{"id":"https://openalex.org/W4242691387","doi":"https://doi.org/10.4193/rhin12.86","title":"Allergen immunotherapy for allergic rhinitis","display_name":"Allergen immunotherapy for allergic rhinitis","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W4242691387","doi":"https://doi.org/10.4193/rhin12.86","pmid":"https://pubmed.ncbi.nlm.nih.gov/23671890"},"language":"en","primary_location":{"id":"doi:10.4193/rhin12.86","doi":"https://doi.org/10.4193/rhin12.86","is_oa":false,"landing_page_url":"https://doi.org/10.4193/rhin12.86","pdf_url":null,"source":{"id":"https://openalex.org/S94555171","display_name":"Rhinology Journal","issn_l":"0300-0729","issn":["0300-0729","1996-8604","2589-0085"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4324277485","host_organization_name":"European Rhinologic Society","host_organization_lineage":["https://openalex.org/P4324277485"],"host_organization_lineage_names":["European Rhinologic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.rhinologyjournal.com/download.php?id=1150","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035178936","display_name":"Konstantinos Petalas","orcid":"https://orcid.org/0000-0003-1680-3062","observed_orcids":["https://orcid.org/0000-0003-1680-3062"]},"institutions":[{"id":"https://openalex.org/I2802113776","display_name":"Hellenic Air Force","ror":"https://ror.org/044xk2674","country_code":"GR","type":"government","lineage":["https://openalex.org/I2802113776"]},{"id":"https://openalex.org/I4210102619","display_name":"Hellenic Airforce General Hospital","ror":"https://ror.org/0169n7f49","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210102619"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"K. Petalas","raw_affiliation_strings":["Department of Allergy and Clinical Immunology, 251 General Air Force Hospital, Athens, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Allergy and Clinical Immunology, 251 General Air Force Hospital, Athens, Greece","institution_ids":["https://openalex.org/I2802113776","https://openalex.org/I4210102619"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075871942","display_name":"S.R. Durham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210096640","display_name":"Royal Brompton Hospital","ror":"https://ror.org/00cv4n034","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800036501","https://openalex.org/I4210096640"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S.R. Durham","raw_affiliation_strings":["Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, London, United Kingdom","institution_ids":["https://openalex.org/I4210096640","https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035178936"],"corresponding_institution_ids":["https://openalex.org/I2802113776","https://openalex.org/I4210102619"],"apc_list":null,"apc_paid":null,"fwci":3.7901,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.93039591,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"51","issue":"2","first_page":"99","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10634","display_name":"Food Allergy and Anaphylaxis Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergen-immunotherapy","display_name":"allergen immunotherapy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.9470000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9868736267089844},{"id":"https://openalex.org/C2779787640","wikidata":"https://www.wikidata.org/wiki/Q1641412","display_name":"Allergen immunotherapy","level":4,"score":0.6393860578536987},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.572029709815979},{"id":"https://openalex.org/C2780510475","wikidata":"https://www.wikidata.org/wiki/Q186752","display_name":"Allergen","level":3,"score":0.5703070163726807},{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.567480206489563},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.4302375912666321},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4224601984024048},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.4216976463794708},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.052688270807266235}],"mesh":[{"descriptor_ui":"D003888","descriptor_name":"Desensitization, Immunologic","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012221","descriptor_name":"Rhinitis, Allergic, Perennial","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D065631","descriptor_name":"Rhinitis, Allergic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.4193/rhin12.86","doi":"https://doi.org/10.4193/rhin12.86","is_oa":false,"landing_page_url":"https://doi.org/10.4193/rhin12.86","pdf_url":null,"source":{"id":"https://openalex.org/S94555171","display_name":"Rhinology