{"id":"https://openalex.org/W4240946036","doi":"https://doi.org/10.1084/jem.2109oia29","title":"Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-\u03baB and MMPs","display_name":"Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-\u03baB and MMPs","publication_year":2013,"publication_date":"2013-08-26","ids":{"openalex":"https://openalex.org/W4240946036","doi":"https://doi.org/10.1084/jem.2109oia29"},"language":"en","primary_location":{"id":"doi:10.1084/jem.2109oia29","doi":"https://doi.org/10.1084/jem.2109oia29","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.2109oia29","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019543378","display_name":"Geou\u2010Yarh Liou","orcid":"https://orcid.org/0000-0003-2728-3752","observed_orcids":["https://orcid.org/0000-0003-2728-3752"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geou-Yarh Liou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062388236","display_name":"Heike R. D\u00f6ppler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heike D\u00f6ppler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038191637","display_name":"Brian M. Necela","orcid":"https://orcid.org/0000-0002-4409-1245","observed_orcids":["https://orcid.org/0000-0002-4409-1245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Necela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089062336","display_name":"Murli Krishna","orcid":"https://orcid.org/0009-0007-7336-2247","observed_orcids":["https://orcid.org/0009-0007-7336-2247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Murli Krishna","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054373028","display_name":"Howard C. Crawford","orcid":"https://orcid.org/0000-0001-9360-3019","observed_orcids":["https://orcid.org/0000-0001-9360-3019"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard C. Crawford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012699718","display_name":"Massimo Raimondo","orcid":"https://orcid.org/0000-0002-3750-1541","observed_orcids":["https://orcid.org/0000-0002-3750-1541"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Massimo Raimondo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5064581175","display_name":"Peter St\u00f6rz","orcid":"https://orcid.org/0000-0002-0132-5128","observed_orcids":["https://orcid.org/0000-0002-0132-5128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Storz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.39627979,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"210","issue":"9","first_page":"2109OIA29","last_page":"2109OIA29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.9409999847412109},{"id":"https://openalex.org/keywords/acinar-to-ductal-metaplasia","display_name":"acinar-to-ductal metaplasia","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.7689999938011169},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9380000233650208},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9900000095367432},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7110000252723694}],"concepts":[{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6669678688049316},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6115539073944092},{"id":"https://openalex.org/C2779357193","wikidata":"https://www.wikidata.org/wiki/Q660713","display_name":"Metaplasia","level":2,"score":0.6112861037254333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4523884952068329},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4478951394557953},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4455749988555908},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.425167441368103},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38490357995033264},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35154277086257935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23817449808120728},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12983331084251404},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09275475144386292}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1084/jem.2109oia29","doi":"https://doi.org/10.1084/jem.2109oia29","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.2109oia29","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Experimental Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2123852594"],"related_works":["https://openalex.org/W2002802600","https://openalex.org/W2095786029","https://openalex.org/W883124643","https://openalex.org/W4372218887","https://openalex.org/W2185586482","https://openalex.org/W2007616458","https://openalex.org/W2003698259","https://openalex.org/W2121985233","https://openalex.org/W2048516883","https://openalex.org/W4252339627"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2022-05-12T00:00:00"}