{"id":"https://openalex.org/W4242819400","doi":"https://doi.org/10.1002/ange.201702901","title":"Structural Basis for Copper\u2013Oxygen Mediated C\u2212H Bond Activation by the Formylglycine\u2010Generating Enzyme","display_name":"Structural Basis for Copper\u2013Oxygen Mediated C\u2212H Bond Activation by the Formylglycine\u2010Generating Enzyme","publication_year":2017,"publication_date":"2017-05-23","ids":{"openalex":"https://openalex.org/W4242819400","doi":"https://doi.org/10.1002/ange.201702901"},"language":"en","primary_location":{"id":"doi:10.1002/ange.201702901","doi":"https://doi.org/10.1002/ange.201702901","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201702901","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064755130","display_name":"Marcel Meury","orcid":"https://orcid.org/0000-0002-8718-2374","observed_orcids":["https://orcid.org/0000-0002-8718-2374"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marcel Meury","raw_affiliation_strings":["Department for Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057659007","display_name":"Matthias Knop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Matthias Knop","raw_affiliation_strings":["Department for Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065756369","display_name":"Florian P. Seebeck","orcid":"https://orcid.org/0000-0003-4625-1369","observed_orcids":["https://orcid.org/0000-0003-4625-1369"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Florian P. Seebeck","raw_affiliation_strings":["Department for Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-4625-1369","affiliations":[{"raw_affiliation_string":"Department for Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5065756369"],"corresponding_institution_ids":["https://openalex.org/I1850255"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":0.7333,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.68472995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"129","issue":"28","first_page":"8227","last_page":"8231"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/formylglycine-generating-enzyme","display_name":"formylglycine-generating enzyme","score":0.9990000128746033},{"id":"https://openalex.org/keywords/copper-proteins","display_name":"copper proteins","score":0.5289999842643738},{"id":"https://openalex.org/keywords/c-h-activation","display_name":"C\u2013H activation","score":0.9290000200271606},{"id":"https://openalex.org/keywords/oxygen-activation","display_name":"oxygen activation","score":0.656000018119812},{"id":"https://openalex.org/keywords/thermomonospora-curvata","display_name":"Thermomonospora curvata","score":0.8460000157356262},{"id":"https://openalex.org/keywords/metal-binding-sites","display_name":"metal binding sites","score":0.7229999899864197},{"id":"https://openalex.org/keywords/silver-complexes","display_name":"silver complexes","score":0.5989999771118164},{"id":"https://openalex.org/keywords/cadmium-complexes","display_name":"cadmium complexes","score":1.0},{"id":"https://openalex.org/keywords/copper-redox-cycling","display_name":"copper redox cycling","score":0.828000009059906},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.656000018119812},{"id":"https://openalex.org/keywords/copper-catalysts","display_name":"copper catalysts","score":0.5149999856948853}],"concepts":[{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.8460918664932251},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8408915996551514},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.6580504179000854},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.6517246961593628},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.5727983713150024},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.5676974058151245},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5630586743354797},{"id":"https://openalex.org/C181312439","wikidata":"https://www.wikidata.org/wiki/Q909712","display_name":"Copper protein","level":3,"score":0.5031635165214539},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.40040358901023865},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.2460661232471466},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16891184449195862},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13515901565551758}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ange.201702901","doi":"https://doi.org/10.1002/ange.201702901","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201702901","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6310232755","display_name":null,"funder_award_id":"336559","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G6601302646","display_name":"Characterization