{"id":"https://openalex.org/W4240862980","doi":"https://doi.org/10.21236/ada602792","title":"Exosomal microRNA Signatures in the Diagnosis and Prognosis of Ovarian Cancer","display_name":"Exosomal microRNA Signatures in the Diagnosis and Prognosis of Ovarian Cancer","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W4240862980","doi":"https://doi.org/10.21236/ada602792"},"language":"en","primary_location":{"id":"doi:10.21236/ada602792","doi":"https://doi.org/10.21236/ada602792","is_oa":true,"landing_page_url":"http://doi.org/10.21236/ada602792","pdf_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a602792.pdf","source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"volume":null,"type":"report","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a602792.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105463797","display_name":"Douglas D. Taylor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]},{"id":"https://openalex.org/I2802581893","display_name":"United States Army Medical Research and Development Command","ror":"https://ror.org/03cd02q50","country_code":"US","type":"facility","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas D. Taylor","raw_affiliation_strings":["U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012","University of Louisville Louisville, KY 40292","Jefferson Davis Highway, Suite 1204, Arlington, VA 22202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012","institution_ids":["https://openalex.org/I2802581893"]},{"raw_affiliation_string":"University of Louisville Louisville, KY 40292","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Jefferson Davis Highway, Suite 1204, Arlington, VA 22202","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5105463797"],"corresponding_institution_ids":["https://openalex.org/I142740786","https://openalex.org/I2802581893"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exosomal-mirna","display_name":"exosomal microRNAs","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9879999756813049},{"id":"https://openalex.org/keywords/liquid-biopsy","display_name":"liquid biopsy","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cancer-diagnosis","display_name":"cancer diagnosis","score":0.675000011920929},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.7300000190734863},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.8159999847412109},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.7269999980926514},{"id":"https://openalex.org/keywords/exosome-isolation","display_name":"exosome isolation","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8110729455947876},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6957962512969971},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49601730704307556},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46592020988464355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4654930830001831},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41503337025642395},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3972497582435608},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28805288672447205},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12179198861122131},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07764264941215515}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21236/ada602792","doi":"https://doi.org/10.21236/ada602792","is_oa":true,"landing_page_url":"http://doi.org/10.21236/ada602792","pdf_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a602792.pdf","source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"}],"best_oa_location":{"id":"doi:10.21236/ada602792","doi":"https://doi.org/10.21236/ada602792","is_oa":true,"landing_page_url":"http://doi.org/10.21236/ada602792","pdf_url":"https://apps.dtic.mil/dtic/tr/fulltext/u2/a602792.pdf","source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"US Dept of the Army","raw_type":"report"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4240862980.pdf","grobid_xml":"https://content.openalex.org/works/W4240862980.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1648301895","https://openalex.org/W1662505552","https://openalex.org/W1762620449","https://openalex.org/W1896442311","https://openalex.org/W1964631913","https://openalex.org/W1964895626","https://openalex.org/W1972755526","https://openalex.org/W1977558989","https://openalex.org/W2002995168","https://openalex.org/W2008652897","https://openalex.org/W2014946489","https://openalex.org/W2023613355","https://openalex.org/W2024726220","https://openalex.org/W2036169252","https://openalex.org/W2036224487","https://openalex.org/W2044024388","https://openalex.org/W2060076119","https://openalex.org/W2091565685","https://openalex.org/W2093252833","https://openalex.org/W2096116951","https://openalex.org/W2122522737","https://openalex.org/W2123214754","https://openalex.org/W2125523949","https://openalex.org/W2129935560","https://openalex.org/W2130979840","https://openalex.org/W2134389439","https://openalex.org/W2135836598","https://openalex.org/W2144753743","https://openalex.org/W2149385948","https://openalex.org/W2150696691","https://openalex.org/W2150727952","https://openalex.org/W2165801731","https://openalex.org/W2168727673","https://openalex.org/W4237473415","https://openalex.org/W4255860694","https://openalex.org/W4312717476","https://openalex.org/W6641097993"],"related_works":["https://openalex.org/W3163490022","https://openalex.org/W7097538341","https://openalex.org/W4283269910","https://openalex.org/W2001962270","https://openalex.org/W4283726900","https://openalex.org/W3142119256","https://openalex.org/W2596884304","https://openalex.org/W4389152297","https://openalex.org/W2886216071","https://openalex.org/W4417184207"],"abstract_inverted_index":{"Our":[0],"original":[1],"goal":[2],"was":[3],"to":[4,129,170],"correlate":[5],"exosomal":[6,36,40,121],"miRNA":[7,95,118,122],"profiles":[8],"within":[9,81,86,108,162],"circulating":[10,18],"tumor-derived":[11,19,35],"exosomes":[12,101],"with":[13,66],"cancer":[14,43,126,149,166],"diagnosis,":[15],"characterization":[16],"of":[17,23,34,39,117,133,158,174,179],"vesicles":[20],"and":[21,141,143,155],"development":[22],"methodology":[24],"for":[25,31,124],"their":[26,73],"specific":[27,32,160,180],"isolation":[28],"were":[29,150,168],"essential":[30],"analyses":[33],"cargoes.Our":[37],"discovery":[38],"microRNA":[41],"in":[42,50,72,91],"patients":[44,127,167],"focused":[45],"on":[46],"miRNAs,":[47],"previously":[48],"demonstrated":[49,169],"tumor":[51,55,68,88,100],"biopsies":[52],"or":[53,69],"ovarian":[54,99,125,148,165],"cells.We":[56],"have":[57],"observed":[58],"that":[59,63,94,105],"while":[60],"some":[61,75,103],"miRNAs":[62,77,84,104,161],"are":[64,78,89,106],"up-regulated":[65,71,80,90],"the":[67,87,109,113,120,177],"also":[70],"exosomes,":[74],"tumor-up-regulated":[76],"not":[79],"exosomes.Further,":[82],"certain":[83],"down-regulated":[85],"exosomes.We":[92],"demonstrate":[93,112],"signatures":[96,123],"derived":[97],"from":[98,164],"exhibit":[102],"undetectable":[107],"tumor.These":[110],"findings":[111],"highly":[114],"selective":[115],"nature":[116],"\"packaging.\"Although":[119],"appear":[128],"be":[130],"similar":[131],"regardless":[132],"stage,":[134],"significant":[135],"differences":[136],"among":[137],"early":[138],"(Stage":[139,146],"I":[140],"II)":[142],"late":[144],"stage":[145],"III)":[147],"demonstrated:":[151],"increase":[152],"expression":[153,157],"level":[154],"elevated":[156,172],"three":[159],"exosomes.Exosomes":[163],"possess":[171],"levels":[173],"RNA,":[175],"including":[176],"presence":[178],"long-noncoding":[181],"RNA.15.":[182]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2022-05-12T00:00:00"}
