{"id":"https://openalex.org/W4240883875","doi":"https://doi.org/10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.0.co;2-5","title":"Issues related to the experimental design and subsequent statistical analysis of in vivo and in vitro comet studies","display_name":"Issues related to the experimental design and subsequent statistical analysis of in vivo and in vitro comet studies","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W4240883875","doi":"https://doi.org/10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.0.co;2-5","mag":"2021629854","pmid":"https://pubmed.ncbi.nlm.nih.gov/10332808"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.0.co;2-5","doi":"https://doi.org/10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.0.co;2-5","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.0.co;2-5","pdf_url":null,"source":{"id":"https://openalex.org/S4394736641","display_name":"Teratogenesis Carcinogenesis and Mutagenesis","issn_l":"0270-3211","issn":["0270-3211","1520-6866"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, Carcinogenesis, and Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021378163","display_name":"D. P. Lovell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134707","display_name":"Bibra International","ror":"https://ror.org/03hvxkc45","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210134707"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"D.P. Lovell","raw_affiliation_strings":["BIBRA International, Carshalton, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIBRA International, Carshalton, Surrey, United Kingdom","institution_ids":["https://openalex.org/I4210134707"]}]},{"author_position":"middle","author":{"id":null,"display_name":"G. Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134707","display_name":"Bibra International","ror":"https://ror.org/03hvxkc45","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210134707"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. Thomas","raw_affiliation_strings":["BIBRA International, Carshalton, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIBRA International, Carshalton, Surrey, United Kingdom","institution_ids":["https://openalex.org/I4210134707"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084791015","display_name":"Robin Dubow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134707","display_name":"Bibra International","ror":"https://ror.org/03hvxkc45","country_code":"GB","type":"other","lineage":["https://openalex.org/I4210134707"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"R. Dubow","raw_affiliation_strings":["BIBRA International, Carshalton, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BIBRA International, Carshalton, Surrey, United Kingdom","institution_ids":["https://openalex.org/I4210134707"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5021378163"],"corresponding_institution_ids":["https://openalex.org/I4210134707"],"apc_list":null,"apc_paid":null,"fwci":2.8948,"has_fulltext":false,"cited_by_count":132,"citation_normalized_percentile":{"value":0.91646489,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"19","issue":"2","first_page":"109","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11798","display_name":"Optimal Experimental Design Methods","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1803","display_name":"Management Science and Operations Research"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13500","display_name":"Probability and Statistical Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/comet-assay","display_name":"comet assay","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.5690000057220459},{"id":"https://openalex.org/keywords/experimental-design","display_name":"experimental design","score":0.8659999966621399},{"id":"https://openalex.org/keywords/statistical-analysis","display_name":"statistical analysis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/misinterpretation-of-results","display_name":"misinterpretation of results","score":0.7009999752044678},{"id":"https://openalex.org/keywords/p-values","display_name":"p-values","score":0.6740000247955322},{"id":"https://openalex.org/keywords/biological-significance","display_name":"biological significance","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C2780358455","wikidata":"https://www.wikidata.org/wiki/Q903780","display_name":"Comet assay","level":4,"score":0.6591982245445251},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6075528860092163},{"id":"https://openalex.org/C2986587452","wikidata":"https://www.wikidata.org/wiki/Q938438","display_name":"Statistical analysis","level":2,"score":0.604137122631073},{"id":"https://openalex.org/C94081185","wikidata":"https://www.wikidata.org/wiki/Q3559","display_name":"Comet","level":2,"score":0.5848730802536011},{"id":"https://openalex.org/C2776639595","wikidata":"https://www.wikidata.org/wiki/Q221696","display_name":"Mutagen","level":3,"score":0.5149720311164856},{"id":"https://openalex.org/C87007009","wikidata":"https://www.wikidata.org/wiki/Q210832","display_name":"Statistical hypothesis testing","level":2,"score":0.438754677772522},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41548746824264526},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.397616982460022},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3291105628013611},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.307096004486084},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2570115327835083},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.1700003445148468},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16753697395324707},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.11747729778289795},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0825345516204834},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004586","descriptor_name":"Electrophoresis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009152","descriptor_name":"Mutagenicity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017408","descriptor_name":"Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.0.co;2-5","doi":"https://doi.org/10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.0.co;2-5","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.0.co;2-5","pdf_url":null,"source":{"id":"https://openalex.org/S4394736641","display_name":"Teratogenesis Carcinogenesis and Mutagenesis","issn_l":"0270-3211","issn":["0270-3211","1520-6866"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, Carcinogenesis, and Mutagenesis","raw_type":"journal-article"},{"id":"doi:10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.3.co;2-x","doi":"https://doi.org/10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.3.co;2-x","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1520-6866(1999)19:2<109::aid-tcm4>3.3.co;2-x","pdf_url":null,"source":{"id":"https://openalex.org/S4394736641","display_name":"Teratogenesis Carcinogenesis and Mutagenesis","issn_l":"0270-3211","issn":["0270-3211","1520-6866"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, Carcinogenesis, and Mutagenesis","raw_type":"journal-article"},{"id":"pmid:10332808","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10332808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Teratogenesis, carcinogenesis, and mutagenesis","raw_type":"Journal Article"},{"id":"mag:2021629854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10332808","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1991455005","https://openalex.org/W1995920508","https://openalex.org/W2018741434","https://openalex.org/W2023841047","https://openalex.org/W2025903114","https://openalex.org/W2107031757","https://openalex.org/W2153135265","https://openalex.org/W2329094530","https://openalex.org/W2417494070","https://openalex.org/W2797868916","https://openalex.org/W3041809645","https://openalex.org/W4210464465","https://openalex.org/W4251662904","https://openalex.org/W4301861531","https://openalex.org/W6676028428"],"related_works":["https://openalex.org/W7099805449","https://openalex.org/W2142519394","https://openalex.org/W7100013482","https://openalex.org/W2915161144","https://openalex.org/W7096469117","https://openalex.org/W2086976931","https://openalex.org/W2160359301","https://openalex.org/W6927207988","https://openalex.org/W1973044893","https://openalex.org/W1989847642"],"abstract_inverted_index":{"A":[0],"wide":[1],"range":[2],"of":[3,59,62,65,74,85],"experimental":[4,43],"designs":[5],"are":[6,21],"used":[7],"in":[8],"investigations":[9],"using":[10],"the":[11,35,39,42,51,63,66,82],"Comet":[12],"assay.":[13],"The":[14],"statistical":[15,87],"issues":[16],"associated":[17],"with":[18],"this":[19],"assay":[20,67],"however":[22,31],"not":[23],"particularly":[24],"unusual":[25],"or":[26],"difficult.":[27],"It":[28],"is":[29,41],"important":[30],"to":[32,56,71],"recognize":[33],"that":[34],"sample":[36],"rather":[37,77],"than":[38,78],"cell":[40],"unit.":[44],"Statistical":[45],"analyses":[46],"based":[47],"upon":[48],"measures":[49],"from":[50],"individual":[52],"cells":[53],"can":[54],"lead":[55],"serious":[57],"misinterpretation":[58],"results.":[60],"Interpretation":[61],"results":[64],"should":[68],"be":[69],"related":[70],"identifying":[72],"changes":[73],"biological":[75],"importance":[76],"relying":[79],"solely":[80],"on":[81],"P":[83],"values":[84],"specific":[86],"tests.":[88]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}
