{"id":"https://openalex.org/W4241875739","doi":"https://doi.org/10.1021/jm701572a","title":"Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum","display_name":"Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum","publication_year":2008,"publication_date":"2008-01-17","ids":{"openalex":"https://openalex.org/W4241875739","doi":"https://doi.org/10.1021/jm701572a"},"language":"en","primary_location":{"id":"doi:10.1021/jm701572a","doi":"https://doi.org/10.1021/jm701572a","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jm701572a","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jm701572a?ref=article_openPDF","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/jm701572a?ref=article_openPDF","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025984430","display_name":"Peter B. Madrid","orcid":"https://orcid.org/0000-0002-4895-5610","observed_orcids":["https://orcid.org/0000-0002-4895-5610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter B. Madrid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086512022","display_name":"Ally P. Liou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ally P. Liou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039824565","display_name":"Joseph L. DeRisi","orcid":"https://orcid.org/0000-0002-4611-9205","observed_orcids":["https://orcid.org/0000-0002-4611-9205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph L. DeRisi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5052097118","display_name":"Rodney Kiplin Guy","orcid":"https://orcid.org/0000-0002-9638-2060","observed_orcids":["https://orcid.org/0000-0002-9638-2060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. Kiplin Guy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.51949967,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"51","issue":"3","first_page":"699","last_page":"699"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.01590000092983246,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/4-aminoquinolines","display_name":"4-aminoquinolines","score":0.9750000238418579},{"id":"https://openalex.org/keywords/intramolecular-hydrogen-bonding","display_name":"intramolecular hydrogen bonding","score":0.9300000071525574},{"id":"https://openalex.org/keywords/benzimidazole","display_name":"benzimidazole","score":0.7250000238418579},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9760000109672546},{"id":"https://openalex.org/keywords/antimalarial-drug-resistance","display_name":"antimalarial drug resistance","score":0.7450000047683716},{"id":"https://openalex.org/keywords/antimalarial-activity","display_name":"antimalarial activity","score":0.8569999933242798},{"id":"https://openalex.org/keywords/side-chain-modification","display_name":"side chain modification","score":0.5270000100135803}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9042692184448242},{"id":"https://openalex.org/C75079739","wikidata":"https://www.wikidata.org/wiki/Q1571801","display_name":"Intramolecular force","level":2,"score":0.8314664363861084},{"id":"https://openalex.org/C2909420918","wikidata":"https://www.wikidata.org/wiki/Q4746467","display_name":"Aminoquinolines","level":2,"score":0.800071120262146},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.6366536021232605},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.5441805124282837},{"id":"https://openalex.org/C32276052","wikidata":"https://www.wikidata.org/wiki/Q908349","display_name":"Motif (music)","level":2,"score":0.5256857872009277},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4886482357978821},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4489544630050659},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4481812119483948},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.42813044786453247},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.27788519859313965},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.16632959246635437},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1603584587574005},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.08348384499549866},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.06826359033584595},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/jm701572a","doi":"https://doi.org/10.1021/jm701572a","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jm701572a","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jm701572a?ref=article_openPDF","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/jm701572a","doi":"https://doi.org/10.1021/jm701572a","is_oa":true,"landing_page_url":"https://doi.org/10.1021/jm701572a","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/jm701572a?ref=article_openPDF","source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4241875739.pdf","grobid_xml":"https://content.openalex.org/works/W4241875739.