Journal","issn_l":"0300-0729","issn":["0300-0729","1996-8604","2589-0085"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4324277485","host_organization_name":"European Rhinologic Society","host_organization_lineage":["https://openalex.org/P4324277485"],"host_organization_lineage_names":["European Rhinologic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology Journal","raw_type":"journal-article"},{"id":"doi:10.4193/rhino12.086","doi":"https://doi.org/10.4193/rhino12.086","is_oa":true,"landing_page_url":"https://doi.org/10.4193/rhino12.086","pdf_url":"https://www.rhinologyjournal.com/download.php?id=1150","source":{"id":"https://openalex.org/S94555171","display_name":"Rhinology Journal","issn_l":"0300-0729","issn":["0300-0729","1996-8604","2589-0085"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4324277485","host_organization_name":"European Rhinologic Society","host_organization_lineage":["https://openalex.org/P4324277485"],"host_organization_lineage_names":["European Rhinologic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology journal","raw_type":"journal-article"},{"id":"pmid:23671890","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23671890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4193/rhino12.086","doi":"https://doi.org/10.4193/rhino12.086","is_oa":true,"landing_page_url":"https://doi.org/10.4193/rhino12.086","pdf_url":"https://www.rhinologyjournal.com/download.php?id=1150","source":{"id":"https://openalex.org/S94555171","display_name":"Rhinology Journal","issn_l":"0300-0729","issn":["0300-0729","1996-8604","2589-0085"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4324277485","host_organization_name":"European Rhinologic Society","host_organization_lineage":["https://openalex.org/P4324277485"],"host_organization_lineage_names":["European Rhinologic Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rhinology journal","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320314903","display_name":"Immune Tolerance Network","ror":"https://ror.org/00pjnm784"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4242691387.pdf","grobid_xml":"https://content.openalex.org/works/W4242691387.grobid-xml"},"referenced_works_count":113,"referenced_works":["https://openalex.org/W161846266","https://openalex.org/W1485987848","https://openalex.org/W1490916211","https://openalex.org/W1502218137","https://openalex.org/W1524200221","https://openalex.org/W1544152039","https://openalex.org/W1551609035","https://openalex.org/W1597390649","https://openalex.org/W1608960808","https://openalex.org/W1914284548","https://openalex.org/W1942126698","https://openalex.org/W1969976800","https://openalex.org/W1970877567","https://openalex.org/W1972463892","https://openalex.org/W1973517527","https://openalex.org/W1975797729","https://openalex.org/W1977868567","https://openalex.org/W1978173920","https://openalex.org/W1981529848","https://openalex.org/W1982130154","https://openalex.org/W1983730076","https://openalex.org/W1984973837","https://openalex.org/W1984996255","https://openalex.org/W1986235780","https://openalex.org/W1991536950","https://openalex.org/W1993190844","https://openalex.org/W1993375385","https://openalex.org/W1996748765","https://openalex.org/W1997120806","https://openalex.org/W2009267110","https://openalex.org/W2010998136","https://openalex.org/W2013244684","https://openalex.org/W2014803071","https://openalex.org/W2015957698","https://openalex.org/W2016895195","https://openalex.org/W2017312401","https://openalex.org/W2017326399","https://openalex.org/W2017910324","https://openalex.org/W2018589247","https://openalex.org/W2022429437","https://openalex.org/W2025695277","https://openalex.org/W2028065290","https://openalex.org/W2028280773","https://openalex.org/W2028287136","https://openalex.org/W2028458285","https://openalex.org/W2028803867","https://openalex.org/W2029420818","https://openalex.org/W2031202979","https://openalex.org/W2032260549","https://openalex.org/W2033222579","https://openalex.org/W2038405674","https://openalex.org/W2039347132","https://openalex.org/W2041068026","https://openalex.org/W2041703033","https://openalex.org/W2042015803","https://openalex.org/W2042658480","https://openalex.org/W2042692333","https://openalex.org/W2046574729","https://openalex.org/W2049033509","https://openalex.org/W2050552280","https://openalex.org/W2058573295","https://openalex.org/W2060328264","https://openalex.org/W2060411425","https://openalex.org/W2061178990","https