{"id":"https://openalex.org/W4240266901","doi":"https://doi.org/10.3410/f.732875431.793544463","title":"Faculty Opinions recommendation of Insulin resistance in cavefish as an adaptation to a nutrient-limited environment.","display_name":"Faculty Opinions recommendation of Insulin resistance in cavefish as an adaptation to a nutrient-limited environment.","publication_year":2018,"publication_date":"2018-04-04","ids":{"openalex":"https://openalex.org/W4240266901","doi":"https://doi.org/10.3410/f.732875431.793544463"},"language":"en","primary_location":{"id":"doi:10.3410/f.732875431.793544463","doi":"https://doi.org/10.3410/f.732875431.793544463","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.732875431.793544463","pdf_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989729/pdf/nihms969509.pdf","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989729/pdf/nihms969509.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018907985","display_name":"Malcolm Maden","orcid":"https://orcid.org/0000-0001-7178-5309","observed_orcids":["https://orcid.org/0000-0001-7178-5309"]},"institutions":[{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Malcolm Maden","raw_affiliation_strings":["Department of Biology & UF Genetics Institute, University of Florida, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology & UF Genetics Institute, University of Florida, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018907985"],"corresponding_institution_ids":["https://openalex.org/I33213144"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11926","display_name":"Subterranean biodiversity and taxonomy","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1911","display_name":"Paleontology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11926","display_name":"Subterranean biodiversity and taxonomy","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1911","display_name":"Paleontology"},"field":{"id":"https://openalex.org/fields/19","display_name":"Earth and Planetary Sciences"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cavefish","display_name":"cavefish","score":0.9769999980926514},{"id":"https://openalex.org/keywords/astyanax-mexicanus","display_name":"Astyanax mexicanus","score":0.996999979019165},{"id":"https://openalex.org/keywords/insulin-receptor-mutations","display_name":"insulin receptor mutations","score":0.9049999713897705},{"id":"https://openalex.org/keywords/blood-glucose-homeostasis","display_name":"blood glucose homeostasis","score":0.8870000243186951},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9359999895095825},{"id":"https://openalex.org/keywords/nutrient-starvation","display_name":"nutrient deprivation","score":0.765999972820282},{"id":"https://openalex.org/keywords/cave-adaptation","display_name":"cave adaptation","score":0.6489999890327454},{"id":"https://openalex.org/keywords/body-weight","display_name":"body weight","score":0.6819999814033508},{"id":"https://openalex.org/keywords/advanced-glycation-end-products","display_name":"advanced glycation end products","score":0.824999988079071},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6140000224113464},{"id":"https://openalex.org/keywords/hybrid-fish","display_name":"hybrid fish","score":0.3630000054836273},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.7880535125732422},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.6712176203727722},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5036908984184265},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4822326600551605},{"id":"https://openalex.org/C142796444","wikidata":"https://www.wikidata.org/wiki/Q181394","display_name":"Nutrient","level":2,"score":0.46596458554267883},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3496793508529663},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3242201805114746},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.2916540205478668},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.2628193199634552},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2613255977630615},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.2468114197254181}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.732875431.793544463","doi":"https://doi.org/10.3410/f.732875431.793544463","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.732875431.793544463","pdf_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989729/pdf/nihms969509.pdf","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":{"id":"doi:10.3410/f.732875431.793544463","doi":"https://doi.org/10.3410/f.732875431.793544463","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.732875431.793544463","pdf_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989729/pdf/nihms969509.pdf","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2573037136","display_name":"Integration of Mechanical Forces and Signaling in the Morphogenesis of the Gut","funder_award_id":"R01HD089934","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G766254292","display_name":null,"funder_award_id":"PE 2807/1-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G8861390639","display_name":"Investigating the physiological mechanisms that allow the blind cavefish Astyanax mexicanus to thrive in a low nutrient environment","funder_award_id":"F32DK108495","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4240266901.pdf","grobid_xml":"https://content.openalex.org/works/W4240266901.