{"id":"https://openalex.org/W4242546579","doi":"https://doi.org/10.1176/foc.4.3.339","title":"Psychiatric Pharmacogenomics","display_name":"Psychiatric Pharmacogenomics","publication_year":2006,"publication_date":"2006-08-01","ids":{"openalex":"https://openalex.org/W4242546579","doi":"https://doi.org/10.1176/foc.4.3.339"},"language":"en","primary_location":{"id":"doi:10.1176/foc.4.3.339","doi":"https://doi.org/10.1176/foc.4.3.339","is_oa":false,"landing_page_url":"https://doi.org/10.1176/foc.4.3.339","pdf_url":null,"source":{"id":"https://openalex.org/S4210193920","display_name":"FOCUS The Journal of Lifelong Learning in Psychiatry","issn_l":"1541-4094","issn":["1541-4094","1541-4108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Focus","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055990260","display_name":"David A. Mrazek","orcid":"https://orcid.org/0000-0002-8179-4601","observed_orcids":["https://orcid.org/0000-0002-8179-4601"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David A. Mrazek","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5055990260"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.54216175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"4","issue":"3","first_page":"339","last_page":"343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.01810000091791153,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.7789999842643738},{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.9409999847412109},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.4440000057220459},{"id":"https://openalex.org/keywords/serotonin-transporter-gene","display_name":"serotonin transporter gene","score":0.8460000157356262},{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9869999885559082},{"id":"https://openalex.org/keywords/pharmacogenetic-testing","display_name":"pharmacogenetic testing","score":0.8420000076293945}],"concepts":[{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.9354145526885986},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.7262716889381409},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.696029543876648},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5001866817474365},{"id":"https://openalex.org/C2994119904","wikidata":"https://www.wikidata.org/wiki/Q1251001","display_name":"Drug response","level":3,"score":0.4592007100582123},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.4457891583442688},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4457368552684784},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.4435775876045227},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3714454174041748},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.3689366579055786},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3583613932132721},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35635262727737427},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32365894317626953},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2967846393585205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2054903209209442},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.20186498761177063},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.17022588849067688}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1176/foc.4.3.339","doi":"https://doi.org/10.1176/foc.4.3.339","is_oa":false,"landing_page_url":"https://doi.org/10.1176/foc.4.3.339","pdf_url":null,"source":{"id":"https://openalex.org/S4210193920","display_name":"FOCUS The Journal of Lifelong Learning in Psychiatry","issn_l":"1541-4094","issn":["1541-4094","1541-4108"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","norway-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Focus","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1972859881","https://openalex.org/W1980676016","https://openalex.org/W1984455353","https://openalex.org/W2001657113","https://openalex.org/W2029995473","https://openalex.org/W2059521766","https://openalex.org/W2074404972","https://openalex.org/W2086311259","https://openalex.org/W2162196924","https://openalex.org/W2314647810"],"related_works":["https://openalex.org/W2078812687","https://openalex.org/W2086849011","https://openalex.org/W3039570146","https://openalex.org/W4293258603","https://openalex.org/W2133221624","https://openalex.org/W2172029095","https://openalex.org/W2401563246","https://openalex.org/W2393482763","https://openalex.org/W4390578831","https://openalex.org/W1511987243"],"abstract_inverted_index":{"The":[0,13,34],"field":[1],"of":[2,16,37,63,90],"psychiatric":[3,17],"genomics":[4],"has":[5,40,83],"developed":[6],"dramatically":[7],"over":[8],"the":[9,73,78,88],"past":[10],"10":[11],"years.":[12],"essential":[14],"goal":[15],"pharmacogenomics":[18],"is":[19],"to":[20,27,31,42,86,92],"measure":[21],"genetic":[22,70],"variation":[23],"in":[24,51,72],"individual":[25],"patients":[26,44,91],"predict":[28,87],"their":[29,52],"response":[30,89],"psychotropic":[32],"medications.":[33],"initial":[35],"application":[36],"pharmacogenetic":[38],"testing":[39],"been":[41,84],"identify":[43],"who":[45],"have":[46],"structural":[47],"and":[48,77],"functional":[49],"changes":[50],"drug-metabolizing":[53],"enzyme":[54],"genes":[55],"that":[56],"are":[57],"associated":[58],"with":[59],"increased":[60],"serum":[61],"levels":[62],"medication":[64],"at":[65],"standard":[66],"doses.":[67],"More":[68],"recently,":[69],"variance":[71],"serotonin":[74,79,94],"transporter":[75],"gene":[76,82],"2A":[80],"receptor":[81],"used":[85],"selective":[93],"reuptake":[95],"inhibitors.":[96]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2022-05-12T00:00:00"}