{"id":"https://openalex.org/W4242053474","doi":"https://doi.org/10.1358/dot.2006.42.10.1042190","title":"Natalizumab","display_name":"Natalizumab","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W4242053474","doi":"https://doi.org/10.1358/dot.2006.42.10.1042190","pmid":"https://pubmed.ncbi.nlm.nih.gov/17136224"},"language":"en","primary_location":{"id":"doi:10.1358/dot.2006.42.10.1042190","doi":"https://doi.org/10.1358/dot.2006.42.10.1042190","is_oa":false,"landing_page_url":"https://doi.org/10.1358/dot.2006.42.10.1042190","pdf_url":null,"source":{"id":"https://openalex.org/S202615048","display_name":"Drugs of today","issn_l":"0025-7656","issn":["0025-7656","1699-3993","1699-4019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969288","host_organization_name":"Prous Science","host_organization_lineage":["https://openalex.org/P4360969288"],"host_organization_lineage_names":["Prous Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs of Today","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066505115","display_name":"Joseph R. Berger","orcid":"https://orcid.org/0000-0002-1540-496X","observed_orcids":["https://orcid.org/0000-0002-1540-496X","https://orcid.org/0000-0002-3821-1749","https://orcid.org/0000-0002-0260-2430"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Berger, J.R.","raw_affiliation_strings":["Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic, Lexington, Kentucky 40536-0284, USA. jrbneuro@uky.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic, Lexington, Kentucky 40536-0284, USA. jrbneuro@uky.edu","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066505115"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":0.933,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.77915717,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"42","issue":"10","first_page":"639","last_page":"639"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.888700008392334,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11827","display_name":"Polyomavirus and related diseases","score":0.09440000355243683,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11735","display_name":"Peripheral Neuropathies and Disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/natalizumab","display_name":"natalizumab","score":1.0},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.8889999985694885},{"id":"https://openalex.org/keywords/integrin-alpha4","display_name":"CD49d","score":0.828000009059906},{"id":"https://openalex.org/keywords/progressive-multifocal-leukoencephalopathy","display_name":"progressive multifocal leukoencephalopathy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/demyelinating-disorders","display_name":"demyelinating disease","score":0.8320000171661377},{"id":"https://openalex.org/keywords/opportunistic-infections","display_name":"opportunistic infections","score":0.703000009059906},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6340000033378601},{"id":"https://openalex.org/keywords/post-marketing-surveillance","display_name":"post-marketing surveillance","score":0.7540000081062317},{"id":"https://openalex.org/keywords/relapse-rate","display_name":"relapse rate","score":0.6100000143051147},{"id":"https://openalex.org/keywords/contrast-enhancing-lesions","display_name":"contrast-enhancing lesions","score":0.871999979019165},{"id":"https://openalex.org/keywords/humanized-antibody","display_name":"humanized monoclonal antibody","score":0.75}],"concepts":[{"id":"https://openalex.org/C2781004633","wikidata":"https://www.wikidata.org/wiki/Q386119","display_name":"Natalizumab","level":3,"score":0.9970757961273193},{"id":"https://openalex.org/C2780644213","wikidata":"https://www.wikidata.org/wiki/Q704930","display_name":"Progressive multifocal leukoencephalopathy","level":3,"score":0.9646991491317749},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9343942403793335},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7863894701004028},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4744623303413391},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.45519790053367615},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4306830167770386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4257628321647644},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3653096556663513},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2641215920448303}],"mesh":[{"descriptor_ui":"D000069442","descriptor_name":"Natalizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007968","descriptor_name":"Leukoencephalopathy, Progressive Multifocal","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007968","descriptor_name":"Leukoencephalopathy, Progressive Multifocal","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D039441","descriptor_name":"Integrin alpha4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1358/dot.2006.42.10.1042190","doi":"https://doi.org/10.1358/dot.2006.42.10.1042190","is_oa":false,"landing_page_url":"https://doi.org/10.1358/dot.2006.42.10.1042190","pdf_url":null,"source":{"id":"https://openalex.org/S202615048","display_name":"Drugs of today","issn_l":"0025-7656","issn":["0025-7656","1699-3993","1699-4019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4360969288","host_organization_name":"Prous Science","host_organization_lineage":["https://openalex.org/P4360969288"],"host_organization_lineage_names":["Prous Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs of Today","raw_type":"journal-article"},{"id":"pmid:17136224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17136224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drugs of today (Barcelona, Spain : 1998)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092037339","https://openalex.org/W2088205067","https://openalex.org/W1963521120","https://openalex.org/W2123056447","https://openalex.org/W2087971145","https://openalex.org/W2563392829","https://openalex.org/W2176642719","https://openalex.org/W3088342871","https://openalex.org/W2080168761","https://openalex.org/W2205390563"],"abstract_inverted_index":{"Medical":[0],"therapeutics":[1],"has":[2],"entered":[3],"a":[4,26,76,123,159],"new":[5],"and":[6,51,164,170,178],"exciting":[7],"era":[8],"with":[9,44,68,105],"the":[10,20,73,81,94,97,101,118,151,183],"development":[11,74,102,119],"of":[12,75,80,93,103,114,120,185],"biological":[13],"agents":[14],"that":[15,130],"target":[16],"specific":[17,160],"sites.":[18],"In":[19],"studies":[21,174],"performed":[22],"to":[23,30,40,46,156,182],"date,":[24],"natalizumab,":[25,163],"humanized":[27],"monoclonal":[28],"antibody":[29],"alpha4":[31,167],"integrin,":[32],"when":[33,154],"administered":[34],"intravenously":[35],"at":[36,147],"monthly":[37],"intervals,":[38],"appeared":[39],"be":[41,134],"highly":[42],"beneficial":[43],"respect":[45],"decreasing":[47],"both":[48],"relapse":[49],"rate":[50],"contrast-enhancing":[52],"lesions":[53],"in":[54,87,90,150],"multiple":[55],"sclerosis.":[56],"Salutary":[57],"actions":[58],"on":[59],"other":[60,141,166,179],"disease":[61,79],"parameters":[62],"were":[63,144],"also":[64],"observed.":[65],"However,":[66],"treatment":[67,107,138],"natalizumab":[69,106],"was":[70],"complicated":[71],"by":[72],"rare":[77],"demyelinating":[78],"brain--progressive":[82],"multifocal":[83],"leukoencephalopathy":[84],"(PML)--that":[85],"developed":[86],"three":[88],"patients":[89],"clinical":[91],"trials":[92],"drug.":[95],"Currently,":[96],"estimated":[98],"incidence":[99],"for":[100],"PML":[104,121],"is":[108,122,127],"1:1,000":[109],"after":[110,136],"approximately":[111],"18":[112],"months":[113],"therapy;":[115],"however,":[116],"as":[117],"stochastic":[124],"event,":[125],"it":[126],"quite":[128],"possible":[129],"higher":[131,148],"rates":[132,149],"will":[133],"observed":[135,146],"longer":[137],"courses.":[139],"Curiously,":[140],"opportunistic":[142],"infections":[143],"not":[145],"treated":[152],"groups":[153],"compared":[155],"controls,":[157],"suggesting":[158],"association":[161],"between":[162],"perhaps":[165],"integrin":[168],"blockers,":[169],"PML.":[171],"Postmarketing":[172],"surveillance":[173],"should":[175],"answer":[176],"this":[177],"questions":[180],"related":[181],"use":[184],"natalizumab.":[186]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}
