{"id":"https://openalex.org/W4241389790","doi":"https://doi.org/10.1158/1538-7445.am2019-4514","title":"Abstract 4514: Intravital imaging at single-cell resolution reveals, for the first time, the mechanism of cancer cell dissemination and metastasis","display_name":"Abstract 4514: Intravital imaging at single-cell resolution reveals, for the first time, the mechanism of cancer cell dissemination and metastasis","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4241389790","doi":"https://doi.org/10.1158/1538-7445.am2019-4514"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-4514","doi":"https://doi.org/10.1158/1538-7445.am2019-4514","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-4514","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090829224","display_name":"Lucia Borriello","orcid":"https://orcid.org/0000-0002-8730-4079","observed_orcids":["https://orcid.org/0000-0002-8730-4079","https://orcid.org/0000-0002-3164-8374"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucia Borriello","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103914594","display_name":"Anouchka Coste","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anouchka Coste","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101644712","display_name":"Yarong Wang","orcid":"https://orcid.org/0000-0002-0551-5412","observed_orcids":["https://orcid.org/0000-0002-0551-5412","https://orcid.org/0009-0000-3755-8401"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yarong Wang","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002393604","display_name":"Maja H. Oktay","orcid":"https://orcid.org/0000-0002-8115-3898","observed_orcids":["https://orcid.org/0000-0002-8115-3898"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maja Oktay","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086159127","display_name":"David R. Entenberg","orcid":"https://orcid.org/0000-0003-0422-7264","observed_orcids":["https://orcid.org/0000-0003-0422-7264"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Entenberg","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014100567","display_name":"John S. Condeelis","orcid":"https://orcid.org/0000-0001-8826-2336","observed_orcids":["https://orcid.org/0000-0001-8826-2336"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Condeelis","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"4514","last_page":"4514"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/disseminated-tumor-cells","display_name":"disseminated tumor cells","score":0.8180000185966492},{"id":"https://openalex.org/keywords/metastatic-cascade","display_name":"metastatic cascade","score":0.7099999785423279},{"id":"https://openalex.org/keywords/experimental-metastasis","display_name":"experimental metastasis","score":0.7250000238418579},{"id":"https://openalex.org/keywords/spontaneous-metastasis","display_name":"spontaneous metastasis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.6940000057220459},{"id":"https://openalex.org/keywords/intravital-imaging","display_name":"intravital imaging","score":0.8080000281333923},{"id":"https://openalex.org/keywords/single-cell-tracking","display_name":"single-cell tracking","score":0.8289999961853027},{"id":"https://openalex.org/keywords/extravasation","display_name":"extravasation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tumor-dormancy","display_name":"tumor dormancy","score":0.6399999856948853},{"id":"https://openalex.org/keywords/stem-like-phenotype","display_name":"stem cell-like phenotype","score":0.8659999966621399},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.5680000185966492},{"id":"https://openalex.org/keywords/micrometastasis","display_name":"micrometastases","score":0.7049999833106995},{"id":"https://openalex.org/keywords/longitudinal-imaging","display_name":"longitudinal imaging","score":0.30799999833106995}],"concepts":[{"id":"https://openalex.org/C2779540182","wikidata":"https://www.wikidata.org/wiki/Q1076345","display_name":"Extravasation","level":2,"score":0.8060176372528076},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.7537492513656616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6083025336265564},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.5955619215965271},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5816414952278137},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4732264280319214},{"id":"https://openalex.org/C2778050619","wikidata":"https://www.wikidata.org/wiki/Q6058567","display_name":"Intravasation","level":4,"score":0.4660654366016388},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.46073195338249207},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4312693178653717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23225948214530945}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-4514","doi":"https://doi.org/10.1158/1538-7445.am2019-4514","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-4514","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2944764406","https://openalex.org/W2740756655","https://openalex.org/W4225736964","https://openalex.org/W4287101310","https://openalex.org/W4313446133","https://openalex.org/W2270196325","https://openalex.org/W4383498081","https://openalex.org/W1979200687","https://openalex.org/W1565417674","https://openalex.org/W2115436106"],"abstract_inverted_index":{"Abstract":[0],