{"id":"https://openalex.org/W4240469607","doi":"https://doi.org/10.1007/s10803-020-04709-8","title":"Bumetanide Oral Liquid Formulation for the Treatment of Children and Adolescents with Autism Spectrum Disorder: Design of Two Phase III Studies (SIGN Trials)","display_name":"Bumetanide Oral Liquid Formulation for the Treatment of Children and Adolescents with Autism Spectrum Disorder: Design of Two Phase III Studies (SIGN Trials)","publication_year":2020,"publication_date":"2020-11-05","ids":{"openalex":"https://openalex.org/W4240469607","doi":"https://doi.org/10.1007/s10803-020-04709-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/33151500","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8254707"},"language":"en","primary_location":{"id":"doi:10.1007/s10803-020-04709-8","doi":"https://doi.org/10.1007/s10803-020-04709-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10803-020-04709-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10803-020-04709-8.pdf","source":{"id":"https://openalex.org/S181451930","display_name":"Journal of Autism and Developmental Disorders","issn_l":"0162-3257","issn":["0162-3257","1573-3432"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Autism and Developmental Disorders","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10803-020-04709-8.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032044129","display_name":"V\u00e9ronique Crutel","orcid":"https://orcid.org/0000-0003-0261-0999","observed_orcids":["https://orcid.org/0000-0003-0261-0999"]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Crutel","raw_affiliation_strings":["Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Estelle Lambert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Estelle Lambert","raw_affiliation_strings":["Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033440471","display_name":"Pierre\u2010Fran\u00e7ois P\u00e9n\u00e9laud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre-Fran\u00e7ois Penelaud","raw_affiliation_strings":["Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060002548","display_name":"Cristina Albarr\u00e1n Severo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cristina Albarr\u00e1n Severo","raw_affiliation_strings":["Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029534973","display_name":"Joaqu\u00edn Fuentes","orcid":"https://orcid.org/0000-0001-5488-5543","observed_orcids":["https://orcid.org/0000-0001-5488-5543"]},"institutions":[{"id":"https://openalex.org/I4210121184","display_name":"Policl\u00ednica Gipuzkoa","ror":"https://ror.org/02rjkjw28","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210121184"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Joaquin Fuentes","raw_affiliation_strings":["Child & Adolescent Psychiatry Service, Policl\u00ednica Gipuzkoa & GAUTENA Autism Society, San Sebasti\u00e1n, Spain"],"raw_orcid":"https://orcid.org/0000-0001-5488-5543","affiliations":[{"raw_affiliation_string":"Child & Adolescent Psychiatry Service, Policl\u00ednica Gipuzkoa & GAUTENA Autism Society, San Sebasti\u00e1n, Spain","institution_ids":["https://openalex.org/I4210121184"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032277016","display_name":"Antoine Rosier","orcid":"https://orcid.org/0000-0002-9286-9699","observed_orcids":["https://orcid.org/0000-0002-9286-9699"]},"institutions":[{"id":"https://openalex.org/I4210126133","display_name":"Centre Hospitalier du Rouvray","ror":"https://ror.org/02y92d036","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210126133"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Antoine Rosier","raw_affiliation_strings":["Department of Neonatal Pediatrics, CHU de Rouen and CHU Le Rouvray, Sotteville les Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatal Pediatrics, CHU de Rouen and CHU Le Rouvray, Sotteville les Rouen, France","institution_ids":["https://openalex.org/I4210126133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084236833","display_name":"Amaia Hervas G","orcid":"https://orcid.org/0000-0003-0051-5752","observed_orcids":["https://orcid.org/0000-0003-0051-5752"]},"institutions":[{"id":"https://openalex.org/I4210096566","display_name":"University Hospital M\u00fatua de Terrassa","ror":"https://ror.org/011335j04","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210096566","https://openalex.org/I4210130102"]},{"id":"https://openalex.org/I4210130102","display_name":"M\u00fatua Terrassa","ror":"https://ror.org/02h74qa12","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210130102"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Amaia Herv\u00e1s","raw_affiliation_strings":["Child and Adolescent Mental Health Service, Hospital Universitari M\u00fatua de Terrassa, and Global Institute of Neurodevelopment Integrated Care (IGAIN), Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Child and Adolescent Mental Health Service, Hospital Universitari M\u00fatua de Terrassa, and Global Institute of Neurodevelopment Integrated Care (IGAIN), Barcelona, Spain","institution_ids":["https://openalex.org/I4210096566","https://openalex.org/I4210130102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023247351","display_name":"St\u00e9phane