{"id":"https://openalex.org/W4242507541","doi":"https://doi.org/10.1097/00000374-200010000-00006","title":"Effects of MDL 72222, a Serotonin3 Antagonist, on Operant Responding for Ethanol by Alcohol-Preferring P Rats","display_name":"Effects of MDL 72222, a Serotonin3 Antagonist, on Operant Responding for Ethanol by Alcohol-Preferring P Rats","publication_year":2000,"publication_date":"2000-10-01","ids":{"openalex":"https://openalex.org/W4242507541","doi":"https://doi.org/10.1097/00000374-200010000-00006","pmid":"https://pubmed.ncbi.nlm.nih.gov/11045857"},"language":"en","primary_location":{"id":"doi:10.1097/00000374-200010000-00006","doi":"https://doi.org/10.1097/00000374-200010000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000374-200010000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074035943","display_name":"David L. McKinzie","orcid":"https://orcid.org/0000-0002-4115-3316","observed_orcids":["https://orcid.org/0000-0002-4115-3316"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. L. McKinzie","raw_affiliation_strings":["Departments of Psychiatry (DLM, WJM, JMM), Medicine (LL, T-KL) and Biochemistry (LL, T-KL), Institute of Psychiatric Research (DLM, WJM, JMM), Indiana University School of Medicine and VA Medical Center (LL), and Department of Psychology (JMM), Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry (DLM, WJM, JMM), Medicine (LL, T-KL) and Biochemistry (LL, T-KL), Institute of Psychiatric Research (DLM, WJM, JMM), Indiana University School of Medicine and VA Medical Center (LL), and Department of Psychology (JMM), Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036789705","display_name":"William J. McBride","orcid":"https://orcid.org/0000-0001-8894-533X","observed_orcids":["https://orcid.org/0000-0001-8894-533X"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"W. J. McBride","raw_affiliation_strings":["Departments of Psychiatry (DLM, WJM, JMM), Medicine (LL, T-KL) and Biochemistry (LL, T-KL), Institute of Psychiatric Research (DLM, WJM, JMM), Indiana University School of Medicine and VA Medical Center (LL), and Department of Psychology (JMM), Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry (DLM, WJM, JMM), Medicine (LL, T-KL) and Biochemistry (LL, T-KL), Institute of Psychiatric Research (DLM, WJM, JMM), Indiana University School of Medicine and VA Medical Center (LL), and Department of Psychology (JMM), Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054806565","display_name":"James M. Murphy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Murphy","raw_affiliation_strings":["Departments of Psychiatry (DLM, WJM, JMM), Medicine (LL, T-KL) and Biochemistry (LL, T-KL), Institute of Psychiatric Research (DLM, WJM, JMM), Indiana University School of Medicine and VA Medical Center (LL), and Department of Psychology (JMM), Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry (DLM, WJM, JMM), Medicine (LL, T-KL) and Biochemistry (LL, T-KL), Institute of Psychiatric Research (DLM, WJM, JMM), Indiana University School of Medicine and VA Medical Center (LL), and Department of Psychology (JMM), Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109992600","display_name":"Lawrence Lumeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. Lumeng","raw_affiliation_strings":["Departments of Psychiatry (DLM, WJM, JMM), Medicine (LL, T-KL) and Biochemistry (LL, T-KL), Institute of Psychiatric Research (DLM, WJM, JMM), Indiana University School of Medicine and VA Medical Center (LL), and Department of Psychology (JMM), Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry (DLM, WJM, JMM), Medicine (LL, T-KL) and Biochemistry (LL, T-KL), Institute of Psychiatric Research (DLM, WJM, JMM), Indiana University School of Medicine and VA Medical Center (LL), and Department of Psychology (JMM), Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110097573","display_name":"Ting\u2010Kai Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T.