{"id":"https://openalex.org/W4241700151","doi":"https://doi.org/10.1002/ange.201609731","title":"Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents","display_name":"Phototriggered Secretion of Membrane Compartmentalized Bioactive Agents","publication_year":2016,"publication_date":"2016-11-22","ids":{"openalex":"https://openalex.org/W4241700151","doi":"https://doi.org/10.1002/ange.201609731"},"language":"en","primary_location":{"id":"doi:10.1002/ange.201609731","doi":"https://doi.org/10.1002/ange.201609731","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201609731","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015871731","display_name":"Robert M. Hughes","orcid":"https://orcid.org/0000-0002-4465-4212","observed_orcids":["https://orcid.org/0000-0002-4465-4212"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I186335123","display_name":"East Carolina University","ror":"https://ror.org/01vx35703","country_code":"US","type":"education","lineage":["https://openalex.org/I186335123"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Hughes","raw_affiliation_strings":["Current address: Department of Chemistry, 300 Science &amp; Technology Building East Carolina University  Greenville NC 27858 USA","Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA","Current address: Department of Chemistry, 300 Science & Technology Building, East Carolina University, Greenville, NC, 27858 USA"],"raw_orcid":"https://orcid.org/0000-0002-4465-4212","affiliations":[{"raw_affiliation_string":"Current address: Department of Chemistry, 300 Science &amp; Technology Building East Carolina University  Greenville NC 27858 USA","institution_ids":["https://openalex.org/I186335123"]},{"raw_affiliation_string":"Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Current address: Department of Chemistry, 300 Science & Technology Building, East Carolina University, Greenville, NC, 27858 USA","institution_ids":["https://openalex.org/I186335123"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024495458","display_name":"Christina M. Marvin","orcid":"https://orcid.org/0000-0002-6024-3261","observed_orcids":["https://orcid.org/0000-0002-6024-3261"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina M. Marvin","raw_affiliation_strings":["Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057747112","display_name":"Zachary L. Rodgers","orcid":"https://orcid.org/0000-0002-8496-8734","observed_orcids":["https://orcid.org/0000-0002-8496-8734"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachary L. Rodgers","raw_affiliation_strings":["Current address: Center for Nanotechnology in Drug Delivery, Department of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599 USA","Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Center for Nanotechnology in Drug Delivery, Department of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078086923","display_name":"Song Ding","orcid":"https://orcid.org/0000-0002-7344-8821","observed_orcids":["https://orcid.org/0000-0002-7344-8821"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Song Ding","raw_affiliation_strings":["Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079584234","display_name":"Nathan P. Oien","orcid":"https://orcid.org/0009-0009-1067-9428","observed_orcids":["https://orcid.org/0009-0009-1067-9428"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan P. Oien","raw_affiliation_strings":["Current address: KBI Biopharma, 1101 Hamlin Rd, Durham, NC, 27704 USA","Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: KBI Biopharma, 1101 Hamlin Rd, Durham, NC, 27704 USA","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058815075","display_name":"Weston J. Smith","orcid":"https://orcid.org/0000-0003-4333-760X","observed_orcids":["https://orcid.org/0000-0003-4333-760X"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weston J. Smith","raw_affiliation_strings":["Current address: Skaggs School of Pharmacy, University of Colorado, 12850 E. Montview Blvd, Aurora, CO, 80045 USA","Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Skaggs School of Pharmacy, University of Colorado, 12850 E. Montview Blvd, Aurora, CO, 80045 USA","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065068715","display_name":"David S. Lawrence","orcid":"https://orcid.org/0000-0002-0901-1617","observed_orcids":["https://orcid.org/0000-0002-0901-1617"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David S. Lawrence","raw_affiliation_strings":["Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA"],"raw_orcid":"https://orcid.org/0000-0002-0901-1617","affiliations":[{"raw_affiliation_string":"Department of Chemistry, Division of Chemical Biology and Medicinal Chemistry, and Department of Pharmacology, University of North Carolina, Chapel Hill, NC, 27599 USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5065068715"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":0.1483,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53962167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"128","issue":"52","first_page":"16314","last_page":"16317"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11708","display_name":"Photochromic and Fluorescence Chemistry","score":0.6234999895095825,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11708","display_name":"Photochromic and Fluorescence Chemistry","score":0.6234999895095825,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.12099999934434891,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.11379999667406082,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photorelease","display_name":"photorelease","score":0.8820000290870667},{"id":"https://openalex.org/keywords/vitamin-b12","display_name":"vitamin