Marret","orcid":"https://orcid.org/0000-0002-2858-148X","observed_orcids":["https://orcid.org/0000-0002-2858-148X"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210154623","display_name":"Centre Hospitalier Universitaire de Rouen","ror":"https://ror.org/04cdk4t75","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210154623"]},{"id":"https://openalex.org/I62396329","display_name":"Universit\u00e9 de Rouen Normandie","ror":"https://ror.org/03nhjew95","country_code":"FR","type":"education","lineage":["https://openalex.org/I4210105918","https://openalex.org/I62396329"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Marret","raw_affiliation_strings":["Department of Neonatal Pediatrics, Intensive Care, and Neuropediatrics, Rouen University Hospital, Rouen, France","INSERM U 1245 team 4 Neovasc, School of Medicine, Normandy University, Rouen, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neonatal Pediatrics, Intensive Care, and Neuropediatrics, Rouen University Hospital, Rouen, France","institution_ids":["https://openalex.org/I4210154623"]},{"raw_affiliation_string":"INSERM U 1245 team 4 Neovasc, School of Medicine, Normandy University, Rouen, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I62396329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030071878","display_name":"Guiomar Oliveira","orcid":"https://orcid.org/0000-0002-7049-1277","observed_orcids":["https://orcid.org/0000-0002-7049-1277"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Guiomar Oliveira","raw_affiliation_strings":["Faculty of Medicine, University Clinic of Pediatrics, University of Coimbra, Coimbra, Portugal","Neurodevelopmental and Autism Unit from Child Developmental Center and Centro de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Cl\u00ednica, Hospital Pedi\u00e1trico, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, University Clinic of Pediatrics, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Neurodevelopmental and Autism Unit from Child Developmental Center and Centro de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Cl\u00ednica, Hospital Pedi\u00e1trico, Centro Hospitalar e Universit\u00e1rio de Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027816426","display_name":"Mara Parellada","orcid":"https://orcid.org/0000-0001-7977-3601","observed_orcids":["https://orcid.org/0000-0001-7977-3601"]},"institutions":[{"id":"https://openalex.org/I2960094004","display_name":"Hospital General Universitario Gregorio Mara\u00f1\u00f3n","ror":"https://ror.org/0111es613","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2960094004","https://openalex.org/I4210139293"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mara Parellada","raw_affiliation_strings":["Servicio de Psiquiatr\u00eda del Ni\u00f1o y del Adolescente Hospital General Universitario Gregorio Mara\u00f1\u00f3n, CIBERSAM, IiSGM, Ibiza 43, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servicio de Psiquiatr\u00eda del Ni\u00f1o y del Adolescente Hospital General Universitario Gregorio Mara\u00f1\u00f3n, CIBERSAM, IiSGM, Ibiza 43, Madrid, Spain","institution_ids":["https://openalex.org/I2960094004","https://openalex.org/I4210090703"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027496019","display_name":"Simon Kyaga","orcid":"https://orcid.org/0000-0003-2985-6403","observed_orcids":["https://orcid.org/0000-0003-2985-6403"]},"institutions":[{"id":"https://openalex.org/I4210135308","display_name":"Servier (France)","ror":"https://ror.org/034e7c066","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210135308"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Simon Kyaga","raw_affiliation_strings":["Global Medical and Patient Affairs, Servier, 35 rue de Verdun, 92284, Suresnes cedex, Suresnes, France. simon.kyaga@servier.com","Global Medical and Patient Affairs, Servier, 35 rue de Verdun, 92284, Suresnes cedex, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Medical and Patient Affairs, Servier, 35 rue de Verdun, 92284, Suresnes cedex, Suresnes, France. simon.kyaga@servier.com","institution_ids":["https://openalex.org/I4210135308"]},{"raw_affiliation_string":"Global Medical and Patient Affairs, Servier, 35 rue de Verdun, 92284, Suresnes cedex, Suresnes, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001651767","display_name":"Sylvie Gouttefangeas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sylvie Gouttefangeas","raw_affiliation_strings":["Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Marianne Bertrand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268767","display_name":"Institut de Recherches Internationales Servier (France)","ror":"https://ror.org/01zej3n42","country_code":"FR","type":"company","lineage":["https://openalex.org/I4405268767"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marianne Bertrand","raw_affiliation_strings":["Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuro Immuno-Inflammation Therapeutic Area, Institut de Recherches Internationales