{"id":"https://openalex.org/W4240718310","doi":"https://doi.org/10.1016/j.jalz.2016.06.610","title":"O4\u201001\u201005: Examining Amyloid and Tau Inter\u2010Regional Pet Association Patterns in Cognitively Normal Older Adults","display_name":"O4\u201001\u201005: Examining Amyloid and Tau Inter\u2010Regional Pet Association Patterns in Cognitively Normal Older Adults","publication_year":2016,"publication_date":"2016-07-01","ids":{"openalex":"https://openalex.org/W4240718310","doi":"https://doi.org/10.1016/j.jalz.2016.06.610"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2016.06.610","doi":"https://doi.org/10.1016/j.jalz.2016.06.610","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2016.06.610","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070112971","display_name":"Samuel Neal Lockhart","orcid":"https://orcid.org/0000-0002-0893-5420","observed_orcids":["https://orcid.org/0000-0002-0893-5420","https://orcid.org/0000-0002-1161-8346"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samuel N. Lockhart","raw_affiliation_strings":["University of California Berkeley, Berkeley, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075964502","display_name":"Michael Sch\u00f6ll","orcid":"https://orcid.org/0000-0001-7800-1781","observed_orcids":["https://orcid.org/0000-0001-7800-1781"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Michael Sch\u00f6ll","raw_affiliation_strings":["University of California Berkeley, Berkeley, CA, USA","University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040970254","display_name":"Taylor J. Mellinger","orcid":"https://orcid.org/0000-0003-2319-631X","observed_orcids":["https://orcid.org/0000-0003-2319-631X"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Taylor J. Mellinger","raw_affiliation_strings":["Lawrence Berkeley National Laboratory, Berkeley, CA, USA","University of California Berkeley, Berkeley, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratory, Berkeley, CA, USA","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"University of California Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044324912","display_name":"Kaitlin N. Swinnerton","orcid":"https://orcid.org/0000-0002-7429-9960","observed_orcids":["https://orcid.org/0000-0002-7429-9960"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlin N. Swinnerton","raw_affiliation_strings":["Lawrence Berkeley National Laboratory, Berkeley, CA, USA","University of California Berkeley, Berkeley, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratory, Berkeley, CA, USA","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"University of California Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064023762","display_name":"Rachel K. Bell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel K. Bell","raw_affiliation_strings":["University of California Berkeley, Berkeley, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035646156","display_name":"James P. O\u2019Neil","orcid":"https://orcid.org/0000-0002-4980-4240","observed_orcids":["https://orcid.org/0000-0002-4980-4240"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James P. O'Neil","raw_affiliation_strings":["Lawrence Berkeley National Laboratory, Berkeley, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratory, Berkeley, CA, USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029869725","display_name":"Mustafa Janabi","orcid":"https://orcid.org/0000-0003-0134-0317","observed_orcids":["https://orcid.org/0000-0003-0134-0317"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mustafa Janabi","raw_affiliation_strings":["Lawrence Berkeley National Laboratory, Berkeley, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratory, Berkeley, CA, USA","institution_ids":["https://openalex.org/I148283060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063801249","display_name":"Suzanne L. Baker","orcid":"https://orcid.org/0000-0003-0209-3127","observed_orcids":["https://orcid.org/0000-0003-0209-3127"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne L. Baker","raw_affiliation_strings":["Lawrence Berkeley National Laboratory, Berkeley, CA, USA","University of California Berkeley, Berkeley, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratory, Berkeley, CA, USA","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"University of California Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061269385","display_name":"William J. Jagust","orcid":"https://orcid.org/0000-0002-4458-113X","observed_orcids":["https://orcid.org/0000-0002-4458-113X"]},"institutions":[{"id":"https://openalex.org/I148283060","display_name":"Lawrence Berkeley National Laboratory","ror":"https://ror.org/02jbv0t02","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I148283060","https://openalex.org/I39565521"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William J. Jagust","raw_affiliation_strings":["Lawrence Berkeley National Laboratory, Berkeley, CA, USA","University of California Berkeley, Berkeley, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence Berkeley National Laboratory, Berkeley, CA, USA","institution_ids":["https://openalex.org/I148283060"]},{"raw_affiliation_string":"University of California