{"id":"https://openalex.org/W4242232655","doi":"https://doi.org/10.1016/s0021-9258(19)61480-8","title":"A Novel Anti-tumor Cytokine Contains an RNA Binding Motif Present in Aminoacyl-tRNA Synthetases","display_name":"A Novel Anti-tumor Cytokine Contains an RNA Binding Motif Present in Aminoacyl-tRNA Synthetases","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W4242232655","doi":"https://doi.org/10.1016/s0021-9258(19)61480-8"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(19)61480-8","doi":"https://doi.org/10.1016/s0021-9258(19)61480-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)61480-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(19)61480-8","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100395859","display_name":"Youngsoo Kim","orcid":"https://orcid.org/0000-0001-8881-0662","observed_orcids":["https://orcid.org/0000-0001-8881-0662"]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Youngsoo Kim","raw_affiliation_strings":["School of Chemical Engineering, Yeungnam University, 214-1 Dae-Dong, Kyungsan Kyungbuk 712-749, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering, Yeungnam University, 214-1 Dae-Dong, Kyungsan Kyungbuk 712-749, South Korea","institution_ids":["https://openalex.org/I55240360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112794555","display_name":"Joongchul Shin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Joongchul Shin","raw_affiliation_strings":["School of Chemical Engineering, Yeungnam University, 214-1 Dae-Dong, Kyungsan Kyungbuk 712-749, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Engineering, Yeungnam University, 214-1 Dae-Dong, Kyungsan Kyungbuk 712-749, South Korea","institution_ids":["https://openalex.org/I55240360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000514275","display_name":"Rongbao Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rongbao Li","raw_affiliation_strings":["Department of Biological Structure, University of Washington, Seattle, Washington 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Structure, University of Washington, Seattle, Washington 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056878388","display_name":"Chaejoon Cheong","orcid":"https://orcid.org/0000-0002-8218-2965","observed_orcids":["https://orcid.org/0000-0002-8218-2965"]},"institutions":[{"id":"https://openalex.org/I4210139925","display_name":"Korea Basic Science Institute","ror":"https://ror.org/0417sdw47","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210139925","https://openalex.org/I4210144908","https://openalex.org/I4387152098"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chaejoon Cheong","raw_affiliation_strings":["Magnetic Resonance Team, Korea Basic Science Institute, Eon-Dong Daejon 305-333, South Korea, and the"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Magnetic Resonance Team, Korea Basic Science Institute, Eon-Dong Daejon 305-333, South Korea, and the","institution_ids":["https://openalex.org/I4210139925"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101836409","display_name":"Kyoung-Hee Kim","orcid":"https://orcid.org/0000-0002-3472-3931","observed_orcids":["https://orcid.org/0000-0002-3472-3931"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyounghee Kim","raw_affiliation_strings":["National Creative Research Initiatives Center for ARS Network, Sung Kyun Kwan University, Chunchun-Dong, Suwon Kyunggido 440-746, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Creative Research Initiatives Center for ARS Network, Sung Kyun Kwan University, Chunchun-Dong, Suwon Kyunggido 440-746, South Korea","institution_ids":["https://openalex.org/I848706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100429324","display_name":"Sung\u2010Hoon Kim","orcid":"https://orcid.org/0000-0002-1570-3230","observed_orcids":["https://orcid.org/0000-0002-1570-3230"]},"institutions":[{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sunghoon Kim","raw_affiliation_strings":["National Creative Research Initiatives Center for ARS Network, Sung Kyun Kwan University, Chunchun-Dong, Suwon Kyunggido 440-746, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Creative Research Initiatives Center for ARS Network, Sung Kyun Kwan University, Chunchun-Dong, Suwon Kyunggido 440-746, South Korea","institution_ids":["https://openalex.org/I848706"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100395859"],"corresponding_institution_ids":["https://openalex.org/I55240360"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.9647,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.7427388,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"275","issue":"35","first_page":"27062","last_page":"27068"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.8945000171661377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.035100001841783524,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/emap-ii","display_name":"EMAP