{"id":"https://openalex.org/W4241372022","doi":"https://doi.org/10.1067/msy.1999.98928","title":"Increased myocardial calcium cycling and reduced myofilament calcium sensitivity in early endotoxemia","display_name":"Increased myocardial calcium cycling and reduced myofilament calcium sensitivity in early endotoxemia","publication_year":1999,"publication_date":"1999-08-01","ids":{"openalex":"https://openalex.org/W4241372022","doi":"https://doi.org/10.1067/msy.1999.98928"},"language":"en","primary_location":{"id":"doi:10.1067/msy.1999.98928","doi":"https://doi.org/10.1067/msy.1999.98928","is_oa":false,"landing_page_url":"https://doi.org/10.1067/msy.1999.98928","pdf_url":null,"source":{"id":"https://openalex.org/S4210173306","display_name":"Surgery","issn_l":"0039-6060","issn":["0039-6060","1532-7361"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021174309","display_name":"Koh Takeuchi","orcid":"https://orcid.org/0000-0002-6227-4627","observed_orcids":["https://orcid.org/0000-0002-6227-4627"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koh Takeuchi","raw_affiliation_strings":["Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001927963","display_name":"Pedro J. del Nido","orcid":"https://orcid.org/0000-0003-4252-8789","observed_orcids":["https://orcid.org/0000-0003-4252-8789"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pedro J. del Nido","raw_affiliation_strings":["Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103537135","display_name":"Andra E. Ibrahim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andra E. Ibrahim","raw_affiliation_strings":["Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086333281","display_name":"Dimitrios Poutias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dimitrios N. Poutias","raw_affiliation_strings":["Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paul Glynn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Glynn","raw_affiliation_strings":["Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085544309","display_name":"Hung Cao-Danh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hung Cao-Danh","raw_affiliation_strings":["Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029063699","display_name":"Douglas B. Cowan","orcid":"https://orcid.org/0000-0002-6309-2737","observed_orcids":["https://orcid.org/0000-0002-6309-2737"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas B. Cowan","raw_affiliation_strings":["Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044364350","display_name":"Francis X. Jr McGowan","orcid":"https://orcid.org/0000-0002-1892-8806","observed_orcids":["https://orcid.org/0000-0002-1892-8806"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis X. McGowan","raw_affiliation_strings":["Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology and Cardiothoracic Surgery, Harvard Medical School and Children's Hospital, Boston, Mass","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4130,"currency":"USD","value_usd":4130},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.44703971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"126","issue":"2","first_page":"0231","last_page":"0238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.6977999806404114,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.1289999932050705,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.972000002861023},{"id":"https://openalex.org/keywords/myofilament-calcium-sensitivity","display_name":"myofilament calcium sensitivity","score":0.9520000219345093},{"id":"https://openalex.org/keywords/myocardial-oxygen-consumption","display_name":"myocardial oxygen consumption","score":0.8100000023841858},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7039999961853027},{"id":"https://openalex.org/keywords/inorganic-phosphate","display_name":"inorganic phosphate","score":0.8619999885559082},{"id":"https://openalex.org/keywords/pyruvate","display_name":"pyruvate","score":0.9660000205039978},{"id":"https://openalex.org/keywords/dobutamine","display_name":"dobutamine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cardiac-dysfunction","display_name":"cardiac dysfunction","score":0.6729999780654907},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.8554555177688599},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.7272331714630127},{"id":"https://openalex.org/C155710745","wikidata":"https://www.wikidata.org/wiki/Q575278","display_name":"Inotrope","level":2,"score":0.7072817087173462},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6647628545761108},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6562588810920715},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6222575902938843},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.5744861364364624},{"id":"https://openalex.org/C174054327","wikidata":"https://www.wikidata.org/wiki/Q6947920","display_name":"Myofilament","level":3,"score":0.5184252262115479},{"id":"https://openalex.org/C7301908","wikidata":"https://www.wikidata.org/wiki/Q318623","display_name":"Myofibril","level":2,"score":0.48243698477745056},{"id":"https://openalex.org/C39078644","wikidata":"https://www.wikidata.org/wiki/Q17092725","display_name":"Isovolumetric contraction","level":4,"score":0.4285157322883606},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.42554742097854614},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.28863176703453064},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.18488821387290955},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.17869094014167786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1067/msy.1999.98928","doi":"https://doi.org/10.1067/msy.1999.98928","is_oa":false,"landing_page_url":"https://doi.org/10.1067/msy.1999.98928","pdf_url":null,"source":{"id":"https://openalex.org/S4210173306","display_name":"Surgery","issn_l":"0039-6060","issn":["0039-6060","1532-7361"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Surgery","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2170268034","https://openalex.org/W2337958508","https://openalex.org/W4386667676","https://openalex.org/W2118483267","https://openalex.org/W2148414806","https://openalex.org/W79838143","https://openalex.org/W2136968990","https://openalex.org/W2419428509","https://openalex.org/W2013615832","https://openalex.org/W2008272418"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2022-05-12T00:00:00"}
