{"id":"https://openalex.org/W4241297529","doi":"https://doi.org/10.1155/2012/425205","title":"Antioxidant Effects of Potassium Ascorbate with Ribose Therapy in a Case with Prader Willi Syndrome","display_name":"Antioxidant Effects of Potassium Ascorbate with Ribose Therapy in a Case with Prader Willi Syndrome","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W4241297529","doi":"https://doi.org/10.1155/2012/425205","pmid":"https://pubmed.ncbi.nlm.nih.gov/22960339","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3810693"},"language":"en","primary_location":{"id":"doi:10.1155/2012/425205","doi":"https://doi.org/10.1155/2012/425205","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/425205","pdf_url":"https://downloads.hindawi.com/journals/dm/2012/425205.pdf","source":{"id":"https://openalex.org/S35392927","display_name":"Disease Markers","issn_l":"0278-0240","issn":["0278-0240","1875-8630"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Disease Markers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/dm/2012/425205.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026173821","display_name":"Cecilia Anichini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Anichini","raw_affiliation_strings":["Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008257260","display_name":"Federica Lotti","orcid":"https://orcid.org/0000-0002-0395-7524","observed_orcids":["https://orcid.org/0000-0002-0395-7524"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Lotti","raw_affiliation_strings":["Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086846309","display_name":"Mariangela Longini","orcid":"https://orcid.org/0000-0003-3979-4955","observed_orcids":["https://orcid.org/0000-0003-3979-4955"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Longini","raw_affiliation_strings":["Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006021911","display_name":"Fabrizio Proietti","orcid":"https://orcid.org/0000-0003-2924-9793","observed_orcids":["https://orcid.org/0000-0003-2924-9793"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Proietti","raw_affiliation_strings":["Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113686758","display_name":"Cosetta Felici","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"C. Felici","raw_affiliation_strings":["Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082965767","display_name":"Serafina Perrone","orcid":"https://orcid.org/0000-0001-5478-5657","observed_orcids":["https://orcid.org/0000-0001-5478-5657"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Perrone","raw_affiliation_strings":["Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080263193","display_name":"Giuseppe Buonocore","orcid":"https://orcid.org/0000-0002-7921-7485","observed_orcids":["https://orcid.org/0000-0002-7921-7485"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"G. Buonocore","raw_affiliation_strings":["Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080263193"],"corresponding_institution_ids":["https://openalex.org/I102064193"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.4399,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.58514539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"33","issue":"4","first_page":"179","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.23350000381469727,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prader-willi-syndrome","display_name":"Prader-Willi syndrome","score":0.9850000143051147},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8149999976158142},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.9259999990463257},{"id":"https://openalex.org/keywords/redox-biomarkers","display_name":"redox biomarkers","score":0.9369999766349792},{"id":"https://openalex.org/keywords/non-protein-bound-iron","display_name":"non-protein-bound iron","score":0.9279999732971191},{"id":"https://openalex.org/keywords/thiols","display_name":"thiols","score":0.9390000104904175},{"id":"https://openalex.org/keywords/advanced-oxidation-protein-products","display_name":"advanced oxidation protein products","score":0.9980000257492065},{"id":"https://openalex.org/keywords/isoprostanes","display_name":"isoprostanes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/growth-hormone-therapy","display_name":"growth hormone therapy","score":0.7250000238418579},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9120000004768372},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.8980000019073486},{"id":"https://openalex.org/keywords/genomic-imprinting-disorders","display_name":"genomic imprinting disorders","score":0.8050000071525574}],"concepts":[{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7855554819107056},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7133674621582031},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5987303853034973},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5741357207298279},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5694161653518677},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5157495141029358},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.48601919412612915},{"id":"https://openalex.org/C94715292","wikidata":"https://www.wikidata.org/wiki/Q624349","display_name":"Imprinting (psychology)","level":3,"score":0.4339299201965332},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.41989022493362427},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.40700697898864746},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3653016686439514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3057088851928711},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2799832820892334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17720171809196472},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1057589054107666}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011218","descriptor_name":"Prader-Willi Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011218","descriptor_name":"Prader-Willi Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012266","descriptor_name":"Ribose","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028421","descriptor_name":"Isoprostanes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D062107","descriptor_name":"Advanced Oxidation Protein