{"id":"https://openalex.org/W4242583108","doi":"https://doi.org/10.1172/jci200215681","title":"Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair","display_name":"Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair","publication_year":2002,"publication_date":"2002-06-01","ids":{"openalex":"https://openalex.org/W4242583108","doi":"https://doi.org/10.1172/jci200215681"},"language":"en","primary_location":{"id":"doi:10.1172/jci200215681","doi":"https://doi.org/10.1172/jci200215681","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci200215681","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100620250","display_name":"Xinping Zhang","orcid":"https://orcid.org/0000-0002-4429-638X","observed_orcids":["https://orcid.org/0000-0002-4429-638X"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinping Zhang","raw_affiliation_strings":["The Center for Musculoskeletal Research, University of Rochester Medical Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Musculoskeletal Research, University of Rochester Medical Center, and","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074891524","display_name":"Edward M. Schwarz","orcid":"https://orcid.org/0000-0002-4854-9698","observed_orcids":["https://orcid.org/0000-0002-4854-9698"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward M. Schwarz","raw_affiliation_strings":["The Center for Musculoskeletal Research, University of Rochester Medical Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Musculoskeletal Research, University of Rochester Medical Center, and","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103966004","display_name":"Donald A. Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald A. Young","raw_affiliation_strings":["Department of Medicine/Endocrinology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine/Endocrinology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112762321","display_name":"J. Edward Puzas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Edward Puzas","raw_affiliation_strings":["The Center for Musculoskeletal Research, University of Rochester Medical Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Musculoskeletal Research, University of Rochester Medical Center, and","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113538634","display_name":"Randy N. Rosier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randy N. Rosier","raw_affiliation_strings":["The Center for Musculoskeletal Research, University of Rochester Medical Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Musculoskeletal Research, University of Rochester Medical Center, and","institution_ids":["https://openalex.org/I28792581"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024783120","display_name":"Regis J. O\u2019Keefe","orcid":"https://orcid.org/0000-0003-4055-0368","observed_orcids":["https://orcid.org/0000-0003-4055-0368"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Regis J. O\u2019Keefe","raw_affiliation_strings":["The Center for Musculoskeletal Research, University of Rochester Medical Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Musculoskeletal Research, University of Rochester Medical Center, and","institution_ids":["https://openalex.org/I28792581"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024783120"],"corresponding_institution_ids":["https://openalex.org/I28792581"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":0.1912,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.45880278,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"109","issue":"11","first_page":"1405","last_page":"1415"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6919000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.2921999990940094,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":1.0},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.7260000109672546},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8270000219345093},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7139999866485596},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8240000009536743},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.6169999837875366},{"id":"https://openalex.org/keywords/nonunion","display_name":"nonunion","score":0.7670000195503235},{"id":"https://openalex.org/keywords/endochondral-ossification","display_name":"endochondral ossification","score":0.859000027179718},{"id":"https://openalex.org/keywords/intramembranous-ossification","display_name":"intramembranous ossification","score":0.9900000095367432},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.8920000195503235},{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":0.8109999895095825},{"id":"https://openalex.org/keywords/osterix","display_name":"Osterix","score":0.9950000047683716},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8360000252723694},{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C17938293","wikidata":"https://www.wikidata.org/wiki/Q3312710","display_name":"Endochondral ossification","level":3,"score":0.6901878714561462},{"id":"https://openalex.org/C188945261","wikidata":"https://www.wikidata.org/wiki/Q10746904","display_name":"Intramembranous