{"id":"https://openalex.org/W4240777609","doi":"https://doi.org/10.1074/jbc.a113.707630","title":"CYP2E1 substrate inhibition. MECHANISTIC INTERPRETATION THROUGH AN EFFECTOR SITE FOR MONOCYCLIC COMPOUNDS.","display_name":"CYP2E1 substrate inhibition. MECHANISTIC INTERPRETATION THROUGH AN EFFECTOR SITE FOR MONOCYCLIC COMPOUNDS.","publication_year":2013,"publication_date":"2013-11-01","ids":{"openalex":"https://openalex.org/W4240777609","doi":"https://doi.org/10.1074/jbc.a113.707630"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.a113.707630","doi":"https://doi.org/10.1074/jbc.a113.707630","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.a113.707630","pdf_url":"http://www.jbc.org/article/S0021925820485965/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820485965/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027272775","display_name":"Samuel L. Collom","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel L. Collom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050322234","display_name":"Ryan M. Laddusaw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ryan M. Laddusaw","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036886557","display_name":"Amber M. Burch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amber M. Burch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008377738","display_name":"Petr Kuzmi\u010d","orcid":"https://orcid.org/0000-0001-5250-8381","observed_orcids":["https://orcid.org/0000-0001-5250-8381"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Petr Kuzmic","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113594641","display_name":"Martin D. Perry","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin D. Perry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013945168","display_name":"Grover Paul Miller","orcid":"https://orcid.org/0000-0002-4743-8187","observed_orcids":["https://orcid.org/0000-0002-4743-8187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grover P. Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.2172,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57824174,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"288","issue":"45","first_page":"32640","last_page":"32640"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2e1","display_name":"CYP2E1","score":0.996999979019165},{"id":"https://openalex.org/keywords/substrate-inhibition","display_name":"substrate inhibition","score":0.7829999923706055},{"id":"https://openalex.org/keywords/allosteric-inhibition","display_name":"allosteric inhibition","score":0.8140000104904175},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.45100000500679016},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.6629999876022339},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.8960000276565552},{"id":"https://openalex.org/keywords/4-nitrophenol","display_name":"p-nitrophenol","score":0.7929999828338623}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.6945228576660156},{"id":"https://openalex.org/C2777530160","wikidata":"https://www.wikidata.org/wiki/Q41796","display_name":"Sentence","level":2,"score":0.6711957454681396},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6269511580467224},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.596388578414917},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.5343477129936218},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5142397284507751},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4575447738170624},{"id":"https://openalex.org/C150757390","wikidata":"https://www.wikidata.org/wiki/Q1985205","display_name":"Non-competitive inhibition","level":3,"score":0.4540454149246216},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.4472172260284424},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.30297988653182983},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22497066855430603},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17794319987297058},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.17647555470466614},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.13894230127334595},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13408637046813965},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1074/jbc.a113.707630","doi":"https://doi.org/10.1074/jbc.a113.707630","