Products","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1155/2012/425205","doi":"https://doi.org/10.1155/2012/425205","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/425205","pdf_url":"https://downloads.hindawi.com/journals/dm/2012/425205.pdf","source":{"id":"https://openalex.org/S35392927","display_name":"Disease Markers","issn_l":"0278-0240","issn":["0278-0240","1875-8630"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Disease Markers","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2842534","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3810693","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:22960339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22960339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Disease markers","raw_type":"Case Reports"},{"id":"pmh:oai:pubmedcentral.nih.gov:3810693","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3810693/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dis Markers","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.789.6282","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.789.6282","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c3/9c/DM33-04-425205.PMC3810693.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:fa8fa80e678841d2a017bd3c2a488fb2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fa8fa80e678841d2a017bd3c2a488fb2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Disease Markers, Vol 33, Iss 4, Pp 179-183 (2012)","raw_type":"article"},{"id":"pmh:oai:usiena-air.unisi.it:11365/41845","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11365/41845","pdf_url":null,"source":{"id":"https://openalex.org/S4377196319","display_name":"Use Siena air (University of Siena)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I102064193","host_organization_name":"University of Siena","host_organization_lineage":["https://openalex.org/I102064193"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1155/2012/425205","doi":"https://doi.org/10.1155/2012/425205","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/425205","pdf_url":"https://downloads.hindawi.com/journals/dm/2012/425205.pdf","source":{"id":"https://openalex.org/S35392927","display_name":"Disease Markers","issn_l":"0278-0240","issn":["0278-0240","1875-8630"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Disease Markers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320313975","display_name":"Universit\u00e0 degli Studi di Siena","ror":"https://ror.org/01tevnk56"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4241297529.pdf","grobid_xml":"https://content.openalex.org/works/W4241297529.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W203743602","https://openalex.org/W1617007149","https://openalex.org/W1975447813","https://openalex.org/W1989221987","https://openalex.org/W1991493636","https://openalex.org/W1992218856","https://openalex.org/W1992689843","https://openalex.org/W1997876667","https://openalex.org/W2003297134","https://openalex.org/W2003471941","https://openalex.org/W2006759718","https://openalex.org/W2008566131","https://openalex.org/W2014945678","https://openalex.org/W2015329101","https://openalex.org/W2020126595","https://openalex.org/W2020770764","https://openalex.org/W2026866344","https://openalex.org/W2027914969","https://openalex.org/W2029299113","https://openalex.org/W2042641359","https://openalex.org/W2043882061","https://openalex.org/W2059350161","https://openalex.org/W2060431825","https://openalex.org/W2069717482","https://openalex.org/W2071169001","https://openalex.org/W2072483375","https://openalex.org/W2093084887","https://openalex.org/W2138674679","https://openalex.org/W2151175198","https://openalex.org/W2152506085","https://openalex.org/W2157354469","https://openalex.org/W2338229728","https://openalex.org/W2413638599","https://openalex.org/W2495707485"],"related_works":["https://openalex.org/W1617007149","https://openalex.org/W1842895509","https://openalex.org/W2007934876","https://openalex.org/W7099558954","https://openalex.org/W4365514245","https://openalex.org/W2900632355","https://openalex.org/W3097878016","https://openalex.org/W4411193956","https://openalex.org/W2419401135","https://openalex.org/W4313330213"],"abstract_inverted_index":{"Oxidative":[0],"stress":[1],"(OS)":[2],"is":[3],"involved":[4],"in":[5,25,31,64,109,120,138,158],"several":[6],"human":[7],"diseases,":[8],"including":[9,88],"obesity,":[10,56],"diabetes,":[11],"atherosclerosis,":[12],"carcinogenesis,":[13],"as":[14,16,28,30],"well":[15,29],"genetic":[17],"diseases.":[18],"We":[19,76],"previously":[20],"found":[21],"that":[22],"OS":[23,81,139],"occurs":[24],"Down":[26],"Syndrome":[27,33,48],"Beckwith-Wiedemann":[32],"(BWS).":[34],"Here":[35],"we":[36,107,126],"describe":[37],"the":[38,78,128,146],"clinical":[39],"case":[40],"of":[41,71,80],"a":[42,50,66,84,148,155],"female":[43],"patient":[44],"with":[45,117,154],"Prader":[46],"Willi":[47],"(PWS),":[49],"genomic":[51],"imprinting":[52],"disorder,":[53],"characterized":[54],"by":[55,82],"atherosclerosis":[57],"and":[58,68,103,125,162],"diabetes":[59],"mellitus":[60],"type":[61],"2,":[62],"pathologies":[63],"which":[65],"continuous":[67],"important":[69],"production":[70],"free":[72],"radicals":[73],"takes":[74],"place.":[75],"verified":[77],"presence":[79],"measuring":[83],"redox":[85,129],"biomarkers":[86,130,140],"profile":[87,131],"total":[89],"hydroperoxides":[90],"(TH),":[91],"non":[92],"protein-bound":[93],"iron":[94],"(NPBI),":[95],"thiols":[96],"(SH),":[97],"advanced":[98],"oxidation":[99],"protein":[100],"products":[101],"(AOPP)":[102],"isoprostanes":[104],"(IPs).":[105],"Thus":[106],"introduced":[108],"therapy":[110,124],"an":[111],"antioxidant":[112],"agent,":[113],"namely":[114],"potassium":[115],"ascorbate":[116],"ribose":[118],"(PAR),":[119],"addition":[121],"to":[122],"GH":[123],"monitored":[127],"for":[132,160],"four":[133],"years.":[134],"A":[135],"progressive":[136],"decrease":[137],"occurred":[141],"until":[142],"their":[143],"normalization.":[144],"In":[145],"meantime":[147],"weight":[149],"loss":[150],"was":[151],"observed":[152],"together":[153],"steady":[156],"growth":[157],"standards":[159],"age":[161],"sex.":[163]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-05-12T00:00:00"}