{"id":"https://openalex.org/W4240470734","doi":"https://doi.org/10.21203/rs.2.503/v1","title":"Effect of acupuncture on menopausal vasomotor symptoms (VMS): A study protocol for a randomized controlled clinical trial","display_name":"Effect of acupuncture on menopausal vasomotor symptoms (VMS): A study protocol for a randomized controlled clinical trial","publication_year":2019,"publication_date":"2019-03-28","ids":{"openalex":"https://openalex.org/W4240470734","doi":"https://doi.org/10.21203/rs.2.503/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.2.503/v1","doi":"https://doi.org/10.21203/rs.2.503/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.503/v1","pdf_url":"https://www.researchsquare.com/article/rs-502/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-502/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047427257","display_name":"Anna Bogachko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135988","display_name":"Shanghai Traditional Chinese Medicine Hospital","ror":"https://ror.org/03p31hk68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135988"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anna Bogachko","raw_affiliation_strings":["Shanghai Municipal Hospital of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Municipal Hospital of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210135988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100371488","display_name":"Shanshan Li","orcid":"https://orcid.org/0000-0002-5466-2152","observed_orcids":["https://orcid.org/0000-0002-5466-2152"]},"institutions":[{"id":"https://openalex.org/I4210135988","display_name":"Shanghai Traditional Chinese Medicine Hospital","ror":"https://ror.org/03p31hk68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135988"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Li","raw_affiliation_strings":["Shanghai Municipal Hospital of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Municipal Hospital of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210135988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345567","display_name":"Tian Li","orcid":"https://orcid.org/0000-0002-8281-4459","observed_orcids":["https://orcid.org/0000-0002-8281-4459","https://orcid.org/0000-0002-1444-832X"]},"institutions":[{"id":"https://openalex.org/I4210135988","display_name":"Shanghai Traditional Chinese Medicine Hospital","ror":"https://ror.org/03p31hk68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135988"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tian Li","raw_affiliation_strings":["Shanghai Municipal Hospital of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Municipal Hospital of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210135988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042341275","display_name":"Xuan Yin","orcid":"https://orcid.org/0000-0002-0173-5936","observed_orcids":["https://orcid.org/0000-0002-0173-5936"]},"institutions":[{"id":"https://openalex.org/I4210135988","display_name":"Shanghai Traditional Chinese Medicine Hospital","ror":"https://ror.org/03p31hk68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135988"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Yin","raw_affiliation_strings":["Shanghai Municipal Hospital of Traditional Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Municipal Hospital of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210135988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011626848","display_name":"Ping Yin","orcid":"https://orcid.org/0000-0003-0869-3772","observed_orcids":["https://orcid.org/0000-0003-0869-3772"]},"institutions":[{"id":"https://openalex.org/I4210135988","display_name":"Shanghai Traditional Chinese Medicine Hospital","ror":"https://ror.org/03p31hk68","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210135988"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Yin","raw_affiliation_strings":["Shanghai Municipal Hospital of Traditional Chinese Medicine","Shanghai Municipal Hospital of Traditional Chinese Medicine Lixing Lao University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Municipal Hospital of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210135988"]},{"raw_affiliation_string":"Shanghai Municipal Hospital of Traditional Chinese Medicine Lixing Lao University of Hong Kong","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015198590","display_name":"Lixing Lao","orcid":"https://orcid.org/0000-0003-0198-9714","observed_orcids":["https://orcid.org/0000-0003-0198-9714"]},"institutions":[{"id":"https://openalex.org/I889458895","display_name":"University