{"id":"https://openalex.org/W4240428187","doi":"https://doi.org/10.1017/cbo9781139025997.031","title":"Developmental disorders","display_name":"Developmental disorders","publication_year":2012,"publication_date":"2012-09-13","ids":{"openalex":"https://openalex.org/W4240428187","doi":"https://doi.org/10.1017/cbo9781139025997.031"},"language":"en","primary_location":{"id":"doi:10.1017/cbo9781139025997.031","doi":"https://doi.org/10.1017/cbo9781139025997.031","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9781139025997.031","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Principles of Psychiatric Genetics","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W617123889","display_name":"Principles of Psychiatric Genetics"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012860439","display_name":"Craig A. Erickson","orcid":"https://orcid.org/0000-0003-4512-398X","observed_orcids":["https://orcid.org/0000-0003-4512-398X","https://orcid.org/0000-0002-5878-507X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Craig A. Erickson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056377576","display_name":"Khendra I. Peay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khendra I. Peay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5019555383","display_name":"Christopher J. McDougle","orcid":"https://orcid.org/0000-0002-6229-9293","observed_orcids":["https://orcid.org/0000-0002-6229-9293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher J. McDougle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.46827795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"363","last_page":"370"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5785999894142151,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.5785999894142151,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.1671999990940094,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10576","display_name":"Opioid Use Disorder Treatment","score":0.12330000102519989,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heroin-dependence","display_name":"heroin addiction","score":0.9549999833106995},{"id":"https://openalex.org/keywords/opioid-use-disorder","display_name":"opioid use disorder","score":0.8100000023841858},{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"pharmacogenomics","score":0.8230000138282776},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"genetic variation","score":0.6320000290870667},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mu-opioid-receptor","display_name":"mu-opioid receptor","score":1.0},{"id":"https://openalex.org/keywords/methadone-maintenance-treatment","display_name":"methadone maintenance treatment","score":0.6439999938011169},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"genome-wide association study","score":0.9229999780654907},{"id":"https://openalex.org/keywords/addiction-vulnerability","display_name":"addiction vulnerability","score":0.5860000252723694},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C48856860","wikidata":"https://www.wikidata.org/wiki/Q12029","display_name":"Addiction","level":2,"score":0.7833375334739685},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.5422507524490356},{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.5073172450065613},{"id":"https://openalex.org/C2780421500","wikidata":"https://www.wikidata.org/wiki/Q290620","display_name":"Dysphoria","level":3,"score":0.4815390706062317},{"id":"https://openalex.org/C2778903686","wikidata":"https://www.wikidata.org/wiki/Q60168","display_name":"Heroin","level":3,"score":0.4647265076637268},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4256504774093628},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.394892156124115},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35542482137680054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3471985459327698},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.32353663444519043},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32042598724365234},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.3030846118927002},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.28527605533599854},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.22768360376358032},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.13070818781852722}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1017/cbo9781139025997.031","doi":"https://doi.org/10.1017/cbo9781139025997.031","is_oa":false,"landing_page_url":"https://doi.org/10.1017/cbo9781139025997.031","pdf_url":null,"source":{"id":"https://openalex.org/S4306462995","display_name":"Cambridge University Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Principles of Psychiatric Genetics","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W292964","https://openalex.org/W1559742681","https://openalex.org/W1598430865","https://openalex.org/W1834174605","https://openalex.org/W1982658236","https://openalex.org/W1982857867","https://openalex.org/W1995058974","https://openalex.org/W1998690664","https://openalex.org/W1999095568","https://openalex.org/W2001854167","https://openalex.org/W2002756576","https://openalex.org/W2002760096","https://openalex.org/W2013655994","https://openalex.org/W2015222390","https://openalex.org/W2015246768","https://openalex.org/W2021084125","https://openalex.org/W2026525122","https://openalex.org/W2031785254","https://openalex.org/W2032474463","https://openalex.org/W2034737696","https://openalex.org/W2037063595","https://openalex.org/W2039499622","https://openalex.org/W2043093705","https://openalex.org/W2043323635","https://openalex.org/W2055573605","https://openalex.org/W2055949248","https://openalex.org/W2061234989","https://openalex.org/W2071028205","https://openalex.org/W2073248118","https://openalex.org/W2076850467","https://openalex.org/W2077822383","https://openalex.org/W2078915276","https://openalex.org/W2079866912","https://openalex.org/W2085839244","https://openalex.org/W2088714361","https://openalex.org/W2088931596","https://openalex.org/W2091506047","https://openalex.org/W2092635740","https://openalex.org/W2094993063","https://openalex.org/W2095006822","https://openalex.org/W2097609138","https://openalex.org/W2102983397","https://openalex.org/W2104973872","https://openalex.org/W2105522795","https://openalex.org/W2116276594","https://openalex.org/W2120574495","https://openalex.org/W2122118417","https://openalex.org/W2129134595","https://openalex.org/W2135186193","https://openalex.org/W2158434083","https://openalex.org/W2163364301","https://openalex.org/W2165372186"],"related_works":["https://openalex.org/W2083332683","https://openalex.org/W2012719507","https://openalex.org/W1986653661","https://openalex.org/W2979494576","https://openalex.org/W1677235772","https://openalex.org/W2017977843","https://openalex.org/W2058997795","https://openalex.org/W4285312303","https://openalex.org/W2056114978","https://openalex.org/W2102675531"],"abstract_inverted_index":{"This":[0],"chapter":[1],"presents":[2],"several":[3],"experimental":[4,53],"approaches":[5],"performed":[6,122],"in":[7,47,52,55,89,107],"the":[8,11,18,38,133],"Laboratory":[9],"of":[10,13,20,37,59,92,94,126,135],"Biology":[12],"Addictive":[14],"Diseases":[15],"to":[16,57,86,103,123,132],"characterize":[17],"relationship":[19],"gene":[21],"variations":[22],"with":[23,74],"heroin":[24],"addiction":[25,64],"and":[26,49],"pharmacogenomics.":[27],"Although":[28],"opioid":[29,108],"receptors":[30],"often":[31],"subserve":[32],"similar":[33],"physiological":[34],"functions,":[35],"activation":[36,58],"kappa-opioid":[39],"receptor":[40,61],"(KOPr)":[41],"by":[42],"exogenous":[43],"agonists":[44],"produces":[45],"dysphoria":[46],"humans":[48],"aversive":[50],"effects":[51],"animals,":[54],"contrast":[56],"mu-opioid":[60],"(MOPr).":[62],"Opiate":[63],"is":[65,71],"a":[66],"chronic":[67],"relapsing":[68],"disorder":[69],"that":[70],"treated":[72],"world-wide":[73],"methadone.":[75],"The":[76],"genes":[77,144],"studied":[78],"are":[79],"usually":[80,139],"those":[81],"which":[82,128],"have":[83,110,120],"been":[84,111,121],"shown":[85],"be":[87,104],"involved":[88,106],"some":[90,97],"aspects":[91],"development":[93,134],"addiction.":[95,136],"In":[96,113],"studies,":[98],"multiple":[99],"genes,":[100],"all":[101],"hypothesized":[102],"potentially":[105],"addiction,":[109],"studied.":[112],"other":[114],"cases,":[115],"genome-wide":[116],"association":[117],"studies":[118,138],"(GWAS)":[119],"identify":[124,142],"regions":[125],"chromosomes":[127],"may":[129],"influence":[130],"vulnerability":[131],"These":[137],"do":[140],"not":[141],"specific":[143],"within":[145],"chromosome":[146],"regions.":[147]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2022-05-12T00:00:00"}
