{"id":"https://openalex.org/W4241815599","doi":"https://doi.org/10.1001/archderm.1994.01690010091014","title":"The Cellular and Molecular Biology of Skin Aging","display_name":"The Cellular and Molecular Biology of Skin Aging","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W4241815599","doi":"https://doi.org/10.1001/archderm.1994.01690010091014","mag":"2061107098","pmid":"https://pubmed.ncbi.nlm.nih.gov/8285746"},"language":"en","primary_location":{"id":"doi:10.1001/archderm.1994.01690010091014","doi":"https://doi.org/10.1001/archderm.1994.01690010091014","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archderm.1994.01690010091014","pdf_url":null,"source":{"id":"https://openalex.org/S115046667","display_name":"Archives of Dermatology","issn_l":"0003-987X","issn":["0003-987X","1538-3652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008580136","display_name":"Michael D. West","orcid":"https://orcid.org/0000-0002-4842-5468","observed_orcids":["https://orcid.org/0000-0002-4842-5468","https://orcid.org/0009-0009-9328-8800"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"M. D. West","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5008580136"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.8892,"has_fulltext":false,"cited_by_count":155,"citation_normalized_percentile":{"value":0.98145286,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"130","issue":"1","first_page":"87","last_page":"87"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.5121999979019165,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.4650999903678894,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skin-aging","display_name":"skin aging","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9290000200271606},{"id":"https://openalex.org/keywords/replicative-lifespan","display_name":"replicative lifespan","score":0.9459999799728394},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.7670000195503235},{"id":"https://openalex.org/keywords/extracellular-matrix-degradation","display_name":"extracellular matrix degradation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/collagen-degeneration","display_name":"collagen degeneration","score":0.6909999847412109},{"id":"https://openalex.org/keywords/elastic-fibers","display_name":"elastic fibers","score":0.8149999976158142},{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.847000002861023},{"id":"https://openalex.org/keywords/dna-damage-checkpoint","display_name":"DNA damage checkpoint","score":0.9110000133514404},{"id":"https://openalex.org/keywords/proteolytic-activity","display_name":"proteolytic activity","score":0.6349999904632568},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.6079999804496765}],"concepts":[{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.721973180770874},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.664242148399353},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.616443932056427},{"id":"https://openalex.org/C2909910311","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Skin Aging","level":2,"score":0.5704825520515442},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5217007994651794},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.48391586542129517},{"id":"https://openalex.org/C518705261","wikidata":"https://www.wikidata.org/wiki/Q25615","display_name":"Connective tissue","level":2,"score":0.45682647824287415},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.42585307359695435},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2820349335670471},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25078892707824707},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.24560928344726562},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1571686863899231},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0762694776058197}],"mesh":[{"descriptor_ui":"D003238","descriptor_name":"Connective Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004817","descriptor_name":"Epidermis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1001/archderm.1994.01690010091014","doi":"https://doi.org/10.1001/archderm.1994.01690010091014","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archderm.1994.01690010091014","pdf_url":null,"source":{"id":"https://openalex.org/S115046667","display_name":"Archives of Dermatology","issn_l":"0003-987X","issn":["0003-987X","1538-3652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Dermatology","raw_type":"journal-article"},{"id":"doi:10.1001/archderm.130.1.87","doi":"https://doi.org/10.1001/archderm.130.1.87","is_oa":false,"landing_page_url":"https://doi.org/10.1001/archderm.130.1.87","pdf_url":null,"source":{"id":"https://openalex.org/S115046667","display_name":"Archives of Dermatology","issn_l":"0003-987X","issn":["0003-987X","1538-3652"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core"],"host_organization":"https://openalex.org/P4310320259","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/P4310320259"],"host_organization_lineage_names":["American Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of Dermatology","raw_type":"journal-article"},{"id":"pmid:8285746","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8285746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Archives of dermatology","raw_type":"Journal