{"id":"https://openalex.org/W4242394686","doi":"https://doi.org/10.1016/j.jalz.2017.06.1070","title":"[P2\u2013414]: CHARACTERISING THE PROGRESSION OF ALZHEIMER's DISEASE SUBTYPES USING SUBTYPE AND STAGE INFERENCE (SUSTAIN)","display_name":"[P2\u2013414]: CHARACTERISING THE PROGRESSION OF ALZHEIMER's DISEASE SUBTYPES USING SUBTYPE AND STAGE INFERENCE (SUSTAIN)","publication_year":2017,"publication_date":"2017-07-01","ids":{"openalex":"https://openalex.org/W4242394686","doi":"https://doi.org/10.1016/j.jalz.2017.06.1070"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2017.06.1070","doi":"https://doi.org/10.1016/j.jalz.2017.06.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.06.1070","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.06.1070","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.06.1070","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028056283","display_name":"Alexandra L. Young","orcid":"https://orcid.org/0000-0002-7772-781X","observed_orcids":["https://orcid.org/0000-0002-7772-781X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Alexandra L. Young","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088193137","display_name":"Razvan Valentin Marinescu","orcid":"https://orcid.org/0000-0003-4042-8493","observed_orcids":["https://orcid.org/0000-0003-4042-8493"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Razvan Valentin Marinescu","raw_affiliation_strings":["Department of Computer Science and Centre for Medical Image Computing, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Centre for Medical Image Computing, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015359108","display_name":"Keir X. X. Yong","orcid":"https://orcid.org/0000-0002-9708-3599","observed_orcids":["https://orcid.org/0000-0002-9708-3599"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Keir Yong","raw_affiliation_strings":["UCL Institute of Neurology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Neurology, London, United Kingdom","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062890799","display_name":"Nicholas C. Firth","orcid":"https://orcid.org/0000-0001-5391-3143","observed_orcids":["https://orcid.org/0000-0001-5391-3143"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicholas C. Firth","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075265609","display_name":"Neil P. Oxtoby","orcid":"https://orcid.org/0000-0003-0203-3909","observed_orcids":["https://orcid.org/0000-0003-0203-3909"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil P. Oxtoby","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042212695","display_name":"David M. Cash","orcid":"https://orcid.org/0000-0001-7833-616X","observed_orcids":["https://orcid.org/0000-0001-7833-616X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David M. Cash","raw_affiliation_strings":["Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, UCL, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Imaging Group, Centre for Medical Image Computing, Department of Medical Physics and Biomedical Engineering, UCL, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018836358","display_name":"Nick C. Fox","orcid":"https://orcid.org/0000-0002-6660-657X","observed_orcids":["https://orcid.org/0000-0002-6660-657X"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick C. Fox","raw_affiliation_strings":["UCL Institute of Neurology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Neurology, London, United Kingdom","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037524623","display_name":"Sebastian James Crutch","orcid":"https://orcid.org/0000-0002-4160-0139","observed_orcids":["https://orcid.org/0000-0002-4160-0139"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sebastian J. Crutch","raw_affiliation_strings":["UCL Institute of Neurology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Neurology, London, United Kingdom","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070348432","display_name":"Jonathan Daniel Rohrer","orcid":"https://orcid.org/0000-0002-6155-8417","observed_orcids":["https://orcid.org/0000-0002-6155-8417"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan D. Rohrer","raw_affiliation_strings":["UCL Institute of Neurology, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UCL Institute of Neurology, London, United Kingdom","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045615014","display_name":"Jonathan M. Schott","orcid":"https://orcid.org/0000-0003-2059-024X","observed_orcids":["https://orcid.org/0000-0003-2059-024X"]},"institutions":[{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan M. Schott","raw_affiliation_strings":["Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom","institution_ids":["https://openalex.org/I4405260083","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033449704","display_name":"Daniel C. Alexander","orcid":"https://orcid.org/0000-0003-2439-350X","observed_orcids":["https://orcid.org/0000-0003-2439-350X"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel C. Alexander","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106733559","display_name":"Alzheimer\u2019s Disease Neuroimaging Initiative","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alzheimer's Disease Neuroimaging Initiative (ADNI)","raw_affiliation_strings":["University College London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College