-K. Li","raw_affiliation_strings":["Departments of Psychiatry (DLM, WJM, JMM), Medicine (LL, T-KL) and Biochemistry (LL, T-KL), Institute of Psychiatric Research (DLM, WJM, JMM), Indiana University School of Medicine and VA Medical Center (LL), and Department of Psychology (JMM), Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Psychiatry (DLM, WJM, JMM), Medicine (LL, T-KL) and Biochemistry (LL, T-KL), Institute of Psychiatric Research (DLM, WJM, JMM), Indiana University School of Medicine and VA Medical Center (LL), and Department of Psychology (JMM), Purdue School of Science, Indiana University-Purdue University at Indianapolis, Indianapolis, Indiana","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5036789705"],"corresponding_institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130","https://openalex.org/I55769427"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":0.5163,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.6,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"24","issue":"10","first_page":"1500","last_page":"1504"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10043","display_name":"Substance Abuse Treatment and Outcomes","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdl-72222","display_name":"MDL 72222","score":0.9980000257492065},{"id":"https://openalex.org/keywords/5-ht3-receptor-antagonists","display_name":"5-HT3 receptor antagonists","score":0.8870000243186951},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.5730000138282776},{"id":"https://openalex.org/keywords/ethanol-self-administration","display_name":"ethanol self-administration","score":0.7870000004768372},{"id":"https://openalex.org/keywords/operant-responding","display_name":"operant responding","score":0.8029999732971191},{"id":"https://openalex.org/keywords/fixed-ratio-schedules","display_name":"fixed-ratio schedules","score":0.6489999890327454},{"id":"https://openalex.org/keywords/scheduled-access","display_name":"scheduled access","score":0.6679999828338623},{"id":"https://openalex.org/keywords/ethanol-reinforcement","display_name":"ethanol reinforcement","score":0.8059999942779541},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.708895742893219},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.6966164112091064},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.6077313423156738},{"id":"https://openalex.org/C163270606","wikidata":"https://www.wikidata.org/wiki/Q847079","display_name":"Operant conditioning","level":3,"score":0.5307714343070984},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.49544060230255127},{"id":"https://openalex.org/C2778555786","wikidata":"https://www.wikidata.org/wiki/Q7448011","display_name":"Self-administration","level":2,"score":0.4757359027862549},{"id":"https://openalex.org/C45262634","wikidata":"https://www.wikidata.org/wiki/Q5159291","display_name":"Conditioning","level":2,"score":0.43241703510284424},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4242829382419586},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.36934730410575867},{"id":"https://openalex.org/C67203356","wikidata":"https://www.wikidata.org/wiki/Q1321905","display_name":"Reinforcement","level":2,"score":0.36597079038619995},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.348455011844635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3232438564300537},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19867411255836487},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18174561858177185},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14616236090660095},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1403925120830536},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1259251832962036},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.07434970140457153},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.05982068181037903}],"mesh":[{"descriptor_ui":"D000428","descriptor_name":"Alcohol Drinking","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004326","descriptor_name":"Drinking","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007279","descriptor_name":"Injections, Subcutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012646","descriptor_name":"Self Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014326","descriptor_name":"Tropanes","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014326","descriptor_name":"Tropanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00000374-200010000-00006","doi":"https://doi.org/10.1097/00000374-200010000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000374-200010000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"pmid:11045857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11045857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1022269698","display_name":null,"funder_award_id":"AA 