{"id":"https://openalex.org/W4242693087","doi":"https://doi.org/10.4161/mabs.2.1.10328","title":"Canakinumab","display_name":"Canakinumab","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W4242693087","doi":"https://doi.org/10.4161/mabs.2.1.10328","pmid":"https://pubmed.ncbi.nlm.nih.gov/20065636","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2828573"},"language":"en","primary_location":{"id":"doi:10.4161/mabs.2.1.10328","doi":"https://doi.org/10.4161/mabs.2.1.10328","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.2.1.10328","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.2.1.10328?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.2.1.10328?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074250265","display_name":"Eugen Dhimolea","orcid":"https://orcid.org/0000-0002-8445-5509","observed_orcids":["https://orcid.org/0000-0002-8445-5509"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Eugen Dhimolea","raw_affiliation_strings":["Tufts University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tufts University School of Medicine","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074250265"],"corresponding_institution_ids":["https://openalex.org/I121934306"],"apc_list":{"value":2915,"currency":"GBP","value_usd":3575},"apc_paid":{"value":2915,"currency":"GBP","value_usd":3575},"fwci":0.7546,"has_fulltext":true,"cited_by_count":269,"citation_normalized_percentile":{"value":0.59856211,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"2","issue":"1","first_page":"3","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11078","display_name":"Inflammasome and immune disorders","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11616","display_name":"Autoimmune and Inflammatory Disorders Research","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/canakinumab","display_name":"canakinumab","score":1.0},{"id":"https://openalex.org/keywords/anti-il-1beta-monoclonal-antibody","display_name":"anti-IL-1\u03b2 monoclonal antibody","score":0.921999990940094},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cryopyrin-associated-periodic-syndromes","display_name":"cryopyrin-associated periodic syndromes","score":0.9210000038146973},{"id":"https://openalex.org/keywords/muckle-wells-syndrome","display_name":"Muckle-Wells syndrome","score":0.996999979019165},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":0.8059999942779541},{"id":"https://openalex.org/keywords/systemic-juvenile-idiopathic-arthritis","display_name":"systemic juvenile idiopathic arthritis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9129999876022339},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.8690000176429749},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9760000109672546},{"id":"https://openalex.org/keywords/eye-diseases","display_name":"eye diseases","score":0.8920000195503235},{"id":"https://openalex.org/keywords/drug-approval","display_name":"drug approval","score":0.49399998784065247},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2779725882","wikidata":"https://www.wikidata.org/wiki/Q3655009","display_name":"Canakinumab","level":4,"score":0.9876245260238647},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9494208097457886},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6500028371810913},{"id":"https://openalex.org/C3018890749","wikidata":"https://www.wikidata.org/wiki/Q204711","display_name":"Food and drug administration","level":2,"score":0.6084709167480469},{"id":"https://openalex.org/C59491497","wikidata":"https://www.wikidata.org/wiki/Q864715","display_name":"Biosimilar","level":2,"score":0.5223811268806458},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5029460787773132},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.48749279975891113},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4732181131839752},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.415547251701355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33338916301727295},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3322063088417053},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2449566125869751},{"id":"https://openalex.org/C2781228260","wikidata":"https://www.wikidata.org/wiki/Q415411","display_name":"Anakinra","level":3,"score":0.1369970440864563}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053583","descriptor_name":"Interleukin-1beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D056587","descriptor_name":"Cryopyrin-Associated Periodic Syndromes","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D056587","descriptor_name":"Cryopyrin-Associated Periodic Syndromes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4161/mabs.2.1.10328","doi":"https://doi.org/10.4161/mabs.2.1.10328","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.2.1.10328","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.2.1.10328?