{"id":"https://openalex.org/W4240636458","doi":"https://doi.org/10.1158/1538-7445.sabcs18-506","title":"Abstract 506: Wnt/\u00e2-Catenin pathway inhibitor RXC004 enhances the immunity of pre-clinical models of cancer","display_name":"Abstract 506: Wnt/\u00e2-Catenin pathway inhibitor RXC004 enhances the immunity of pre-clinical models of cancer","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4240636458","doi":"https://doi.org/10.1158/1538-7445.sabcs18-506"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-506","doi":"https://doi.org/10.1158/1538-7445.sabcs18-506","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-506","pdf_url":null,"source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Caroline Phillips","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Caroline Phillips","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082399428","display_name":"Inder Bhamra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Inder Bhamra","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063198530","display_name":"Catherine Eagle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Catherine Eagle","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045023434","display_name":"Alicia Edmenson Cook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alicia Edmenson Cook","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Cliff Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cliff Jones","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003246050","display_name":"Simon A. Woodcock","orcid":"https://orcid.org/0000-0001-7363-757X","observed_orcids":["https://orcid.org/0000-0001-7363-757X"]},"institutions":[{"id":"https://openalex.org/I4210162142","display_name":"Redx Pharma (United Kingdom)","ror":"https://ror.org/04wysdg63","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210162142"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Simon Woodcock","raw_affiliation_strings":["Redx Pharma, Macclesfield, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Redx Pharma, Macclesfield, United Kingdom","institution_ids":["https://openalex.org/I4210162142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210162142"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"506","last_page":"506"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.7470999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.7470999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.23929999768733978,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcupine-inhibitor","display_name":"porcupine inhibitor","score":0.8880000114440918},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7649999856948853},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9150000214576721},{"id":"https://openalex.org/keywords/myeloid-derived-suppressor-cells","display_name":"myeloid-derived suppressor cells","score":0.875},{"id":"https://openalex.org/keywords/b16f10-melanoma","display_name":"B16F10 melanoma","score":0.9210000038146973},{"id":"https://openalex.org/keywords/cxcl9","display_name":"CXCL9","score":0.8759999871253967},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cd103","display_name":"CD103","score":0.6290000081062317},{"id":"https://openalex.org/keywords/tumor-associated-macrophages","display_name":"tumor-associated macrophages","score":0.574999988079071},{"id":"https://openalex.org/keywords/mhc-class-i","display_name":"MHC class I","score":0.40799999237060547},{"id":"https://openalex.org/keywords/tumor-associated-neutrophils","display_name":"tumor-associated neutrophils","score":0.4779999852180481},{"id":"https://openalex.org/keywords/chemokine-signaling","display_name":"chemokine signaling","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8059330582618713},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5226231217384338},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5060228705406189},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5003025531768799},{"id":"https://openalex.org/C30145163","wikidata":"https://www.wikidata.org/wiki/Q384104","display_name":"Catenin","level":4,"score":0.4415881037712097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3705592155456543},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2566350996494293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23504889011383057},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21879270672798157},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.20757794380187988},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.18449601531028748},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17851310968399048}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-506","doi":"https://doi.org/10.1158/1538-7445.sabcs18-506","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-506","pdf_url":null,"source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2885208058","https://openalex.org/W4290803731","https://openalex.org/W2956140870","https://openalex.org/W3178579248","https://openalex.org/W4308383995","https://openalex.org/W3202221618","https://openalex.org/W4362541190","https://openalex.org/W4393988384","https://openalex.org/W4281858602