{"id":"https://openalex.org/W4241494067","doi":"https://doi.org/10.3410/f.736643716.793575117","title":"Faculty Opinions recommendation of Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development.","display_name":"Faculty Opinions recommendation of Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development.","publication_year":2020,"publication_date":"2020-06-02","ids":{"openalex":"https://openalex.org/W4241494067","doi":"https://doi.org/10.3410/f.736643716.793575117"},"language":"en","primary_location":{"id":"doi:10.3410/f.736643716.793575117","doi":"https://doi.org/10.3410/f.736643716.793575117","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.736643716.793575117","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018907985","display_name":"Malcolm Maden","orcid":"https://orcid.org/0000-0001-7178-5309","observed_orcids":["https://orcid.org/0000-0001-7178-5309"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Malcolm Maden","raw_affiliation_strings":["Department of Biology & UF Genetics Institute, University of Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology & UF Genetics Institute, University of Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018907985"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13107","display_name":"Congenital limb and hand anomalies","score":0.05990000069141388,"subfield":{"id":"https://openalex.org/subfields/1309","display_name":"Developmental Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fgf-signaling","display_name":"FGF signaling","score":0.9240000247955322},{"id":"https://openalex.org/keywords/sonic-hedgehog-signaling","display_name":"Sonic hedgehog signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/limb-development","display_name":"limb development","score":0.7570000290870667},{"id":"https://openalex.org/keywords/axolotl","display_name":"axolotl","score":0.9079999923706055},{"id":"https://openalex.org/keywords/apical-ectodermal-ridge","display_name":"apical ectodermal ridge","score":0.9240000247955322},{"id":"https://openalex.org/keywords/fgf8","display_name":"FGF8","score":0.8209999799728394},{"id":"https://openalex.org/keywords/mesenchyme","display_name":"mesenchyme","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8349999785423279},{"id":"https://openalex.org/keywords/anteroposterior-patterning","display_name":"anterior-posterior patterning","score":0.9340000152587891},{"id":"https://openalex.org/keywords/digit-patterning","display_name":"digit patterning","score":0.5479999780654907},{"id":"https://openalex.org/keywords/tetrapod-limb-evolution","display_name":"tetrapod limb evolution","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.8873090147972107},{"id":"https://openalex.org/C2779999439","wikidata":"https://www.wikidata.org/wiki/Q53663","display_name":"Salamander","level":2,"score":0.8839238882064819},{"id":"https://openalex.org/C86370654","wikidata":"https://www.wikidata.org/wiki/Q2277862","display_name":"Limb development","level":3,"score":0.7915447354316711},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.7431113719940186},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46280544996261597},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3645935356616974},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.338740736246109},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.3375489115715027},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.3374847173690796},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1309027373790741},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.09136968851089478},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.736643716.793575117","doi":"https://doi.org/10.3410/f.736643716.793575117","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.736643716.793575117","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G802878165","display_name":"Collaborative Research: Immune tradeoffs during tissue regeneration in mammals","funder_award_id":"1353713","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W1507573241","https://openalex.org/W1536345725","https://openalex.org/W1583338361","https://openalex.org/W1590010957","https://openalex.org/W1597858723","https://openalex.org/W1647384020","https://openalex.org/W1693747101","https://openalex.org/W1898298130","https://openalex.org/W1904331578","https://openalex.org/W1957895400","https://openalex.org/W1967198448","https://openalex.org/W1971943177","https://openalex.org/W1973849150","https://openalex.org/W1977022255","https://openalex.org/W1978596841","https://openalex.org/W1984215512","https://openalex.org/W1989659478","https://openalex.org/W1992388470","https://openalex.org/W1992865216","https://openalex.org/W1993035406","https://openalex.org/W1993101422","https://openalex.org/W2000572145","https://openalex.org/W2002256459","https://openalex.org/W2002