{"id":"https://openalex.org/W4240894652","doi":"https://doi.org/10.1055/s-0038-1645981","title":"Increased Aggregation and Secretion Responses of Human Platelets when Loaded with the Calcium Fluorescent Probes Quin2 and Fura-2","display_name":"Increased Aggregation and Secretion Responses of Human Platelets when Loaded with the Calcium Fluorescent Probes Quin2 and Fura-2","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W4240894652","doi":"https://doi.org/10.1055/s-0038-1645981"},"language":"en","primary_location":{"id":"doi:10.1055/s-0038-1645981","doi":"https://doi.org/10.1055/s-0038-1645981","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1645981","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104978331","display_name":"Frarn\u00e7ois Lanza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Frarn\u00e7ois Lanza","raw_affiliation_strings":["The INSERM U.311, Biologie et Pharmacologie des Interactions du Sang avec les Vaisseaux et les Biomat\u00e9riaux, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The INSERM U.311, Biologie et Pharmacologie des Interactions du Sang avec les Vaisseaux et les Biomat\u00e9riaux, Strasbourg, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032430969","display_name":"Alain Beretz","orcid":"https://orcid.org/0000-0002-1479-1697","observed_orcids":["https://orcid.org/0000-0002-1479-1697"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Beretz","raw_affiliation_strings":["The INSERM U.311, Biologie et Pharmacologie des Interactions du Sang avec les Vaisseaux et les Biomat\u00e9riaux, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The INSERM U.311, Biologie et Pharmacologie des Interactions du Sang avec les Vaisseaux et les Biomat\u00e9riaux, Strasbourg, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113551403","display_name":"Martial Kubina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I68947357","display_name":"Universit\u00e9 de Strasbourg","ror":"https://ror.org/00pg6eq24","country_code":"FR","type":"education","lineage":["https://openalex.org/I68947357"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Martial Kubina","raw_affiliation_strings":["Centre R\u00e9gional de Transfusion Sanguine, Strasbourg, and the Laboratoire de Biophysique UA 491 du CNRS, Universit\u00e9 Louis Pasteur, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre R\u00e9gional de Transfusion Sanguine, Strasbourg, and the Laboratoire de Biophysique UA 491 du CNRS, Universit\u00e9 Louis Pasteur, Strasbourg, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I68947357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088441623","display_name":"Jean\u2010Pierre Cazenave","orcid":"https://orcid.org/0000-0001-9944-950X","observed_orcids":["https://orcid.org/0000-0001-9944-950X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Cazenave","raw_affiliation_strings":["The INSERM U.311, Biologie et Pharmacologie des Interactions du Sang avec les Vaisseaux et les Biomat\u00e9riaux, Strasbourg, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The INSERM U.311, Biologie et Pharmacologie des Interactions du Sang avec les Vaisseaux et les Biomat\u00e9riaux, Strasbourg, France","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.373,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.82379233,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"58","issue":"02","first_page":"737","last_page":"743"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.8100000023841858},{"id":"https://openalex.org/keywords/platelet-secretion","display_name":"platelet secretion","score":0.9919999837875366},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.7409999966621399},{"id":"https://openalex.org/keywords/quin-2","display_name":"quin-2","score":0.9309999942779541},{"id":"https://openalex.org/keywords/fura-2","display_name":"fura-2","score":0.984000027179718},{"id":"https://openalex.org/keywords/calcium-chelators","display_name":"calcium chelators","score":0.7990000247955322},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.8989999890327454},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.8309999704360962},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.949999988079071},{"id":"https://openalex.org/keywords/platelet-shape-change","display_name":"platelet shape