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1532215545","https://openalex.org/W1539118047","https://openalex.org/W1587026990","https://openalex.org/W1869105380","https://openalex.org/W1919257374","https://openalex.org/W1969264427","https://openalex.org/W1973358400","https://openalex.org/W1980763614","https://openalex.org/W1999109874","https://openalex.org/W2007455703","https://openalex.org/W2014887370","https://openalex.org/W2020775714","https://openalex.org/W2022343395","https://openalex.org/W2024499299","https://openalex.org/W2036897871","https://openalex.org/W2037637732","https://openalex.org/W2037940400","https://openalex.org/W2074454145","https://openalex.org/W2091712368","https://openalex.org/W2092817365","https://openalex.org/W2100422758","https://openalex.org/W2121937735","https://openalex.org/W2131271579","https://openalex.org/W2149992227","https://openalex.org/W2156369645","https://openalex.org/W2160018509","https://openalex.org/W2333911194","https://openalex.org/W2509220708","https://openalex.org/W2541640046","https://openalex.org/W2594626182","https://openalex.org/W2773481792","https://openalex.org/W3022542742","https://openalex.org/W4247053599","https://openalex.org/W4252828689"],"related_works":["https://openalex.org/W2749109001","https://openalex.org/W2808067338","https://openalex.org/W2791756715","https://openalex.org/W7216226485","https://openalex.org/W2914681522","https://openalex.org/W4224261336","https://openalex.org/W2956578905","https://openalex.org/W7212701","https://openalex.org/W7163153021","https://openalex.org/W3020302237"],"abstract_inverted_index":{"Periodic":[0],"food":[1,125],"shortages":[2],"are":[3,54,166],"a":[4,66,118,137,148,184],"major":[5],"challenge":[6],"faced":[7],"by":[8],"organisms":[9],"in":[10,68,78,115,131,162,183],"natural":[11],"habitats.Cavedwelling":[12],"animals":[13],"must":[14],"withstand":[15],"long":[16],"periods":[17],"of":[18,24,42,140,172],"nutrient":[19],"deprivation,":[20],"as-in":[21],"the":[22,43,69,101,128,132,158,163,170,200],"absence":[23],"photosynthesis-caves":[25],"depend":[26],"on":[27],"external":[28],"energy":[29],"sources":[30],"such":[31],"as":[32,117],"seasonal":[33],"floods":[34],"1":[35],".Here":[36],"we":[37],"show":[38],"that":[39,61,72,165,177,188,195],"cave-adapted":[40],"populations":[41,64],"Mexican":[44],"tetra,":[45],"Astyanax":[46],"mexicanus,":[47],"have":[48,103,147,191],"dysregulated":[49],"blood":[50,164,209],"glucose":[51,210],"homeostasis":[52],"and":[53,80,95,107,143,154,187],"insulin-resistant":[55],"compared":[56],"to":[57,74,82,99,120,136,151,198,207],"river-adapted":[58],"populations.We":[59],"found":[60],"multiple":[62],"cave":[63],"carry":[65,100],"mutation":[67,90,102,130],"insulin":[70,76,108,133,141,179],"receptor":[71,134],"leads":[73,135],"decreased":[75],"binding":[77],"vitro":[79],"contributes":[81],"hyperglycaemia.Hybrid":[83],"fish":[84,153],"from":[85],"surface-cave":[86],"crosses":[87],"carrying":[88],"this":[89],"weigh":[91],"more":[92],"than":[93],"non-carriers,":[94],"zebrafish":[96],"genetically":[97],"engineered":[98],"increased":[104],"body":[105,110],"weight":[106,111],"resistance.Higher":[109],"may":[112,190],"be":[113],"advantageous":[114],"caves":[116],"strategy":[119],"cope":[121],"with":[122,169,205],"an":[123],"infrequent":[124],"supply.In":[126],"humans,":[127],"identical":[129],"severe":[138],"form":[139],"resistance":[142],"reduced":[144],"lifespan.However,":[145],"cavefish":[146,189],"similar":[149],"lifespan":[150],"surface":[152],"do":[155],"not":[156],"accumulate":[157],"advanced":[159],"glycation":[160],"end-products":[161],"typically":[167],"associated":[168,204],"progression":[171],"diabetes-associated":[173],"pathologies.Our":[174],"findings":[175],"suggest":[176],"diminished":[178],"signalling":[180],"is":[181],"beneficial":[182],"nutrient-limited":[185],"environment":[186],"acquired":[192],"compensatory":[193],"mechanisms":[194],"enable":[196],"them":[197],"circumvent":[199],"typical":[201],"negative":[202],"effects":[203],"failure":[206],"regulate":[208],"levels.":[211]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-05-12T00:00:00"}