Servier, Suresnes, France","institution_ids":["https://openalex.org/I4405268767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030903371","display_name":"Denis Ravel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162836","display_name":"Neurochlore (France)","ror":"https://ror.org/05dngkv23","country_code":"FR","type":"company","lineage":["https://openalex.org/I4210162836"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Denis Ravel","raw_affiliation_strings":["Neurochlore, Marseille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurochlore, Marseille, France","institution_ids":["https://openalex.org/I4210162836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026960163","display_name":"Bruno Falissard","orcid":"https://orcid.org/0000-0002-2418-4954","observed_orcids":["https://orcid.org/0000-0002-2418-4954"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159"]},{"id":"https://openalex.org/I4387156284","display_name":"Universit\u00e9 Paris Descartes","ror":"https://ror.org/0220k9r37","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387156284"]},{"id":"https://openalex.org/I4405258679","display_name":"Sant\u00e9 mentale et sant\u00e9 publique","ror":"https://ror.org/012asnv87","country_code":"FR","type":"facility","lineage":["https://openalex.org/I277688954","https://openalex.org/I4405258679"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Bruno Falissard","raw_affiliation_strings":["University Paris-Sud, Univ. Paris-Descartes, AP-HP, INSERM U1178, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Paris-Sud, Univ. Paris-Descartes, AP-HP, INSERM U1178, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210097159","https://openalex.org/I4387156284","https://openalex.org/I4405258679"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5027496019"],"corresponding_institution_ids":["https://openalex.org/I4210135308"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":{"value":2750,"currency":"USD","value_usd":2750},"fwci":2.8672,"has_fulltext":true,"cited_by_count":32,"citation_normalized_percentile":{"value":0.91583483,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"51","issue":"8","first_page":"2959","last_page":"2972"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13393","display_name":"Child Nutrition and Feeding Issues","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bumetanide","display_name":"bumetanide","score":0.9800000190734863},{"id":"https://openalex.org/keywords/autism-spectrum-disorder","display_name":"autism spectrum disorder","score":0.953000009059906},{"id":"https://openalex.org/keywords/oral-liquid-formulation","display_name":"oral liquid formulation","score":0.9679999947547913},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.746999979019165},{"id":"https://openalex.org/keywords/social-reciprocity","display_name":"social reciprocity","score":0.9399999976158142},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.6840000152587891},{"id":"https://openalex.org/keywords/drug-efficacy-and-safety","display_name":"drug safety and efficacy","score":0.6449999809265137},{"id":"https://openalex.org/keywords/phase-iii-clinical-trial-design","display_name":"phase III clinical trial design","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.8550136685371399},{"id":"https://openalex.org/C2778538070","wikidata":"https://www.wikidata.org/wiki/Q1436063","display_name":"Autism spectrum disorder","level":3,"score":0.7439555525779724},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6391239166259766},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.571276843547821},{"id":"https://openalex.org/C2778212192","wikidata":"https://www.wikidata.org/wiki/Q275926","display_name":"Bumetanide","level":4,"score":0.4986250400543213},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.48384132981300354},{"id":"https://openalex.org/C83849319","wikidata":"https://www.wikidata.org/wiki/Q7295720","display_name":"Rating scale","level":2,"score":0.4630447030067444},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.388802707195282},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.34120211005210876},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.31766560673713684},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24461773037910461},{"id":"https://openalex.org/C188053792","wikidata":"https://www.wikidata.org/wiki/Q3640664","display_name":"Cotransporter","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000067877","descriptor_name":"Autism Spectrum Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002034","descriptor_name":"Bumetanide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002034","descriptor_name":"Bumetanide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012919","descriptor_name":"Social Behavior","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10803-020-04709-8","doi":"https://doi.org/10.1007/s10803-020-04709-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10803-020-04709-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10803-020-04709-8.pdf","source":{"id":"https://openalex.org/S181451930","display_name":"Journal of Autism and Developmental