{"id":"https://openalex.org/W4241118596","doi":"https://doi.org/10.1002/jps.20556","title":"Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution","display_name":"Reversible self-association increases the viscosity of a concentrated monoclonal antibody in aqueous solution","publication_year":2005,"publication_date":"2005-11-28","ids":{"openalex":"https://openalex.org/W4241118596","doi":"https://doi.org/10.1002/jps.20556"},"language":"en","primary_location":{"id":"doi:10.1002/jps.20556","doi":"https://doi.org/10.1002/jps.20556","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jps.20556","pdf_url":"http://jpharmsci.org/article/S0022354916319384/pdf","source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://jpharmsci.org/article/S0022354916319384/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100362020","display_name":"Jun Liu","orcid":"https://orcid.org/0000-0003-0717-8082","observed_orcids":["https://orcid.org/0000-0003-0717-8082"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Liu","raw_affiliation_strings":["Late Stage Pharmaceutical and Device Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Late Stage Pharmaceutical and Device Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103520383","display_name":"Mary D.H. Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary D.H. Nguyen","raw_affiliation_strings":["Late Stage Pharmaceutical and Device Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Late Stage Pharmaceutical and Device Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000961644","display_name":"James D. Andya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James D. Andya","raw_affiliation_strings":["Early Stage Pharmaceutical Development, Genentech, Inc., South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Early Stage Pharmaceutical Development, Genentech, Inc., South San Francisco, California 94080","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110296609","display_name":"Steven J. Shire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":"US","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven J. Shire","raw_affiliation_strings":["Late Stage Pharmaceutical and Device Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Late Stage Pharmaceutical and Device Development, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080","institution_ids":["https://openalex.org/I183934855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100362020"],"corresponding_institution_ids":["https://openalex.org/I183934855"],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":0.1032,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.42581301,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"95","issue":"1","first_page":"234","last_page":"235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10962","display_name":"Thermodynamic properties of mixtures","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1507","display_name":"Fluid Flow and Transfer Processes"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9350000023841858},{"id":"https://openalex.org/keywords/protein-self-association","display_name":"protein self-association","score":0.9210000038146973},{"id":"https://openalex.org/keywords/viscosity","display_name":"viscosity","score":0.597000002861023},{"id":"https://openalex.org/keywords/concentrated-protein-solutions","display_name":"concentrated protein solutions","score":0.7689999938011169},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.6959999799728394},{"id":"https://openalex.org/keywords/ionic-strength","display_name":"ionic strength","score":0.7260000109672546},{"id":"https://openalex.org/keywords/ph-effect","display_name":"pH effect","score":0.703000009059906},{"id":"https://openalex.org/keywords/sedimentation-equilibrium","display_name":"sedimentation equilibrium","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C93356670","wikidata":"https://www.wikidata.org/wiki/Q868743","display_name":"Viscometer","level":3,"score":0.7366093397140503},{"id":"https://openalex.org/C127172972","wikidata":"https://www.wikidata.org/wiki/Q128709","display_name":"Viscosity","level":2,"score":0.7039037942886353},{"id":"https://openalex.org/C2910425616","wikidata":"https://www.wikidata.org/wiki/Q85741465","display_name":"Analytical Ultracentrifugation","level":3,"score":0.6965696215629578},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6651251316070557},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6586366891860962},{"id":"https://openalex.org/C54689828","wikidata":"https://www.wikidata.org/wiki/Q2029259","display_name":"Ultracentrifuge","level":2,"score":0.6547979116439819},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6072456240653992},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.6045402884483337},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.4786739945411682},{"id":"https://openalex.org/C187428577","wikidata":"https://www.wikidata.org/wiki/Q898396","display_name":"Ionic strength","level":3,"score":0.4762830138206482},{"id":"https://openalex.org/C196445361","wikidata":"https://www.wikidata.org/wiki/Q1424279","display_name":"Rheometer","level":3,"score":0.4745279848575592},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.3404806852340698},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.26339733600616455},{"id":"https://openalex.org/C200990466","wikidata":"https://www.wikidata.org/wiki/Q271707","display_name":"Rheology","level":2,"score":0.23561227321624756},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.20284491777420044},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15064719319343567},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.11637493968009949},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07407459616661072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/jps.20556","doi":"https://doi.org/10.1002/jps.20556","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jps.20556","pdf_url":"http://jpharmsci.org/article/S0022354916319384/pdf","source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1002/jps.20556","doi":"https://doi.org/10.1002/jps.20556","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jps.20556","pdf_url":"http://jpharmsci.org/article/S0022354916319384/pdf","source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4241118596.pdf","grobid_xml":"https://content.openalex.org/works/W4241118596.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2788893965","https://openalex.org/W3037537681","https://openalex.org/W178083006","https://openalex.org/W3208190095","https://openalex.org/W2975755535","https://openalex.org/W2067271590","https://openalex.org/W1972844363","https://openalex.org/W2411517854","https://openalex.org/W2062214242","https://openalex.org/W2076876086"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-12T00:00:00"}