London, London, United Kingdom","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5028056283"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.45692413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"7S_Part_16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0723000019788742,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease-subtypes","display_name":"Alzheimer's disease subtypes","score":0.9470000267028809},{"id":"https://openalex.org/keywords/amyloid-pet","display_name":"amyloid PET","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2778373026","wikidata":"https://www.wikidata.org/wiki/Q4738819","display_name":"Alzheimer's Disease Neuroimaging Initiative","level":4,"score":0.6784090995788574},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.6115337610244751},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.500413179397583},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4935339689254761},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.44861310720443726},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.446336567401886},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.4401886463165283},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4382568597793579},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.43806177377700806},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.42682433128356934},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40287473797798157},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3959803581237793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37571364641189575},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.33528199791908264},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10578593611717224},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09799772500991821}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2017.06.1070","doi":"https://doi.org/10.1016/j.jalz.2017.06.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.06.1070","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.06.1070","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2017.06.1070","doi":"https://doi.org/10.1016/j.jalz.2017.06.1070","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2017.06.1070","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2017.06.1070","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4242394686.pdf","grobid_xml":"https://content.openalex.org/works/W4242394686.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2767139302","https://openalex.org/W2791819857","https://openalex.org/W4414491269","https://openalex.org/W4415397114","https://openalex.org/W2766549568","https://openalex.org/W2982572611","https://openalex.org/W1561315863","https://openalex.org/W2037787270","https://openalex.org/W2322105514","https://openalex.org/W4390199304"],"abstract_inverted_index":{"modelled":[0],"regional":[1,221],"declines":[2],"in":[3,101,103,119,220,223],"[":[4,15,104,122,129,224],"18":[5,16,105,123,130,225],"F]FDG":[6,106,124,226],"over":[7,107,152,227],"2":[8,108],"years":[9,109],"as":[10,31,51,62,203],"a":[11,76,88,147,160,204,207,228],"function":[12],"of":[13,34,56,99,135,150,179,194,200,215],"baseline":[14],"F]florbetapir":[17,131],"amyloid-b":[18,196],"positron":[19],"emission":[20],"tomography":[21],"(PET)":[22],"and":[23,28,44,197,217],"cerebrospinal":[24],"phosphorylated":[25],"tau":[26,198],"thresholds.Rsquared":[27],"F-test":[29],"served":[30],"the":[32,35,38,63,66,73,83,156,180,192,213],"basis":[33],"goodness-of-fit,":[36],"while":[37],"Akaike":[39],"information":[40],"criterion":[41],"compared":[42],"linear":[43],"non-linear":[45,47],"functions.The":[46],"associations":[48],"were":[49,60],"assumed":[50],"sigmoidal:":[52],"Y\u00bca+(b/(1+e^((-(x-c))/d))).The":[53],"thresholds":[54,134,168,199],"predictive":[55],"imminent":[57,136,201],"metabolic":[58],"decline":[59],"defined":[61],"value":[64],"where":[65],"curvatures":[67],"changed":[68],"signs":[69],"(X\u00bcc).We":[70],"performed,":[71],"for":[72,87,145,173,211],"first":[74],"time,":[75],"voxelwise":[77],"power":[78,100,210],"analysis":[79],"calculation":[80],"to":[81],"define":[82],"sample":[84],"size":[85,114],"needed":[86],"disease-modifying":[89],"therapy":[90],"test":[91,155],"an":[92],"estimated":[93],"25%":[94,151],"drug":[95,148,158],"effect":[96,149],"with":[97,166,206],"80%":[98],"changes":[102,222],"across":[110],"biomarker":[111],"groups.Results:":[112],"Sample":[113],"calculation,":[115],"using":[116,128,162,176],"averaged":[117],"change":[118],"mediobasal":[120],"temporal":[121],"revealed":[125],"that":[126],"studies":[127],"plus":[132],"p-tau":[133],"neurodegeneration":[137,202],"would":[138,169],"require":[139,170],"87":[140],"individuals":[141,165,172,178],"per":[142,184],"trial":[143],"arm":[144,186],"testing":[146,212],"24":[153],"months.For":[154],"same":[157],"effect,":[159],"study":[161],"preclinical":[163],"AD":[164],"standard":[167],"422":[171],"arm,":[174],"whereas":[175],"all":[177],"population":[181],"756":[182],"individual":[183],"trail":[185],"(Fig.":[187],"1).Conclusions:":[188],"These":[189],"results":[190],"highlight":[191],"concept":[193],"combined":[195],"framework":[205],"high":[208],"statistical":[209],"effects":[214],"anti-amyloid":[216],"anti-tau":[218],"therapies":[219],"typical":[229],"2-year":[230],"clinical":[231],"trial.":[232]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}