{"id":"https://openalex.org/W4241929933","doi":"https://doi.org/10.1097/00005392-199704000-00108","title":"Vascular Endothelial Growth Factor Expression is Increased in Renal Cell Carcinoma","display_name":"Vascular Endothelial Growth Factor Expression is Increased in Renal Cell Carcinoma","publication_year":1997,"publication_date":"1997-04-01","ids":{"openalex":"https://openalex.org/W4241929933","doi":"https://doi.org/10.1097/00005392-199704000-00108","mag":"1970649977","pmid":"https://pubmed.ncbi.nlm.nih.gov/9120987"},"language":"en","primary_location":{"id":"doi:10.1097/00005392-199704000-00108","doi":"https://doi.org/10.1097/00005392-199704000-00108","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005392-199704000-00108","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Urology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107843164","display_name":"David L. Nicol","orcid":"https://orcid.org/0000-0002-5623-7467","observed_orcids":["https://orcid.org/0000-0002-5623-7467","https://orcid.org/0000-0003-0107-6990"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Nicol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112716772","display_name":"Su-Ing Hii","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Su-Ing Hii","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083110534","display_name":"Michael D. Walsh","orcid":"https://orcid.org/0000-0002-2855-6743","observed_orcids":["https://orcid.org/0000-0002-2855-6743"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Walsh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039053890","display_name":"Bin Tean Teh","orcid":"https://orcid.org/0000-0003-1514-1124","observed_orcids":["https://orcid.org/0000-0003-1514-1124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Teh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112351935","display_name":"Les C. Thompson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Les Thompson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075236665","display_name":"Colin Kennett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colin Kennett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074100708","display_name":"David C. Gotley","orcid":"https://orcid.org/0000-0002-8604-253X","observed_orcids":["https://orcid.org/0000-0002-8604-253X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Gotley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":1.6873,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.84810911,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"157","issue":"4","first_page":"1482","last_page":"1486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9223999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9850000143051147},{"id":"https://openalex.org/keywords/vegf-isoforms","display_name":"VEGF isoforms","score":0.9169999957084656},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.7269999980926514},{"id":"https://openalex.org/keywords/oncocytoma","display_name":"oncocytoma","score":0.7580000162124634},{"id":"https://openalex.org/keywords/tumor-vasculature","display_name":"tumor vasculature","score":0.7490000128746033}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9173319339752197},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.6697863936424255},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.576248824596405},{"id":"https://openalex.org/C103041312","wikidata":"https://www.wikidata.org/wiki/Q7916457","display_name":"Vascular endothelial growth factor C","level":5,"score":0.5063217878341675},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4712158739566803},{"id":"https://openalex.org/C15215337","wikidata":"https://www.wikidata.org/wiki/Q18032325","display_name":"Vascular endothelial growth factor B","level":5,"score":0.4633173942565918},{"id":"https://openalex.org/C146285616","wikidata":"https://www.wikidata.org/wiki/Q7916455","display_name":"Vascular endothelial growth factor A","level":4,"score":0.43928077816963196},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3715113401412964},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3685593008995056},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.33744892477989197}],"mesh":[{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D008222","descriptor_name":"Lymphokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D016228","descriptor_name":"Endothelial Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042442","descriptor_name":"Vascular Endothelial Growth Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00005392-199704000-00108","doi":"https://doi.org/10.1097/00005392-199704000-00108","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005392-199704000-00108","pdf_url":null,"source":{"id":"https://openalex.org/S30525748","display_name":"The Journal of Urology","issn_l":"0022-5347","issn":["0022-5347","1527-3792"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Urology","raw_type":"journal-article"},{"id":"pmid:9120987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9120987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of urology","raw_type":"Journal Article"},{"id":"mag:1970649977","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9120987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1044883788","https://openalex.org/W1556931607","https://openalex.org/W1784095256","https://openalex.org/W1968601696","https://openalex.org/W1980755389","https://openalex.org/W2013038209","https://openalex.org/W2013674529","https://openalex.org/W2015344488","https://openalex.org/W2016904444","https://openalex.org/W2023387637","https://openalex.org/W2047408781","https://openalex.org/W2053375897","https://openalex.org/W2054979979","https://openalex.org/W2060937867","https://openalex.org/W2069826874","https://openalex.org/W2070039198","https://openalex.org/W2071872174","https://openalex.org/W2072446438","https://openalex.org/W2074070420","https://openalex.org/W2114098415","https://openalex.org/W2133138712","https://openalex.org/W2410162261","https://openalex.org/W4255042798"],"related_works":["https://openalex.org/W2016915197","https://openalex.org/W2368440945","https://openalex.org/W3126216789","https://openalex.org/W2036441426","https://openalex.org/W2803572126","https://openalex.org/W2794036432","https://openalex.org/W2327116791","https://openalex.org/W2033317944","https://openalex.org/W2068279657","https://openalex.org/W1979404993"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"compare":[2],"the":[3,112],"expression":[4,86,125],"of":[5,52,96],"VEGF":[6,54,85,94,119,124],"in":[7,48,58,71,84,128,136,139],"renal":[8,60],"cell":[9],"carcinoma":[10],"(RCC)":[11],"and":[12,19,27,37,62,100,116,130],"normal":[13,28,59,90],"kidney.":[14],"MATERIALS":[15],"AND":[16],"METHODS:":[17],"RT-PCR":[18],"Western":[20,77],"blot":[21,78],"analysis":[22,79],"were":[23],"performed":[24],"on":[25],"tumour":[26,98],"adjacent":[29,101],"kidney":[30,105],"collected":[31],"from":[32],"31":[33],"patients":[34],"(29":[35],"RCC":[36,115,129],"2":[38,113],"oncocytomas)":[39],"as":[40,42],"well":[41],"proliferating":[43,72],"vascular":[44,102],"endothelial":[45],"cells":[46,99],"(VEC)":[47],"culture.":[49],"RESULTS:":[50],"Expression":[51],"3":[53],"isoforms":[55],"was":[56,68,120],"detected":[57],"parenchyma":[61],"all":[63],"ROC":[64],"by":[65],"RT-PCR,":[66],"but":[67],"not":[69,121],"apparent":[70],"VEC.":[73],"In":[74,111],"27":[75],"RCC,":[76],"demonstrated":[80,93],"3-37":[81],"fold":[82],"increases":[83],"when":[87],"compared":[88],"to":[89],"parenchyma.":[91],"Immunohistochemistry":[92],"staining":[95,108],"both":[97,117],"endothelium.":[103],"Normal":[104],"showed":[106],"no":[107],"for":[109],"VEGF.":[110],"remaining":[114],"oncocytomas":[118],"increased.":[122],"CONCLUSIONS:":[123],"is":[126],"increased":[127],"may":[131],"have":[132],"a":[133],"paracrine":[134],"effect":[135],"these":[137],"tumours":[138],"stimulating":[140],"angiogenesis.":[141]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}