Berkeley, Berkeley, CA, USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5070112971"],"corresponding_institution_ids":["https://openalex.org/I95457486"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.38629765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"7S_Part_6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9208999872207642,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.07649999856948853,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6790000200271606},{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.728243350982666},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5315176248550415},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.49076780676841736},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4667995572090149},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4417663812637329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4307449460029602},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.36744916439056396},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36198651790618896},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3254644274711609},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.23449772596359253},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.11846750974655151}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2016.06.610","doi":"https://doi.org/10.1016/j.jalz.2016.06.610","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2016.06.610","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.44999998807907104}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2539203521","https://openalex.org/W2590897488","https://openalex.org/W4241901102","https://openalex.org/W2332314885","https://openalex.org/W2461941736","https://openalex.org/W2594520623","https://openalex.org/W2756641284","https://openalex.org/W2414194418","https://openalex.org/W2290598353","https://openalex.org/W2341489896"],"abstract_inverted_index":{"\u03b2-amyloid":[0],"[A\u03b2]":[1],"and":[2,24,48,81,90,121,131,147,159,169,188,193,315,321,338,355],"tau":[3,25,316,356,384],"pathology":[4],"become":[5],"increasingly":[6],"prevalent":[7],"with":[8,52,108,207,343],"age;":[9],"however,":[10],"the":[11,15,53,351,365],"spatial":[12],"relationship":[13],"between":[14,185,353],"two":[16],"pathologies":[17],"remains":[18],"unknown.":[19],"In":[20,331,349],"vivo":[21],"amyloid":[22],"(PiB)":[23],"(AV-1451)":[26],"PET":[27,89],"enable":[28],"examination":[29],"of":[30,55,128,204,234,367,376,387],"regional":[31,57,205,374],"pathological":[32],"associations":[33,172,203,326],"in":[34,39,59,190,262,271,281],"cognitively":[35,63,328],"normal":[36,64,329],"elderly":[37],"potentially":[38],"preclinical":[40],"Alzheimer\u2019s":[41],"disease.":[42],"We":[43,115,137,197],"examined":[44,138,276],"cross-sectional":[45],"inter-regional":[46,152,250,300,308],"PiB":[47,122,135,206,221,235,261,320,334],"AV-1451":[49,120,187,209,213,226,270,322,347],"association":[50,153],"patterns,":[51],"aim":[54],"characterizing":[56],"specificity":[58],"PiB\u2014AV-1451":[60,142,171,249,299,307],"relations.":[61],"43":[62],"older":[65],"adults":[66],"(78.70":[67],"\u00b1":[68,97,103],"5.2":[69],"y,":[70],"30":[71],"female)":[72],"received":[73],"18F-AV-1451":[74],"(80-100":[75],"min":[76,84],"SUVR,":[77],"cerebellar":[78,86],"grey":[79,87],"ref.)":[80,88],"11C-PiB":[82],"(35-90":[83],"DVR,":[85],"1.5T":[91],"magnetic":[92],"resonance":[93],"imaging":[94],"(MRI;":[95],"80.58":[96],"112.6":[98],"d":[99,105],"AV-1451\u2014PiB":[100],"difference;":[101],"98.95":[102],"119.7":[104],"AV-1451\u2014MRI":[106],"difference),":[107],"images":[109],"transformed":[110],"to":[111,149,361,383],"a":[112,132,244,373],"common":[113],"space.":[114,284],"calculated":[116],"each":[117],"subject\u2019s":[118],"mean":[119],"uptake":[123,216,335],"values":[124,304],"within":[125,337],"87":[126],"regions":[127,379],"interest":[129],"(ROI),":[130],"global":[133,160,267],"cortical":[134,195],"value.":[136],"all":[139],"pairwise":[140],"ROI":[141,165,222,236,256,264,273],"partial":[143,181,251,257,301,309],"correlations":[144,182,230,258,352],"for":[145,156],"strength":[146],"significance":[148],"identify":[150],"inter-tracer,":[151],"patterns":[154],"(covaried":[155],"age,":[157,291],"sex,":[158,292],"gray":[161,295],"matter":[162],"volume).":[163],"Pairwise":[164,255],"analysis":[166],"demonstrated":[167],"positive":[168,180,202],"negative":[170],"(Figure":[173,210,247],"1).":[174],"Importantly,":[175],"strong":[176,229],"(p":[177],"<":[178],".01)":[179],"were":[183,231,241],"identified":[184],"temporal":[186,192,340,345,381],"PIB":[189],"extensive":[191],"extra-temporal":[194],"ROIs.":[196],"also":[198],"found":[199],"less":[200],"frequent":[201],"frontoparietal":[208],"2).":[211],"For":[212],"ROIs":[214],"where":[215,388],"was":[217],"strongly":[218],"predicted":[219,269],"by":[220,305,364],"(e.g.,":[223],"temporal,":[224],"frontal":[225],"uptake),":[227],"these":[228],"present":[232],"regardless":[233,386],"location.":[237],"Overall":[238],"correlation":[239,252,302,310],"strengths":[240],"visualized":[242],"on":[243],"brain":[245,294,378],"template":[246],"3).":[248],"(r)":[253,303],"values.":[254],"investigating":[259],"whether":[260],"any":[263,272],"(y-axis,":[265],"plus":[266],"PiB)":[268],"(x-axis).":[274],"Data":[275],"using":[277,319],"in-house":[278],"FreeSurfer-based":[279],"atlas":[280],"MNI":[282],"2mm":[283],"DV":[285],"=":[286,289],"AV-1451,":[287],"IVs":[288],"PiB,":[290],"total":[293],"matter.":[296],"Mean":[297],"significant":[298,325],"lobe.":[306],"lobar":[311],"summary":[312],"figure.":[313],"A\u03b2":[314,354,368,389],"pathology,":[317],"measured":[318],"PET,":[323],"show":[324],"among":[327],"elderly.":[330],"particular,":[332],"increased":[333,344],"both":[336],"outside":[339],"lobes":[341],"correlates":[342],"lobe":[346],"uptake.":[348],"addition,":[350],"accumulation":[357,385],"do":[358],"not":[359],"appear":[360],"be":[362],"explained":[363],"location":[366],"accumulation.":[369],"These":[370],"results":[371],"suggest":[372],"vulnerability":[375],"certain":[377],"(e.g.":[380],"lobe)":[382],"accumulates.":[390]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}