of Hong Kong","ror":"https://ror.org/02zhqgq86","country_code":"HK","type":"education","lineage":["https://openalex.org/I889458895"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Lixing Lao","raw_affiliation_strings":["University of Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hong Kong","institution_ids":["https://openalex.org/I889458895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007588331","display_name":"Shifen Xu","orcid":"https://orcid.org/0000-0001-5595-3480","observed_orcids":["https://orcid.org/0000-0001-5595-3480"]},"institutions":[{"id":"https://openalex.org/I4210098460","display_name":"Shanghai University of Traditional Chinese Medicine","ror":"https://ror.org/00z27jk27","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210098460"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shifen Xu","raw_affiliation_strings":["Shanghai Municipal Hospital of Traditonal Chinese Medicine, Shanghai University of Traditional Chinese Medicine"],"raw_orcid":"https://orcid.org/0000-0001-5595-3480","affiliations":[{"raw_affiliation_string":"Shanghai Municipal Hospital of Traditonal Chinese Medicine, Shanghai University of Traditional Chinese Medicine","institution_ids":["https://openalex.org/I4210098460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acupuncture","display_name":"acupuncture","score":1.0},{"id":"https://openalex.org/keywords/menopausal-vasomotor-symptoms","display_name":"menopausal vasomotor symptoms","score":0.9229999780654907},{"id":"https://openalex.org/keywords/hot-flashes","display_name":"hot flashes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/night-sweats","display_name":"night sweats","score":0.9950000047683716},{"id":"https://openalex.org/keywords/menopause","display_name":"menopause","score":0.7490000128746033},{"id":"https://openalex.org/keywords/syndrome-differentiation","display_name":"syndrome differentiation","score":0.8899999856948853},{"id":"https://openalex.org/keywords/traditional-chinese-medicine","display_name":"traditional Chinese medicine","score":0.8180000185966492},{"id":"https://openalex.org/keywords/menqol","display_name":"MENQOL","score":0.8700000047683716},{"id":"https://openalex.org/keywords/hormone-therapy-alternatives","display_name":"hormone therapy alternatives","score":0.6869999766349792},{"id":"https://openalex.org/keywords/antidepressant-alternatives","display_name":"antidepressant alternatives","score":0.6729999780654907}],"concepts":[{"id":"https://openalex.org/C2776214587","wikidata":"https://www.wikidata.org/wiki/Q3430227","display_name":"Vasomotor","level":2,"score":0.857135534286499},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.827430248260498},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.684765100479126},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.650700569152832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6461964249610901},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.42878013849258423},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26719504594802856},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.2023257315158844},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.047776639461517334}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.2.503/v1","doi":"https://doi.org/10.21203/rs.2.503/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.503/v1","pdf_url":"https://www.researchsquare.com/article/rs-502/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.2.503/v1","doi":"https://doi.org/10.21203/rs.2.503/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.503/v1","pdf_url":"https://www.researchsquare.com/article/rs-502/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/study-protocol","display_name":"Study Protocol"}],"awards":[{"id":"https://openalex.org/G1902889393","display_name":null,"funder_award_id":"201640026","funder_id":"https://openalex.org/F4320325338","funder_display_name":"Shanghai Hospital Development Center"},{"id":"https://openalex.org/G2215579450","display_name":null,"funder_award_id":"JDZX2015024","funder_id":"https://openalex.org/F4320323484","funder_display_name":"State Administration of Traditional Chinese Medicine of the People's Republic of China"},{"id":"https://openalex.org/G3393495781","display_name":null,"funder_award_id":"SHDC12016124","funder_id":"https://openalex.org/F4320325338","funder_display_name":"Shanghai Hospital Development Center"}],"funders":[{"id":"https://openalex.org/F4320323484","display_name":"State Administration of Traditional Chinese Medicine of the People's Republic of China","ror":"https://ror.org/003cpqh10"},{"id":"https://openalex.org/F4320325338","display_name":"Shanghai Hospital Development Center","ror":"https://ror.org/02zrtve16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4240470734.pdf","grobid_xml":"https://content.openalex.org/works/W4240470734.