Article"},{"id":"mag:2061107098","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8285746","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W159681246","https://openalex.org/W1537309584","https://openalex.org/W1557288618","https://openalex.org/W1560360966","https://openalex.org/W1872370876","https://openalex.org/W1903437184","https://openalex.org/W1960431623","https://openalex.org/W1964285275","https://openalex.org/W1964480364","https://openalex.org/W1965147385","https://openalex.org/W1968785754","https://openalex.org/W1970220568","https://openalex.org/W1971717315","https://openalex.org/W1972580560","https://openalex.org/W1973466541","https://openalex.org/W1974558953","https://openalex.org/W1977389200","https://openalex.org/W1977688658","https://openalex.org/W1980480613","https://openalex.org/W1981224048","https://openalex.org/W1983673827","https://openalex.org/W1985810210","https://openalex.org/W1986311309","https://openalex.org/W1987582912","https://openalex.org/W1990047337","https://openalex.org/W1991949119","https://openalex.org/W1992520556","https://openalex.org/W1996563850","https://openalex.org/W1997964645","https://openalex.org/W1998663807","https://openalex.org/W2002019908","https://openalex.org/W2002440725","https://openalex.org/W2004314923","https://openalex.org/W2004799558","https://openalex.org/W2009026769","https://openalex.org/W2009686395","https://openalex.org/W2017784130","https://openalex.org/W2018730365","https://openalex.org/W2022302688","https://openalex.org/W2022604404","https://openalex.org/W2023237675","https://openalex.org/W2023755198","https://openalex.org/W2023903736","https://openalex.org/W2028163122","https://openalex.org/W2029084279","https://openalex.org/W2041123199","https://openalex.org/W2041966597","https://openalex.org/W2042864040","https://openalex.org/W2044383840","https://openalex.org/W2047330128","https://openalex.org/W2047447995","https://openalex.org/W2049954179","https://openalex.org/W2051146905","https://openalex.org/W2052605451","https://openalex.org/W2054774190","https://openalex.org/W2056479851","https://openalex.org/W2057933888","https://openalex.org/W2064196833","https://openalex.org/W2065791199","https://openalex.org/W2066185836","https://openalex.org/W2067592423","https://openalex.org/W2072310852","https://openalex.org/W2075443452","https://openalex.org/W2076400941","https://openalex.org/W2079506023","https://openalex.org/W2080717926","https://openalex.org/W2081327669","https://openalex.org/W2082921795","https://openalex.org/W2111052817","https://openalex.org/W2114056631","https://openalex.org/W2119906116","https://openalex.org/W2125238692","https://openalex.org/W2128445946","https://openalex.org/W2151491857","https://openalex.org/W2164870555","https://openalex.org/W2229775693","https://openalex.org/W2321834854","https://openalex.org/W2327776826","https://openalex.org/W2331196355","https://openalex.org/W2406477783","https://openalex.org/W2411873285","https://openalex.org/W2419053098","https://openalex.org/W2428056587","https://openalex.org/W2461782787","https://openalex.org/W2462269914","https://openalex.org/W2481857159","https://openalex.org/W4321317603"],"related_works":["https://openalex.org/W4281691456","https://openalex.org/W4381414098","https://openalex.org/W2058650920","https://openalex.org/W2114701545","https://openalex.org/W2912149155","https://openalex.org/W4411394747","https://openalex.org/W4285984807","https://openalex.org/W4254717972","https://openalex.org/W4249647704","https://openalex.org/W2990644998"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,137],"dramatic":[2],"alterations":[3,107],"in":[4,15,50,57,90,104,114,116,144],"the":[5,8,22,26,31,43,51,68,98,129,145,149,168],"appearance":[6],"of":[7,21,25,30,45,53,60,71,82,100,132,140,148],"integument":[9],"with":[10,42,109,151],"increasing":[11],"age":[12],"are":[13,63],"due":[14],"part":[16],"to":[17,67,84,92,97,165,176,180],"a":[18,39,78,112,141],"progressive":[19],"destruction":[20],"delicate":[23],"architecture":[24],"connective":[27],"tissue":[28],"components":[29,37],"dermis.":[32],"Both":[33],"collagenous":[34],"and":[35,154,174],"elastic":[36],"display":[38,106],"degeneration":[40],"consistent":[41,108],"overexpression":[44],"proteolytic":[46],"activity.":[47],"Recent":[48],"advances":[49],"field":[52],"molecular":[54,169,183],"gerontology,":[55],"using":[56],"vitro":[58,105],"models":[59],"cellular":[61,152,172],"aging,":[62],"yielding":[64],"clues":[65],"as":[66],"fundamental":[69],"causes":[70],"dermal":[72,121],"aging.":[73],"OBSERVATIONS:":[74],"Dermal":[75],"fibroblasts":[76,122],"possess":[77],"finite":[79],"replicative":[80,102],"capacity":[81],"50":[83],"100":[85],"doublings,":[86],"then":[87],"cease":[88],"replicating":[89],"response":[91],"growth":[93],"factors.":[94],"Cells":[95],"cultivated":[96],"end":[99],"their":[101,110],"lifespan":[103],"playing":[111],"role":[113],"aging":[115,153,173],"vivo.":[117],"In":[118],"particular,":[119],"senescent":[120],"overexpress":[123],"metalloproteinase":[124],"activities":[125],"that":[126],"may":[127],"explain":[128],"age-related":[130],"atrophy":[131],"extracellular":[133],"matrix":[134],"architecture.":[135],"CONCLUSIONS:":[136],"recent":[138],"discovery":[139],"structural":[142],"change":[143],"telomeric":[146],"region":[147],"genome":[150],"new":[155,163,178],"insights":[156],"into":[157],"DNA":[158],"damage":[159],"checkpoint":[160],"mechanisms":[161,170],"offer":[162],"opportunities":[164],"uncover":[166],"both":[167],"regulating":[171],"possibly":[175],"devise":[177],"strategies":[179],"manipulate":[181],"these":[182],"events":[184],"for":[185],"therapeutic":[186],"effect.":[187]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}
