{"id":"https://openalex.org/W4241536795","doi":"https://doi.org/10.1158/1538-7445.sabcs18-5245","title":"Abstract 5245: Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma multiforme","display_name":"Abstract 5245: Integrative analysis of KIF4A, 9, 18A, and 23 and their clinical significance in low-grade glioma and glioblastoma multiforme","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4241536795","doi":"https://doi.org/10.1158/1538-7445.sabcs18-5245"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-5245","doi":"https://doi.org/10.1158/1538-7445.sabcs18-5245","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-5245","pdf_url":null,"source":{"id":"https://openalex.org/S4306520151","display_name":"Molecular and Cellular Biology / Genetics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology / Genetics","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089954459","display_name":"SangYeon Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"SangYeon Cho","raw_affiliation_strings":["Medical School of Chungnam National University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School of Chungnam National University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100756664","display_name":"Dongwoon Kim","orcid":"https://orcid.org/0000-0003-2349-5037","observed_orcids":["https://orcid.org/0000-0003-2349-5037"]},"institutions":[{"id":"https://openalex.org/I196345858","display_name":"Chungnam National University","ror":"https://ror.org/0227as991","country_code":"KR","type":"education","lineage":["https://openalex.org/I196345858"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"DongWoon Kim","raw_affiliation_strings":["Medical School of Chungnam National University, Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical School of Chungnam National University, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I196345858"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I196345858"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kif4a","display_name":"KIF4A","score":0.9869999885559082},{"id":"https://openalex.org/keywords/kif18a","display_name":"KIF18A","score":0.996999979019165},{"id":"https://openalex.org/keywords/kif23","display_name":"KIF23","score":0.9990000128746033},{"id":"https://openalex.org/keywords/low-grade-glioma","display_name":"low-grade glioma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9380000233650208},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6800000071525574},{"id":"https://openalex.org/keywords/histologic-grade","display_name":"histologic grade","score":0.8930000066757202},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"cell cycle","score":0.6539999842643738},{"id":"https://openalex.org/keywords/e2f-target-genes","display_name":"E2F target genes","score":0.7919999957084656},{"id":"https://openalex.org/keywords/g2-m-checkpoint","display_name":"G2/M checkpoint","score":0.9100000262260437},{"id":"https://openalex.org/keywords/mitotic-spindle","display_name":"mitotic spindle","score":0.9480000138282776},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9800000190734863},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9950000047683716}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7346450090408325},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5525097846984863},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5509377121925354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4501570761203766},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4339861571788788},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42930108308792114},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.41731971502304077},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4132940173149109},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.4132826626300812},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37223997712135315},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3310718238353729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3175945281982422},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.1560414433479309},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.066170334815979}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-5245","doi":"https://doi.org/10.1158/1538-7445.sabcs18-5245","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-5245","pdf_url":null,"source":{"id":"https://openalex.org/S4306520151","display_name":"Molecular and Cellular Biology / Genetics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology / Genetics","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2921939018","https://openalex.org/W3164055036","https://openalex.org/W4225966529","https://openalex.org/W4223997258","https://openalex.org/W4408158830","https://openalex.org/W4321378141","https://openalex.org/W2306059038","https://openalex.org/W4400090010","https://openalex.org/W1992917818","https://openalex.org/W4312845306"],"abstract_inverted_index":{"To":[0],"determine":[1],"the":[2,74,94,109,157,207,237,284,319],"prognostic":[3],"significance":[4,308],"of":[5,57,82,111,114,124,162,192,224,262,288,299,318],"kinesin":[6],"superfamily":[7],"gene":[8,126,129,145],"(KIF)":[9],"expression":[10,55,80,161,191,223],"in":[11,28,46,66,73,88,93,176,197,226,268,309],"patients":[12,139,201,231],"with":[13,71,98,100,140,150,159,172,206,236,252],"brain":[14],"cancer,":[15],"including":[16,128],"low-grade":[17,310],"glioma":[18,311],"(LGG)":[19],"and":[20,31,40,49,53,61,68,86,118,133,143,166,179,195,199,216,229,242,254,266,270,272,286,290,303,305,312],"glioblastoma":[21,313],"multiforme":[22,314],"(GBM),":[23],"we":[24],"comprehensively":[25],"analyzed":[26],"KIFs":[27],"515":[29],"LGG":[30,48,67,89,138,178,198,228,269,289],"595":[32],"GBM":[33,69,180,200,230,271],"patients.":[34,181],"Among":[35],"KIFs,":[36],"KIF4A,":[37,58,83,141,163,193,263,300],"9,":[38,59,84,116,164,264,301],"18A,":[39,60,85,117,142,165,194,265,302],"23":[41,62,87,119,144,167,196,267,304],"showed":[42,107,202],"significant":[43,203],"clinical":[44,277,307],"implications":[45],"both":[47,177,227],"GBM.":[50],"The":[51,78],"mRNA":[52,79,112,168,190,222],"protein":[54],"levels":[56,81],"were":[63,90,147],"significantly":[64,91,148,170,233,249],"increased":[65,92],"compared":[70,97],"those":[72,99],"normal":[75],"control":[76],"groups.":[77],"high-histologic-grade":[95],"group":[96,158],"a":[101,151,173],"low":[102],"histologic":[103],"grade.":[104],"Genomic":[105],"analysis":[106,298],"that":[108,123,188],"percent":[110],"upregulation":[113],"KIF4,":[115],"was":[120,169,232,248],"higher":[121],"than":[122],"other":[125],"alterations,":[127],"amplification,":[130],"deep":[131],"deletion,":[132],"missense":[134],"mutation.":[135],"In":[136,154],"addition,":[137],"alterations":[146],"associated":[149,171],"poor":[152,174],"prognosis.":[153],"survival":[155],"analysis,":[156],"high":[160,189,221],"prognosis":[175,287],"Gene":[182],"Set":[183],"Enrichment":[184],"Analysis":[185],"(GSEA)":[186],"revealed":[187],"positive":[204],"correlations":[205],"cell":[208,238],"cycle,":[209,239],"E2F":[210],"targets,":[211],"G2M":[212,240],"checkpoint,":[213,241],"Myc":[214],"target,":[215],"mitotic":[217,243],"spindle.":[218],"By":[219],"contrast,":[220],"KIF9":[225],"negatively":[234],"correlated":[235,251],"spindle":[244],"pathway.":[245],"However,":[246],"it":[247],"positively":[250],"EMT":[253],"angiogenesis.":[255],"This":[256],"study":[257],"has":[258],"extended":[259],"our":[260],"knowledge":[261],"shed":[273],"light":[274],"on":[275],"their":[276,306],"relevance,":[278],"which":[279],"should":[280],"help":[281],"to":[282],"improve":[283],"treatment":[285],"GBM.Citation":[291],"Format:":[292],"SangYeon":[293],"Cho,":[294],"DongWoon":[295],"Kim.":[296],"Integrative":[297],"[abstract].":[315],"In:":[316],"Proceedings":[317],"American":[320],"Association":[321],"for":[322],"Cancer":[323,337],"Research":[324],"Annual":[325],"Meeting":[326],"2019;":[327],"2019":[328],"Mar":[329],"29-Apr":[330],"3;":[331],"Atlanta,":[332],"GA.":[333],"Philadelphia":[334],"(PA):":[335],"AACR;":[336],"Res":[338],"2019;79(13":[339],"Suppl):Abstract":[340],"nr":[341],"5245.":[342]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2022-05-12T00:00:00"}
