{"id":"https://openalex.org/W4241740574","doi":"https://doi.org/10.1016/j.celrep.2021.108943","title":"Cell-type-specific immune dysregulation in severely ill COVID-19 patients","display_name":"Cell-type-specific immune dysregulation in severely ill COVID-19 patients","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W4241740574","doi":"https://doi.org/10.1016/j.celrep.2021.108943"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2021.108943","doi":"https://doi.org/10.1016/j.celrep.2021.108943","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.108943","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.celrep.2021.108943","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013011780","display_name":"Changfu Yao","orcid":"https://orcid.org/0000-0003-1357-5017","observed_orcids":["https://orcid.org/0000-0003-1357-5017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Changfu Yao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109441309","display_name":"Stephanie A. Bora","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie A. Bora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012074341","display_name":"Tanyalak Parimon","orcid":"https://orcid.org/0000-0002-4790-0730","observed_orcids":["https://orcid.org/0000-0002-4790-0730","https://orcid.org/0009-0001-2525-300X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanyalak Parimon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066866898","display_name":"Tanzira Zaman","orcid":"https://orcid.org/0000-0003-0286-4382","observed_orcids":["https://orcid.org/0000-0003-0286-4382"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tanzira Zaman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041888031","display_name":"Oren Friedman","orcid":"https://orcid.org/0000-0001-7771-1554","observed_orcids":["https://orcid.org/0000-0001-7771-1554"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oren A. Friedman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023902750","display_name":"Joseph Alexander Palatinus","orcid":"https://orcid.org/0000-0002-6424-0105","observed_orcids":["https://orcid.org/0000-0002-6424-0105"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph A. Palatinus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001129857","display_name":"Nirmala S. Surapaneni","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nirmala S. Surapaneni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047853596","display_name":"Yuri P. Matusov","orcid":"https://orcid.org/0000-0002-6614-2314","observed_orcids":["https://orcid.org/0000-0002-6614-2314"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuri P. Matusov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006278267","display_name":"Giuliana Cerro Chiang","orcid":"https://orcid.org/0000-0003-0517-9233","observed_orcids":["https://orcid.org/0000-0003-0517-9233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuliana Cerro Chiang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103917373","display_name":"Alexander G. Kassar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander G. Kassar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081014317","display_name":"Nayan M Patel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nayan Patel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024376527","display_name":"Chelsi E.R. Green","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chelsi E.R. Green","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064830121","display_name":"Adam W. Aziz","orcid":"https://orcid.org/0000-0003-4992-1962","observed_orcids":["https://orcid.org/0000-0003-4992-1962"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam W. Aziz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082508565","display_name":"Harshpreet Suri","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harshpreet Suri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055461889","display_name":"Jo Suda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jo Suda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049299370","display_name":"Andres A. Lopez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andres A. Lopez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045555501","display_name":"Gisl\u00e2ine A. Martins","orcid":"https://orcid.org/0000-0001-6976-5819","observed_orcids":["https://orcid.org/0000-0001-6976-5819"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gisl\u00e2ine A. Martins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062224123","display_name":"Barry R. Stripp","orcid":"https://orcid.org/0000-0003-4348-2137","observed_orcids":["https://orcid.org/0000-0003-4348-2137"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barry R. Stripp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084644058","display_name":"Sina A. Gharib","orcid":"https://orcid.org/0000-0002-2480-4367","observed_orcids":["https://orcid.org/0000-0002-2480-4367"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Sina A. Gharib","raw_affiliation_strings":["Corresponding author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding author","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042050280","display_name":"Helen S. Goodridge","orcid":"https://orcid.org/0000-0001-8097-2413","observed_orcids":["https://orcid.org/0000-0001-8097-2413"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Helen S. Goodridge","raw_affiliation_strings":["Corresponding author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding author","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100651978","display_name":"Peter Chen","orcid":"https://orcid.org/0000-0002-5330-1718","observed_orcids":["https://orcid.org/0000-0002-5330-1718"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Peter Chen","raw_affiliation_strings":["Corresponding author"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding