{"id":"https://openalex.org/W4242775475","doi":"https://doi.org/10.5505/tjh.2012.93546","title":"Successful Treatment Of Homozygous Familial Hypercholesterolemia Using Cascade Filtration Plasmapheresis","display_name":"Successful Treatment Of Homozygous Familial Hypercholesterolemia Using Cascade Filtration Plasmapheresis","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W4242775475","doi":"https://doi.org/10.5505/tjh.2012.93546"},"language":"en","primary_location":{"id":"doi:10.5505/tjh.2012.93546","doi":"https://doi.org/10.5505/tjh.2012.93546","is_oa":true,"landing_page_url":"https://doi.org/10.5505/tjh.2012.93546","pdf_url":"https://doi.org/10.5505/tjh.2012.93546","source":{"id":"https://openalex.org/S4210174942","display_name":"Turkish Journal of Hematology","issn_l":"1300-7777","issn":["1300-7777","1308-5263"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Hematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.5505/tjh.2012.93546","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047702121","display_name":"Fatih Karda\u015f","orcid":"https://orcid.org/0000-0002-2276-7611","observed_orcids":["https://orcid.org/0000-0002-2276-7611"]},"institutions":[{"id":"https://openalex.org/I87673952","display_name":"Erciyes University","ror":"https://ror.org/047g8vk19","country_code":"TR","type":"education","lineage":["https://openalex.org/I87673952"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Fatih Kardas","raw_affiliation_strings":["Erciyes University, School of Medicine, Department of Pediatric Metabolism, Kayseri, Turkey","Erciyes \u00dcniversitesi T\u0131p Fak\u00fcltesi , \u00c7ocuk Metabolizma Bilim Dal\u0131 , Kayseri , Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erciyes University, School of Medicine, Department of Pediatric Metabolism, Kayseri, Turkey","institution_ids":["https://openalex.org/I87673952"]},{"raw_affiliation_string":"Erciyes \u00dcniversitesi T\u0131p Fak\u00fcltesi , \u00c7ocuk Metabolizma Bilim Dal\u0131 , Kayseri , Turkey","institution_ids":["https://openalex.org/I87673952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083295221","display_name":"Aysun \u00c7etin","orcid":"https://orcid.org/0000-0003-4959-7955","observed_orcids":["https://orcid.org/0000-0003-4959-7955"]},"institutions":[{"id":"https://openalex.org/I87673952","display_name":"Erciyes University","ror":"https://ror.org/047g8vk19","country_code":"TR","type":"education","lineage":["https://openalex.org/I87673952"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Aysun Cetin","raw_affiliation_strings":["Erciyes University, School of Medicine, Department of Biochemistry, Kayseri, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erciyes University, School of Medicine, Department of Biochemistry, Kayseri, Turkey","institution_ids":["https://openalex.org/I87673952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009122009","display_name":"Musa Solmaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87673952","display_name":"Erciyes University","ror":"https://ror.org/047g8vk19","country_code":"TR","type":"education","lineage":["https://openalex.org/I87673952"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Musa Solmaz","raw_affiliation_strings":["Erciyes University, School of Medicine, Department of Hematology, Kayseri, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erciyes University, School of Medicine, Department of Hematology, Kayseri, Turkey","institution_ids":["https://openalex.org/I87673952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056415895","display_name":"Ruksan B\u00fcy\u00fcko\u011flan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I87673952","display_name":"Erciyes University","ror":"https://ror.org/047g8vk19","country_code":"TR","type":"education","lineage":["https://openalex.org/I87673952"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ruksan Buyukoglan","raw_affiliation_strings":["Erciyes University, School of Medicine, Department of Hematology, Kayseri, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erciyes University, School of Medicine, Department of Hematology, Kayseri, Turkey","institution_ids":["https://openalex.org/I87673952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035484545","display_name":"Leylag\u00fcl Kaynar","orcid":"https://orcid.org/0000-0002-2035-9462","observed_orcids":["https://orcid.org/0000-0002-2035-9462"]},"institutions":[{"id":"https://openalex.org/I87673952","display_name":"Erciyes