and engineering of lignin:protein interactions","funder_award_id":"138739","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W192250034","https://openalex.org/W236739974","https://openalex.org/W1856913850","https://openalex.org/W1931904185","https://openalex.org/W1963874808","https://openalex.org/W1964635284","https://openalex.org/W1972337182","https://openalex.org/W1974939001","https://openalex.org/W1978656549","https://openalex.org/W1978754214","https://openalex.org/W1979491356","https://openalex.org/W1983639577","https://openalex.org/W1989418439","https://openalex.org/W1995732138","https://openalex.org/W1999978156","https://openalex.org/W2000291296","https://openalex.org/W2001325843","https://openalex.org/W2022897757","https://openalex.org/W2043825890","https://openalex.org/W2053829702","https://openalex.org/W2054905327","https://openalex.org/W2056952624","https://openalex.org/W2061774444","https://openalex.org/W2064259630","https://openalex.org/W2065692348","https://openalex.org/W2067054261","https://openalex.org/W2068251763","https://openalex.org/W2072471477","https://openalex.org/W2080493328","https://openalex.org/W2082867535","https://openalex.org/W2083921257","https://openalex.org/W2091605104","https://openalex.org/W2094709506","https://openalex.org/W2111010990","https://openalex.org/W2114306033","https://openalex.org/W2129774902","https://openalex.org/W2131032705","https://openalex.org/W2149640957","https://openalex.org/W2151998614","https://openalex.org/W2159794836","https://openalex.org/W2160451558","https://openalex.org/W2165920356","https://openalex.org/W2169442257","https://openalex.org/W2268458306","https://openalex.org/W2274736795","https://openalex.org/W2313035794","https://openalex.org/W2320446052","https://openalex.org/W2322161127","https://openalex.org/W2329077447","https://openalex.org/W2413395909","https://openalex.org/W2418221895","https://openalex.org/W2468674131","https://openalex.org/W2531718714","https://openalex.org/W2551998204","https://openalex.org/W2554142923","https://openalex.org/W2570966101","https://openalex.org/W2578282122","https://openalex.org/W4230365383","https://openalex.org/W4231385139","https://openalex.org/W4244689731"],"related_works":["https://openalex.org/W2922511278","https://openalex.org/W2551998204","https://openalex.org/W2920095441","https://openalex.org/W6950417429","https://openalex.org/W4409161028","https://openalex.org/W4213272059","https://openalex.org/W2763376447","https://openalex.org/W1856913850","https://openalex.org/W4312193857","https://openalex.org/W2950399791"],"abstract_inverted_index":{"Abstract":[0],"The":[1,49],"formylglycine\u2010generating":[2],"enzyme":[3,75],"(FGE)":[4],"is":[5,92,98],"a":[6,42,52,77],"unique":[7],"copper":[8,86,102,106],"protein":[9],"that":[10],"catalyzes":[11],"oxygen\u2010dependent":[12],"C\u2212H":[13],"activation.":[14],"We":[15],"describe":[16],"1.66":[17],"\u00c5\u2010":[18],"and":[19,60],"1.28":[20],"\u00c5\u2010resolution":[21],"crystal":[22],"structures":[23,50],"of":[24,56,63,79,85],"FGE":[25],"from":[26],"Thermomonospora":[27],"curvata":[28],"in":[29,46,72],"complex":[30],"with":[31],"either":[32],"Ag":[33],"I":[34],"or":[35,104],"Cd":[36],"II":[37],"providing":[38],"definitive":[39],"evidence":[40],"for":[41,100],"high\u2010affinity":[43],"metal\u2010binding":[44],"site":[45],"this":[47],"enzyme.":[48],"reveal":[51],"bis\u2010cysteine":[53],"linear":[54],"coordination":[55,62,68],"the":[57,64,73],"monovalent":[58],"metal,":[59],"tetrahedral":[61],"bivalent":[65],"metal.":[66],"Similar":[67],"changes":[69],"may":[70],"occur":[71],"active":[74],"as":[76],"result":[78],"Cu":[80],"I/II":[81],"redox":[82],"cycling.":[83],"Complexation":[84],"atoms":[87],"by":[88],"two":[89],"cysteine":[90],"residues":[91],"common":[93],"among":[94],"copper\u2010trafficking":[95],"proteins,":[96],"but":[97],"unprecedented":[99],"redox\u2010active":[101],"enzymes":[103],"synthetic":[105],"catalysts.":[107]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}