ossification","level":2,"score":0.6347863078117371},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.6252926588058472},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5395973920822144},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49730733036994934},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.48082292079925537},{"id":"https://openalex.org/C2779918246","wikidata":"https://www.wikidata.org/wiki/Q613203","display_name":"Calvaria","level":3,"score":0.4622698724269867},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4474765658378601},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.43592873215675354},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.41510745882987976},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37537145614624023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3649890720844269},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24352788925170898},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.21468129754066467},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.1373578906059265},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10082978010177612},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07154631614685059}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1172/jci200215681","doi":"https://doi.org/10.1172/jci200215681","is_oa":false,"landing_page_url":"https://doi.org/10.1172/jci200215681","pdf_url":null,"source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306775","display_name":"Musculoskeletal Transplant Foundation","ror":"https://ror.org/011398447"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1968470656","https://openalex.org/W1979242330","https://openalex.org/W1983895021","https://openalex.org/W1984701700","https://openalex.org/W1985298426","https://openalex.org/W1987504060","https://openalex.org/W1990862652","https://openalex.org/W1993418277","https://openalex.org/W1993840273","https://openalex.org/W1994596418","https://openalex.org/W1997473015","https://openalex.org/W1997812904","https://openalex.org/W2017433566","https://openalex.org/W2017544681","https://openalex.org/W2017859346","https://openalex.org/W2023194934","https://openalex.org/W2025356399","https://openalex.org/W2032491472","https://openalex.org/W2032936560","https://openalex.org/W2033798360","https://openalex.org/W2040040765","https://openalex.org/W2046080398","https://openalex.org/W2048492086","https://openalex.org/W2052029436","https://openalex.org/W2055023858","https://openalex.org/W2056652223","https://openalex.org/W2071393577","https://openalex.org/W2076326230","https://openalex.org/W2077178159","https://openalex.org/W2080470462","https://openalex.org/W2080694567","https://openalex.org/W2083651943","https://openalex.org/W2084754981","https://openalex.org/W2096925272","https://openalex.org/W2100200742","https://openalex.org/W2106412983","https://openalex.org/W2107010463","https://openalex.org/W2117858791","https://openalex.org/W2122367477","https://openalex.org/W2140039015","https://openalex.org/W2156409625","https://openalex.org/W2988816971","https://openalex.org/W4295836001"],"related_works":["https://openalex.org/W2245547928","https://openalex.org/W1965100070","https://openalex.org/W1981828273","https://openalex.org/W4412881169","https://openalex.org/W7099754602","https://openalex.org/W2064724993","https://openalex.org/W2792076556","https://openalex.org/W2006344121","https://openalex.org/W1871273491","https://openalex.org/W2152121980"],"abstract_inverted_index":{"Preclinical":[0],"and":[1,13,32,46,68,81,147,201,210,231,249,254,287],"clinical":[2],"studies":[3],"suggest":[4],"a":[5,76,82,90,189,278],"possible":[6],"role":[7,42],"for":[8,236],"cyclooxygenases":[9],"in":[10,23,43,62,85,89,96,110,114,131,138,156,161,198,221,251,270],"bone":[11,48,102,133,139,179,183,237],"repair":[12],"create":[14],"concerns":[15],"about":[16],"the":[17,97,105,128,173,176,219,258,283],"use":[18],"of":[19,55,78,93,117,168,178,213,229,240,260,273,285],"nonsteroidal":[20],"antiinflammatory":[21],"drugs":[22],"patients":[24],"with":[25,66,120,195,225],"skeletal":[26,51,292],"injury.":[27],"We":[28],"utilized":[29],"wild-type,":[30],"COX-1\u2013/\u2013,":[31],"COX-2\u2013/\u2013":[33,63,98,111,146,157,202,222,253],"mice":[34,64,112],"to":[35,172,188,289],"demonstrate":[36],"that":[37,87,193,205,218,266],"COX-2":[38,208,267,281],"plays":[39],"an":[40],"essential":[41],"both":[44,199,252],"endochondral":[45],"intramembranous":[47,101],"formation":[49,103,152,185],"during":[50],"repair.":[52,293],"The":[53,71,159],"healing":[54],"stabilized":[56],"tibia":[57],"fractures":[58],"was":[59,73,107,136,153,163,186],"significantly":[60,226],"delayed":[61],"compared":[65,119],"COX-1\u2013/\u2013":[67,122],"wild-type":[69,124,148,255],"controls.":[70],"histology":[72],"characterized":[74],"by":[75,166],"persistence":[77],"undifferentiated":[79],"mesenchyme":[80],"marked":[83],"reduction":[84],"osteoblastogenesis":[86,135],"resulted":[88],"high":[91],"incidence":[92],"fibrous":[94],"nonunion":[95],"mice.":[99,125,149,158],"Similarly,":[100],"on":[104],"calvaria":[106],"reduced":[108,132,154,227],"60%":[109],"following":[113],"vivo":[115],"injection":[116],"FGF-1":[118],"either":[121],"or":[123],"To":[126],"elucidate":[127],"mechanism":[129],"involved":[130,269],"formation,":[134],"studied":[137],"marrow":[140],"stromal":[141],"cell":[142],"cultures":[143,223],"obtained":[144],"from":[145],"Bone":[150],"nodule":[151,184],"50%":[155],"defect":[160,220],"osteogenesis":[162],"completely":[164],"rescued":[165,242],"addition":[167],"prostaglandin":[169],"E2":[170],"(PGE2)":[171],"cultures.":[174,256],"In":[175],"presence":[177],"morphogenetic":[180],"protein":[181],"(BMP-2),":[182],"enhanced":[187,247],"similar":[190],"level":[191],"above":[192],"observed":[194],"PGE2":[196,241],"alone":[197],"control":[200],"cultures,":[203],"indicating":[204,265],"BMPs":[206],"complement":[207],"deficiency":[209],"are":[211],"downstream":[212],"prostaglandins.":[214],"Furthermore,":[215],"we":[216],"found":[217],"correlated":[224],"levels":[228],"cbfa1":[230,248,286],"osterix,":[232],"two":[233],"genes":[234],"necessary":[235],"formation.":[238],"Addition":[239],"this":[243],"defect,":[244],"while":[245],"BMP-2":[246],"osterix":[250,288],"Finally,":[257],"effects":[259],"these":[261],"agents":[262],"were":[263],"additive,":[264],"is":[268],"maximal":[271],"induction":[272,284],"osteogenesis.":[274],"These":[275],"results":[276],"provide":[277],"model":[279],"whereby":[280],"regulates":[282],"mediate":[290],"normal":[291]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}