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098959914","https://openalex.org/W2306167218","https://openalex.org/W1989627030","https://openalex.org/W1992377381","https://openalex.org/W4293568142","https://openalex.org/W2059362250","https://openalex.org/W2769840670","https://openalex.org/W3213132018","https://openalex.org/W644914258","https://openalex.org/W7098259538"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVAddition/CorrectionNEXTORIGINAL":[3],"ARTICLEThis":[4],"notice":[5],"is":[6,65,77,152,204],"a":[7,153,160,173],"correctionIncorporation":[8],"of":[9,18,70,95,130,156],"an":[10],"Intramolecular":[11],"Hydrogen-Bonding":[12],"Motif":[13],"in":[14],"the":[15,92,123,128,157,168,181,184,189,196,202],"Side":[16],"Chain":[17],"4-Aminoquinolines":[19],"Enhances":[20],"Activity":[21],"against":[22],"Drug-Resistant":[23],"P.":[24,29],"falciparumPeter":[25],"B.":[26],"Madrid,":[27],"Ally":[28],"Liou,":[30],"Joseph":[31],"L.":[32],"DeRisi,":[33],"and":[34,105,110,139,183,200,216,218],"R.":[35],"Kiplin":[36],"Guy*Cite":[37],"this:":[38],"J.":[39],"Med.":[40],"Chem.":[41],"2008,":[42],"51,":[43],"3,":[44],"699Publication":[45],"Date":[46],"(Web):January":[47],"17,":[48],"2008Publication":[49],"History":[50],"Published":[51],"online17":[52],"January":[53],"2008Published":[54],"inissue":[55],"1":[56],"February":[57],"2008https://pubs.acs.org/doi/10.1021/jm701572ahttps://doi.org/10.1021/jm701572acorrectionACS":[58],"PublicationsCopyright":[59],"\u00a9":[60],"2008":[61,102],".":[62],"This":[63,75],"publication":[64,76],"available":[66],"under":[67],"these":[68],"Terms":[69],"Use.":[71],"Request":[72],"reuse":[73],"permissions":[74],"free":[78],"to":[79,117,122],"access":[80],"through":[81],"this":[82,134],"site.":[83],"Learn":[84],"MoreArticle":[85],"Views490Altmetric-Citations1LEARN":[86],"ABOUT":[87],"THESE":[88],"METRICSArticle":[89],"Views":[90],"are":[91,114,127],"COUNTER-compliant":[93],"sum":[94],"full":[96],"text":[97],"article":[98,162],"downloads":[99],"since":[100],"November":[101],"(both":[103],"PDF":[104,224],"HTML)":[106],"across":[107],"all":[108],"institutions":[109],"individuals.":[111],"These":[112],"metrics":[113],"regularly":[115],"updated":[116,140],"reflect":[118],"usage":[119],"leading":[120],"up":[121],"last":[124],"few":[125],"days.Citations":[126],"number":[129],"other":[131],"articles":[132],"citing":[133],"article,":[135],"calculated":[136],"by":[137],"Crossref":[138,146],"daily.":[141],"Find":[142,192],"more":[143,193],"information":[144,194],"about":[145,180],"citation":[147],"counts.The":[148],"Altmetric":[149,197],"Attention":[150,198],"Score":[151,199],"quantitative":[154],"measure":[155],"attention":[158],"that":[159],"research":[161],"has":[163],"received":[164],"online.":[165],"Clicking":[166],"on":[167,195],"donut":[169],"icon":[170],"will":[171],"load":[172],"page":[174],"at":[175],"altmetric.com":[176],"with":[177,212],"additional":[178],"details":[179],"score":[182,203],"social":[185],"media":[186],"presence":[187],"for":[188],"given":[190],"article.":[191],"how":[201],"calculated.":[205],"Share":[206,221],"Add":[207],"toView":[208],"InAdd":[209],"Full":[210],"Text":[211],"ReferenceAdd":[213],"Description":[214],"ExportRISCitationCitation":[215],"abstractCitation":[217],"referencesMore":[219],"Options":[220],"onFacebookTwitterWechatLinked":[222],"InRedditEmail":[223],"(29":[225],"KB)":[226],"Get":[227,233],"e-AlertscloseSUBJECTS:High-performance":[228],"liquid":[229],"chromatography,Inorganic":[230],"carbon":[231],"compounds,Silica,Solvents,Vacuum":[232],"e-Alerts":[234]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}