{"id":"https://openalex.org/W4241055846","doi":"https://doi.org/10.1158/1538-7445.am2012-3958","title":"Abstract 3958: Multi-Reg: An integrative parallel approach to uncover drivers of cancer","display_name":"Abstract 3958: Multi-Reg: An integrative parallel approach to uncover drivers of cancer","publication_year":2012,"publication_date":"2012-04-01","ids":{"openalex":"https://openalex.org/W4241055846","doi":"https://doi.org/10.1158/1538-7445.am2012-3958"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2012-3958","doi":"https://doi.org/10.1158/1538-7445.am2012-3958","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3958","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045420729","display_name":"Uri David Akavia","orcid":"https://orcid.org/0000-0003-2609-4693","observed_orcids":["https://orcid.org/0000-0003-2609-4693"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uri David Akavia","raw_affiliation_strings":["1Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088235840","display_name":"Carla Danussi","orcid":"https://orcid.org/0000-0002-7474-1982","observed_orcids":["https://orcid.org/0000-0002-7474-1982"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carla Danussi","raw_affiliation_strings":["1Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060278752","display_name":"F\u00e9lix Sanchez-Garcia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felix Sanchez-Garcia","raw_affiliation_strings":["1Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078024735","display_name":"Antonio Iavarone","orcid":"https://orcid.org/0000-0002-0683-4634","observed_orcids":["https://orcid.org/0000-0002-0683-4634"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Iavarone","raw_affiliation_strings":["1Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074451448","display_name":"Dana Pe\u2019er","orcid":"https://orcid.org/0000-0002-9259-8817","observed_orcids":["https://orcid.org/0000-0002-9259-8817"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana Pe'er","raw_affiliation_strings":["1Columbia University, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Columbia University, New York, NY","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"8_Supplement","first_page":"3958","last_page":"3958"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/driver-gene-identification","display_name":"driver gene identification","score":0.765999972820282},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.746999979019165},{"id":"https://openalex.org/keywords/gene-expression-signatures","display_name":"gene expression signatures","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.5960000157356262},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.6299999952316284},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.6240000128746033},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neurofibromatosis-type-1","display_name":"neurofibromatosis type 1","score":0.996999979019165},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8320000171661377},{"id":"https://openalex.org/keywords/mesenchymal-subtype","display_name":"mesenchymal subtype","score":0.75},{"id":"https://openalex.org/keywords/proneural-subtype","display_name":"proneural subtype","score":0.7670000195503235},{"id":"https://openalex.org/keywords/bayesian-algorithm","display_name":"Bayesian algorithm","score":0.42399999499320984},{"id":"https://openalex.org/keywords/tumor-dependency","display_name":"tumor dependency","score":0.4699999988079071}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.6990798711776733},{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.5537883043289185},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5328125953674316},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5116939544677734},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5103966593742371},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4969816505908966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4885907769203186},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.47018587589263916},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.44620954990386963},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.38137346506118774},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36187222599983215},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2816287875175476},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.28140467405319214},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.11642098426818848},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.09851491451263428}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2012-3958","doi":"https://doi.org/10.1158/1538-7445.am2012-3958","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2012-3958","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1987155963","https://openalex.org/W2060002797","https://openalex.org/W2013728