change","score":0.7739999890327454},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tma-dph","display_name":"TMA-DPH","score":0.8970000147819519},{"id":"https://openalex.org/keywords/u46619","display_name":"U46619","score":0.7979999780654907},{"id":"https://openalex.org/keywords/adp","display_name":"ADP","score":0.6340000033378601},{"id":"https://openalex.org/keywords/collagen","display_name":"collagen","score":0.5920000076293945},{"id":"https://openalex.org/keywords/thrombin","display_name":"thrombin","score":0.925000011920929},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.832915186882019},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7814849019050598},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7671899795532227},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.6825392246246338},{"id":"https://openalex.org/C181080969","wikidata":"https://www.wikidata.org/wiki/Q60097","display_name":"Calcium in biology","level":3,"score":0.656822681427002},{"id":"https://openalex.org/C2779014961","wikidata":"https://www.wikidata.org/wiki/Q415168","display_name":"Ionophore","level":3,"score":0.62335604429245},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6108248233795166},{"id":"https://openalex.org/C2778470358","wikidata":"https://www.wikidata.org/wiki/Q908761","display_name":"Fura-2","level":4,"score":0.6055546402931213},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4859517812728882},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4679407477378845},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.41252508759498596},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.31349653005599976},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23336565494537354},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11456388235092163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.05354323983192444},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.05113425850868225},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1055/s-0038-1645981","doi":"https://doi.org/10.1055/s-0038-1645981","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0038-1645981","pdf_url":null,"source":{"id":"https://openalex.org/S206235894","display_name":"Thrombosis and Haemostasis","issn_l":"0340-6245","issn":["0340-6245","2567-689X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis and Haemostasis","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.4043000042438507}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2889541905","https://openalex.org/W2464822600","https://openalex.org/W1964620148","https://openalex.org/W1964100059","https://openalex.org/W2007067565","https://openalex.org/W2006172972","https://openalex.org/W84220812","https://openalex.org/W2093673615","https://openalex.org/W7100680520","https://openalex.org/W2196351397"],"abstract_inverted_index":{"Summary":[0],"Incorporation":[1],"into":[2],"human":[3],"platelets":[4,47,98,151,172],"of":[5,26,29,42,57,103,122,132,136,142,164,171,199],"the":[6,24,27,60,65,92,123,130,139,154,197],"calcium":[7,21,66,104,156,201,209],"fluorescent":[8],"indicators":[9],"quin2":[10,43,165],"or":[11,44],"fura-2":[12,45,72],"at":[13,203],"low":[14,55,162],"concentrations":[15,56,102,163,204],"used":[16,205],"to":[17,23,79,110,138,206],"measure":[18],"intracellular":[19,186,200,208],"free":[20],"leads":[22],"potentiation":[25],"effects":[28],"agonists":[30],"on":[31],"platelets.":[32],"This":[33,114],"was":[34,86,117],"shown":[35],"by":[36,88,119,129,185,196],"increased":[37,120],"aggregatory":[38],"and":[39,53,64,71,128,179],"secretory":[40],"responses":[41,109,193],"loaded":[46,99,152],"after":[48],"stimulation":[49],"with":[50,54,91,100,146,153,174],"ADP,":[51],"PAP":[52],"thrombin,":[58],"collagen,":[59],"endoperoxide":[61],"analog":[62,158],"U-46619":[63],"ionophore":[67],"A":[68],"23187.":[69],"Quin2":[70],"mediated":[73],"platelet":[74,124,192],"sensitisation":[75],"could":[76],"be":[77,182],"due":[78],"altered":[80,195],"arachidonic":[81],"acid":[82],"metabolism":[83],"since":[84],"it":[85],"inhibited":[87],"prior":[89],"treatment":[90],"cydooxygenase":[93],"inhibitor":[94],"acetylsalicylate.":[95],"In":[96,160],"contrast,":[97,161],"higher":[101],"chelators":[105,202],"exhibited":[106],"diminished":[107],"aggregation":[108,180],"all":[111],"aggregating":[112],"agents.":[113],"latter":[115],"effect":[116],"accompanied":[118],"fluidity":[121],"plasma":[125],"membrane":[126],"bilayer":[127],"exposure":[131],"a":[133],"new":[134],"pool":[135],"membranes":[137],"outer":[140],"surface":[141],"platelets,":[143],"as":[144],"monitored":[145],"trimethylammonium-":[147],"diphenylhexatriene":[148],"(TMA-DPH)":[149],"in":[150],"non-fluorescent":[155],"probe":[157],"MAPT.":[159],"did":[166],"not":[167],"potentiate":[168],"shape":[169,177],"change":[170,178],"activated":[173],"ADP.":[175],"Thus,":[176],"can":[181],"influenced":[183],"separately":[184],"Ca2+":[187],"chelators.":[188],"We":[189],"conclude":[190],"that":[191],"are":[194],"incorporation":[198],"monitor":[207],"changes.":[210]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2022-05-12T00:00:00"}