{"id":"https://openalex.org/W4242376751","doi":"https://doi.org/10.1210/endo.150.11.9998","title":"Hypercortisolemia Is Associated with Severity of Bone Loss and Depression in Hypothalamic Amenorrhea and Anorexia Nervosa","display_name":"Hypercortisolemia Is Associated with Severity of Bone Loss and Depression in Hypothalamic Amenorrhea and Anorexia Nervosa","publication_year":2009,"publication_date":"2009-11-01","ids":{"openalex":"https://openalex.org/W4242376751","doi":"https://doi.org/10.1210/endo.150.11.9998"},"language":"en","primary_location":{"id":"doi:10.1210/endo.150.11.9998","doi":"https://doi.org/10.1210/endo.150.11.9998","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.150.11.9998","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088073213","display_name":"Elizabeth Austen Lawson","orcid":"https://orcid.org/0000-0001-8619-3349","observed_orcids":["https://orcid.org/0000-0001-8619-3349"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth A. Lawson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023033992","display_name":"Daniel A. Donoho","orcid":"https://orcid.org/0000-0002-0531-1436","observed_orcids":["https://orcid.org/0000-0002-0531-1436"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Donoho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052169338","display_name":"Karen Klahr Miller","orcid":"https://orcid.org/0000-0001-9438-2449","observed_orcids":["https://orcid.org/0000-0001-9438-2449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen K. Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071356764","display_name":"Madhusmita Misra","orcid":"https://orcid.org/0000-0002-9405-2981","observed_orcids":["https://orcid.org/0000-0002-9405-2981"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhusmita Misra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053314988","display_name":"Erinne M. Meenaghan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erinne Meenaghan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078977437","display_name":"Janet A. Lydecker","orcid":"https://orcid.org/0000-0001-6425-514X","observed_orcids":["https://orcid.org/0000-0001-6425-514X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet Lydecker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088831526","display_name":"T Wexler","orcid":"https://orcid.org/0000-0002-0919-2382","observed_orcids":["https://orcid.org/0000-0002-0919-2382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tamara Wexler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114009540","display_name":"David B. Herzog","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David B. Herzog","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5034090492","display_name":"Anne Klibanski","orcid":"https://orcid.org/0000-0003-4878-0205","observed_orcids":["https://orcid.org/0000-0003-4878-0205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Klibanski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.53211834,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"150","issue":"11","first_page":"5191","last_page":"5192"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10263","display_name":"Eating Disorders and Behaviors","score":0.7035999894142151,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.09709999710321426,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.07129999995231628,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypercortisolism","display_name":"hypercortisolism","score":0.996999979019165},{"id":"https://openalex.org/keywords/hypothalamic-amenorrhea","display_name":"hypothalamic amenorrhea","score":0.8679999709129333},{"id":"https://openalex.org/keywords/anorexia-nervosa","display_name":"anorexia nervosa","score":1.0},{"id":"https://openalex.org/keywords/bone-loss","display_name":"bone loss","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bone-mineral-density","display_name":"bone mineral density","score":0.8690000176429749},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.906000018119812},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cortisol-dysregulation","display_name":"cortisol dysregulation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mood-disturbance","display_name":"mood disturbance","score":0.890999972820282},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.3269999921321869}],"concepts":[{"id":"https://openalex.org/C2910616045","wikidata":"https://www.wikidata.org/wiki/Q219102","display_name":"Hypercortisolemia","level":3,"score":0.9125407934188843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7205188274383545},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6908754706382751},{"id":"https://openalex.org/C2777031586","wikidata":"https://www.wikidata.org/wiki/Q131749","display_name":"Anorexia