{"id":"https://openalex.org/W4241617543","doi":"https://doi.org/10.1038/ncomms7085","title":"Substrate stiffness-modulated registry phase correlations in cardiomyocytes map structural order to coherent beating","display_name":"Substrate stiffness-modulated registry phase correlations in cardiomyocytes map structural order to coherent beating","publication_year":2015,"publication_date":"2015-01-19","ids":{"openalex":"https://openalex.org/W4241617543","doi":"https://doi.org/10.1038/ncomms7085"},"language":"en","primary_location":{"id":"doi:10.1038/ncomms7085","doi":"https://doi.org/10.1038/ncomms7085","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms7085","pdf_url":"https://www.nature.com/articles/ncomms7085.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/ncomms7085.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084127261","display_name":"Kinjal Dasbiswas","orcid":"https://orcid.org/0000-0002-5741-8200","observed_orcids":["https://orcid.org/0000-0002-5741-8200"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"K. Dasbiswas","raw_affiliation_strings":["Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot 76100, Israel","Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108412577","display_name":"Stephanie Majkut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Majkut","raw_affiliation_strings":["1] Department of Molecular and Biophysical Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Physics and Astronomy Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","Department of Molecular and Biophysical Engineering, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Department of Molecular and Biophysical Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Physics and Astronomy Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Molecular and Biophysical Engineering, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085597391","display_name":"Dennis E. Discher","orcid":"https://orcid.org/0000-0001-6163-2229","observed_orcids":["https://orcid.org/0000-0001-6163-2229"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. E. Discher","raw_affiliation_strings":["1] Department of Molecular and Biophysical Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Physics and Astronomy Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [3] Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","Department of Molecular and Biophysical Engineering, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1] Department of Molecular and Biophysical Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [2] Physics and Astronomy Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA [3] Cell and Molecular Biology Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Molecular and Biophysical Engineering, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053211414","display_name":"Samuel A. Safran","orcid":"https://orcid.org/0000-0002-0798-1492","observed_orcids":["https://orcid.org/0000-0002-0798-1492"]},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Samuel A. Safran","raw_affiliation_strings":["Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot 76100, Israel","Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot, 76100, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot 76100, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot, 76100, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5053211414"],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":3.5572,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.92819704,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/substrate-stiffness","display_name":"substrate stiffness","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.984000027179718},{"id":"https://openalex.org/keywords/striations","display_name":"striations","score":0.6230000257492065},{"id":"https://openalex.org/keywords/cardiac-muscle-contraction","display_name":"cardiac muscle contraction","score":0.4259999990463257},{"id":"https://openalex.org/keywords/mechanobiology","display_name":"mechanobiology","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C7301908","wikidata":"https://www.wikidata.org/wiki/Q318623","display_name":"Myofibril","level":2,"score":0.7150407433509827},{"id":"https://openalex.org/C2779372316","wikidata":"https://www.wikidata.org/wiki/Q569057","display_name":"Stiffness","level":2,"score":0.6911233067512512},{"id":"https://openalex.org/C2779015724","wikidata":"https://www.wikidata.org/wiki/Q7623560","display_name":"Striation","level":2,"score":0.6848186254501343},{"id":"https://openalex.org/C121854251","wikidata":"https://www.wikidata.org/wiki/Q62932","display_name":"Elasticity (physics)","level":2,"score":0.5752005577087402},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5092858076095581},{"id":"https://openalex.org/C160343418","wikidata":"https://www.wikidata.org/wiki/Q185256","display_name":"Rigidity (electromagnetism)","level":2,"score":0.4871635138988495},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.47149986028671265},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.43158888816833496},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.329855352640152},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.2521723210811615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1745920181274414},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1265614926815033},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11597543954849243}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/ncomms7085","doi":"https://doi.org/10.1038/ncomms7085","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms7085","pdf_url":"https://www.nature.com/articles/ncomms7085.