{"id":"https://openalex.org/W4241201451","doi":"https://doi.org/10.1097/tp.0000000000001332","title":"Research Highlights","display_name":"Research Highlights","publication_year":2016,"publication_date":"2016-06-20","ids":{"openalex":"https://openalex.org/W4241201451","doi":"https://doi.org/10.1097/tp.0000000000001332"},"language":"en","primary_location":{"id":"doi:10.1097/tp.0000000000001332","doi":"https://doi.org/10.1097/tp.0000000000001332","is_oa":false,"landing_page_url":"https://doi.org/10.1097/tp.0000000000001332","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071342347","display_name":"Elmi Muller","orcid":"https://orcid.org/0000-0003-4891-5296","observed_orcids":["https://orcid.org/0000-0003-4891-5296"]},"institutions":[{"id":"https://openalex.org/I2802258008","display_name":"Groote Schuur Hospital","ror":"https://ror.org/00c879s84","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I1307091933","https://openalex.org/I2802258008"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Elmi Muller","raw_affiliation_strings":["Elmi Muller, MBChB, MMED, Groote Schuur Hospital, Main Road, Observatory, Cape Town, Western Cape, 7925, South Africa. ([email\u00a0protected])","The author declares no funding or conflicts of interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elmi Muller, MBChB, MMED, Groote Schuur Hospital, Main Road, Observatory, Cape Town, Western Cape, 7925, South Africa. ([email\u00a0protected])","institution_ids":["https://openalex.org/I2802258008"]},{"raw_affiliation_string":"The author declares no funding or conflicts of interest","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071342347"],"corresponding_institution_ids":["https://openalex.org/I2802258008"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33846593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"100","issue":"7","first_page":"1389","last_page":"1390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.444599986076355,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.444599986076355,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10999","display_name":"Organ Transplantation Techniques and Outcomes","score":0.23929999768733978,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.18359999358654022,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion-injury","display_name":"renal ischemia-reperfusion injury","score":0.9300000071525574},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9010000228881836},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/delayed-graft-function","display_name":"delayed graft function","score":0.9890000224113464},{"id":"https://openalex.org/keywords/sex-hormones","display_name":"sex hormones","score":0.8270000219345093},{"id":"https://openalex.org/keywords/estrogen","display_name":"estrogen","score":0.777999997138977},{"id":"https://openalex.org/keywords/ovariectomy","display_name":"ovariectomy","score":0.7799999713897705},{"id":"https://openalex.org/keywords/donor-sex","display_name":"donor sex","score":0.5260000228881836},{"id":"https://openalex.org/keywords/recipient-sex","display_name":"recipient sex","score":0.6299999952316284},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/warm-ischemia","display_name":"warm ischemia","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8416889905929565},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6895580291748047},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.6157726645469666},{"id":"https://openalex.org/C2780227381","wikidata":"https://www.wikidata.org/wiki/Q1357376","display_name":"Nephrectomy","level":3,"score":0.60953688621521},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.5446824431419373},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5038363337516785},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.47095948457717896},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.45612633228302},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4187372922897339},{"id":"https://openalex.org/C2775961468","wikidata":"https://www.wikidata.org/wiki/Q7487374","display_name":"Sham