","https://openalex.org/W2890507523"],"abstract_inverted_index":{"Background:":[0],"RXC004,":[1],"a":[2,17,64,142,152,180,262,317,328],"potent":[3],"and":[4,19,47,76,85,122,129,164,186,280,308,397,408,411],"selective":[5],"inhibitor":[6,437],"of":[7,43,74,78,97,141,144,154,194,231,254,261,264,278,310,319,330,340,357,391,402,442,445,450],"the":[8,34,40,44,95,109,116,127,137,168,219,229,242,258,285,289,305,346,381,400,403,440,451],"Wnt/\u03b2-Catenin":[9],"pathway":[10,246,250,374,436],"regulator":[11],"porcupine,":[12],"is":[13,212,295,314],"being":[14],"investigated":[15],"in":[16,22,38,69,102,108,126,151,179,209,234,241,284,304,360],"safety":[18],"tolerability":[20],"study":[21],"cancer":[23,158,334,395,446],"patients":[24],"with":[25,222,343],"solid":[26],"tumors":[27,344,385],"(NCT03447470).":[28],"We":[29],"present":[30],"pre-clinical":[31,443],"data":[32],"confirming":[33],"potential":[35],"for":[36,82,454],"RXC004":[37,51,79,101,148,173,195,207,224,272,336,377,438],"modulating":[39],"immune":[41,98,123,265,347,382],"system":[42,348],"tumor":[45,90,110,177],"microenvironment.Materials":[46],"Methods:":[48],"To":[49,92],"evaluate":[50],"as":[52,288],"an":[53,366],"immunomodulatory":[54],"anti-cancer":[55],"agent":[56],"we":[57],"took":[58],"two":[59],"complementary":[60],"approaches;":[61],"first":[62],"utilizing":[63],"syngeneic":[65,103,169],"B16F10":[66,170],"melanoma":[67,171],"model":[68,211],"C57BL/6":[70],"mice.":[71],"A":[72],"range":[73,143],"doses":[75],"schedules":[77],"were":[80,131,353],"tested":[81],"28":[83],"days":[84,198,201],"efficacy":[86],"was":[87,113,149],"measured":[88],"by":[89,100,133,147,300,376,386,405],"volume.":[91],"further":[93],"probe":[94],"mechanism":[96],"modulation":[99,140],"models,":[104],"global":[105],"gene":[106,120,165],"expression":[107,277,351],"microenvironment":[111],"(TME)":[112],"analyzed":[114,132],"using":[115,161,267],"Nanostring":[117,268],"IO":[118,269],"360":[119,270],"set,":[121],"cell":[124,159,291,321],"populations":[125],"blood":[128],"spleen":[130],"flow":[134,162],"cytometry.":[135],"In":[136,167,190,327],"second":[138],"approach,":[139],"immune-relevant":[145,392],"biomarkers":[146],"assessed":[150],"panel":[153,263,329],"Wnt":[155,245,249,331,373],"ligand-dependent":[156,332],"human":[157,333],"lines":[160],"cytometry":[163],"expression.Results:":[166],"model,":[172],"treatment":[174,208,225,273,337,378],"significantly":[175],"reduced":[176,354],"volume":[178],"dose-dependent":[181],"manner":[182],"at":[183],"0.5,":[184],"1.5":[185],"5":[187,197],"mg/kg":[188],"QD.":[189],"addition,":[191],"5mg/kg":[192],"QD":[193],"scheduled":[196],"on,":[199],"2":[200],"off":[202],"also":[203],"gave":[204],"significant":[205],"efficacy.":[206],"this":[210],"known":[213],"to":[214,257,297,316,369],"decrease":[215],"myeloid-derived-suppressor-cells":[216],"(MDSCs)":[217],"within":[218],"TME.":[220,259],"Consistent":[221],"this,":[223],"(5mg/kg":[226,274],"QD)":[227,275],"increased":[228,276],"proportion":[230],"MDSCs":[232,236,407],"circulating":[233],"blood.":[235],"are":[237],"therefore":[238],"either":[239],"retained":[240],"TME":[243,307,404],"through":[244],"signaling,":[247],"or":[248],"signaling":[251,282],"promotes":[252],"chemotaxis":[253],"these":[255,311],"cells":[256,303,313],"Analysis":[260],"genes":[266],"demonstrated":[271],"chemokine":[279,410],"cytokine":[281,412],"components":[283],"TME,":[286],"such":[287,358],"T":[290,320],"chemoattractant":[292],"CXCL9.":[293],"CXCL9":[294],"reported":[296],"be":[298],"produced":[299],"CD103+ve":[301],"dendritic":[302,312],"mouse":[306],"absence":[309],"linked":[315],"lack":[318],"infiltrate":[322],"(Spranger":[323],"et":[324,414],"al.,":[325],"2017).":[326],"cells,":[335,396],"regulated":[338],"levels":[339,352,390],"markers":[341,359,393],"associated":[342],"evading":[345],"e.g.":[349],"MYC":[350],"significantly.":[355],"Modulation":[356],"paired":[361],"clinical":[362],"sample":[363],"may":[364],"indicate":[365],"immune-modulatory":[367],"response":[368,383],"RXC004.Conclusion:":[370],"Taken":[371],"together,":[372],"suppression":[375],"can":[379],"enhance":[380],"against":[384],"1)":[387],"directly":[388],"regulating":[389],"on":[394],"2)":[398],"enhancing":[399],"immunity":[401,441],"decreasing":[406],"increasing":[409],"signaling.Spranger":[413],"al":[415],"Cancer":[416,455,469],"Cell":[417],"2017":[418],"8":[419],"31(5):711-723Citation":[420],"Format:":[421],"Caroline":[422],"Phillips,":[423],"Inder":[424],"Bhamra,":[425],"Catherine":[426],"Eagle,":[427],"Alicia":[428],"Edmenson":[429],"Cook,":[430],"Cliff":[431],"Jones,":[432],"Simon":[433],"Woodcock.":[434],"Wnt/\u00e2-Catenin":[435],"enhances":[439],"models":[444],"[abstract].":[447],"In:":[448],"Proceedings":[449],"American":[452],"Association":[453],"Research":[456],"Annual":[457],"Meeting":[458],"2019;":[459],"2019":[460],"Mar":[461],"29-Apr":[462],"3;":[463],"Atlanta,":[464],"GA.":[465],"Philadelphia":[466],"(PA):":[467],"AACR;":[468],"Res":[470],"2019;79(13":[471],"Suppl):Abstract":[472],"nr":[473],"506.":[474]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-05-12T00:00:00"}
