{"id":"https://openalex.org/W4241004193","doi":"https://doi.org/10.1111/j.1939-1676.2002.tb02388.x","title":"Endostatin Concentrations in Healthy Dogs and Dogs with Selected Neoplasms","display_name":"Endostatin Concentrations in Healthy Dogs and Dogs with Selected Neoplasms","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W4241004193","doi":"https://doi.org/10.1111/j.1939-1676.2002.tb02388.x","pmid":"https://pubmed.ncbi.nlm.nih.gov/12322707"},"language":"en","primary_location":{"id":"doi:10.1111/j.1939-1676.2002.tb02388.x","doi":"https://doi.org/10.1111/j.1939-1676.2002.tb02388.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2002.tb02388.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2002.tb02388.x","source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2002.tb02388.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029454626","display_name":"John Henry Rossmeisl","orcid":"https://orcid.org/0000-0003-1655-7076","observed_orcids":["https://orcid.org/0000-0003-1655-7076"]},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John H Rossmeisl","raw_affiliation_strings":["Virginia-Maryland Regional College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, VA","Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061-0442, USA. jrossmei@vt.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia-Maryland Regional College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, VA","institution_ids":["https://openalex.org/I39822340"]},{"raw_affiliation_string":"Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, VA 24061-0442, USA. jrossmei@vt.edu","institution_ids":["https://openalex.org/I39822340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004749855","display_name":"Patricia L. Bright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Bright","raw_affiliation_strings":["Virginia-Maryland Regional College of Veterinary Medicine , College Park, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia-Maryland Regional College of Veterinary Medicine , College Park, MD","institution_ids":["https://openalex.org/I39822340"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020478643","display_name":"Lawrence Tamarkin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lawrence Tamarkin","raw_affiliation_strings":["Cytim-mune Sciences , Inc, College Park, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytim-mune Sciences , Inc, College Park, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022763741","display_name":"Byron W. Simpson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Byron W Simpson","raw_affiliation_strings":["Cytim-mune Sciences , Inc, College Park, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cytim-mune Sciences , Inc, College Park, MD","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110315590","display_name":"Gregory C. Troy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory C Troy","raw_affiliation_strings":["Virginia-Maryland Regional College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia-Maryland Regional College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, VA","institution_ids":["https://openalex.org/I39822340"]}]},{"author_position":"middle","author":{"id":null,"display_name":"William Hueston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William Hueston","raw_affiliation_strings":["Virginia-Maryland Regional College of Veterinary Medicine , College Park, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia-Maryland Regional College of Veterinary Medicine , College Park, MD","institution_ids":["https://openalex.org/I39822340"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071751892","display_name":"Daniel Lee Ward","orcid":"https://orcid.org/0000-0003-2234-2610","observed_orcids":["https://orcid.org/0000-0003-2234-2610"]},"institutions":[{"id":"https://openalex.org/I39822340","display_name":"Virginia\u2013Maryland College of Veterinary Medicine","ror":"https://ror.org/010prmy50","country_code":"US","type":"education","lineage":["https://openalex.org/I39822340","https://openalex.org/I66946132","https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel L Ward","raw_affiliation_strings":["Virginia-Maryland Regional College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, VA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia-Maryland Regional College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, VA","institution_ids":["https://openalex.org/I39822340"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029454626"],"corresponding_institution_ids":["https://openalex.org/I39822340"],"apc_list":{"value":2000,"currency":"USD","value_usd":2000},"apc_paid":null,"fwci":0.2716,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.68693203,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"16","issue":"5","first_page":"565","last_page":"565"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/endostatin","display_name":"endostatin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.5839999914169312},{"id":"https://openalex.org/keywords/canine-cancer","display_name":"canine cancer","score":0.8299999833106995},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.7919999957084656},{"id":"https://openalex.org/keywords/hemangiosarcoma","display_name":"hemangiosarcoma","score":0.9950000047683716},{"id":"https://openalex.org/keywords/reference-values","display_name":"reference