surgery","level":3,"score":0.41390901803970337},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3876776695251465},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.34625887870788574},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.34184616804122925},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.21739593148231506},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19071564078330994},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/tp.0000000000001332","doi":"https://doi.org/10.1097/tp.0000000000001332","is_oa":false,"landing_page_url":"https://doi.org/10.1097/tp.0000000000001332","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2342063582","https://openalex.org/W2773863971","https://openalex.org/W2435463981","https://openalex.org/W3083758880","https://openalex.org/W2076649548","https://openalex.org/W7165367072","https://openalex.org/W4415476273","https://openalex.org/W2342181665","https://openalex.org/W2032925403","https://openalex.org/W7124830569"],"abstract_inverted_index":{"Improved":[0],"Renal":[1],"Ischemia":[2],"Tolerance":[3],"in":[4,70,149,198,248,260,410,433,462,521,528,554,575,629,666,672,687,721,726,733,756,799,872],"Females":[5],"Influences":[6],"Kidney":[7],"Transplantation":[8],"Outcomes":[9],"Aufhauser":[10],"DD,":[11],"Jr,":[12],"Wang":[13],"Z,":[14],"and":[15,28,105,126,135,175,190,300,429,435,442,474,506,534,560,573,612,643,657,679,748,805,869],"Murken":[16],"DR":[17],"J":[18],"Clin":[19],"Invest,":[20],"2016;126(5):1968-77.":[21],"This":[22],"interesting":[23],"publication":[24],"provides":[25],"both,":[26],"experimental":[27,42,387],"clinical":[29,393],"evidence":[30,543],"of":[31,83,115,122,164,236,257,292,312,315,399,423,460,470,499,542,568,590,599,623,636,651,669,676,690,705,765,768,776,791,796,815,824,850,875],"a":[32,120,154,159,232,323,326,396,424,466,496,509,516,551,584,634,702,766,816],"sex-impacted":[33],"recovery":[34,344],"subsequent":[35,137,278,345],"to":[36,129,138,217,279,282,295,298,302,308,346,444,487,526,558,586,620,626,648,696,736,783,809],"ischemia-reperfusion":[37],"injury":[38,134],"(IRI).":[39],"In":[40,73,86,140,181,209,318,395,580,607,788],"their":[41,56,141,221,386,734],"mice":[43,50,172,186,200,214,228,264,338],"model,":[44,143,183],"the":[45,81,87,90,96,113,144,165,206,252,255,287,353,382,421,447,482,546,556,566,595,667,711,717,763,789,794,797,813,822,847,873],"authors":[46,91,118,145,253,288,383,448,564,632],"show":[47],"that":[48,151,339,545,707],"female":[49,71,199,263,297,301,319,327,341,366,413,430,450,471,491],"recover":[51],"from":[52,80,476,481,638,646,710,714,751],"IRI":[53,84,280,329,348],"better":[54,334],"than":[55,238,245,357],"male":[57,185,213,227,294,324,337,368,411,428,489,493],"counterparts.":[58],"Clinically,":[59],"one":[60],"would":[61],"therefore":[62],"expect":[63],"reduced":[64],"delayed":[65],"graft":[66],"function":[67],"(DGF)":[68],"rates":[69,406,459,622],"recipients.":[72],"theory,":[74],"hormonal":[75,354,513],"treatment":[76],"might":[77],"protect":[78],"organs":[79],"consequences":[82,114],"tolerance.":[85],"current":[88],"study,":[89,212],"address":[92],"whether":[93,106],"sex":[94,100,110,147,258,472],"\u201cprotects\u201d":[95],"kidney":[97,359],"itself,":[98],"if":[99,385],"impacts":[101],"host":[102],"immune":[103,740,746,758],"response":[104],"recipient":[107,436],"or":[108,325,367,490],"donor":[109,434,484],"will":[111],"affect":[112],"IRI.":[116,139],"The":[117,563,631,841],"developed":[119,187],"series":[121],"murine":[123],"renal":[124,188,233,249,276,347,517],"ischemia":[125],"transplant":[127,369,403,451],"models":[128],"investigate":[130],"sex-specific":[131],"effects":[132,148,256,422],"on":[133,819,821,834],"repair":[136],"first":[142],"characterized":[146],"animals":[150],"initially":[152],"underwent":[153],"unilateral":[155],"nephrectomy":[156],"followed":[157,644],"by":[158,193,392,762,831],"prolonged":[160],"(28":[161],"minutes)":[162],"clamping":[163],"remaining":[166],"single":[167],"kidney.":[168],"By":[169],"28":[170],"days,":[171],"were":[173,177,215,306,389,407,440,485,660,663],"sacrificed":[174],"kidneys":[176,197,222,305,480],"examined":[178],"for":[179,511,614,745,846],"fibrosis.":[180],"this":[182,246],"all":[184],"failure":[189],"required":[191],"sacrifice":[192],"48":[194],"hours,":[195],"whereas":[196,779],"showed":[201],"significant":[202],"fibrosis,":[203],"but":[204],"survived":[205],"ischemic":[207,234,242,310],"injury.":[208],"an":[210,267,309,688,738,785,844],"additional":[211,372,378],"tested":[216,254,384],"see":[218],"how":[219],"long":[220],"could":[223],"tolerate":[224],"ischemia.":[225,317],"Here,":[226],"only":[229],"recovered":[230],"after":[231],"time":[235,243],"longer":[237,244],"15":[239],"minutes.":[240],"Any":[241],"resulted":[247],"failure.":[250],"Next,":[251,381],"hormones":[259,473],"more":[261,274,683],"detail:":[262],"who":[265],"received":[266,340],"ovarectomy":[268],"at":[269],"3":[270,290,576,640,649,674],"weeks":[271],"had":[272,330,349,828],"significantly":[273,333,408],"pronounced":[275],"damage":[277],"compared":[281,335,441,593,695],"hormonally":[283],"active":[284],"females.":[285],"Lastly,":[286,478],"transplanted":[289],"groups":[291,675],"mice,":[293],"female,":[296,299],"male.":[303],"Transplanted":[304],"exposed":[307],"period":[311],"25":[313],"minutes":[314],"warm":[316],"recipients":[320,370,414,452,494],"receiving":[321],"either":[322,365,488