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.a113.707630","pdf_url":"http://www.jbc.org/article/S0021925820485965/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2913334","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3820898","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3820898","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3820898","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1074/jbc.a113.707630","doi":"https://doi.org/10.1074/jbc.a113.707630","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.a113.707630","pdf_url":"http://www.jbc.org/article/S0021925820485965/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4240777609.pdf","grobid_xml":"https://content.openalex.org/works/W4240777609.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2012603856","https://openalex.org/W2155994626","https://openalex.org/W1971015803","https://openalex.org/W1799482251","https://openalex.org/W2044901017","https://openalex.org/W2093107388","https://openalex.org/W7095375503","https://openalex.org/W1968446972","https://openalex.org/W2154345732","https://openalex.org/W7097326404"],"abstract_inverted_index":{"VOLUME":[0],"283":[1],"(2008)":[2],"PAGES":[3],"3487\u20133496":[4],"The":[5,26,63,90,130,157,197],"\u201cExperimental":[6],"Procedures\u201d":[7],"and":[8,15,21,68,176,179,208,266],"\u201cResults\u201d":[9],"sections":[10],"contained":[11],"errors":[12],"in":[13,16],"nomenclature":[14],"references":[17],"to":[18,30,42,49,57,233,291],"specific":[19],"models":[20],"schemes,":[22],"respectively.":[23],"PAGE":[24,195],"3489:":[25],"following":[27,64,91,131,158,198],"sentence,":[28,65,92,132,159,199],"\u201cSimilar":[29],"the":[31,37,46,74,136,142,161,174,177,209,224,246,267,282,304,314,317],"traditional":[32],"mechanism":[33],"for":[34,215,273],"competitive":[35],"inhibition,":[36,167],"inhibitor":[38,69,104,110,140],"could":[39,70],"bind":[40],"only":[41,96,143],"free":[43],"enzyme":[44],"at":[45,218,245,276,303],"catalytic":[47,247,305],"site":[48,238,248,296,306],"yield":[50],"single-site":[51],"inhibition,\u201d":[52],"should":[53,79,119,146,184,254],"include":[54],"a":[55,202,229,260,287],"reference":[56,80,120,147,185],"model":[58,81,88,94,121,128,148,155,168,186,193],"1":[59],"of":[60,73,83,87,123,127,150,154,163,188,192,212,270,316,321],"Scheme":[61,84,124,151,189],"2.":[62,129],"\u201cBoth":[66],"substrate":[67,97,102,114],"alter":[71],"binding":[72,105,115],"other":[75],"molecule":[76,231,289],"(model":[77],"1),\u201d":[78],"2a":[82],"2":[85,125,152,190],"instead":[86,126,153,191],"1.":[89],"\u201cFor":[93],"2,":[95],"acted":[98],"allosterically,":[99],"such":[100],"that":[101],"affected":[103],"(Ki":[106],"\u2260":[107],"Ksi)":[108],"but":[109],"did":[111],"not":[112,312],"affect":[113],"(Ks":[116,239],"=":[117],"Kis),\u201d":[118],"2b":[122],"\u201cModel":[133],"3":[134],"described":[135],"alternative":[137],"possibility":[138],"wherein":[139],"was":[141,251],"allosteric":[144],"effector,\u201d":[145],"2c":[149],"3.":[156],"\u201cIn":[160],"absence":[162],"allosterism":[164],"(traditional":[165],"noncompetitive":[166],"4),":[169],"all":[170],"inhibition":[171],"constants":[172],"were":[173,182],"same":[175],"ESI":[178],"EIS":[180],"complexes":[181],"equivalent,\u201d":[183],"2d":[187],"4.":[194],"3490:":[196],"\u201cCYP2E1":[200,258],"demonstrated":[201,259],"relatively":[203,261],"low":[204,262],"Kss":[205],"(24":[206,264],"\u03bcm)":[207,265],"rapid":[210,268],"turnover":[211,269],"47":[213,271],"min\u22121":[214,272],"pNP;":[216,274],"nevertheless,":[217,275],"higher":[219,277],"pNP":[220,278],"concentrations":[221,279],"(>100":[222,280],"\u03bcm),":[223,241,281,299],"activity":[225,244,283,302],"gradually":[226,284],"decreased":[227,285],"as":[228,256,286],"second":[230,288],"bound":[232,290],"CYP2E1":[234,292],"through":[235,293],"an":[236,294],"effector":[237,295],"260":[240,298],"which":[242,300],"inhibited":[243,301],"(Table":[249,307],"3),\u201d":[250],"incorrect.":[252],"It":[253],"read":[255],"follows.":[257],"Km":[263],"(Kss":[297],"3).\u201d":[308],"These":[309],"corrections":[310],"do":[311],"change":[313],"interpretation":[315],"results":[318],"or":[319],"conclusions":[320],"this":[322],"article.":[323]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-12T00:00:00"}