{"id":"https://openalex.org/W4241392018","doi":"https://doi.org/10.1172/jci0213972","title":"A role for p53 in terminal epithelial cell differentiation","display_name":"A role for p53 in terminal epithelial cell differentiation","publication_year":2002,"publication_date":"2002-04-15","ids":{"openalex":"https://openalex.org/W4241392018","doi":"https://doi.org/10.1172/jci0213972"},"language":"en","primary_location":{"id":"doi:10.1172/jci0213972","doi":"https://doi.org/10.1172/jci0213972","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci0213972","pdf_url":"http://www.jci.org/articles/view/13972/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/13972/files/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016168447","display_name":"Zubaida R. Saifudeen","orcid":"https://orcid.org/0000-0002-4377-5119","observed_orcids":["https://orcid.org/0000-0002-4377-5119"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I199117387","display_name":"Promega (United States)","ror":"https://ror.org/01dra3713","country_code":"US","type":"company","lineage":["https://openalex.org/I199117387"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Zubaida Saifudeen","raw_affiliation_strings":["Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana, USA","(Dana Farber Cancer Institute, Boston, Mass-achusetts, USA","(Emory Uni-versity, Atlanta, Georgia, USA","(University Tor Vergata, Rome, Italy","(University of Cincinnati, Cincinnati, Ohio, USA","Columbia University (New York, New York, USA","Promega Corp., Madison, Wisconsin, USA","Tulane University Health Sciences Center, Department of Pediatrics, SL-37, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA","University of Utah, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"(Dana Farber Cancer Institute, Boston, Mass-achusetts, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"(Emory Uni-versity, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"(University Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"(University of Cincinnati, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Columbia University (New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Promega Corp., Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I199117387"]},{"raw_affiliation_string":"Tulane University Health Sciences Center, Department of Pediatrics, SL-37, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"University of Utah, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089950604","display_name":"Susana Dipp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I199117387","display_name":"Promega (United States)","ror":"https://ror.org/01dra3713","country_code":"US","type":"company","lineage":["https://openalex.org/I199117387"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Susana Dipp","raw_affiliation_strings":["Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana, USA","(Dana Farber Cancer Institute, Boston, Mass-achusetts, USA","(Emory Uni-versity, Atlanta, Georgia, USA","(University Tor Vergata, Rome, Italy","(University of Cincinnati, Cincinnati, Ohio, USA","Columbia University (New York, New York, USA","Promega Corp., Madison, Wisconsin, USA","Tulane University Health Sciences Center, Department of Pediatrics, SL-37, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA","University of Utah, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"(Dana Farber Cancer Institute, Boston, Mass-achusetts, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"(Emory Uni-versity, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"(University Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"(University of Cincinnati, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Columbia University (New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Promega Corp., Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I199117387"]},{"raw_affiliation_string":"Tulane University Health Sciences Center, Department of Pediatrics, SL-37, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"University of Utah, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044765791","display_name":"Samir Sayem El-Dahr","orcid":"https://orcid.org/0000-0001-7571-4292","observed_orcids":["https://orcid.org/0000-0001-7571-4292"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]},{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]},{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]},{"id":"https://openalex.org/I199117387","display_name":"Promega (United States)","ror":"https://ror.org/01dra3713","country_code":"US","type":"company","lineage":["https://openalex.org/I199117387"]},{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["IT","US"],"is_corresponding":true,"raw_author_name":"Samir S. El-Dahr","raw_affiliation_strings":["Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana, USA","Tulane University Health Sciences Center, Department of Pediatrics, SL-37, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA","(Dana Farber Cancer Institute, Boston, Mass-achusetts, USA","(Emory Uni-versity, Atlanta, Georgia, USA","(University Tor Vergata, Rome, Italy","(University of Cincinnati, Cincinnati, Ohio, USA","Columbia University (New York, New York, USA","Promega Corp., Madison, Wisconsin, USA","University of Utah, Salt Lake City, Utah, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Tulane University Health Sciences Center, New Orleans, Louisiana, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Tulane University Health Sciences Center, Department of Pediatrics, SL-37, 1430 Tulane Avenue, New Orleans, Louisiana 70112, USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"(Dana Farber Cancer Institute, Boston, Mass-achusetts, USA","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"(Emory Uni-versity, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"(University Tor Vergata, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]},{"raw_affiliation_string":"(University of Cincinnati, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Columbia University (New York, New York, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Promega Corp., Madison, Wisconsin, USA","institution_ids":["https://openalex.org/I199117387"]},{"raw_affiliation_string":"University of Utah, Salt Lake City, Utah, USA","institution_ids":["https://openalex.org/I223532165"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5044765791"],"corresponding_institution_ids":["https://openalex.org/I114832834","https://openalex.org/I116067653","https://openalex.org/I150468666","https://openalex.org/I199117387","https://openalex.org/I223532165","https://openalex.org/I4210117453","https://openalex.org/I63135867","https://openalex.org/I78577930"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":1.1581,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.76749436,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"109","issue":"8","first_page":"1021","last_page":"1030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.010099999606609344,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9990000128746033},{"id":"https://openalex.org/keywords/renal-epithelium","display_name":"renal