author","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042050280","https://openalex.org/A5084644058","https://openalex.org/A5100651978"],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":1.983,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.89474182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"34","issue":"13","first_page":"108943","last_page":"108943"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9717000126838684,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.019999999552965164,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9959999918937683},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9449999928474426},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.8100000023841858},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.6980000138282776},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9020000100135803},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.7860000133514404},{"id":"https://openalex.org/keywords/plasma-cells","display_name":"plasma cells","score":0.9259999990463257},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.9049999713897705},{"id":"https://openalex.org/keywords/interferon-signaling","display_name":"interferon signaling","score":0.921999990940094},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7620000243186951},{"id":"https://openalex.org/keywords/t-cell-exhaustion","display_name":"T cell exhaustion","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.6306380033493042},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4296375811100006},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3920424282550812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3685241937637329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34135153889656067},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25250571966171265}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.celrep.2021.108943","doi":"https://doi.org/10.1016/j.celrep.2021.108943","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.108943","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d1095ed61182462a817f5dee782da1c7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d1095ed61182462a817f5dee782da1c7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell Reports, Vol 34, Iss 13, Pp 108943- (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2021.108943","doi":"https://doi.org/10.1016/j.celrep.2021.108943","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2021.108943","pdf_url":null,"source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W6925217494","https://openalex.org/W4309561663","https://openalex.org/W4206833715","https://openalex.org/W3160422429","https://openalex.org/W3174251697","https://openalex.org/W3126710954","https://openalex.org/W4413105292","https://openalex.org/W3128961456","https://openalex.org/W3193311393","https://openalex.org/W4385186248"],"abstract_inverted_index":{"(Cell":[0],"Reports":[1],"34,":[2],"108590-1\u2013108590-15.e1\u2013e3;":[3],"January":[4],"5,":[5],"2021)":[6],"In":[7],"the":[8,57,66,77,92,106,129,150,160],"originally":[9],"published":[10],"version":[11],"of":[12,25,56,65,137,142,152,181,204,224,244,263,303,335],"this":[13,178],"article,":[14],"some":[15,86],"scRNA-seq":[16],"data":[17,134],"analysis":[18],"was":[19,33,44],"presented":[20],"for":[21],"individual":[22,108,143],"patients.":[23,144],"Multiplexing":[24],"paired":[26,156],"samples":[27,59,138,171],"within":[28,172],"each":[29,173],"disease":[30,316],"severity":[31],"group":[32,162],"performed":[34,45,72,167],"by":[35,91,168],"\u201ccell":[36],"hashing\u201d":[37],"using":[38,46],"barcoded":[39],"antibodies,":[40],"and":[41,49,84,118,123,127,163,189,206,208,226,228,246,249,265,268,338],"sample":[42],"demultiplexing":[43],"CITE-seq-Count":[47],"1.4.3":[48],"HTOdemux,":[50],"which":[51],"assigned":[52,104],"cells":[53,87],"to":[54,105,132,327],"one":[55],"two":[58,67,107],"based":[60],"on":[61],"their":[62],"relative":[63],"expression":[64,213,233,252,271,334],"barcode":[68],"hashtags.":[69],"Additional":[70],"analyses":[71,165],"after":[73],"publication":[74],"revealed":[75],"that":[76,85,88,299],"hashing":[78,93],"had":[79,101],"not":[80,148],"worked":[81],"very":[82],"efficiently":[83],"were":[89,158,166],"unstained":[90],"antibodies":[94],"(negative,":[95],"but":[96],"otherwise":[97],"passed":[98],"quality":[99],"control)":[100],"been":[102,116],"inappropriately":[103],"patient":[109],"samples.":[110],"The":[111,175],"main":[112],"text":[113],"has":[114],"now":[115],"corrected,":[117],"revised":[119],"Figures":[120],"1D,":[121],"S3,":[122],"S4":[124],"appear":[125],"here":[126],"with":[128,309],"article":[130],"online":[131],"present":[133],"as":[135],"pairs":[136],"sequenced":[139],"together":[140],"instead":[141],"This":[145],"issue":[146],"does":[147],"change":[149],"conclusions":[151],"our":[153],"study":[154],"because":[155],"patients":[157,308],"from":[159],"same":[161],"most":[164],"pooling":[169],"all":[170],"group.":[174],"authors":[176],"regret":[177],"error.Figure":[179],"1Evaluation":[180],"Blood":[182],"Cells":[183],"Subsets":[184],"in":[185,284,306],"Moderate,":[186],"Severe":[187],"(ARDS),":[188],"Recovering":[190],"(post-ARDS)":[191],"COVID-19":[192,287,307],"Patients":[193],"(original)View":[194,234,272],"Large":[195,215,235,254,273],"Image":[196,216,236,255,274],"Figure":[197,217,237,256,275],"ViewerDownload":[198,218,238,257,276],"Hi-res":[199,219,239,258,277],"image":[200,220,240,259,278],"Download":[201,221,241,260,279],"(PPT)Figure":[202,222,242,261],"S3Comparison":[203,223],"NK":[205,225],"CD8":[207,227],"CD4":[209,229],"T":[210,230],"cell":[211,231,248,267,341],"gene":[212,232,251,270],"(corrected)View":[214,253],"S4Comparison":[243,262],"B":[245,264,340],"plasma":[247,266],"monocyte":[250,269,325],"(PPT)":[280],"Cell-Type-Specific":[281],"Immune":[282],"Dysregulation":[283],"Severely":[285],"Ill":[286],"PatientsYao":[288],"et":[289,295],"al.Cell":[290],"ReportsDecember":[291],"16,":[292],"2020In":[293],"BriefYao":[294],"al.":[296],"provide":[297],"evidence":[298],"widespread,":[300],"cell-specific":[301],"dysregulation":[302],"immune":[304],"responses":[305],"acute":[310],"respiratory":[311],"distress":[312],"syndrome":[313],"may":[314],"underlie":[315],"severity.":[317],"Defects":[318],"include":[319],"impaired":[320],"antigen":[321],"presentation":[322],"pathways,":[323],"suppressed":[324],"response":[326],"early":[328],"antiviral":[329],"interferon":[330],"signals,":[331],"deficient":[332],"lymphocyte":[333],"cytotoxicity":[336],"genes,":[337],"reduced":[339],"activation.":[342],"Full-Text":[343],"PDF":[344],"Open":[345],"Access":[346]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":10}],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2022-05-12T00:00:00"}