://openalex.org/W2063177917","https://openalex.org/W2068981067","https://openalex.org/W2073231491","https://openalex.org/W2073342172","https://openalex.org/W2075790711","https://openalex.org/W2075875408","https://openalex.org/W2079088504","https://openalex.org/W2079900469","https://openalex.org/W2080229642","https://openalex.org/W2084209671","https://openalex.org/W2085138702","https://openalex.org/W2085196853","https://openalex.org/W2086794365","https://openalex.org/W2090201912","https://openalex.org/W2093542094","https://openalex.org/W2093751390","https://openalex.org/W2104772500","https://openalex.org/W2104822273","https://openalex.org/W2106625253","https://openalex.org/W2109893012","https://openalex.org/W2110567864","https://openalex.org/W2116810696","https://openalex.org/W2118553245","https://openalex.org/W2121760095","https://openalex.org/W2125803815","https://openalex.org/W2128140264","https://openalex.org/W2128645497","https://openalex.org/W2132197286","https://openalex.org/W2138023977","https://openalex.org/W2142388937","https://openalex.org/W2150187523","https://openalex.org/W2153011983","https://openalex.org/W2154126700","https://openalex.org/W2156787187","https://openalex.org/W2158341249","https://openalex.org/W2159285246","https://openalex.org/W2161074777","https://openalex.org/W2163513100","https://openalex.org/W2166685437","https://openalex.org/W2312829609","https://openalex.org/W2339514173","https://openalex.org/W2394530894","https://openalex.org/W2400369656","https://openalex.org/W4240287158","https://openalex.org/W4244436034","https://openalex.org/W4252123508","https://openalex.org/W4252295499","https://openalex.org/W4290767528","https://openalex.org/W4301662855"],"related_works":["https://openalex.org/W3143861514","https://openalex.org/W2472770584","https://openalex.org/W2984590715","https://openalex.org/W2334910320","https://openalex.org/W2140605800","https://openalex.org/W2154805243","https://openalex.org/W4311376652","https://openalex.org/W4240430066","https://openalex.org/W2045839560","https://openalex.org/W2025046672"],"abstract_inverted_index":{"Allergic":[0],"rhinitis,":[1],"a":[2,9,60,108,127],"risk":[3,87],"factor":[4],"for":[5,111,204],"bronchial":[6],"asthma,":[7,93,117],"is":[8,107,121,175],"global":[10],"health":[11],"problem":[12],"that":[13,119],"impairs":[14],"patients`":[15],"physical":[16],"and":[17,20,47,75,84,134,141,151,197],"social":[18],"activity":[19],"consequently":[21],"their":[22],"quality":[23],"of":[24,35,38,81,88,99,126,159,166,171,183,186,192],"life.":[25],"Specific":[26],"Immunotherapy":[27,67,138],"(SIT)":[28],"involves":[29],"the":[30,39,86,97,124,169,184,193],"administration,":[31],"subcutaneously":[32],"or":[33],"sublingually,":[34],"increasing":[36],"doses":[37],"causative":[40],"allergen,":[41],"in":[42,57,77,123,164,177],"order":[43],"to":[44,54,63,71,92,103,144,154,195],"induce":[45],"clinical":[46],"immunologic":[48],"tolerance.":[49,180],"SIT":[50],"has":[51,68,188],"been":[52,69],"shown":[53,70],"be":[55],"effective":[56,207],"those":[58],"with":[59,202],"poor":[61],"response":[62,194],"conventional":[64],"drug":[65],"therapy.":[66],"have":[72],"disease-modifying":[73],"effects":[74],"result":[76],"long":[78],"term":[79],"remission":[80],"allergic":[82,112],"symptoms":[83],"reduces":[85],"progression":[89],"from":[90],"rhinitis":[91,113],"as":[94,96],"well":[95],"chances":[98],"developing":[100],"new":[101,199],"sensitizations":[102],"allergens.":[104,156],"Injection":[105],"immunotherapy":[106,187],"safe":[109],"treatment":[110,196],"with/without":[114],"mild":[115],"controlled":[116],"provided":[118],"it":[120],"performed":[122],"context":[125],"harmonious":[128],"interaction":[129],"between":[130],"trained":[131],"medical":[132],"personnel":[133],"appropriately":[135],"selected":[136],"patients.":[137],"suppresses":[139],"early":[140],"late":[142],"responses":[143,153,163],"allergen":[145],"exposure":[146],"by":[147],"modifying":[148],"both":[149],"T-cell":[150],"B-cell":[152],"inhaled":[155],"Immune":[157],"deviation":[158],"allergen-specific":[160],"T":[161,173],"cell":[162],"favour":[165],"Th1":[167],"and/or":[168],"induction":[170],"regulatory":[172],"cells":[174],"crucial":[176],"achieving":[178],"immune":[179],"Increased":[181],"understanding":[182],"mechanisms":[185],"identified":[189],"potential":[190,203],"biomarkers":[191],"highlighted":[198],"therapeutic":[200],"pathways":[201],"even":[205],"more":[206],"future":[208],"standardized":[209],"vaccines.":[210]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}