Disorders","issn_l":"0162-3257","issn":["0162-3257","1573-3432"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Autism and Developmental Disorders","raw_type":"journal-article"},{"id":"pmid:33151500","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33151500","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of autism and developmental disorders","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8254707","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8254707/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Autism Dev Disord","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10803-020-04709-8","doi":"https://doi.org/10.1007/s10803-020-04709-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10803-020-04709-8","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10803-020-04709-8.pdf","source":{"id":"https://openalex.org/S181451930","display_name":"Journal of Autism and Developmental Disorders","issn_l":"0162-3257","issn":["0162-3257","1573-3432"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Autism and Developmental Disorders","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320327235","display_name":"Servier","ror":"https://ror.org/034e7c066"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4240469607.pdf","grobid_xml":"https://content.openalex.org/works/W4240469607.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W14179519","https://openalex.org/W1613369435","https://openalex.org/W1997388980","https://openalex.org/W2000616772","https://openalex.org/W2007833018","https://openalex.org/W2014310721","https://openalex.org/W2018851253","https://openalex.org/W2020831457","https://openalex.org/W2036544783","https://openalex.org/W2044182049","https://openalex.org/W2045867444","https://openalex.org/W2050947021","https://openalex.org/W2074258117","https://openalex.org/W2078981560","https://openalex.org/W2080580645","https://openalex.org/W2086413948","https://openalex.org/W2089020381","https://openalex.org/W2096512339","https://openalex.org/W2098251401","https://openalex.org/W2104834189","https://openalex.org/W2112163143","https://openalex.org/W2113420497","https://openalex.org/W2119379172","https://openalex.org/W2124474476","https://openalex.org/W2141645563","https://openalex.org/W2143807595","https://openalex.org/W2144236040","https://openalex.org/W2151382043","https://openalex.org/W2151566815","https://openalex.org/W2158738489","https://openalex.org/W2161121393","https://openalex.org/W2165182480","https://openalex.org/W2171607710","https://openalex.org/W2272786625","https://openalex.org/W2280843891","https://openalex.org/W2281288657","https://openalex.org/W2320983896","https://openalex.org/W2336678555","https://openalex.org/W2465837042","https://openalex.org/W2474627757","https://openalex.org/W2537346844","https://openalex.org/W2604697269","https://openalex.org/W2606925384","https://openalex.org/W2748619143","https://openalex.org/W2751884637","https://openalex.org/W2775647200","https://openalex.org/W2799912831","https://openalex.org/W2896314914","https://openalex.org/W2898523669","https://openalex.org/W2910215740","https://openalex.org/W2936336589","https://openalex.org/W2959289532","https://openalex.org/W2964555688","https://openalex.org/W2996077740","https://openalex.org/W3001586219","https://openalex.org/W3045998212","https://openalex.org/W4239498725","https://openalex.org/W4239915163","https://openalex.org/W4247665917"],"related_works":["https://openalex.org/W4220752015","https://openalex.org/W4387357013","https://openalex.org/W2955925429","https://openalex.org/W4285222477","https://openalex.org/W2903304724","https://openalex.org/W3045998212","https://openalex.org/W3116942098","https://openalex.org/W2388717461","https://openalex.org/W7153787227","https://openalex.org/W2995304948"],"abstract_inverted_index":{"There":[0],"are":[1,42],"currently":[2],"no":[3],"approved":[4],"pharmacological":[5,106],"treatments":[6],"to":[7,57,72,103,108],"improve":[8,109],"social":[9,110],"reciprocity":[10,111],"and":[11,14,51,112,115,120],"limit":[12,113],"repetitive":[13,114],"rigid":[15,116],"behaviors":[16,117],"in":[17,39,49,87,118],"autism":[18],"spectrum":[19],"disorder":[20],"(ASD).":[21],"We":[22],"describe":[23],"the":[24,32,104],"design":[25],"of":[26,34,83],"two":[27],"Phase":[28],"III":[29],"studies":[30,48,100],"evaluating":[31],"efficacy/safety":[33],"bumetanide":[35],"oral":[36],"liquid":[37],"formulation":[38],"ASD.":[40,123],"These":[41,99],"international,":[43],"multicenter,":[44],"randomized,":[45],"double-blind,":[46],"placebo-controlled":[47],"children":[50,67,119],"adolescents":[52,121],"with":[53,68,122],"ASD":[54,69],"aged":[55,70],"7":[56],"17":[58],"years":[59,74],"(n":[60,75],"=":[61,76],"200;":[62,77],"study":[63,78],"1),":[64],"or":[65],"younger":[66],"2":[71,92],"6":[73,97],"2).":[79],"The":[80],"primary":[81],"endpoint":[82],"each":[84],"is":[85],"change":[86],"Childhood":[88],"Autism":[89],"Rating":[90],"Scale":[91],"total":[93],"raw":[94],"score":[95],"after":[96],"months.":[98],"could":[101],"contribute":[102],"first":[105],"treatment":[107]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-05-12T00:00:00"}
