{"id":"https://openalex.org/W4241925164","doi":"https://doi.org/10.1158/1538-7445.sabcs18-4377","title":"Abstract 4377: Liver X receptor mediated lipotoxicity represents a treatment option for liver cancer","display_name":"Abstract 4377: Liver X receptor mediated lipotoxicity represents a treatment option for liver cancer","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4241925164","doi":"https://doi.org/10.1158/1538-7445.sabcs18-4377"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-4377","doi":"https://doi.org/10.1158/1538-7445.sabcs18-4377","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-4377","pdf_url":null,"source":{"id":"https://openalex.org/S4306520151","display_name":"Molecular and Cellular Biology / Genetics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology / Genetics","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013998080","display_name":"Ramona Rudalska","orcid":"https://orcid.org/0000-0002-1742-0912","observed_orcids":["https://orcid.org/0000-0002-1742-0912"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ramona Rudalska","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054933967","display_name":"Jule Harbig","orcid":"https://orcid.org/0000-0001-8171-3843","observed_orcids":["https://orcid.org/0000-0001-8171-3843"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jule Harbig","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088143377","display_name":"Marteinn Thor Snaebjornsson","orcid":"https://orcid.org/0009-0008-4457-5726","observed_orcids":["https://orcid.org/0009-0008-4457-5726"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marteinn Snaebjoernsson","raw_affiliation_strings":["University of Wuerzburg, Wuerzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wuerzburg, Wuerzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049068482","display_name":"Lyudmyla Taranets","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lyudmyla Taranets","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068131001","display_name":"Florian Heinzmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Florian Heinzmann","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Stefan Zwirner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Zwirner","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073689699","display_name":"Wei Ciu Hu","orcid":"https://orcid.org/0000-0003-2222-4024","observed_orcids":["https://orcid.org/0000-0003-2222-4024"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wei Ciu Hu","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081007016","display_name":"Thales Kronenberger","orcid":"https://orcid.org/0000-0001-6933-7590","observed_orcids":["https://orcid.org/0000-0001-6933-7590"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thales Kronenberger","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tae-Won Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tae-Won Kang","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074083544","display_name":"Antti Poso","orcid":"https://orcid.org/0000-0003-4196-4204","observed_orcids":["https://orcid.org/0000-0003-4196-4204"]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE","FI"],"is_corresponding":false,"raw_author_name":"Antti Poso","raw_affiliation_strings":["University of Eastern Finland and University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Eastern Finland and University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I175532246","https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031324853","display_name":"Stefan Laufer","orcid":"https://orcid.org/0000-0001-6952-1486","observed_orcids":["https://orcid.org/0000-0001-6952-1486"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Laufer","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082290482","display_name":"Mathias Tillmann Rosenfeldt","orcid":"https://orcid.org/0000-0001-7650-8458","observed_orcids":["https://orcid.org/0000-0001-7650-8458"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias Rosenfeldt","raw_affiliation_strings":["University of Wuerzburg, Wuerzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wuerzburg, Wuerzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056667390","display_name":"Nisar P. Malek","orcid":"https://orcid.org/0000-0002-9916-4608","observed_orcids":["https://orcid.org/0000-0002-9916-4608"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nisar P. Malek","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018788118","display_name":"Bernd J\u00fcrgen Pichler","orcid":"https://orcid.org/0000-0001-6784-5524","observed_orcids":["https://orcid.org/0000-0001-6784-5524"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bernd Pichler","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078664968","display_name":"Nikita