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1909229","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2828573","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:2828573","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2828573","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MAbs","raw_type":"Text"},{"id":"pmid:20065636","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20065636","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4161/mabs.2.1.10328","doi":"https://doi.org/10.4161/mabs.2.1.10328","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.2.1.10328","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.2.1.10328?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4242693087.pdf","grobid_xml":"https://content.openalex.org/works/W4242693087.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1967436988","https://openalex.org/W1977075910","https://openalex.org/W1978462186","https://openalex.org/W1986156986","https://openalex.org/W1991385627","https://openalex.org/W1995428027","https://openalex.org/W2009004909","https://openalex.org/W2015157276","https://openalex.org/W2016963118","https://openalex.org/W2017296296","https://openalex.org/W2030062071","https://openalex.org/W2091075158","https://openalex.org/W2100379211","https://openalex.org/W2110348886","https://openalex.org/W2110995918","https://openalex.org/W2117703822","https://openalex.org/W2122152368","https://openalex.org/W2132024570","https://openalex.org/W2132133634","https://openalex.org/W2133938345","https://openalex.org/W2147594818","https://openalex.org/W2149026148","https://openalex.org/W2149374693","https://openalex.org/W2156584537","https://openalex.org/W2156895888","https://openalex.org/W2158299272","https://openalex.org/W2159587574","https://openalex.org/W2165275387","https://openalex.org/W2412551333","https://openalex.org/W2432418760"],"related_works":["https://openalex.org/W2432418760","https://openalex.org/W2209493621","https://openalex.org/W7008339222","https://openalex.org/W2101059767","https://openalex.org/W2118389134","https://openalex.org/W2928442245","https://openalex.org/W2059548274","https://openalex.org/W7039147984","https://openalex.org/W2046383163","https://openalex.org/W2147976326"],"abstract_inverted_index":{"Canakinumab":[0],"(ACZ885,":[1],"Ilaris)":[2],"is":[3,16,72,108],"a":[4],"human":[5],"anti-IL-1beta":[6],"monoclonal":[7],"antibody":[8],"developed":[9],"by":[10,43],"Novartis.":[11],"Its":[12],"mode":[13],"of":[14,21,27,33,53,82],"action":[15],"based":[17],"on":[18],"the":[19,39,44,51,80],"neutralization":[20],"IL-1beta":[22],"signaling,":[23],"resulting":[24],"in":[25,29,79,110,136],"suppression":[26],"inflammation":[28],"patients":[30],"with":[31],"disorders":[32],"autoimmune":[34],"origin.":[35],"In":[36],"June":[37],"2009":[38],"drug":[40,71,122],"was":[41],"approved":[42,134],"US":[45],"Food":[46],"and":[47,58,95,98,113,133],"Drug":[48],"Administration":[49],"for":[50,76],"treatment":[52,81],"familial":[54],"cold":[55],"auto-inflammatory":[56],"syndrome":[57],"Muckle-Wells":[59],"syndrome,":[60],"which":[61],"are":[62],"inflammatory":[63],"diseases":[64],"related":[65],"to":[66],"cryopyrin-associated":[67],"periodic":[68],"syndromes.":[69],"The":[70,121],"currently":[73],"being":[74],"evaluated":[75],"its":[77],"potential":[78],"rheumatoid":[83],"arthritis,":[84,88],"systemic-onset":[85],"juvenile":[86],"idiopathic":[87],"chronic":[89],"obstructive":[90],"pulmonary":[91],"disease,":[92],"type":[93],"1":[94],"2":[96],"diabetes":[97],"ocular":[99],"diseases.":[100],"Reports":[101],"from":[102],"clinical":[103],"trials":[104],"suggest":[105],"that":[106],"canakinumab":[107],"well-tolerated":[109],"most":[111],"patients,":[112],"no":[114],"serious":[115],"adverse":[116],"effects":[117],"have":[118],"been":[119],"reported.":[120],"provides":[123],"significant":[124],"advantages":[125],"over":[126],"existing":[127],"competitive":[128],"therapies,":[129],"including":[130],"bimonthly":[131],"administration":[132],"use":[135],"children.":[137]},"counts_by_year":[{"year":2026,"cited_by_count":15},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":27},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":34},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}