{"id":"https://openalex.org/W4241968643","doi":"https://doi.org/10.1126/science.163.3865.391-b","title":"Histone Structure: Asymmetric Distribution of Lysine Residues in Lysine-rich Histone","display_name":"Histone Structure: Asymmetric Distribution of Lysine Residues in Lysine-rich Histone","publication_year":1969,"publication_date":"1969-01-24","ids":{"openalex":"https://openalex.org/W4241968643","doi":"https://doi.org/10.1126/science.163.3865.391-b"},"language":"en","primary_location":{"id":"doi:10.1126/science.163.3865.391-b","doi":"https://doi.org/10.1126/science.163.3865.391-b","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.163.3865.391-b","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039096120","display_name":"Michael Bustin","orcid":"https://orcid.org/0000-0002-5147-7242","observed_orcids":["https://orcid.org/0000-0002-5147-7242"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Bustin","raw_affiliation_strings":["Department of Biochemistry, University of California, Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108565654","display_name":"S. Carlton Rall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. C. Rall","raw_affiliation_strings":["Department of Biochemistry, University of California, Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079328774","display_name":"Robert H. Stellwagen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert H. Stellwagen","raw_affiliation_strings":["Department of Biochemistry, University of California, Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109844257","display_name":"R. David Cole","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R. David Cole","raw_affiliation_strings":["Department of Biochemistry, University of California, Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of California, Berkeley","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":null,"apc_paid":null,"fwci":1.4292,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.80151753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"163","issue":"3865","first_page":"391","last_page":"393"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-structure","display_name":"histone structure","score":0.9449999928474426},{"id":"https://openalex.org/keywords/lysine-rich-histones","display_name":"lysine-rich histones","score":0.9850000143051147},{"id":"https://openalex.org/keywords/c-terminal-domain","display_name":"C-terminal domain","score":0.7099999785423279},{"id":"https://openalex.org/keywords/n-terminal-domain","display_name":"N-terminal domain","score":0.6809999942779541},{"id":"https://openalex.org/keywords/acidic-residues","display_name":"acidic residues","score":0.6510000228881836},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.5979999899864197},{"id":"https://openalex.org/keywords/histone-dna-interactions","display_name":"histone-DNA interactions","score":0.7639999985694885},{"id":"https://openalex.org/keywords/nonhistone-chromosomal-proteins","display_name":"non-histone proteins","score":0.6930000185966492},{"id":"https://openalex.org/keywords/proline-rich-region","display_name":"proline-rich region","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.8441261649131775},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.722619354724884},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5868207216262817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5390938520431519},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4612634778022766},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3549835979938507}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1126/science.163.3865.391-b","doi":"https://doi.org/10.1126/science.163.3865.391-b","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.163.3865.391-b","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"doi:10.1126/science.163.3865.391.b","doi":"https://doi.org/10.1126/science.163.3865.391.b","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.163.3865.391.b","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W214725109","https://openalex.org/W1419481270","https://openalex.org/W1476151697","https://openalex.org/W1532458240","https://openalex.org/W2050477142"],"related_works":["https://openalex.org/W2002617002","https://openalex.org/W1483258156","https://openalex.org/W1575311161","https://openalex.org/W4230937991","https://openalex.org/W1556841387","https://openalex.org/W1514888080","https://openalex.org/W1977836915","https://openalex.org/W1507760373","https://openalex.org/W2067907815","https://openalex.org/W1886509027"],"abstract_inverted_index":{"Structural":[0],"studies":[1],"on":[2],"a":[3,26],"very":[4],"lysine-rich":[5],"histone":[6],"show":[7],"that":[8,23],"the":[9,13,38],"carboxyl-terminal":[10],"half":[11],"of":[12,37],"molecule":[14],"is":[15,25],"enriched":[16],"in":[17],"lysine":[18],"(and":[19],"proline),":[20],"which":[21],"suggests":[22],"it":[24],"site":[27],"for":[28,50],"binding":[29],"to":[30],"DNA.":[31,54],"The":[32],"amino-terminal":[33],"half,":[34],"containing":[35],"most":[36],"acidic":[39],"residues,":[40],"resembles":[41],"small,":[42],"nonhistone":[43],"proteins":[44],"and":[45],"so":[46],"might":[47],"have":[48],"specificity":[49],"factors":[51],"other":[52],"than":[53]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}