Popov","orcid":"https://orcid.org/0000-0002-9543-8640","observed_orcids":["https://orcid.org/0000-0002-9543-8640"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nikita Popov","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077374712","display_name":"Almut Schulze","orcid":"https://orcid.org/0000-0002-8199-6422","observed_orcids":["https://orcid.org/0000-0002-8199-6422"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Almut Schulze","raw_affiliation_strings":["University of Wuerzburg, Wuerzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Wuerzburg, Wuerzburg, Germany","institution_ids":["https://openalex.org/I25974101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052075637","display_name":"Lars Zender","orcid":"https://orcid.org/0000-0001-7626-2849","observed_orcids":["https://orcid.org/0000-0001-7626-2849"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars Zender","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077726833","display_name":"Daniel Dauch","orcid":"https://orcid.org/0000-0002-9805-5784","observed_orcids":["https://orcid.org/0000-0002-9805-5784"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Daniel Dauch","raw_affiliation_strings":["University of Tuebingen, Tuebingen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tuebingen, Tuebingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"4377","last_page":"4377"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receptors","display_name":"receptors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lipotoxicity","display_name":"lipotoxicity","score":0.8840000033378601},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9160000085830688},{"id":"https://openalex.org/keywords/raf-1","display_name":"Raf-1","score":0.7279999852180481},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase-1","display_name":"stearoyl-CoA desaturase 1","score":0.9300000071525574},{"id":"https://openalex.org/keywords/lipogenesis","display_name":"lipogenesis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.8130000233650208},{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":0.8700000047683716},{"id":"https://openalex.org/keywords/t0901317","display_name":"T0901317","score":0.9679999947547913},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7450000047683716},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.781000018119812},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.515999972820282},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7080000042915344},{"id":"https://openalex.org/keywords/metabolic-plasticity","display_name":"metabolic plasticity","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C141359234","wikidata":"https://www.wikidata.org/wiki/Q2734301","display_name":"Lipogenesis","level":3,"score":0.8334307670593262},{"id":"https://openalex.org/C44353895","wikidata":"https://www.wikidata.org/wiki/Q6556772","display_name":"Lipotoxicity","level":4,"score":0.7926340699195862},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5826879143714905},{"id":"https://openalex.org/C2776231280","wikidata":"https://www.wikidata.org/wiki/Q623031","display_name":"Liver cancer","level":3,"score":0.5602824687957764},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.5345961451530457},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5006725788116455},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4691188633441925},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4580283761024475},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4454023241996765},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4273178279399872},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.41083475947380066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3825756907463074},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3655816316604614},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.35997211933135986},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35040077567100525},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.3493618965148926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32404255867004395},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21416613459587097},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.11601009964942932},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.08490943908691406},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-4377","doi":"https://doi.org/10.1158/1538-7445.sabcs18-4377","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-4377","pdf_url":null,"source":{"id":"https://openalex.org/S4306520151","display_name":"Molecular and Cellular Biology / Genetics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology / Genetics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3184345043","https://openalex.org/W2960692008","https://openalex.org/W3132731663","https://openalex.org/W3016556893","https://openalex.org/W6893347115","https://openalex.org/W2983568369","https://openalex.org/W3049026092","https://openalex.org/W2952033977","https://openalex.org/W2498275461","https://openalex.org/W1541739901"],"abstract_inverted_index":{"Solid":[0],"tumors":[1],"evolve":[2],"significant":[3],"changes":[4],"in":[5,60,66,134,146,168,199,223,231,312],"metabolic":[6,56,221,283,321],"pathways":[7,64],"during":[8],"development":[9,34,263],"by":[10,99,206,288,291],"virtue":[11],"of":[12,24,35,45,55,62,70,103,117,123,138,148,165,187,204,216,240,249,269,309,323,382],"their":[13,17],"specific":[14],"biosynthetic":[15,46],"demands,":[16],"particular":[18],"microenvironment":[19],"and":[20,75,129,144,151,193,220,237,254,264,285],"the":[21,33,43,52,76,104,115,181,185,250,267,383],"potential":[22],"occurrence":[23],"toxic":[25,214,310],"metabolites":[26,71,311],"such":[27,80],"as":[28,161,315],"reactive":[29],"oxygen":[30],"species.":[31],"However,":[32],"cancer":[36,73,154,224,234,262,313,378],"treatment":[37,116,374],"approaches":[38],"that":[39,94,173,244,293],"are":[40],"based":[41],"on":[42],"inhibition":[44,203],"routes":[47],"is":[48,256],"impaired":[49],"due":[50],"to":[51,213,259,265],"high":[53],"plasticity":[54],"networks,":[57],"e.g.":[58],"resulting":[59],"activation":[61,102],"compensatory":[63],"or":[65],"an":[67,95,162],"increased":[68],"exchange":[69],"between":[72],"cells":[74,225,314],"tumor":[77,270],"environment.":[78],"Therefore,":[79],"therapies":[81],"could":[82],"not":[83],"be":[84],"translated":[85],"into":[86,189],"efficient":[87,277,320],"clinical":[88],"applications":[89],"so":[90],"far.Here":[91],"we":[92,302],"show":[93],"enhanced":[96],"lipogenesis,":[97],"triggered":[98],"a":[100,110,139,245,274,297,305,316,373],"pharmacological":[101],"Liver":[105,367],"X":[106,368],"receptor":[107,369],"(LXR),":[108],"represents":[109,372],"new":[111,317],"therapeutic":[112],"strategy":[113,318],"for":[114,184,319,376,386],"liver":[118,153,169,233,261,299,377],"carcinoma":[119],"(HCC).":[120],"A":[121],"combination":[122],"LXR":[124,251],"mediated":[125,370],"fatty":[126,191,218,298],"acid":[127],"synthesis":[128],"concomitant":[130],"Raf":[131,160,205],"suppression":[132],"results":[133],"oxidative":[135],"stress,":[136],"induction":[137],"critical":[140],"ER":[141],"stress":[142,222],"response":[143],"subsequently":[145],"apoptosis":[147],"different":[149,282],"murine":[150],"human":[152,241],"cells.":[155,201],"Our":[156],"mechanistic":[157],"studies":[158,230],"identified":[159],"important":[163],"regulator":[164],"lipid":[166],"metabolism":[167],"cancer.":[170],"We":[171],"found":[172],"Raf-1":[174],"directly":[175],"interacts":[176],"with":[177,281],"Stearoyl-CoA":[178],"desaturase-1":[179],"(Scd1),":[180],"central":[182],"enzyme":[183],"conversion":[186],"saturated":[188,217],"mono-unsaturated":[190],"acids":[192,219],"thereby":[194],"maintains":[195],"Scd1":[196,209],"protein":[197,210],"stability":[198],"HCC":[200,242],"Thus,":[202],"Sorafenib":[207,255],"diminished":[208],"abundance":[211],"leading":[212],"accumulation":[215,308],"under":[226],"sustained":[227],"lipogenesis.":[228],"Treatment":[229],"autochthonous":[232],"mouse":[235],"models":[236,239],"xenograft":[238],"revealed":[243],"combinatorial":[246],"therapy,":[247],"consisting":[248],"agonist":[252],"T0901317":[253],"highly":[257],"potent":[258],"suppress":[260],"extend":[266],"survival":[268],"bearing":[271],"animals.":[272],"Such":[273],"therapy":[275,324],"was":[276],"against":[278],"hepatic":[279],"neoplasia":[280],"phenotypes":[284],"well":[286],"tolerated":[287],"mice,":[289],"even":[290],"animals":[292],"already":[294],"suffer":[295],"from":[296],"disease.Taken":[300],"together,":[301],"here":[303],"propose":[304],"pharmacologically":[306],"induced":[307],"targeting":[322],"refractory":[325],"solid":[326],"tumors.Citation":[327],"Format:":[328],"Ramona":[329],"Rudalska,":[330],"Jule":[331],"Harbig,":[332],"Marteinn":[333],"Snaebjoernsson,":[334],"Lyudmyla":[335],"Taranets,":[336],"Florian":[337],"Heinzmann,":[338],"Stefan":[339,350],"Zwirner,":[340],"Wei":[341],"Ciu":[342],"Hu,":[343],"Thales":[344],"Kronenberger,":[345],"Tae-Won":[346],"Kang,":[347],"Antti":[348],"Poso,":[349],"Laufer,":[351],"Mathias":[352],"Rosenfeldt,":[353],"Nisar":[354],"P.":[355],"Malek,":[356],"Bernd":[357],"Pichler,":[358],"Nikita":[359],"Popov,":[360],"Almut":[361],"Schulze,":[362],"Lars":[363],"Zender,":[364],"Daniel":[365],"Dauch.":[366],"lipotoxicity":[371],"option":[375],"[abstract].":[379],"In:":[380],"Proceedings":[381],"American":[384],"Association":[385],"Cancer":[387,401],"Research":[388],"Annual":[389],"Meeting":[390],"2019;":[391],"2019":[392],"Mar":[393],"29-Apr":[394],"3;":[395],"Atlanta,":[396],"GA.":[397],"Philadelphia":[398],"(PA):":[399],"AACR;":[400],"Res":[402],"2019;79(13":[403],"Suppl):Abstract":[404],"nr":[405],"4377.":[406]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}