epithelium","score":0.9660000205039978},{"id":"https://openalex.org/keywords/kidney-development","display_name":"kidney development","score":0.9200000166893005},{"id":"https://openalex.org/keywords/p73","display_name":"p73","score":0.675000011920929},{"id":"https://openalex.org/keywords/cyst-formation","display_name":"cyst formation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6389999985694885},{"id":"https://openalex.org/keywords/dominant-negative-p53","display_name":"dominant-negative p53","score":0.7289999723434448},{"id":"https://openalex.org/keywords/p53-null-mice","display_name":"p53-null mice","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7260991334915161},{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.6033890247344971},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.5906673669815063},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.553292453289032},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5127986073493958},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5052621960639954},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.46690207719802856},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46574079990386963},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.44742798805236816},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3004167675971985},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25020503997802734},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1210368275642395},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08693131804466248}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1172/jci0213972","doi":"https://doi.org/10.1172/jci0213972","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci0213972","pdf_url":"http://www.jci.org/articles/view/13972/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1172/jci0213972","doi":"https://doi.org/10.1172/jci0213972","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci0213972","pdf_url":"http://www.jci.org/articles/view/13972/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320310142","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4241392018.pdf","grobid_xml":"https://content.openalex.org/works/W4241392018.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W190488077","https://openalex.org/W240498459","https://openalex.org/W1482923899","https://openalex.org/W1534987406","https://openalex.org/W1881393103","https://openalex.org/W1903324674","https://openalex.org/W1965785388","https://openalex.org/W1993137058","https://openalex.org/W1997222931","https://openalex.org/W1999494313","https://openalex.org/W2003282728","https://openalex.org/W2006565381","https://openalex.org/W2015519364","https://openalex.org/W2018884388","https://openalex.org/W2026637815","https://openalex.org/W2038173255","https://openalex.org/W2044057392","https://openalex.org/W2044799513","https://openalex.org/W2055385195","https://openalex.org/W2056079046","https://openalex.org/W2059741204","https://openalex.org/W2065144515","https://openalex.org/W2074222004","https://openalex.org/W2082094973","https://openalex.org/W2082399676","https://openalex.org/W2084163213","https://openalex.org/W2086565810","https://openalex.org/W2088740611","https://openalex.org/W2093340562","https://openalex.org/W2100287099","https://openalex.org/W2104521784","https://openalex.org/W2108081874","https://openalex.org/W2115595595","https://openalex.org/W2124139409","https://openalex.org/W2126679757","https://openalex.org/W2131167529","https://openalex.org/W2135765283","https://openalex.org/W2146861083","https://openalex.org/W2148958834","https://openalex.org/W2150710841","https://openalex.org/W2154381385","https://openalex.org/W2159199900","https://openalex.org/W2317301418","https://openalex.org/W2335970603"],"related_works":["https://openalex.org/W2156611705","https://openalex.org/W2396892283","https://openalex.org/W2045573741","https://openalex.org/W2131167529","https://openalex.org/W2607092026","https://openalex.org/W2117918076","https://openalex.org/W2148969043","https://openalex.org/W1979341432","https://openalex.org/W2428600920","https://openalex.org/W2143763180"],"abstract_inverted_index":{"Terminal":[0],"epithelial":[1,52,69,130],"cell":[2],"differentiation":[3,16,38,123,181,190],"is":[4,48,126,155],"a":[5,99,139,194],"crucial":[6],"step":[7],"in":[8,36,51,187,196],"development.":[9],"In":[10,43,74,95],"the":[11,31,40,44,65,91,116,122,151,161,177,183,197],"kidney,":[12,46],"failure":[13],"of":[14,28,39,93,98,104,112,118,148,163,182,199],"terminal":[15,37,189],"causes":[17],"dysplasia,":[18],"cystogenesis,":[19],"and":[20,68,71,89,125,145,165,179,202],"cancer.":[21],"The":[22],"present":[23],"study":[24],"provides":[25],"multiple":[26],"lines":[27],"evidence":[29],"implicating":[30],"tumor":[32],"suppressor":[33],"protein":[34,153],"p53":[35,47,83,86,105,114,164,175],"renal":[41,55,77,129,143,184],"epithelium.":[42,185],"developing":[45],"highly":[49],"enriched":[50],"cells":[53,131],"expressing":[54],"function":[56],"genes":[57],"(RFGs),":[58],"such":[59],"as":[60],"receptors":[61],"for":[62,160],"vasoactive":[63],"hormones,":[64],"sodium":[66,70],"pump,":[67],"water":[72],"channels.":[73],"comparison,":[75],"proliferating":[76],"progenitors":[78],"express":[79],"little":[80],"if":[81],"any":[82],"or":[84],"RFGs.":[85,94,149],"binds":[87],"to":[88,115,157,167],"transactivates":[90],"promoters":[92,117],"contrast,":[96],"expression":[97],"dominant":[100],"negative":[101],"mutant":[102],"form":[103],"inhibits":[106],"endogenous":[107,113],"RFG":[108,170],"expression.":[109],"Moreover,":[110],"binding":[111],"RFGs":[119],"coincides":[120],"with":[121],"process":[124],"attenuated":[127],"once":[128],"are":[132],"fully":[133],"differentiated.":[134],"Finally,":[135],"p53-null":[136],"pups":[137],"exhibit":[138],"previously":[140],"unrecognized":[141],"aberrant":[142],"phenotype":[144],"spatial":[146],"disorganization":[147],"Interestingly,":[150],"p53-related":[152],"p73":[154],"unable":[156],"functionally":[158],"compensate":[159],"loss":[162],"fails":[166],"efficiently":[168],"activate":[169],"transcription.":[171],"We":[172],"conclude":[173],"that":[174],"promotes":[176],"biochemical":[178],"morphological":[180],"Aberrations":[186],"p53-mediated":[188],"may":[191],"therefore":[192],"play":[193],"role":[195],"pathogenesis":[198],"nephron":[200],"dysgenesis":[201],"dysfunction.":[203]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}