University","ror":"https://ror.org/047g8vk19","country_code":"TR","type":"education","lineage":["https://openalex.org/I87673952"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Leylagul Kaynar","raw_affiliation_strings":["Erciyes University, School of Medicine, Department of Hematology, Kayseri, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erciyes University, School of Medicine, Department of Hematology, Kayseri, Turkey","institution_ids":["https://openalex.org/I87673952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066062860","display_name":"Mustafa Kend\u0131rc\u0131","orcid":"https://orcid.org/0000-0002-2100-3628","observed_orcids":["https://orcid.org/0000-0002-2100-3628"]},"institutions":[{"id":"https://openalex.org/I87673952","display_name":"Erciyes University","ror":"https://ror.org/047g8vk19","country_code":"TR","type":"education","lineage":["https://openalex.org/I87673952"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Kendirci","raw_affiliation_strings":["Erciyes University, School of Medicine, Department of Pediatric Metabolism, Kayseri, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erciyes University, School of Medicine, Department of Pediatric Metabolism, Kayseri, Turkey","institution_ids":["https://openalex.org/I87673952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056007441","display_name":"B\u00fclent Eser","orcid":"https://orcid.org/0000-0002-4513-3486","observed_orcids":["https://orcid.org/0000-0002-4513-3486"]},"institutions":[{"id":"https://openalex.org/I87673952","display_name":"Erciyes University","ror":"https://ror.org/047g8vk19","country_code":"TR","type":"education","lineage":["https://openalex.org/I87673952"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bulent Eser","raw_affiliation_strings":["Erciyes University, School of Medicine, Department of Hematology, Kayseri, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erciyes University, School of Medicine, Department of Hematology, Kayseri, Turkey","institution_ids":["https://openalex.org/I87673952"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036762565","display_name":"Ali \u00dcnal","orcid":"https://orcid.org/0000-0001-7011-3412","observed_orcids":["https://orcid.org/0000-0001-7011-3412"]},"institutions":[{"id":"https://openalex.org/I87673952","display_name":"Erciyes University","ror":"https://ror.org/047g8vk19","country_code":"TR","type":"education","lineage":["https://openalex.org/I87673952"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ali Unal","raw_affiliation_strings":["Erciyes University, School of Medicine, Department of Hematology, Kayseri, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Erciyes University, School of Medicine, Department of Hematology, Kayseri, Turkey","institution_ids":["https://openalex.org/I87673952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5047702121"],"corresponding_institution_ids":["https://openalex.org/I87673952"],"apc_list":null,"apc_paid":null,"fwci":0.3257,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.71471305,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"29","issue":"4","first_page":"334","last_page":"341"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/homozygous-familial-hypercholesterolemia","display_name":"homozygous familial hypercholesterolemia","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.8130000233650208},{"id":"https://openalex.org/keywords/ldl-cholesterol-lowering","display_name":"LDL cholesterol lowering","score":0.8450000286102295},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.5419999957084656},{"id":"https://openalex.org/keywords/adverse-effects","display_name":"adverse effects","score":0.765999972820282},{"id":"https://openalex.org/keywords/hypotension","display_name":"hypotension","score":0.9100000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9254319667816162},{"id":"https://openalex.org/C2779120738","wikidata":"https://www.wikidata.org/wiki/Q2711291","display_name":"Familial hypercholesterolemia","level":3,"score":0.7762484550476074},{"id":"https://openalex.org/C2778842783","wikidata":"https://www.wikidata.org/wiki/Q603502","display_name":"Plasmapheresis","level":3,"score":0.7725428938865662},{"id":"https://openalex.org/C128489963","wikidata":"https://www.wikidata.org/wiki/Q1187724","display_name":"Filtration (mathematics)","level":2,"score":0.5537621974945068},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.43628358840942383},{"id":"https://openalex.org/C34146451","wikidata":"https://www.wikidata.org/wiki/Q5048094","display_name":"Cascade","level":2,"score":0.42737966775894165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31500110030174255},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.1723456084728241},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.105174720287323},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.09171596169471741},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.05403774976730347},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5505/tjh.2012.93546","doi":"https://doi.org/10.5505/tjh.2012.93546","is_oa":true,"landing_page_url":"https://doi.org/10.5505/tjh.2012.93546","pdf_url":"https://doi.org/10.5505/tjh.2012.93546","source":{"id":"https://openalex.org/S4210174942","display_name":"Turkish Journal of Hematology","issn_l":"1300-7777","issn":["1300-7777","1308-5263"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Hematology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.5505/tjh.2012.93546","doi":"https://doi.org/10.5505/tjh.2012.93546","is_oa":true,"landing_page_url":"https://doi.org/10.5505/tjh.2012.93546","pdf_url":"https://doi.org/10.5505/tjh.2012.93546","source":{"id":"https://openalex.org/S4210174942","display_name":"Turkish Journal of Hematology","issn_l":"1300-7777","issn":["1300-7777","1308-5263"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-20","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Turkish Journal of Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4242775475.pdf","grobid_xml":"https://content.openalex.org/works/W4242775475.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W25277136","https://openalex.org/W1973197241","https://openalex.org/W1992113380","https://openalex.org/W2009891109","https://openalex.org/W2048162291","https://openalex.org/W2050576940","https://openalex.org/W2116970126","https://openalex.org/W2119028588","https://openalex.org/W2152644556","https://openalex.org/W2165607486","https://openalex.org/W2168699093","https://openalex.org/W2308659417","https://openalex.org/W2423809522","https://openalex.org/W4232081576","https://openalex.org/W4252708508"],"related_works":["https://openalex.org/W7099093114","https://openalex.org/W1519691810","https://openalex.org/W2050576940","https://openalex.org/W2091875163","https://openalex.org/W2903495115","https://openalex.org/W2046536156","https://openalex.org/W2001170912","https://openalex.org/W2090205882","https://openalex.org/W2069203057","https://openalex.org/W2207874312"],"abstract_inverted_index":{"Objective:":[0],"The":[1],"aim":[2],"of":[3,11,95],"this":[4],"study":[5],"was":[6,48],"to":[7,31,78],"report":[8],"the":[9,33,69,92,134],"efficacy":[10],"low-density":[12],"lipoprotein":[13,102],"cholesterol":[14,97,103],"(LDL-C)":[15],"apheresis":[16,42,60],"using":[17,43,133],"a":[18,44],"cascade":[19,45,135],"filtration":[20,46,65,136],"system":[21,47,137],"in":[22,50,57,91,116,122,127],"pediatric":[23,52],"patients":[24,53,140],"with":[25,54,138],"homozygous":[26,55],"familial":[27],"hypercholesterolemia":[28],"(FH),":[29],"and":[30,37,39,100,125,145,150,154],"clarify":[32],"associated":[34],"adverse":[35,112,152],"effects":[36,113,153],"difficulties.Material":[38],"Methods:":[40],"LDL-C":[41,71],"performed":[49],"3":[51,117,128,139],"FH;":[56],"total,":[58],"120":[59],"sessions":[61,118,129],"were":[62,106,114],"performed.Results:":[63],"Cascade":[64],"therapy":[66],"significantly":[67],"reduced":[68],"mean":[70,89],"values":[72],"from":[73],"418":[74],"\u00b1":[75,80],"62":[76],"mg/dL":[77],"145":[79],"43":[81],"mg/":[82],"dL":[83],"(p=":[84],"0.011).We":[85],"observed":[86],"an":[87],"acute":[88],"reduction":[90],"plasma":[93],"level":[94],"total":[96],"(57.9%),LDL-C":[98],"(70.8%),":[99],"high-density":[101],"(HDL-C)":[104],"(40.7%).Treatments":[105],"well":[107],"tolerated.The":[108],"most":[109],"frequent":[110],"clinical":[111,143],"hypotension":[115],"(2.5%),":[119],"chills":[120],"(1.7%)":[121],"2":[123],"sessions,":[124],"nausea/vomiting":[126],"(2.5%).Conclusion:":[130],"Our":[131],"experience":[132],"included":[141],"good":[142],"outcomes":[144],"laboratory":[146],"findings,":[147],"safe":[148],"usage,":[149],"minor":[151],"technical":[155],"problems.":[156]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}