"Metastatic":[1],"dissemination":[2,334,490],"is":[3,11,105,335,348],"the":[4,21,25,38,51,54,85,91,108,118,136,143,149,157,166,172,176,184,190,208,213,243,274,294,308,345,353,358,378,384,388,394,398,410,413,423,449,482,485,497],"major":[5],"cause":[6],"of":[7,40,53,87,110,142,159,168,171,242,311,380,383,405,412,425,455,487,496],"cancer":[8,123,456,488],"mortality":[9],"and":[10,80,98,162,181,211,306,325,364,371,403,491],"responsible":[12],"for":[13,138,148,448,481,500],"over":[14,93,129],"1/2":[15],"million":[16],"deaths":[17],"each":[18,111,160,169,381],"year":[19],"in":[20,64,70,90,113,125,155,175,183,207,228,252,263,273,289,293,316,352,387,409,432,435],"U.S.":[22],"alone.":[23],"Over":[24],"past":[26],"decades,":[27],"metastasis":[28,77,492],"has":[29,59,373],"been":[30,60],"speculated":[31],"to":[32,48,83,117,120,152,195,261,280,299,319,360,396,420,429],"be":[33],"an":[34,126,235],"inefficient":[35],"process,":[36,340],"as":[37,216,218,417,419],"majority":[39,310],"disseminated":[41,88,426],"tumor":[42,230,407,415,427],"cells":[43,89,124,231,428],"(DTCs)":[44],"are":[45,67,146,201,271,323],"not":[46],"believed":[47],"complete":[49],"all":[50],"steps":[52,200],"metastatic":[55,114,122,173,258,385,406],"cascade.":[56],"This":[57,390],"conclusion":[58],"reached":[61],"by":[62],"studies":[63],"which":[65,229],"TCs":[66],"intravenously":[68],"injected":[69],"mice":[71],"-":[72,79],"a":[73,132,219,255,327,337,349,436],"process":[74],"called":[75,224],"experimental":[76,365],"(EM)":[78],"then":[81],"attempt":[82],"quantify":[84],"number":[86],"lung":[92,185,275,295,451],"time":[94,151,434],"using":[95,212],"low":[96],"resolution":[97,479],"indirect":[99],"methods.":[100],"To":[101],"date,":[102],"very":[103,296,338],"little":[104],"known":[106],"about":[107],"efficiency":[109,167,259,379],"step":[112,170,351,382],"cascade":[115,174,386],"due":[116],"inability":[119],"track":[121,154],"intact":[127],"organ":[128],"time.":[130],"Using":[131],"new":[133,375],"cutting-edge":[134],"technology,":[135],"Window":[137],"High":[139],"Resolution":[140],"Imaging":[141],"Lung1,":[144],"we":[145,267],"able":[147],"first":[150,483],"(1)":[153],"real-time":[156],"fate":[158],"DTC":[161,179],"(2)":[163],"quantitatively":[164],"assess":[165],"lung,":[177],"from":[178,234],"arrival":[180],"retention":[182],"vasculature,":[186],"extravasation,":[187],"interaction":[188],"with":[189,367],"host":[191],"microenvironment,":[192,416],"survival,":[193],"dormancy,":[194],"growth":[196,343],"into":[197,377],"micro-metastases.":[198],"All":[199],"studied":[202],"at":[203,344,477],"single-cell":[204,478],"resolution,":[205,370],"longitudinally,":[206,372],"same":[209],"animal,":[210],"EM":[214,281,300,317],"model":[215,223],"well":[217,418],"more":[220,277],"clinically":[221],"relevant":[222],"Spontaneous":[225],"Metastasis":[226],"(SM)":[227],"spontaneously":[232],"disseminate":[233],"orthotopic":[236],"primary":[237],"tumor.":[238],"A":[239,445],"comparative":[240],"analysis":[241],"two":[244],"models":[245],"(EM":[246],"vs.":[247,283,303],"SM)":[248],"demonstrated":[249],"that":[250,269,288,307,333,342],"DTCs":[251,262,270,291,312,322],"SM":[253,320,354],"have":[254],"drastically":[256],"increased":[257],"compared":[260,279,298,318],"EM.":[264],"In":[265,356],"particular,":[266],"found":[268],"retained":[272],"10-times":[276],"efficiently":[278],"(62%":[282],"6%).":[284],"We":[285],"further":[286],"observe":[287,361],"SM,":[290],"extravasate":[292],"rapidly":[297],"(8":[301],"hrs":[302],"24":[304],"hrs)":[305],"vast":[309],"after":[313],"extravasation":[314],"died":[315],"where":[321],"dormant":[324],"express":[326],"stem-like":[328],"phenotype.":[329],"These":[330],"data":[331],"indicate":[332],"indeed":[336],"efficient":[339],"but":[341],"secondary":[346],"site":[347],"rate-limiting":[350],"model.":[355],"conclusion,":[357],"ability":[359,395],"both":[362],"spontaneous":[363],"metastasis,":[366],"single":[368],"cell":[369,489],"provided":[374],"insight":[376],"lung.":[389],"approach":[391],"additionally":[392],"gives":[393],"investigate":[397],"molecular":[399],"mechanisms":[400],"underlying":[401],"seeding":[402],"dormancy":[404],"cells,":[408],"presence":[411],"full":[414],"directly":[421],"evaluate":[422],"response":[424],"therapeutic":[430],"treatment":[431],"real":[433],"live":[437],"mouse.":[438],"(1).":[439],"Entenberg":[440],"D,":[441],"et":[442],"al.,":[443],"(2017).":[444],"permanent":[446],"window":[447],"murine":[450],"enables":[452],"high-resolution":[453],"imaging":[454,476],"metastasis.":[457],"Nat":[458],"Methods.":[459],"15(1):73-80.":[460],"Citation":[461],"Format:":[462],"Lucia":[463],"Borriello,":[464],"Anouchka":[465],"Coste,":[466],"Yarong":[467],"Wang,":[468],"Maja":[469],"Oktay,":[470],"David":[471],"Entenberg,":[472],"John":[473],"Condeelis.":[474],"Intravital":[475],"reveals,":[480],"time,":[484],"mechanism":[486],"[abstract].":[493],"In:":[494],"Proceedings":[495],"American":[498],"Association":[499],"Cancer":[501,515],"Research":[502],"Annual":[503],"Meeting":[504],"2019;":[505],"2019":[506],"Mar":[507],"29-Apr":[508],"3;":[509],"Atlanta,":[510],"GA.":[511],"Philadelphia":[512],"(PA):":[513],"AACR;":[514],"Res":[516],"2019;79(13":[517],"Suppl):Abstract":[518],"nr":[519],"4514.":[520]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2022-05-12T00:00:00"}