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7085","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/ncomms7085","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/ncomms7085","doi":"https://doi.org/10.1038/ncomms7085","is_oa":true,"landing_page_url":"https://doi.org/10.1038/ncomms7085","pdf_url":"https://www.nature.com/articles/ncomms7085.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1499434410","display_name":null,"funder_award_id":"8UL1TR000003","funder_id":"https://openalex.org/F4320337472","funder_display_name":"National Center for Advancing Translational Sciences"},{"id":"https://openalex.org/G290685402","display_name":null,"funder_award_id":"R01-HL062352","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3458893715","display_name":null,"funder_award_id":"R01 EB007049","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G6084019037","display_name":null,"funder_award_id":"P01-DK032094","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000020610","display_name":null,"funder_award_id":"8UL1TR000003","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000109509","display_name":null,"funder_award_id":"P01DK032094","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000164404","display_name":null,"funder_award_id":"R01HL062352","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"},{"id":"https://openalex.org/F4320324256","display_name":"Y\u00fcksek\u00f6\u011fretim Kurulu","ror":"https://ror.org/00j1q0b46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333422","display_name":"Materials Research Science and Engineering Center, Harvard University","ror":"https://ror.org/01qa5ep47"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4241617543.pdf","grobid_xml":"https://content.openalex.org/works/W4241617543.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1970944947","https://openalex.org/W1972887127","https://openalex.org/W1973089587","https://openalex.org/W1983805504","https://openalex.org/W1985540153","https://openalex.org/W1985693198","https://openalex.org/W2004667080","https://openalex.org/W2007530020","https://openalex.org/W2025003977","https://openalex.org/W2030600914","https://openalex.org/W2033896815","https://openalex.org/W2037426481","https://openalex.org/W2046986640","https://openalex.org/W2049566642","https://openalex.org/W2054635074","https://openalex.org/W2057046635","https://openalex.org/W2058846791","https://openalex.org/W2061897774","https://openalex.org/W2068299384","https://openalex.org/W2074878885","https://openalex.org/W2086321200","https://openalex.org/W2098082531","https://openalex.org/W2102121146","https://openalex.org/W2106297262","https://openalex.org/W2107575131","https://openalex.org/W2141557806","https://openalex.org/W2157023104","https://openalex.org/W2167243609","https://openalex.org/W2408569695"],"related_works":["https://openalex.org/W1882833270","https://openalex.org/W2996425211","https://openalex.org/W2055408892","https://openalex.org/W1964750489","https://openalex.org/W2015907424","https://openalex.org/W2042249618","https://openalex.org/W2092328422","https://openalex.org/W2396474634","https://openalex.org/W2389442813","https://openalex.org/W1976581333"],"abstract_inverted_index":{"Recent":[0],"experiments":[1],"show":[2,35],"that":[3,50,70,84,122,170],"both":[4,100],"striation,":[5],"an":[6],"indication":[7],"of":[8,42,51,99,105,116,126,136,175,181,187],"the":[9,18,38,43,52,57,72,96,123,133,137,152,155,165,172,176,182,188],"structural":[10,59,134],"registry":[11,44,60,177],"in":[12,77,92,110,140],"muscle":[13,25],"fibres,":[14],"as":[15,17,61,185],"well":[16],"contractile":[19],"strains":[20],"produced":[21],"by":[22,30,132,144],"beating":[23,125,183],"cardiac":[24],"cells":[26,128],"can":[27,46],"be":[28,47,130],"optimized":[29],"substrate":[31,39,108,162,189],"stiffness.":[32,163],"Here":[33,164],"we":[34,94],"theoretically":[36],"how":[37],"rigidity":[40],"dependence":[41,98],"data":[45],"mapped":[48],"onto":[49],"strain":[53,103,160,184],"measurements.":[54],"We":[55],"express":[56],"elasticity-mediated":[58],"a":[62,66,111,168],"phase-order":[63],"parameter":[64],"using":[65],"statistical":[67],"physics":[68],"approach":[69],"takes":[71],"noise":[73],"and":[74,102,161],"disorder":[75],"inherent":[76],"biological":[78],"systems":[79],"into":[80],"account.":[81],"By":[82],"assuming":[83],"structurally":[85],"registered":[86],"myofibrils":[87],"also":[88],"tend":[89],"to":[90,179],"beat":[91],"phase,":[93],"explain":[95],"observed":[97],"striation":[101],"measurements":[104],"cardiomyocytes":[106],"on":[107,151],"stiffness":[109],"unified":[112],"manner.":[113],"The":[114],"agreement":[115],"our":[117],"ideas":[118],"with":[119],"experiment":[120],"suggests":[121],"correlated":[124],"heart":[127],"may":[129],"limited":[131],"order":[135],"myofibrils,":[138],"which":[139],"turn":[141],"is":[142],"regulated":[143],"their":[145],"elastic":[146],"environment.":[147],"Cardiomyocyte":[148],"function":[149],"depends":[150],"interplay":[153],"between":[154],"intracellular":[156],"fibrillar":[157],"organization,":[158],"contraction":[159],"authors":[166],"present":[167],"model":[169],"maps":[171],"measured":[173],"values":[174],"striations":[178],"those":[180],"functions":[186],"rigidity.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}