172","https://openalex.org/W1510270256","https://openalex.org/W1968667083","https://openalex.org/W7100748241","https://openalex.org/W2532527181","https://openalex.org/W7169526992","https://openalex.org/W2614671305","https://openalex.org/W6921736278"],"abstract_inverted_index":{"Abstract":[0],"Tumor":[1],"samples":[2],"harbor":[3],"a":[4,55,153,162,343,348],"vast":[5],"number":[6,41,77,210],"of":[7,10,53,183,203,238,298,314,335,408,413],"genomic":[8],"alterations":[9,20],"various":[11],"kinds,":[12],"and":[13,65,78,105,107,157,199,211,234,258,324,392],"it":[14,97,116,367],"is":[15,140,181,200],"difficult":[16],"to":[17,23,50,68,90,110,152,194,208,218,262,353,386],"distinguish":[18],"driver":[19,32,61],"that":[21,58,188,247,358,376],"contribute":[22],"oncogenesis":[24],"from":[25,92,221],"passenger":[26],"alterations.":[27,42],"Most":[28],"computational":[29],"methods":[30],"identify":[31,332],"genes":[33,62,256,302],"by":[34,74,250,267,281,305],"focusing":[35],"on":[36,166,364],"the":[37,51,137,167,254,290,295,311,322,387,394,409,414],"most":[38],"frequent":[39],"copy":[40,76,209,230],"Previous":[43],"work":[44],"in":[45,63,124,192,206,260,275,370],"our":[46,329],"lab":[47],"has":[48,243,356,361],"led":[49],"development":[52],"CONEXIC,":[54,171,251],"Bayesian":[56],"algorithm":[57,87,177],"identifies":[59],"candidate":[60,186,272],"cancer":[64],"links":[66],"them":[67,109,280,385],"gene":[69,79,212,232,349],"expression":[70,80,155,197,213,233,350],"signatures":[71],"they":[72,390],"govern":[73],"integrating":[75,204],"(Akavia":[81],"et":[82],"al,":[83],"Cell,":[84],"2010).":[85],"This":[86,227,309,374],"was":[88],"applied":[89,216],"data":[91,220,228],"melanoma":[93],"cell":[94,365,372],"lines,":[95],"where":[96,134,317],"correctly":[98,331],"identified":[99,244,340],"known":[100,112,255,312,333],"drivers,":[101,381],"such":[102,252],"as":[103,170,253,342],"MITF":[104],"KLF6,":[106],"connected":[108],"their":[111],"targets.":[113,283],"In":[114],"addition,":[115],"predicted":[117],"novel":[118,344],"tumor":[119,240],"dependencies":[120],"not":[121,135],"previously":[122],"implicated":[123],"melanoma,":[125],"which":[126,293],"were":[127,248],"validated":[128],"experimentally.":[129],"Drivers":[130],"may":[131],"act":[132,191,274],"concurrently,":[133],"only":[136,379],"strongest":[138],"one":[139],"important.":[141],"For":[142,284],"example,":[143,285],"either":[144],"PTEN":[145],"deletion":[146],"or":[147],"AKT":[148],"activation":[149],"can":[150,189,278,383],"lead":[151],"similar":[154],"signature":[156,351],"phenotype.":[158],"Therefore,":[159],"we":[160,277],"developed":[161],"new":[163,176],"algorithm,":[164],"based":[165],"same":[168,291,301],"principles":[169],"with":[172],"multiple":[173,185],"improvements.":[174],"The":[175,222],"-":[178,180],"Multi-Reg":[179,217,242,271,338,377],"capable":[182,202],"detecting":[184],"regulators":[187],"all":[190],"parallel":[193],"regulate":[195],"an":[196],"signature,":[198],"also":[201],"mutations":[205,235],"addition":[207,261],"data.":[214],"We":[215],"glioblastoma":[219,315,371],"Cancer":[223,418,429],"Genome":[224],"Atlas":[225],"(TCGA).":[226],"includes":[229],"number,":[231],"for":[236,398,417],"hundreds":[237],"primary":[239],"samples.":[241],"putative":[245],"drivers":[246,273,334],"missed":[249],"PDGFRA":[257,306,320],"NF1,":[259],"EGFR":[263,286,318],"&":[264,287,307,319],"ERB2":[265],"(identified":[266],"CONEXIC).":[268],"Additionally,":[269,337],"since":[270],"parallel,":[276],"group":[279],"shared":[282],"ERRB2":[288],"induce":[289],"genes,":[292],"represent":[294],"Mesenchymal":[296,323],"subtype":[297],"glibolastoma.":[299],"These":[300],"are":[303],"repressed":[304],"NF1.":[308],"matches":[310],"behavior":[313],"subtypes,":[316,326],"characterize":[321],"Proneural":[325],"respectively.":[327],"Thus,":[328],"results":[330,339],"glioblastoma.":[336],"RHPN2":[341,360],"oncogenic":[345,388],"factor":[346],"controlling":[347],"related":[352],"adhesion.":[354],"Validation":[355],"shown":[357],"while":[359],"no":[362],"effect":[363],"proliferation":[366],"induces":[368],"invasiveness":[369],"lines.":[373],"shows":[375],"cannot":[378],"discover":[380],"but":[382],"link":[384],"phenomena":[389],"controls,":[391],"suggest":[393],"appropriate":[395],"biological":[396],"validation":[397],"it.":[399],"Citation":[400],"Format:":[401],"{Authors}.":[402],"{Abstract":[403],"title}":[404],"[abstract].":[405],"In:":[406],"Proceedings":[407],"103rd":[410],"Annual":[411],"Meeting":[412],"American":[415],"Association":[416],"Research;":[419],"2012":[420],"Mar":[421],"31-Apr":[422],"4;":[423],"Chicago,":[424],"IL.":[425],"Philadelphia":[426],"(PA):":[427],"AACR;":[428],"Res":[430],"2012;72(8":[431],"Suppl):Abstract":[432],"nr":[433],"3958.":[434],"doi:1538-7445.AM2012-3958":[435]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2022-05-12T00:00:00"}