],"kidney,":[328],"been":[331,350,618,829],"tolerated":[332],"with":[336,352,358,371,594,731],"kidneys.":[342],"Thus,":[343],"associated":[351,730],"environment":[355],"rather":[356],"intrinsic":[360],"effects.":[361,380],"Of":[362],"note,":[363],"treating":[364],"estrogen":[373],"did":[374],"not":[375],"add":[376],"any":[377],"protective":[379,518],"data":[388],"also":[390],"reflected":[391],"findings.":[394],"univariate":[397],"analysis":[398],"almost":[400],"47":[401],"000":[402],"recipients,":[404,492],"DGF":[405,461],"higher":[409,458,497,588],"versus":[412],"(29.2%":[415],"vs":[416],"23.3%,":[417],"respectively).":[418],"To":[419],"exclude":[420],"size":[425],"mismatch":[426],"between":[427,468,803],"kidneys,":[431],"differences":[432,665,725,798],"body":[437,541],"weight":[438],"ratios":[439],"found":[443],"be":[445,550,810],"insignificant.When":[446],"stratified":[449],"into":[453],"age":[454],"groups,":[455],"they":[456],"detected":[457],"postmenopausal":[463],"women":[464],"suggesting":[465],"link":[467],"levels":[469,775],"protection":[475],"DGF.":[477,500],"when":[479],"same":[483],"allocated":[486],"experienced":[495],"rate":[498],"These":[501],"findings":[502],"have":[503,617],"particular":[504],"relevance":[505],"may":[507,549],"provide":[508],"rationale":[510],"testing":[512],"interventions":[514],"as":[515,760],"strategy.":[519],"Variation":[520],"Microbiome":[522],"LPS":[523,706,712,727,749,772,801,820],"Immunogenicity":[524],"Contributes":[525],"Autoimmunity":[527],"Humans":[529],"Vatanen":[530],"T,":[531],"Kostic":[532],"AD,":[533],"d'Hennezel":[535],"E":[536,770],"Cell,":[537],"2016;165(4):842-53.":[538],"A":[539],"growing":[540],"suggests":[544],"gut":[547,670],"microbiome":[548,671,719],"key":[552],"factor":[553],"influencing":[555],"predisposition":[557],"autoimmunity":[559],"allergic":[561],"diseases.1":[562],"studied":[565],"incidence":[567,589],"autoimmune":[569,591],"diseases":[570,659],"including":[571],"allergies":[572],"diabetes":[574,827],"environmentally":[577],"disparate":[578],"populations.":[579],"Finland":[581],"there":[582],"is":[583,603,743],"2-":[585],"6-fold":[587],"disease":[592],"neighbouring":[596],"Russian":[597,697,722,804],"republic":[598],"Karelia":[600],"where":[601],"sanitation":[602],"less":[604],"well":[605],"advanced.":[606],"nearby":[608],"Estonia,":[609],"economic":[610],"development":[611,874],"improvement":[613],"living":[615],"standards":[616],"linked":[619],"increasing":[621],"atopy":[624],"(comparable":[625],"those":[627],"observed":[628,720],"Finland).":[630],"provided":[633],"cohort":[635],"infants":[637],"these":[639,673],"geographic":[641],"areas":[642],"them":[645],"birth":[647],"years":[650],"age.":[652],"Stool":[653],"sampling":[654],"was":[655],"done":[656],"immune-mediated":[658],"documented.":[661],"There":[662],"substantial":[664],"composition":[668],"children.":[677,698,723],"Finnish":[678,806],"Estonian":[680],"children":[681,807],"harbored":[682],"Bacteroides":[684,699],"species,":[685],"resulting":[686],"enrichment":[689],"lipopolysaccharide":[691],"(LPS)":[692],"biosynthesis-encoding":[693],"genes":[694],"species":[700,754,781],"produce":[701],"distinct":[703],"form":[704],"differs":[708],"dramatically":[709],"derived":[713,750],"Escherichia":[715],"coli,":[716],"prevalent":[718],"Inter-species":[724],"structure":[728],"are":[729],"alterations":[732],"capacity":[735],"elicit":[737],"innate":[739],"response.":[741],"Lipopolysaccharide":[742],"responsible":[744],"signalling":[747],"different":[752,757],"bacterial":[753],"results":[755],"responses":[759],"measured":[761],"production":[764],"variety":[767],"cytokines.":[769],"Coli-derived":[771],"elicits":[773],"high":[774],"luciferase":[777],"activity,":[778],"Bacteriodes":[780],"fail":[782],"induce":[784],"inflammatory":[786],"signal.":[787],"absence":[790],"specific":[792],"biomarkers,":[793],"impact":[795,818],"early":[800],"exposure":[802],"remains":[808],"seen.":[811],"However,":[812],"proposition":[814],"direct":[817],"pathophysiology":[823],"type":[825,876],"1":[826,877],"supported":[830],"previous":[832],"studies":[833],"mice.2":[835],"REFERENCES":[836],"Bach":[837],"JF,":[838],"Chatenoud":[839],"L.":[840],"hygiene":[842],"hypothesis:":[843],"explanation":[845],"increased":[848],"frequency":[849],"insulin-dependent":[851],"diabetes.":[852,878],"Cold":[853],"Spring":[854],"Harb":[855],"Perspect":[856],"Med":[857],"2012;2:a007799.":[858],"Wen":[859],"L,":[860],"Ley":[861],"RE,":[862],"Volchkov":[863],"PY,":[864],"et":[865],"al.":[866],"Innate":[867],"immunity":[868],"intestinal":[870],"microbiota":[871],"Nature.":[879],"2008;455:1109\u20131113.":[880]},"counts_by_year":[],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2022-05-12T00:00:00"}