values","score":0.6809999942779541},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.6119999885559082},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C75920679","wikidata":"https://www.wikidata.org/wiki/Q359012","display_name":"Endostatin","level":3,"score":0.9950666427612305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.777925968170166},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.570372462272644},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.4258136749267578},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3872709274291992},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33493882417678833},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31219881772994995},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.29949063062667847}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006262","descriptor_name":"Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006394","descriptor_name":"Hemangiosarcoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006394","descriptor_name":"Hemangiosarcoma","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D043169","descriptor_name":"Endostatins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1939-1676.2002.tb02388.x","doi":"https://doi.org/10.1111/j.1939-1676.2002.tb02388.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2002.tb02388.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2002.tb02388.x","source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},{"id":"doi:10.1892/0891-6640(2002)016<0565:ecihda>2.3.co;2","doi":"https://doi.org/10.1892/0891-6640(2002)016<0565:ecihda>2.3.co;2","is_oa":false,"landing_page_url":"https://doi.org/10.1892/0891-6640(2002)016<0565:ecihda>2.3.co;2","pdf_url":null,"source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},{"id":"pmid:12322707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12322707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary internal medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1939-1676.2002.tb02388.x","doi":"https://doi.org/10.1111/j.1939-1676.2002.tb02388.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1939-1676.2002.tb02388.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1939-1676.2002.tb02388.x","source":{"id":"https://openalex.org/S69093139","display_name":"Journal of Veterinary Internal Medicine","issn_l":"0891-6640","issn":["0891-6640","1939-1676"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4241004193.pdf","grobid_xml":"https://content.openalex.org/works/W4241004193.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W58834805","https://openalex.org/W72344367","https://openalex.org/W193867311","https://openalex.org/W309342242","https://openalex.org/W336219641","https://openalex.org/W1579870652","https://openalex.org/W1658860190","https://openalex.org/W1885134561","https://openalex.org/W1940292938","https://openalex.org/W1975111610","https://openalex.org/W2008438789","https://openalex.org/W2015809080","https://openalex.org/W2027467237","https://openalex.org/W2035613227","https://openalex.org/W2037286214","https://openalex.org/W2061524005","https://openalex.org/W2069363135","https://openalex.org/W2073308580","https://openalex.org/W2131798870","https://openalex.org/W2132623147","https://openalex.org/W2146916102","https://openalex.org/W2152222295","https://openalex.org/W2179410198","https://openalex.org/W2324677651","https://openalex.org/W4232101001","https://openalex.org/W4242565185","https://openalex.org/W4255434939","https://openalex.org/W4298213432"],"related_works":["https://openalex.org/W4302887813","https://openalex.org/W2054109241","https://openalex.org/W4226285194","https://openalex.org/W2027467237","https://openalex.org/W4200196641","https://openalex.org/W857536806","https://openalex.org/W2741336160","https://openalex.org/W86286990","https://openalex.org/W1954700423","https://openalex.org/W2272937669"],"abstract_inverted_index":{"Endostatin":[0,36,73],"prevents":[1],"angiogenesis":[2],"and":[3,11,28,62,84,100,107,130,140],"tumor":[4],"growth":[5],"by":[6],"inhibiting":[7],"endothelial":[8],"cell":[9],"proliferation":[10],"migration.":[12],"The":[13],"purpose":[14],"of":[15,60,71,87,113],"this":[16,120],"study":[17,121],"was":[18,38,78],"to":[19],"determine":[20],"serum":[21,69,92],"endostatin":[22,55,93,111,124,132],"concentrations":[23,112,133],"in":[24,29,75,95,128,136],"53":[25],"healthy":[26,76,96],"dogs":[27,31,77,97,129,137],"38":[30],"with":[32,40,46,67,104,138],"confirmed":[33],"malignant":[34],"neoplasms.":[35],"concentration":[37,70,74,94],"determined":[39],"a":[41,52],"competitive":[42],"enzymatic":[43],"immunoassay":[44],"(EIA)":[45],"rabbit":[47],"polyclonal":[48],"antibody":[49],"generated":[50],"against":[51],"recombinant":[53],"canine":[54],"protein.":[56],"Both":[57],"the":[58,88],"presence":[59],"cancer":[61],"increasing":[63],"age":[64],"were":[65,98],"associated":[66],"increased":[68],"endostatin.":[72],"87.7":[79],"+/-":[80,115],"3.5":[81],"ng/mL.":[82,102,117],"Upper":[83],"lower":[85],"limits":[86],"reference":[89],"range":[90],"for":[91],"60":[99],"113":[101],"Dogs":[103],"lymphoma":[105],"(LSA)":[106],"hemangiosarcoma":[108],"(HSA)":[109],"had":[110],"107":[114],"9.3":[116],"In":[118],"conclusion,":[119],"demonstrates":[122],"that":[123,131],"can":[125],"be":[126],"quantified":[127],"are":[134],"high":[135],"HSA":[139],"LSA.":[141]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-05-12T00:00:00"}