nervosa","level":3,"score":0.6472989320755005},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6246287822723389},{"id":"https://openalex.org/C2778058571","wikidata":"https://www.wikidata.org/wiki/Q334655","display_name":"Amenorrhea","level":3,"score":0.5972888469696045},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.597231924533844},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.5916107892990112},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.4593075215816498},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.43994519114494324},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.30243998765945435},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.25836050510406494},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.19849303364753723},{"id":"https://openalex.org/C2776394216","wikidata":"https://www.wikidata.org/wiki/Q373822","display_name":"Eating disorders","level":2,"score":0.14308300614356995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08745723962783813},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1210/endo.150.11.9998","doi":"https://doi.org/10.1210/endo.150.11.9998","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.150.11.9998","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-2","ki-jl-2","medline","norway-2"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W140223017","https://openalex.org/W1593916107","https://openalex.org/W2072756474","https://openalex.org/W2798200589","https://openalex.org/W2374274635","https://openalex.org/W2100018795","https://openalex.org/W2041064092","https://openalex.org/W1980929884","https://openalex.org/W192714804","https://openalex.org/W2060417855"],"abstract_inverted_index":{"ABSTRACT":[0],"Context:":[1],"Anorexia":[2],"nervosa":[3],"(AN)":[4],"and":[5,17,22,42,68,75,78,105,124,143,146,154,165,172,184,191,206,211,226,229,243],"functional":[6,103],"hypothalamic":[7],"amenorrhea":[8],"(HA)":[9],"are":[10],"associated":[11,64,215,223,231],"with":[12,20,65,73,102,109,216,224,232],"low":[13,49],"bone":[14,35,50,66,241],"density,":[15],"anxiety,":[16],"depression.":[18],"Women":[19],"AN":[21,53,164,175,186],"HA":[23,74,166,177,192],"have":[24],"elevated":[25],"cortisol":[26,45,128],"levels.":[27,129],"Significant":[28],"hypercortisolemia,":[29],"as":[30],"in":[31,52,71,85,163,174,201,204,208,246],"Cushing\u2019s":[32],"disease,":[33],"causes":[34],"loss.":[36],"It":[37],"is":[38,63,236],"unknown":[39],"whether":[40,61],"anxiety":[41],"depression":[43],"and/or":[44],"dysregulation":[46],"contribute":[47],"to":[48,59],"density":[51,132],"or":[54],"HA.":[55],"Objective:":[56],"Ourobjective":[57],"was":[58,134,161],"investigate":[60],"hypercortisolemia":[62],"loss":[67,242],"mood":[69,244],"disturbance":[70,245],"women":[72,94,101,108],"AN.":[76],"Design":[77],"Setting:":[79],"We":[80,91],"conducted":[81],"a":[82,86,237],"cross-sectional":[83],"study":[84],"clinical":[87],"research":[88],"center.":[89],"Participants:":[90],"studied":[92],"52":[93],"[21":[95],"healthy":[96],"controls":[97],"(HC),":[98],"13":[99],"normal-weight":[100],"HA,":[104,190,205],"18":[106],"amenorrheic":[107],"AN].":[110],"Outcome":[111],"Measures:":[112],"Serum":[113],"samples":[114],"were":[115,157,199,214,221],"measured":[116],"every":[117],"20":[118],"min":[119],"for":[120,126,151],"12":[121],"h":[122],"overnight":[123],"pooled":[125],"average":[127],"Bone":[130],"mineral":[131],"(BMD)":[133],"assessed":[135],"by":[136],"dual-energy":[137],"x-ray":[138],"absorptiometry":[139],"(DXA)":[140],"at":[141,169,178],"anteroposterior":[142],"lateral":[144],"spine":[145],"hip.":[147],"Hamilton":[148],"Rating":[149],"Scales":[150],"Anxiety":[152],"(HAM-A)":[153],"Depression":[155],"(HAM-D)":[156],"administered.":[158],"Results:":[159],"BMD":[160],"lower":[162,173],"than":[167,176,189,195],"HC":[168],"all":[170],"sites":[171],"the":[179,182],"spine.":[180],"On":[181],"HAM-D":[183,212,227],"HAM-A,":[185],"scored":[187,193],"higher":[188,194],"HC.":[196,209],"Cortisol":[197,219],"levels":[198,220],"highest":[200],"AN,":[202],"intermediate":[203],"lowest":[207],"HAM-A":[210,225],"scores":[213,228],"decreased":[217],"BMD.":[218,233],"positively":[222],"negatively":[230],"Conclusions:":[234],"Hypercortisolemia":[235],"potential":[238],"mediator":[239],"of":[240],"these":[247],"disorders.":[248]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}