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2081175041","https://openalex.org/W2117920697","https://openalex.org/W2143039964","https://openalex.org/W2331798914","https://openalex.org/W2519047305","https://openalex.org/W6808472500"],"related_works":["https://openalex.org/W2143039964","https://openalex.org/W2781846570","https://openalex.org/W2331798914","https://openalex.org/W2081175041","https://openalex.org/W7098611212","https://openalex.org/W1966066015","https://openalex.org/W2077063764","https://openalex.org/W3083319549","https://openalex.org/W3183253374","https://openalex.org/W2473410693"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"During":[2],"menopause,":[3],"many":[4],"women":[5,148,179],"are":[6,31],"troubled":[7],"by":[8,263],"vasomotor":[9],"symptoms":[10],"(VMS)":[11],"when":[12],"hot":[13],"flashes,":[14],"night":[15],"sweats,":[16],"or":[17],"both,":[18],"interfere":[19],"with":[20,136,156],"normal":[21],"daily":[22],"life.":[23],"Both":[24],"hormone":[25],"therapy":[26],"(HT)":[27],"and":[28,47,62,92,117,153,158,188,206,259,279,293],"taking":[29],"antidepressants":[30],"common":[32],"ways":[33],"to":[34,53,59,80,105,120,140,275,283,295],"reduce":[35,60,89,284],"VMS":[36,61,95,197,224,285],"but":[37],"they":[38,236],"have":[39,65],"associated":[40],"health":[41],"risks":[42],"such":[43],"as":[44,113,210],"breast":[45],"cancer":[46],"thromboembolic":[48],"events.":[49],"Acupuncture":[50],"is":[51,129,234],"found":[52],"be":[54,164,255,276],"a":[55,101,110,114,130,171,246],"safe":[56,280],"treatment":[57,193],"option":[58],"recent":[63],"studies":[64],"demonstrated":[66],"positive":[67],"results":[68],"applying":[69],"personalized":[70],"selections":[71],"of":[72,85,94,144,177,222,227,251,270],"acupuncture":[73,145,175,186,243,274,299],"points.":[74],"Hence,":[75],"we":[76,189,289],"hypothesize":[77],"acupuncture,":[78],"according":[79],"Chinese":[81,154],"Medicine's":[82],"basic":[83],"principle":[84],"pattern":[86,118],"differentiation,":[87],"can":[88],"both":[90],"frequency":[91],"severity":[93],"in":[96,146,149,286],"menopausal":[97,287],"women.":[98],"We":[99],"designed":[100],"randomized":[102,133],"controlled":[103],"trial":[104,135],"test":[106],"the":[107,142,150,219,230,239,268],"hypothesis":[108],"using":[109],"wait-list":[111],"group":[112,116,176,216],"control":[115,134,215],"differentiation":[119],"find":[121,297],"an":[122,277],"optimal":[123,298],"therapeutic":[124],"treatment.":[125,244],"Method/Design":[126],"The":[127],"study":[128,272],"single-center,":[131],"pragmatic,":[132],"two":[137,168],"parallel":[138],"arms,":[139],"assess":[141],"effectiveness":[143],"60":[147],"Shanghai":[151],"international":[152],"community":[155],"peri-":[157],"postmenopausal":[159],"VMS.":[160],"Eligible":[161],"participants":[162],"will":[163,180,190,217,237,254],"randomly":[165],"assigned":[166],"into":[167],"groups":[169],"on":[170],"ratio":[172],"1:1.":[173],"An":[174],"30":[178],"twice":[181,207,260],"weekly":[182],"receive":[183,238],"totally":[184],"12":[185,241],"treatments":[187],"follow":[191],"their":[192,196,223],"response":[194],"through":[195],"self-rating":[198],"journal":[199],"entries":[200],"recorded":[201],"at":[202,257],"baseline,":[203],"during":[204],"intervention":[205,209,262],"post":[208,261],"primary":[211],"outcome.":[212],"A":[213],"waitlisted":[214],"record":[218],"same":[220,240],"self-ratings":[221],"for":[225],"purposes":[226],"comparison.":[228],"After":[229],"six-week":[231],"wait":[232],"period":[233],"over,":[235],"sessions":[242],"As":[245],"second":[247],"outcome,":[248],"menopause-specific":[249],"quality":[250],"life":[252],"indicators":[253],"assessed":[256],"baseline":[258],"all":[264],"participants.":[265],"Discussion":[266],"If":[267],"outcome":[269],"this":[271],"confirms":[273],"effective":[278],"management":[281],"method":[282],"women,":[288],"expect":[290],"further":[291],"investigations":[292],"trials":[294],"clinically":[296],"treating":[300],"strategies.":[301]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}