II","score":0.8460000157356262},{"id":"https://openalex.org/keywords/endothelial-monocyte-activating-polypeptide-ii","display_name":"endothelial monocyte-activating polypeptide II","score":0.8659999966621399},{"id":"https://openalex.org/keywords/rna-binding-motif","display_name":"RNA-binding motif","score":0.777999997138977},{"id":"https://openalex.org/keywords/aminoacyl-trna-synthetase","display_name":"aminoacyl-tRNA synthetase","score":0.9639999866485596},{"id":"https://openalex.org/keywords/anticodon-binding-domain","display_name":"anticodon-binding domain","score":0.7459999918937683},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2779315393","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Aminoacyl tRNA synthetase","level":5,"score":0.6378766894340515},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.5983821153640747},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4945997893810272},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4081258773803711},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40390297770500183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3892356753349304},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.347744345664978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14004918932914734}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s0021-9258(19)61480-8","doi":"https://doi.org/10.1016/s0021-9258(19)61480-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)61480-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(19)61480-8","doi":"https://doi.org/10.1016/s0021-9258(19)61480-8","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(19)61480-8","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W10876090","https://openalex.org/W174069803","https://openalex.org/W333518702","https://openalex.org/W1501329139","https://openalex.org/W1539796472","https://openalex.org/W1591680814","https://openalex.org/W1965277349","https://openalex.org/W1975860634","https://openalex.org/W1980467950","https://openalex.org/W1986191025","https://openalex.org/W1990077400","https://openalex.org/W1995017064","https://openalex.org/W2001641653","https://openalex.org/W2003461701","https://openalex.org/W2004955970","https://openalex.org/W2008335672","https://openalex.org/W2009155017","https://openalex.org/W2011017551","https://openalex.org/W2013083986","https://openalex.org/W2022058405","https://openalex.org/W2024510500","https://openalex.org/W2028231353","https://openalex.org/W2041418072","https://openalex.org/W2069599749","https://openalex.org/W2074500256","https://openalex.org/W2074756868","https://openalex.org/W2080528351","https://openalex.org/W2082149601","https://openalex.org/W2082750498","https://openalex.org/W2083976355","https://openalex.org/W2101436113","https://openalex.org/W2101446086","https://openalex.org/W2136990296","https://openalex.org/W2139305314","https://openalex.org/W2147919483","https://openalex.org/W3142354940"],"related_works":["https://openalex.org/W2004955970","https://openalex.org/W2123025858","https://openalex.org/W2141420543","https://openalex.org/W2136990296","https://openalex.org/W2045026617","https://openalex.org/W2069599749","https://openalex.org/W1750588665","https://openalex.org/W2033495952","https://openalex.org/W2135240540","https://openalex.org/W2120843102"],"abstract_inverted_index":{"Endothelialmonocyte-activating":[0],"polypeptideII":[1],"(EMAP":[2],"II)":[3],"is":[4,28,62,107,121,126,137],"a":[5,59,143],"novel":[6],"pro-apoptotic":[7],"cytokine":[8,124],"that":[9,61,120],"shares":[10],"sequence":[11,119],"homology":[12],"with":[13,30],"the":[14,23,31,51,72,83,93,115,129,133],"C-terminal":[15],"regions":[16,141],"of":[17,25,41,76,87,104],"several":[18],"tRNA":[19],"synthetases.":[20],"Pro-EMAP":[21],"II,":[22,27,44],"precursor":[24],"EMAP":[26,43,77,105],"associated":[29],"multi-tRNA":[32],"synthetase":[33,90],"complex":[34],"and":[35,58,92],"facilitates":[36],"aminoacylation":[37],"activity.":[38],"The":[39,68,100,117],"structure":[40],"human":[42],"solved":[45],"at":[46],"1.8":[47],"\u212b":[48],"resolution,":[49],"revealed":[50],"oligomer-binding":[52],"fold":[53],"for":[54,123,128],"binding":[55,74,85,102],"different":[56],"tRNAs":[57],"domain":[60,86,95],"structurally":[63],"homologous":[64],"to":[65,71,109,114],"other":[66],"chemokines.":[67],"similar":[69],"structures":[70],"RNA":[73,101],"motif":[75],"II":[78,106],"was":[79],"previously":[80],"observed":[81],"in":[82,112,132],"anticodon":[84],"yeast":[88],"Asp-tRNA":[89],"(AspRSSC)":[91],"B2":[94],"ofThermus":[96],"thermophilus":[97],"Phe-tRNA":[98],"synthetase.":[99],"pattern":[103],"likely":[108],"be":[110],"nonspecific,":[111],"contrast":[113],"AspRSSC.":[116],"peptide":[118],"responsible":[122],"activity":[125],"located,":[127],"most":[130],"part,":[131],"\u03b21":[134],"strand.":[135],"It":[136],"divided":[138],"into":[139],"two":[140],"by":[142],"neighboring":[144],"loop.":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-26T11:51:55.731654","created_date":"2022-05-12T00:00:00"}
