003-3643-2684","observed_orcids":["https://orcid.org/0000-0003-3643-2684"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi Kuang","raw_affiliation_strings":["Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454 (USA) http://people.brandeis.edu/\u223cbxu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454 (USA) http://people.brandeis.edu/\u223cbxu","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023389264","display_name":"Junfeng Shi","orcid":"https://orcid.org/0000-0001-7705-8866","observed_orcids":["https://orcid.org/0000-0001-7705-8866"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junfeng Shi","raw_affiliation_strings":["Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454 (USA) http://people.brandeis.edu/\u223cbxu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454 (USA) http://people.brandeis.edu/\u223cbxu","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428146","display_name":"Jie Li","orcid":"https://orcid.org/0000-0002-5114-2450","observed_orcids":["https://orcid.org/0000-0002-5114-2450","https://orcid.org/0000-0002-4547-1258","https://orcid.org/0009-0000-6778-6587"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Li","raw_affiliation_strings":["Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454 (USA) http://people.brandeis.edu/\u223cbxu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454 (USA) http://people.brandeis.edu/\u223cbxu","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dan Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Yuan","raw_affiliation_strings":["Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454 (USA) http://people.brandeis.edu/\u223cbxu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454 (USA) http://people.brandeis.edu/\u223cbxu","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060872895","display_name":"Kyle A. Alberti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle A. Alberti","raw_affiliation_strings":["Department of Biomedical Engineering, Tufts University, 419 Boston Ave, Medford, MA 02155 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Tufts University, 419 Boston Ave, Medford, MA 02155 (USA)","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019138735","display_name":"Qiaobing Xu","orcid":"https://orcid.org/0000-0001-7323-7795","observed_orcids":["https://orcid.org/0000-0001-7323-7795"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiaobing Xu","raw_affiliation_strings":["Department of Biomedical Engineering, Tufts University, 419 Boston Ave, Medford, MA 02155 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Tufts University, 419 Boston Ave, Medford, MA 02155 (USA)","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100602838","display_name":"Bing Xu","orcid":"https://orcid.org/0000-0002-4639-387X","observed_orcids":["https://orcid.org/0000-0002-4639-387X","https://orcid.org/0000-0001-7138-8936","https://orcid.org/0000-0002-7385-9954","https://orcid.org/0000-0002-7242-6495"]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bing Xu","raw_affiliation_strings":["Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454 (USA) http://people.brandeis.edu/\u223cbxu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Brandeis University, 415 South St, Waltham, MA 02454 (USA) http://people.brandeis.edu/\u223cbxu","institution_ids":["https://openalex.org/I6902469"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100602838"],"corresponding_institution_ids":["https://openalex.org/I6902469"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":2.6532,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.89555193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"126","issue":"31","first_page":"8242","last_page":"8245"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11419","display_name":"Supramolecular Self-Assembly in Materials","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nanonets","display_name":"nanonets","score":0.9350000023841858},{"id":"https://openalex.org/keywords/phosphatase-dephosphorylation","display_name":"phosphatase dephosphorylation","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tumor-cell-apoptosis","display_name":"tumor cell apoptosis","score":0.6489999890327454},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tumor-cell-growth-inhibition","display_name":"tumor cell growth inhibition","score":0.5899999737739563},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.6990000009536743},{"id":"https://openalex.org/keywords/extracellular-matrix-microenvironment","display_name":"extracellular matrix microenvironment","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6732873320579529},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6320628523826599},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4821052849292755},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3832210600376129},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3532944321632385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29946279525756836},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ange.201402216","doi":"https://doi.org/10.1002/ange.201402216","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201402216","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W75660270","https://openalex.org/W204424443","https://openalex.org/W1835205965","https://openalex.org/W1967265143","https://openalex.org/W1974222323","https://openalex.org/W2015889028","https://openalex.org/W2024829972","https://openalex.org/W2028792162","https://openalex.org/W2047179731","https://openalex.org/W2057793836","https://openalex.org/W2069507241","https://openalex.org/W2072984130","https://openalex.org/W2074363870","https://openalex.org/W2078583903","https://openalex.org/W2091970663","https://openalex.org/W2095023547","https://openalex.org/W2096642770","https://openalex.org/W2097116232","https://openalex.org/W2102279271","https://openalex.org/W2107602208","https://openalex.org/W2112647556","https://openalex.org/W2121955821","https://openalex.org/W2124632458","https://openalex.org/W2126891861","https://openalex.org/W2129927147","https://openalex.org/W2132707012","https://openalex.org/W2133419018","https://openalex.org/W2135905231","https://openalex.org/W2145808237","https://openalex.org/W2156881542","https://openalex.org/W2164611493","https://openalex.org/W2169247784","https://openalex.org/W4232140881","https://openalex.org/W4237976776","https://openalex.org/W4238394233","https://openalex.org/W4250944293","https://openalex.org/W4253794346","https://openalex.org/W4255874271"],"related_works":["https://openalex.org/W2958525000","https://openalex.org/W2144858362","https://openalex.org/W2588614136","https://openalex.org/W7097254057","https://openalex.org/W4396912296","https://openalex.org/W2744578405","https://openalex.org/W7122686510","https://openalex.org/W7128522051","https://openalex.org/W1948355810","https://openalex.org/W2496591839"],"abstract_inverted_index":{"Abstract":[0],"Fibrils":[1],"formed":[2],"by":[3],"proteins":[4],"are":[5],"vital":[6],"components":[7],"for":[8,119],"cells.":[9],"However,":[10],"selective":[11],"formation":[12],"of":[13,16,33,35,50,57,88,99],"xenogenous":[14],"nanofibrils":[15],"small":[17,37,100],"molecules":[18,101],"on":[19],"mammalian":[20],"cells":[21,70],"has":[22],"yet":[23],"to":[24,53,61,85,102,111],"be":[25],"observed.":[26],"Here":[27],"we":[28],"report":[29],"an":[30],"unexpected":[31],"observation":[32],"hydrogel/nanonets":[34,65,80,98],"a":[36,48,51,107],"D\u2010peptide":[38],"derivative":[39],"in":[40,63,116],"pericellular":[41,64,79],"space.":[42],"Surface":[43],"and":[44,60,124],"secretory":[45],"phosphatases":[46],"dephosphorylate":[47],"precursor":[49],"hydrogelator":[52,59],"trigger":[54],"the":[55,58,68,78],"self\u2010assembly":[56],"result":[62],"selectively":[66],"around":[67],"cancer":[69,89,94,121],"that":[71,77],"overexpress":[72],"phosphatases.":[73],"Cell\u2010based":[74],"assays":[75],"confirm":[76],"block":[81],"cellular":[82,117],"mass":[83],"exchange":[84],"induce":[86],"apoptosis":[87],"cells,":[90,95],"including":[91],"multidrug\u2010resistance":[92],"(MDR)":[93],"MES\u2010SA/Dx5.":[96],"Pericellular":[97],"exhibit":[103],"distinct":[104],"functions":[105],"illustrates":[106],"fundamentally":[108],"new":[109],"way":[110],"engineer":[112],"molecular":[113],"assemblies":[114],"spatiotemporally":[115],"microenvironment":[118],"inhibiting":[120],"cell":[122],"growth":[123],"even":[125],"metastasis.":[126]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":10}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-05-12T00:00:00"}