B12","score":0.628000020980835},{"id":"https://openalex.org/keywords/photocleavable-linker","display_name":"photocleavable linker","score":0.7889999747276306},{"id":"https://openalex.org/keywords/membrane-impermeability","display_name":"membrane impermeability","score":0.6460000276565552},{"id":"https://openalex.org/keywords/bioactive-compound-delivery","display_name":"bioactive compound delivery","score":0.5669999718666077},{"id":"https://openalex.org/keywords/erythrocytes","display_name":"erythrocytes","score":0.7570000290870667},{"id":"https://openalex.org/keywords/bodipy","display_name":"BODIPY","score":0.8709999918937683},{"id":"https://openalex.org/keywords/colchicine","display_name":"colchicine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":1.0},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":1.0},{"id":"https://openalex.org/keywords/red-and-near-infrared-light","display_name":"red and near-infrared light","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6652916073799133},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6303167343139648},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5809441804885864},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.547887921333313},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5145887136459351},{"id":"https://openalex.org/C2778617687","wikidata":"https://www.wikidata.org/wiki/Q2448456","display_name":"Fluorophore","level":3,"score":0.4957824647426605},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.47102293372154236},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.4237176477909088},{"id":"https://openalex.org/C2781374752","wikidata":"https://www.wikidata.org/wiki/Q679174","display_name":"BODIPY","level":3,"score":0.4235013425350189},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2901005744934082},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.2751198410987854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14813479781150818},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.136807382106781},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ange.201609731","doi":"https://doi.org/10.1002/ange.201609731","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201609731","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.4300000071525574,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W107809161","https://openalex.org/W1980989869","https://openalex.org/W1981027894","https://openalex.org/W1993251792","https://openalex.org/W1999608828","https://openalex.org/W2011048582","https://openalex.org/W2032304520","https://openalex.org/W2039931639","https://openalex.org/W2060415328","https://openalex.org/W2066411052","https://openalex.org/W2071790421","https://openalex.org/W2075653003","https://openalex.org/W2086367502","https://openalex.org/W2087647309","https://openalex.org/W2122027991","https://openalex.org/W2125160663","https://openalex.org/W2136698583","https://openalex.org/W2140319488","https://openalex.org/W2153663592","https://openalex.org/W2165710187","https://openalex.org/W2173646698","https://openalex.org/W2466402497","https://openalex.org/W2469713039","https://openalex.org/W4212911524","https://openalex.org/W4214710674","https://openalex.org/W4214736665","https://openalex.org/W4214813679","https://openalex.org/W4254685545"],"related_works":["https://openalex.org/W2124740859","https://openalex.org/W4287218451","https://openalex.org/W2949391657","https://openalex.org/W4280563300","https://openalex.org/W4229831384","https://openalex.org/W4400361186","https://openalex.org/W3047096572","https://openalex.org/W2530896854","https://openalex.org/W2097527344","https://openalex.org/W7036250942"],"abstract_inverted_index":{"Abstract":[0],"A":[1],"strategy":[2],"for":[3],"the":[4,50,58,65,68,81,96,101],"light\u2010activated":[5],"release":[6],"of":[7,60,67],"bioactive":[8,69],"compounds":[9,110],"(BODIPY,":[10],"colchicine,":[11],"paclitaxel,":[12],"and":[13,84,114],"methotrexate)":[14],"from":[15,71,117],"membrane\u2010enclosed":[16],"depots":[17],"is":[18,76],"described.":[19],"We":[20],"have":[21],"found":[22],"that":[23],"membrane\u2010permeable":[24],"bioagents":[25],"can":[26,88],"be":[27,89,112],"rendered":[28],"membrane":[29],"impermeable":[30],"by":[31,54,78,91],"covalent":[32],"attachment":[33],"to":[34,100,111],"cobalamin":[35],"(Cbl)":[36],"through":[37],"a":[38,93],"photocleavable":[39],"linker.":[40],"These":[41],"Cbl\u2010bioagent":[42,102],"conjugates":[43],"are":[44],"imprisoned":[45],"within":[46],"lipid\u2010enclosed":[47],"compartments":[48],"in":[49,57,80],"dark,":[51],"as":[52],"exemplified":[53],"their":[55],"retention":[56],"interior":[59],"erythrocytes.":[61],"Subsequent":[62],"illumination":[63],"drives":[64],"secretion":[66],"species":[70],"red":[72],"blood":[73],"cells.":[74],"Photorelease":[75],"triggered":[77],"wavelengths":[79,105],"red,":[82],"far\u2010red,":[83],"near\u2010IR":[85],"regions,":[86],"which":[87],"pre\u2010assigned":[90],"affixing":[92],"fluorophore":[94],"with":[95],"desired":[97],"excitation":[98],"wavelength":[99],"conjugate.":[103],"Pre\u2010assigned":[104],"allow":[106],"different":[107],"biologically":[108],"active":[109],"specifically":[113],"unambiguously":[115],"photoreleased":[116],"common":[118],"carriers.":[119]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}