10721","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G2124721182","display_name":null,"funder_award_id":"AA-07611","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G2830253936","display_name":"CNS Sites Mediating Alcohol Drinking Behavior","funder_award_id":"R01AA010717","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G4146957554","display_name":"Neurobiology of high alcohol-seeking behavior","funder_award_id":"R01AA010721","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G5646784260","display_name":null,"funder_award_id":"AA10717","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W9321131","https://openalex.org/W1500971499","https://openalex.org/W1797218635","https://openalex.org/W1918535853","https://openalex.org/W1969181676","https://openalex.org/W1973693683","https://openalex.org/W1973775860","https://openalex.org/W1991671180","https://openalex.org/W1998757791","https://openalex.org/W1999407810","https://openalex.org/W2009679260","https://openalex.org/W2016873572","https://openalex.org/W2034387660","https://openalex.org/W2053948802","https://openalex.org/W2070325433","https://openalex.org/W2074924355","https://openalex.org/W2074991868","https://openalex.org/W2089736075","https://openalex.org/W2158141537","https://openalex.org/W2162565570"],"related_works":["https://openalex.org/W2162565570","https://openalex.org/W9321131","https://openalex.org/W4249560189","https://openalex.org/W2028192160","https://openalex.org/W2074924355","https://openalex.org/W2054290729","https://openalex.org/W2070360496","https://openalex.org/W2053948802","https://openalex.org/W1973775860","https://openalex.org/W2158141537"],"abstract_inverted_index":{"BACKGROUND:":[0],"Previous":[1],"studies":[2],"indicated":[3],"that,":[4],"under":[5,33],"continuous":[6],"access":[7,35,40,139],"conditions,":[8,36],"the":[9,38,48,67,72,100,122,159,169,173,186,191,206,209,222,231,246,257,268],"5-HT3":[10,239,271],"antagonist":[11],"MDL":[12,24,51,112,127,178,214],"72222":[13],"(MDL)":[14],"effectively":[15],"reduced":[16,197,227],"ethanol":[17,39,56,82,133,182,202,228,260,275],"drinking":[18],"of":[19,50,93,124,177,190,213,249,259,270],"alcohol-preferring":[20,62],"P":[21,63],"rats.":[22,64],"However,":[23],"was":[25,42,140],"without":[26],"effect":[27,217],"when":[28,137],"similar":[29],"doses":[30],"were":[31,75,105],"tested":[32,121],"scheduled":[34,149,163],"unless":[37],"period":[41],"randomly":[43],"presented.":[44],"This":[45,194],"study":[46],"examined":[47],"effects":[49,123,248],"on":[52,85,128,218],"operant":[53,102,129,138,219],"responding":[54,130,180,200,220,229],"for":[55,80,131,181,201],"and":[57,83,90,203,251],"water":[58,84],"by":[59,221,230],"adult":[60],"male":[61],"METHODS:":[65],"During":[66],"dark":[68,160],"cycle,":[69],"subjects":[70],"in":[71,134,244,266],"first":[73,170,187],"experiment":[74,120],"trained":[76],"to":[77,273],"respond":[78],"concurrently":[79],"15%":[81,132],"a":[86,143],"fixed-ratio":[87],"5":[88,116,174],"(FR-5)":[89],"FR-1":[91],"schedule":[92],"reinforcement,":[94],"respectively.":[95],"Approximately":[96],"30":[97,188],"min":[98,189],"before":[99],"4-hr":[101,192,199],"session,":[103],"rats":[104],"injected":[106],"subcutaneously":[107],"(sc)":[108],"with":[109,256],"saline":[110],"or":[111,115,153],"(1,":[113],"3,":[114],"mg/kg).":[117],"A":[118],"second":[119,207],"1":[125,210],"mg/kg":[126,175,211],"1-hr":[135],"sessions":[136],"given":[141],"at":[142,154],"fixed":[144],"time":[145,156],"each":[146],"day":[147],"(fixed":[148],"access,":[150,164],"FSA":[151,223],"group)":[152],"variable":[155],"periods":[157],"throughout":[158],"cycle":[161],"(variable":[162],"VSA":[165,232],"group).":[166],"RESULTS:":[167],"In":[168,205],"experiment,":[171,208],"only":[172],"dose":[176,195,212],"decreased":[179],"(approximately":[183],"20%)":[184],"during":[185],"session.":[193],"also":[196],"total":[198],"water.":[204],"had":[215],"no":[216],"group,":[224],"but":[225],"significantly":[226],"group.":[233],"CONCLUSIONS:":[234],"These":[235],"results":[236],"suggest":[237],"that":[238,252],"receptors":[240],"may":[241,261],"be":[242,262],"involved":[243,265],"mediating":[245],"reinforcing":[247],"ethanol,":[250],"temporal-environmental":[253],"cues":[254],"associated":[255],"presentation":[258],"one":[263],"factor":[264],"reducing":[267],"effectiveness":[269],"antagonists":[272],"attenuate":[274],"intake.":[276]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}