391499","https://openalex.org/W2004763139","https://openalex.org/W2007821628","https://openalex.org/W2008850214","https://openalex.org/W2013801772","https://openalex.org/W2014254246","https://openalex.org/W2015518796","https://openalex.org/W2015520895","https://openalex.org/W2016350172","https://openalex.org/W2017549518","https://openalex.org/W2025909669","https://openalex.org/W2030789263","https://openalex.org/W2035011842","https://openalex.org/W2037357385","https://openalex.org/W2037369918","https://openalex.org/W2037739471","https://openalex.org/W2038170814","https://openalex.org/W2041387737","https://openalex.org/W2042222943","https://openalex.org/W2042535733","https://openalex.org/W2046915665","https://openalex.org/W2049413252","https://openalex.org/W2053073820","https://openalex.org/W2053127298","https://openalex.org/W2053583521","https://openalex.org/W2054195724","https://openalex.org/W2059506271","https://openalex.org/W2059614045","https://openalex.org/W2070560929","https://openalex.org/W2073908723","https://openalex.org/W2075317095","https://openalex.org/W2077802746","https://openalex.org/W2086013207","https://openalex.org/W2089494613","https://openalex.org/W2092937035","https://openalex.org/W2095257048","https://openalex.org/W2095607199","https://openalex.org/W2099002558","https://openalex.org/W2101325866","https://openalex.org/W2103244701","https://openalex.org/W2104131674","https://openalex.org/W2105505995","https://openalex.org/W2108067027","https://openalex.org/W2110873651","https://openalex.org/W2111484349","https://openalex.org/W2114570899","https://openalex.org/W2134072927","https://openalex.org/W2136049840","https://openalex.org/W2137608147","https://openalex.org/W2157659365","https://openalex.org/W2158859599","https://openalex.org/W2161282017","https://openalex.org/W2161736514","https://openalex.org/W2166705426","https://openalex.org/W2169314202","https://openalex.org/W2170107220","https://openalex.org/W2170149088","https://openalex.org/W2187023039","https://openalex.org/W2198463284","https://openalex.org/W2202605954","https://openalex.org/W2296189441","https://openalex.org/W2312242630","https://openalex.org/W2343303489","https://openalex.org/W2410573780","https://openalex.org/W2444619274","https://openalex.org/W2465176764","https://openalex.org/W2578613951","https://openalex.org/W2588292852","https://openalex.org/W2603970523","https://openalex.org/W2617122600","https://openalex.org/W2789747275","https://openalex.org/W2794632917","https://openalex.org/W2892640601","https://openalex.org/W2945792041","https://openalex.org/W6903095889"],"related_works":["https://openalex.org/W2974771884","https://openalex.org/W4225864307","https://openalex.org/W4280635556","https://openalex.org/W2014849293","https://openalex.org/W4210256233","https://openalex.org/W3011032586","https://openalex.org/W7163827670","https://openalex.org/W2092573782","https://openalex.org/W3112861869","https://openalex.org/W4224231301"],"abstract_inverted_index":{"Although":[0],"decades":[1],"of":[2,84,116],"studies":[3],"have":[4],"produced":[5],"a":[6,85,95],"generalized":[7],"model":[8],"for":[9],"tetrapod":[10],"limb":[11,53,128],"development,":[12],"urodeles":[13],"deviate":[14],"from":[15],"anurans":[16,133],"and":[17,31,46,68,77,101,105,134,141],"amniotes":[18,135],"in":[19,55,112,130],"at":[20],"least":[21],"two":[22],"key":[23],"respects:":[24],"their":[25,106],"limbs":[26,92],"exhibit":[27],"preaxial":[28],"skeletal":[29],"differentiation":[30],"do":[32],"not":[33],"develop":[34],"an":[35],"apical":[36],"ectodermal":[37],"ridge":[38],"(AER).Here,":[39],"we":[40,88],"investigated":[41],"how":[42],"Sonic":[43],"hedgehog":[44],"(Shh)":[45],"Fibroblast":[47],"growth":[48],"factor":[49],"(Fgf)":[50],"signaling":[51],"regulate":[52],"development":[54],"the":[56,64,113],"axolotl.We":[57],"found":[58,89,98],"that":[59,69,90,99,119],"Shh-expressing":[60],"cells":[61],"contributed":[62],"to":[63,82,132],"most":[65],"posterior":[66],"digit,":[67],"inhibiting":[70],"Shh-signaling":[71],"inhibited":[72],"Fgf8":[73],"expression,":[74],"anteroposterior":[75],"patterning,":[76],"distal":[78],"cell":[79,123,139],"proliferation.In":[80],"addition":[81],"lack":[83,94],"morphological":[86],"AER,":[87],"salamander":[91],"also":[93],"molecular":[96],"AER.We":[97],"amniote":[100],"anuran":[102],"AER-specific":[103],"Fgfs":[104],"cognate":[107],"receptors":[108],"were":[109],"expressed":[110],"entirely":[111],"mesenchyme.Broad":[114],"inhibition":[115],"Fgfsignaling":[117],"demonstrated":[118],"this":[120],"pathway":[121],"regulates":[122,138],"proliferation":[124],"across":[125],"all":[126],"three":[127],"axes,":[129],"contrast":[131],"where":[136],"Fgf-signaling":[137],"survival":[140],"proximodistal":[142],"patterning.":[143]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-05-12T00:00:00"}
